Incidental Mutation 'IGL01402:Tgm4'
ID 79688
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tgm4
Ensembl Gene ENSMUSG00000025787
Gene Name transglutaminase 4 (prostate)
Synonyms Eapa1, 9530008N10Rik, experimental autoimmune prostatitis antigen 1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL01402
Quality Score
Status
Chromosome 9
Chromosomal Location 122863806-122896623 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 122880519 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 307 (K307E)
Ref Sequence ENSEMBL: ENSMUSP00000026893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026893] [ENSMUST00000215247] [ENSMUST00000217607]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000026893
AA Change: K307E

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000026893
Gene: ENSMUSG00000025787
AA Change: K307E

DomainStartEndE-ValueType
Pfam:Transglut_N 8 118 4e-26 PFAM
TGc 247 340 6.25e-42 SMART
Pfam:Transglut_C 573 670 3e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128572
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171897
Predicted Effect probably benign
Transcript: ENSMUST00000215247
Predicted Effect probably benign
Transcript: ENSMUST00000217607
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired copulatory plug formation, reduced fertilization and few litters sired. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T C 18: 6,638,653 (GRCm39) S351P possibly damaging Het
Abca2 T C 2: 25,332,015 (GRCm39) S1376P probably damaging Het
Ablim3 A G 18: 62,004,754 (GRCm39) Y12H probably damaging Het
Akr1b7 A G 6: 34,398,052 (GRCm39) R294G possibly damaging Het
Aldh3b1 A C 19: 3,971,205 (GRCm39) V153G probably benign Het
Alk A T 17: 72,181,173 (GRCm39) H1372Q probably damaging Het
Ano9 A C 7: 140,681,955 (GRCm39) Y731* probably null Het
Apol11b G A 15: 77,522,219 (GRCm39) T26M probably damaging Het
Asl T C 5: 130,048,645 (GRCm39) E43G probably damaging Het
Cd4 G A 6: 124,856,341 (GRCm39) T50I probably benign Het
Cfap43 T C 19: 47,784,105 (GRCm39) D476G probably benign Het
Cpa1 A G 6: 30,645,275 (GRCm39) H417R possibly damaging Het
Cpeb3 T C 19: 37,065,948 (GRCm39) D407G probably benign Het
Dcaf15 A T 8: 84,825,026 (GRCm39) C469S probably damaging Het
Dpy19l4 C A 4: 11,273,006 (GRCm39) probably null Het
E4f1 A T 17: 24,663,208 (GRCm39) L699Q probably damaging Het
Eif4g2 A G 7: 110,676,234 (GRCm39) F349S possibly damaging Het
Ermap T C 4: 119,044,355 (GRCm39) Y147C probably damaging Het
Frk A C 10: 34,423,381 (GRCm39) E153A probably damaging Het
Fubp3 G A 2: 31,494,733 (GRCm39) probably null Het
Gdi2 A G 13: 3,614,611 (GRCm39) T319A probably benign Het
Gjc3 A G 5: 137,956,120 (GRCm39) F55S probably damaging Het
Gm10762 C T 2: 128,809,005 (GRCm39) probably benign Het
Got1 A G 19: 43,493,048 (GRCm39) I291T possibly damaging Het
Gpr179 C A 11: 97,229,012 (GRCm39) G1048* probably null Het
Hectd3 G T 4: 116,853,262 (GRCm39) R163L probably damaging Het
Hectd4 T C 5: 121,477,480 (GRCm39) probably benign Het
Ifnb1 T C 4: 88,440,480 (GRCm39) R178G probably benign Het
Ino80 T A 2: 119,287,199 (GRCm39) D56V possibly damaging Het
Kctd1 T A 18: 15,102,610 (GRCm39) Q857L probably damaging Het
Kdm5a T A 6: 120,367,640 (GRCm39) L445* probably null Het
Lins1 G A 7: 66,363,676 (GRCm39) V524I probably damaging Het
Lrp1 A T 10: 127,430,901 (GRCm39) Y383N probably damaging Het
Malrd1 G A 2: 16,106,768 (GRCm39) probably null Het
Mgam A C 6: 40,621,879 (GRCm39) K84Q probably benign Het
Mlh3 A T 12: 85,314,703 (GRCm39) F494L probably benign Het
Mpped1 T C 15: 83,676,414 (GRCm39) F60S possibly damaging Het
Myo1e A G 9: 70,245,048 (GRCm39) Y382C probably benign Het
Ncor1 C A 11: 62,231,300 (GRCm39) V836F probably damaging Het
Nktr G A 9: 121,570,218 (GRCm39) probably null Het
Or10al4 A G 17: 38,037,193 (GRCm39) T93A probably benign Het
Or4d5 A G 9: 40,012,558 (GRCm39) I76T probably benign Het
Or5k8 G A 16: 58,644,958 (GRCm39) T38I probably damaging Het
Rnf144a T A 12: 26,377,300 (GRCm39) Y93F probably benign Het
Rubcn G A 16: 32,647,666 (GRCm39) T636M probably damaging Het
Scn5a A C 9: 119,315,536 (GRCm39) L1724R probably damaging Het
Sel1l A G 12: 91,808,607 (GRCm39) S45P possibly damaging Het
Serpina3k A G 12: 104,306,882 (GRCm39) D38G probably benign Het
Sh3bgr A C 16: 96,007,690 (GRCm39) K18N probably damaging Het
Slc28a2 T G 2: 122,282,538 (GRCm39) I287M probably damaging Het
St8sia6 T C 2: 13,670,318 (GRCm39) N214S probably damaging Het
Syt11 A G 3: 88,669,523 (GRCm39) I123T probably benign Het
Tcerg1l A T 7: 137,861,568 (GRCm39) I387N probably damaging Het
Tfg C A 16: 56,514,856 (GRCm39) probably benign Het
Tmem177 T C 1: 119,837,791 (GRCm39) D296G probably damaging Het
Tmem270 C T 5: 134,930,763 (GRCm39) probably benign Het
Tnrc6b G T 15: 80,764,745 (GRCm39) G749V possibly damaging Het
Trp63 C A 16: 25,639,135 (GRCm39) probably benign Het
Ugt1a8 T C 1: 88,015,617 (GRCm39) L10P probably benign Het
Vmn2r107 A T 17: 20,596,009 (GRCm39) K854M probably damaging Het
Vmn2r45 T C 7: 8,484,467 (GRCm39) N446S probably damaging Het
Vps13c A T 9: 67,820,486 (GRCm39) probably null Het
Wdr91 G A 6: 34,865,998 (GRCm39) P518L probably benign Het
Yap1 G A 9: 7,934,742 (GRCm39) probably benign Het
Zfp282 A C 6: 47,874,770 (GRCm39) D325A probably damaging Het
Other mutations in Tgm4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Tgm4 APN 9 122,891,447 (GRCm39) unclassified probably benign
IGL02000:Tgm4 APN 9 122,885,531 (GRCm39) missense probably damaging 1.00
IGL02120:Tgm4 APN 9 122,875,594 (GRCm39) missense probably damaging 0.98
IGL03130:Tgm4 APN 9 122,885,580 (GRCm39) missense probably damaging 1.00
IGL03188:Tgm4 APN 9 122,874,101 (GRCm39) missense probably null 0.06
R0329:Tgm4 UTSW 9 122,877,622 (GRCm39) critical splice donor site probably null
R0480:Tgm4 UTSW 9 122,891,484 (GRCm39) missense probably benign
R0644:Tgm4 UTSW 9 122,880,523 (GRCm39) missense probably damaging 1.00
R0990:Tgm4 UTSW 9 122,875,576 (GRCm39) missense probably benign 0.02
R1604:Tgm4 UTSW 9 122,874,129 (GRCm39) missense probably benign 0.39
R1644:Tgm4 UTSW 9 122,880,481 (GRCm39) missense probably damaging 1.00
R2056:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2058:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2059:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2076:Tgm4 UTSW 9 122,880,160 (GRCm39) missense probably benign 0.24
R2437:Tgm4 UTSW 9 122,877,614 (GRCm39) nonsense probably null
R4392:Tgm4 UTSW 9 122,895,817 (GRCm39) missense probably benign 0.10
R4407:Tgm4 UTSW 9 122,885,595 (GRCm39) missense probably damaging 1.00
R4752:Tgm4 UTSW 9 122,880,451 (GRCm39) missense probably damaging 1.00
R5288:Tgm4 UTSW 9 122,885,559 (GRCm39) missense probably damaging 1.00
R5365:Tgm4 UTSW 9 122,895,866 (GRCm39) missense probably damaging 1.00
R5386:Tgm4 UTSW 9 122,885,559 (GRCm39) missense probably damaging 1.00
R5790:Tgm4 UTSW 9 122,890,808 (GRCm39) missense probably damaging 0.98
R5890:Tgm4 UTSW 9 122,890,703 (GRCm39) missense probably damaging 1.00
R6102:Tgm4 UTSW 9 122,885,600 (GRCm39) missense probably benign
R6358:Tgm4 UTSW 9 122,885,583 (GRCm39) missense probably damaging 1.00
R6956:Tgm4 UTSW 9 122,893,768 (GRCm39) missense possibly damaging 0.93
R6966:Tgm4 UTSW 9 122,880,207 (GRCm39) missense possibly damaging 0.68
R7091:Tgm4 UTSW 9 122,869,525 (GRCm39) missense probably damaging 1.00
R7258:Tgm4 UTSW 9 122,891,556 (GRCm39) missense probably benign 0.02
R7313:Tgm4 UTSW 9 122,891,556 (GRCm39) missense probably benign 0.02
R7369:Tgm4 UTSW 9 122,885,749 (GRCm39) critical splice donor site probably null
R7802:Tgm4 UTSW 9 122,880,401 (GRCm39) intron probably benign
R8219:Tgm4 UTSW 9 122,874,117 (GRCm39) missense probably benign
R8787:Tgm4 UTSW 9 122,890,910 (GRCm39) missense probably damaging 1.00
R8936:Tgm4 UTSW 9 122,869,541 (GRCm39) missense possibly damaging 0.92
R9045:Tgm4 UTSW 9 122,877,616 (GRCm39) missense possibly damaging 0.94
R9328:Tgm4 UTSW 9 122,885,697 (GRCm39) missense possibly damaging 0.93
R9359:Tgm4 UTSW 9 122,881,837 (GRCm39) missense probably damaging 1.00
R9403:Tgm4 UTSW 9 122,881,837 (GRCm39) missense probably damaging 1.00
R9471:Tgm4 UTSW 9 122,869,444 (GRCm39) missense probably benign
R9746:Tgm4 UTSW 9 122,875,634 (GRCm39) missense possibly damaging 0.95
Posted On 2013-11-05