Incidental Mutation 'IGL01401:Ckap2l'
| ID |
79638 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ckap2l
|
| Ensembl Gene |
ENSMUSG00000048327 |
| Gene Name |
cytoskeleton associated protein 2-like |
| Synonyms |
Radmis, 2010016H04Rik, 2610318C08Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.263)
|
| Stock # |
IGL01401
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
129110130-129139132 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 129111136 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 687
(V687E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000056145
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000052708]
|
| AlphaFold |
Q7TS74 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000052708
AA Change: V687E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000056145
Gene: ENSMUSG00000048327
AA Change: V687E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
58 |
N/A |
INTRINSIC |
|
Pfam:CKAP2_C
|
425 |
644 |
3e-32 |
PFAM |
|
Pfam:CKAP2_C
|
675 |
734 |
6.9e-18 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141964
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrl3 |
T |
C |
5: 81,836,516 (GRCm39) |
V758A |
possibly damaging |
Het |
| Arf4 |
T |
C |
14: 26,359,609 (GRCm39) |
L12P |
probably damaging |
Het |
| Bltp1 |
A |
G |
3: 36,996,441 (GRCm39) |
N1051S |
probably benign |
Het |
| C4bp |
A |
T |
1: 130,575,801 (GRCm39) |
V230E |
possibly damaging |
Het |
| Carm1 |
T |
A |
9: 21,480,878 (GRCm39) |
|
probably null |
Het |
| Cd4 |
G |
A |
6: 124,856,341 (GRCm39) |
T50I |
probably benign |
Het |
| Ceacam16 |
T |
C |
7: 19,595,054 (GRCm39) |
Y8C |
probably benign |
Het |
| Dcaf4 |
A |
G |
12: 83,588,148 (GRCm39) |
D449G |
probably damaging |
Het |
| Dhx38 |
T |
C |
8: 110,278,746 (GRCm39) |
Y1113C |
probably benign |
Het |
| Fry |
A |
G |
5: 150,362,253 (GRCm39) |
I161V |
probably benign |
Het |
| Gm17093 |
A |
C |
14: 44,758,984 (GRCm39) |
M169L |
unknown |
Het |
| Gm20721 |
A |
G |
2: 174,187,295 (GRCm39) |
D999G |
probably damaging |
Het |
| Grin2b |
T |
C |
6: 135,713,361 (GRCm39) |
H840R |
probably damaging |
Het |
| Hoxc12 |
C |
A |
15: 102,845,755 (GRCm39) |
H156Q |
probably benign |
Het |
| Htr3b |
T |
C |
9: 48,858,934 (GRCm39) |
D68G |
probably damaging |
Het |
| Inpp5b |
T |
C |
4: 124,639,880 (GRCm39) |
V99A |
probably damaging |
Het |
| Klhl42 |
C |
T |
6: 147,009,241 (GRCm39) |
T360M |
probably benign |
Het |
| Lmo7 |
C |
T |
14: 102,031,713 (GRCm39) |
R36* |
probably null |
Het |
| Lmod3 |
T |
G |
6: 97,229,513 (GRCm39) |
N7T |
probably damaging |
Het |
| Malrd1 |
G |
A |
2: 16,106,768 (GRCm39) |
|
probably null |
Het |
| Mthfd2l |
T |
A |
5: 91,148,425 (GRCm39) |
I284K |
possibly damaging |
Het |
| Myo1e |
T |
A |
9: 70,234,448 (GRCm39) |
I267N |
probably damaging |
Het |
| Or13c7d |
T |
C |
4: 43,770,112 (GRCm39) |
R300G |
probably damaging |
Het |
| Or2y1g |
T |
A |
11: 49,171,314 (GRCm39) |
V113E |
possibly damaging |
Het |
| Prkce |
T |
C |
17: 86,476,268 (GRCm39) |
V83A |
probably damaging |
Het |
| Pxdn |
G |
T |
12: 30,051,983 (GRCm39) |
C540F |
probably damaging |
Het |
| Resf1 |
A |
G |
6: 149,228,394 (GRCm39) |
E480G |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,606,238 (GRCm39) |
E4448V |
possibly damaging |
Het |
| Scn1a |
A |
T |
2: 66,119,455 (GRCm39) |
N1349K |
probably damaging |
Het |
| Smarcc1 |
T |
C |
9: 109,979,033 (GRCm39) |
I172T |
possibly damaging |
Het |
| Syt16 |
T |
C |
12: 74,269,437 (GRCm39) |
V92A |
possibly damaging |
Het |
| Tenm4 |
A |
G |
7: 96,523,474 (GRCm39) |
Y1672C |
probably damaging |
Het |
| Tmem131 |
A |
G |
1: 36,838,468 (GRCm39) |
Y1486H |
probably damaging |
Het |
| Tmem132a |
A |
G |
19: 10,838,888 (GRCm39) |
|
probably benign |
Het |
| Usp40 |
A |
T |
1: 87,921,920 (GRCm39) |
D314E |
probably damaging |
Het |
| Vmn2r79 |
G |
A |
7: 86,686,481 (GRCm39) |
V621I |
probably benign |
Het |
| Wnk4 |
A |
G |
11: 101,167,509 (GRCm39) |
|
probably benign |
Het |
| Wwc1 |
C |
A |
11: 35,789,445 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Ckap2l |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02120:Ckap2l
|
APN |
2 |
129,127,542 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03085:Ckap2l
|
APN |
2 |
129,126,967 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03175:Ckap2l
|
APN |
2 |
129,127,437 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03333:Ckap2l
|
APN |
2 |
129,138,228 (GRCm39) |
splice site |
probably null |
|
|
R0196:Ckap2l
|
UTSW |
2 |
129,127,342 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0501:Ckap2l
|
UTSW |
2 |
129,127,411 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0715:Ckap2l
|
UTSW |
2 |
129,127,636 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0834:Ckap2l
|
UTSW |
2 |
129,138,224 (GRCm39) |
splice site |
probably benign |
|
|
R1119:Ckap2l
|
UTSW |
2 |
129,114,492 (GRCm39) |
splice site |
probably benign |
|
|
R1561:Ckap2l
|
UTSW |
2 |
129,112,645 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1677:Ckap2l
|
UTSW |
2 |
129,127,087 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1823:Ckap2l
|
UTSW |
2 |
129,117,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Ckap2l
|
UTSW |
2 |
129,127,342 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4803:Ckap2l
|
UTSW |
2 |
129,111,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Ckap2l
|
UTSW |
2 |
129,127,389 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5264:Ckap2l
|
UTSW |
2 |
129,127,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5297:Ckap2l
|
UTSW |
2 |
129,127,290 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R5535:Ckap2l
|
UTSW |
2 |
129,127,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5606:Ckap2l
|
UTSW |
2 |
129,127,959 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6327:Ckap2l
|
UTSW |
2 |
129,127,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6489:Ckap2l
|
UTSW |
2 |
129,111,034 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6726:Ckap2l
|
UTSW |
2 |
129,111,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Ckap2l
|
UTSW |
2 |
129,126,975 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7220:Ckap2l
|
UTSW |
2 |
129,117,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7329:Ckap2l
|
UTSW |
2 |
129,127,284 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7374:Ckap2l
|
UTSW |
2 |
129,126,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7383:Ckap2l
|
UTSW |
2 |
129,111,172 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7484:Ckap2l
|
UTSW |
2 |
129,114,455 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7611:Ckap2l
|
UTSW |
2 |
129,127,600 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7868:Ckap2l
|
UTSW |
2 |
129,127,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Ckap2l
|
UTSW |
2 |
129,126,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8514:Ckap2l
|
UTSW |
2 |
129,127,788 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8790:Ckap2l
|
UTSW |
2 |
129,111,172 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9043:Ckap2l
|
UTSW |
2 |
129,126,892 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9215:Ckap2l
|
UTSW |
2 |
129,123,826 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9496:Ckap2l
|
UTSW |
2 |
129,112,595 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9526:Ckap2l
|
UTSW |
2 |
129,111,161 (GRCm39) |
nonsense |
probably null |
|
|
RF037:Ckap2l
|
UTSW |
2 |
129,112,569 (GRCm39) |
small deletion |
probably benign |
|
|
Z1176:Ckap2l
|
UTSW |
2 |
129,127,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-11-05 |
Incidental Mutation