Incidental Mutation 'IGL01399:Klf17'
ID 79584
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klf17
Ensembl Gene ENSMUSG00000048626
Gene Name Kruppel-like factor 17
Synonyms D4Ertd561e, 7420700M05Rik, Zfp393
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01399
Quality Score
Status
Chromosome 4
Chromosomal Location 117757836-117765648 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 117759159 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 325 (F325S)
Ref Sequence ENSEMBL: ENSMUSP00000052316 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062747]
AlphaFold Q8CFA7
Predicted Effect probably damaging
Transcript: ENSMUST00000062747
AA Change: F325S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000052316
Gene: ENSMUSG00000048626
AA Change: F325S

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 142 157 N/A INTRINSIC
low complexity region 202 213 N/A INTRINSIC
ZnF_C2H2 256 280 4.47e-3 SMART
ZnF_C2H2 286 310 1.92e-2 SMART
ZnF_C2H2 316 338 1.1e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apol11b G A 15: 77,638,019 T26M probably damaging Het
Asic4 T A 1: 75,469,146 N206K possibly damaging Het
Bsn A G 9: 108,107,187 Y3223H unknown Het
Btaf1 C T 19: 37,000,170 R1463* probably null Het
Ccdc146 A G 5: 21,294,613 I857T possibly damaging Het
Ccnf G A 17: 24,225,012 S594L probably damaging Het
Chd5 T C 4: 152,356,687 W195R probably damaging Het
Cntn1 A G 15: 92,305,144 Y769C probably damaging Het
Cwc22 T C 2: 77,917,064 E435G probably benign Het
Dct A G 14: 118,036,478 F339S probably damaging Het
Ddx54 G T 5: 120,623,903 E554* probably null Het
Dock3 G T 9: 106,993,471 S581R probably benign Het
Dst A G 1: 34,117,517 H176R probably benign Het
Emc8 A G 8: 120,659,006 M123T probably damaging Het
Evc T A 5: 37,333,013 D55V probably damaging Het
Gm5424 A G 10: 62,071,493 noncoding transcript Het
Gpr149 A T 3: 62,604,431 L49Q probably damaging Het
Hcfc1 C T X: 73,949,909 V1217I possibly damaging Het
Hoxa4 G T 6: 52,190,413 Q263K probably damaging Het
Ift172 T C 5: 31,266,248 E790G probably benign Het
Ipp A G 4: 116,515,187 N138D probably damaging Het
Isg20 A T 7: 78,920,088 T158S possibly damaging Het
Lilrb4a T C 10: 51,494,065 L233P probably benign Het
Malrd1 G A 2: 16,101,957 probably null Het
Myh9 A T 15: 77,767,270 L1544Q probably damaging Het
Nexmif T A X: 104,087,180 D377V probably damaging Het
Nobox T C 6: 43,304,038 T501A probably benign Het
Noc3l T C 19: 38,815,655 D93G possibly damaging Het
Nrcam G T 12: 44,575,884 A938S probably benign Het
Nup205 T C 6: 35,219,689 I1120T possibly damaging Het
Olfr1446 A T 19: 12,890,439 M46K probably benign Het
Olfr186 C T 16: 59,027,266 V214I probably benign Het
Ptpn3 T C 4: 57,225,775 D480G probably benign Het
Selenof C T 3: 144,596,908 T148I probably damaging Het
Sgce C A 6: 4,746,997 G31V probably damaging Het
Slc35e1 C A 8: 72,484,690 A325S probably damaging Het
Slc4a4 A G 5: 89,228,935 D1016G probably damaging Het
Synj2 T G 17: 6,009,771 C149W probably damaging Het
Tecpr1 A G 5: 144,208,593 probably null Het
Utp20 A G 10: 88,758,302 probably null Het
Vmn2r63 T A 7: 42,904,119 K571M probably damaging Het
Wdr53 A G 16: 32,251,900 D21G possibly damaging Het
Zbtb3 T C 19: 8,803,455 L144S probably damaging Het
Zfp185 T A X: 73,000,048 S154T probably damaging Het
Other mutations in Klf17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Klf17 APN 4 117761038 missense probably benign 0.06
R0047:Klf17 UTSW 4 117761032 missense probably benign 0.00
R0051:Klf17 UTSW 4 117760392 missense probably damaging 1.00
R0051:Klf17 UTSW 4 117760392 missense probably damaging 1.00
R1513:Klf17 UTSW 4 117760935 missense probably damaging 0.96
R3103:Klf17 UTSW 4 117760608 missense possibly damaging 0.72
R4112:Klf17 UTSW 4 117760701 missense possibly damaging 0.85
R4180:Klf17 UTSW 4 117759186 missense probably benign 0.14
R4669:Klf17 UTSW 4 117760371 missense probably damaging 1.00
R4715:Klf17 UTSW 4 117760536 missense probably benign 0.44
R5063:Klf17 UTSW 4 117760659 missense possibly damaging 0.85
R7578:Klf17 UTSW 4 117760719 missense possibly damaging 0.85
R7765:Klf17 UTSW 4 117760615 missense probably benign 0.08
R9041:Klf17 UTSW 4 117760359 missense probably damaging 1.00
Z1176:Klf17 UTSW 4 117760351 missense probably benign 0.06
Posted On 2013-11-05