Incidental Mutation 'IGL01401:Olfr159'
ID79628
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr159
Ensembl Gene ENSMUSG00000044801
Gene Nameolfactory receptor 159
SynonymsOlfr37e, mOR37e, MOR262-5, GA_x6K02T2N78B-16165641-16166600
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.120) question?
Stock #IGL01401
Quality Score
Status
Chromosome4
Chromosomal Location43770050-43771009 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 43770112 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glycine at position 300 (R300G)
Ref Sequence ENSEMBL: ENSMUSP00000060784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053931]
Predicted Effect probably damaging
Transcript: ENSMUST00000053931
AA Change: R300G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000060784
Gene: ENSMUSG00000044801
AA Change: R300G

DomainStartEndE-ValueType
Pfam:7tm_4 32 315 6.9e-60 PFAM
Pfam:7tm_1 42 297 2.4e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120783
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810474O19Rik A G 6: 149,326,896 E480G probably damaging Het
4932438A13Rik A G 3: 36,942,292 N1051S probably benign Het
Adgrl3 T C 5: 81,688,669 V758A possibly damaging Het
Arf4 T C 14: 26,638,454 L12P probably damaging Het
C4bp A T 1: 130,648,064 V230E possibly damaging Het
Carm1 T A 9: 21,569,582 probably null Het
Cd4 G A 6: 124,879,378 T50I probably benign Het
Ceacam16 T C 7: 19,861,129 Y8C probably benign Het
Ckap2l A T 2: 129,269,216 V687E probably damaging Het
Dcaf4 A G 12: 83,541,374 D449G probably damaging Het
Dhx38 T C 8: 109,552,114 Y1113C probably benign Het
Fry A G 5: 150,438,788 I161V probably benign Het
Gm17093 A C 14: 44,521,527 M169L unknown Het
Gm20721 A G 2: 174,345,502 D999G probably damaging Het
Grin2b T C 6: 135,736,363 H840R probably damaging Het
Hoxc12 C A 15: 102,937,320 H156Q probably benign Het
Htr3b T C 9: 48,947,634 D68G probably damaging Het
Inpp5b T C 4: 124,746,087 V99A probably damaging Het
Klhl42 C T 6: 147,107,743 T360M probably benign Het
Lmo7 C T 14: 101,794,277 R36* probably null Het
Lmod3 T G 6: 97,252,552 N7T probably damaging Het
Malrd1 G A 2: 16,101,957 probably null Het
Mthfd2l T A 5: 91,000,566 I284K possibly damaging Het
Myo1e T A 9: 70,327,166 I267N probably damaging Het
Olfr1393 T A 11: 49,280,487 V113E possibly damaging Het
Prkce T C 17: 86,168,840 V83A probably damaging Het
Pxdn G T 12: 30,001,984 C540F probably damaging Het
Ryr2 T A 13: 11,591,352 E4448V possibly damaging Het
Scn1a A T 2: 66,289,111 N1349K probably damaging Het
Smarcc1 T C 9: 110,149,965 I172T possibly damaging Het
Syt16 T C 12: 74,222,663 V92A possibly damaging Het
Tenm4 A G 7: 96,874,267 Y1672C probably damaging Het
Tmem131 A G 1: 36,799,387 Y1486H probably damaging Het
Tmem132a A G 19: 10,861,524 probably benign Het
Usp40 A T 1: 87,994,198 D314E probably damaging Het
Vmn2r79 G A 7: 87,037,273 V621I probably benign Het
Wnk4 A G 11: 101,276,683 probably benign Het
Wwc1 C A 11: 35,898,618 probably null Het
Other mutations in Olfr159
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02701:Olfr159 APN 4 43770366 missense probably benign 0.31
IGL02839:Olfr159 APN 4 43770943 nonsense probably null
IGL02956:Olfr159 APN 4 43770399 missense probably benign 0.15
IGL03058:Olfr159 APN 4 43770255 missense probably damaging 1.00
R1164:Olfr159 UTSW 4 43770991 missense probably benign 0.03
R1796:Olfr159 UTSW 4 43770495 missense possibly damaging 0.90
R1812:Olfr159 UTSW 4 43770230 nonsense probably null
R4906:Olfr159 UTSW 4 43770476 missense possibly damaging 0.76
R5426:Olfr159 UTSW 4 43770168 missense probably benign 0.04
R5684:Olfr159 UTSW 4 43770624 missense probably benign 0.03
R6002:Olfr159 UTSW 4 43770063 missense probably benign
R7174:Olfr159 UTSW 4 43770691 missense not run
R7431:Olfr159 UTSW 4 43770882 missense probably damaging 1.00
R8423:Olfr159 UTSW 4 43770598 missense possibly damaging 0.65
R8770:Olfr159 UTSW 4 43770813 missense probably damaging 1.00
R8789:Olfr159 UTSW 4 43770793 missense probably damaging 0.96
Z1176:Olfr159 UTSW 4 43770267 missense probably damaging 1.00
Posted On2013-11-05