Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01403:Ly6g'

79691

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ly6g

Ensembl Gene

ENSMUSG00000022582

Gene Name

lymphocyte antigen 6 complex, locus G

Synonyms

Gr1, Ly-6G, Gr-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL01403

Quality Score

Status

Chromosome

Chromosomal Location

75155240-75159126 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 75158648 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 82 (N82S)

Ref Sequence

ENSEMBL: ENSMUSP00000023246 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023246] [ENSMUST00000190262]

AlphaFold

P35461

Predicted Effect

probably damaging
Transcript: ENSMUST00000023246
AA Change: N82S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000023246
Gene: ENSMUSG00000022582
AA Change: N82S

Domain	Start	End	E-Value	Type
LU	4	95	1.64e-33	SMART
low complexity region	97	107	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000190262
AA Change: N105S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000140173
Gene: ENSMUSG00000022582
AA Change: N105S

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
LU	27	118	8.2e-36	SMART
low complexity region	120	130	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930430A15Rik	T	C	2: 111,229,170		probably benign	Het
Abcb5	A	T	12: 118,872,867	L1103Q	probably damaging	Het
Adam12	T	A	7: 133,919,610	Q605L	probably benign	Het
Adk	A	G	14: 21,234,915	K102R	probably damaging	Het
Afdn	C	T	17: 13,903,870	P1761S	probably damaging	Het
Ascc1	A	G	10: 60,012,458		probably benign	Het
Aspdh	A	G	7: 44,466,559		probably null	Het
Bbx	T	C	16: 50,202,513	I753V	probably benign	Het
Ccdc33	T	C	9: 58,117,385	Y186C	probably damaging	Het
Ccdc78	T	A	17: 25,788,244		probably null	Het
Ckmt1	T	C	2: 121,362,966		probably benign	Het
Csf1r	A	G	18: 61,114,825	T322A	probably benign	Het
Dnah7b	T	C	1: 46,116,300		probably benign	Het
Dr1	A	G	5: 108,269,710	N41D	possibly damaging	Het
Ehmt1	G	A	2: 24,839,626	T633I	possibly damaging	Het
Fgf7	T	A	2: 126,035,940	Y76N	probably damaging	Het
Hmcn1	A	T	1: 150,593,097	W5038R	probably damaging	Het
Ighv14-1	A	G	12: 113,932,242	V21A	probably damaging	Het
Igkv5-37	T	A	6: 69,963,436	I75F	probably damaging	Het
Inhbc	T	A	10: 127,370,099	I100F	probably damaging	Het
Irs3	A	G	5: 137,645,319	F68L	probably damaging	Het
Itpr3	T	A	17: 27,118,595	C2460S	probably damaging	Het
Krt34	A	G	11: 100,038,290	C365R	possibly damaging	Het
Krt81	G	A	15: 101,463,388	H104Y	probably benign	Het
Mrpl58	A	T	11: 115,406,578	I72F	probably damaging	Het
Myo9a	G	A	9: 59,871,563	R1534H	probably damaging	Het
Npat	T	A	9: 53,555,129	F239L	probably benign	Het
Nsd2	A	G	5: 33,885,378		probably benign	Het
Nuggc	T	C	14: 65,623,186	V427A	probably benign	Het
Olfr476	A	G	7: 107,967,621	T75A	possibly damaging	Het
Olfr690	G	A	7: 105,329,398	R265C	probably benign	Het
Pde4a	A	T	9: 21,205,116	I467F	probably damaging	Het
Pkhd1l1	T	A	15: 44,483,833	C198*	probably null	Het
Pla2r1	A	G	2: 60,424,288	V1312A	probably damaging	Het
Pola2	T	C	19: 5,959,093	H79R	probably benign	Het
Pramef20	A	T	4: 144,377,133	M141K	probably benign	Het
Psen2	A	T	1: 180,234,983		probably benign	Het
Rnf213	A	G	11: 119,443,300	K3112E	probably damaging	Het
Slc6a4	G	T	11: 77,031,672	V630L	probably benign	Het
Smg1	A	T	7: 118,158,132		probably benign	Het
Tmc8	A	G	11: 117,791,074	T510A	possibly damaging	Het
Usp18	T	A	6: 121,268,668	H334Q	possibly damaging	Het
Vmn2r103	T	C	17: 19,792,967	Y117H	probably benign	Het
Vps13b	T	A	15: 35,709,479	D1857E	probably benign	Het

Other mutations in Ly6g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02294:Ly6g	APN	15	75158564	missense	possibly damaging	0.87
R1389:Ly6g	UTSW	15	75156766	missense	probably benign	0.10
R1450:Ly6g	UTSW	15	75158633	missense	probably benign	0.16
R4179:Ly6g	UTSW	15	75155718	splice site	probably null
R5746:Ly6g	UTSW	15	75156747	missense	possibly damaging	0.92
R6514:Ly6g	UTSW	15	75156732	missense	probably benign	0.00
R6777:Ly6g	UTSW	15	75158582	missense	probably benign	0.04
R6967:Ly6g	UTSW	15	75158549	missense	possibly damaging	0.81
R7574:Ly6g	UTSW	15	75158564	missense	probably benign	0.39
R8744:Ly6g	UTSW	15	75155669	missense	probably benign	0.02
R9261:Ly6g	UTSW	15	75158680	missense	probably damaging	0.99
R9746:Ly6g	UTSW	15	75158609	missense	probably benign	0.13

Posted On

2013-11-05