Incidental Mutation 'IGL01403:Igkv5-37'
ID 79698
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igkv5-37
Ensembl Gene ENSMUSG00000076571
Gene Name immunoglobulin kappa variable 5-37
Synonyms IgVk 23-37, LOC384417
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # IGL01403
Quality Score
Status
Chromosome 6
Chromosomal Location 69940296-69940845 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 69940420 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 75 (I75F)
Ref Sequence ENSEMBL: ENSMUSP00000100173 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103372]
AlphaFold A0A140T8N4
Predicted Effect probably damaging
Transcript: ENSMUST00000103372
AA Change: I75F

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000100173
Gene: ENSMUSG00000076571
AA Change: I75F

DomainStartEndE-ValueType
IGv 38 110 8.89e-19 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A T 12: 118,836,602 (GRCm39) L1103Q probably damaging Het
Adam12 T A 7: 133,521,339 (GRCm39) Q605L probably benign Het
Adk A G 14: 21,284,983 (GRCm39) K102R probably damaging Het
Afdn C T 17: 14,124,132 (GRCm39) P1761S probably damaging Het
Ascc1 A G 10: 59,848,280 (GRCm39) probably benign Het
Aspdh A G 7: 44,115,983 (GRCm39) probably null Het
Bbx T C 16: 50,022,876 (GRCm39) I753V probably benign Het
Ccdc33 T C 9: 58,024,668 (GRCm39) Y186C probably damaging Het
Ccdc78 T A 17: 26,007,218 (GRCm39) probably null Het
Ckmt1 T C 2: 121,193,447 (GRCm39) probably benign Het
Csf1r A G 18: 61,247,897 (GRCm39) T322A probably benign Het
Dnah7b T C 1: 46,155,460 (GRCm39) probably benign Het
Dr1 A G 5: 108,417,576 (GRCm39) N41D possibly damaging Het
Ehmt1 G A 2: 24,729,638 (GRCm39) T633I possibly damaging Het
Fgf7 T A 2: 125,877,860 (GRCm39) Y76N probably damaging Het
Hmcn1 A T 1: 150,468,848 (GRCm39) W5038R probably damaging Het
Ighv14-1 A G 12: 113,895,862 (GRCm39) V21A probably damaging Het
Inhbc T A 10: 127,205,968 (GRCm39) I100F probably damaging Het
Irs3 A G 5: 137,643,581 (GRCm39) F68L probably damaging Het
Itpr3 T A 17: 27,337,569 (GRCm39) C2460S probably damaging Het
Krt34 A G 11: 99,929,116 (GRCm39) C365R possibly damaging Het
Krt81 G A 15: 101,361,269 (GRCm39) H104Y probably benign Het
Ly6g A G 15: 75,030,497 (GRCm39) N82S probably damaging Het
Mrpl58 A T 11: 115,297,404 (GRCm39) I72F probably damaging Het
Myo9a G A 9: 59,778,846 (GRCm39) R1534H probably damaging Het
Npat T A 9: 53,466,429 (GRCm39) F239L probably benign Het
Nsd2 A G 5: 34,042,722 (GRCm39) probably benign Het
Nuggc T C 14: 65,860,635 (GRCm39) V427A probably benign Het
Or52b1 G A 7: 104,978,605 (GRCm39) R265C probably benign Het
Or5p55 A G 7: 107,566,828 (GRCm39) T75A possibly damaging Het
Pde4a A T 9: 21,116,412 (GRCm39) I467F probably damaging Het
Pkhd1l1 T A 15: 44,347,229 (GRCm39) C198* probably null Het
Pla2r1 A G 2: 60,254,632 (GRCm39) V1312A probably damaging Het
Pola2 T C 19: 6,009,121 (GRCm39) H79R probably benign Het
Potefam1 T C 2: 111,059,515 (GRCm39) probably benign Het
Pramel15 A T 4: 144,103,703 (GRCm39) M141K probably benign Het
Psen2 A T 1: 180,062,548 (GRCm39) probably benign Het
Rnf213 A G 11: 119,334,126 (GRCm39) K3112E probably damaging Het
Slc6a4 G T 11: 76,922,498 (GRCm39) V630L probably benign Het
Smg1 A T 7: 117,757,355 (GRCm39) probably benign Het
Tmc8 A G 11: 117,681,900 (GRCm39) T510A possibly damaging Het
Usp18 T A 6: 121,245,627 (GRCm39) H334Q possibly damaging Het
Vmn2r103 T C 17: 20,013,229 (GRCm39) Y117H probably benign Het
Vps13b T A 15: 35,709,625 (GRCm39) D1857E probably benign Het
Other mutations in Igkv5-37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01936:Igkv5-37 APN 6 69,940,323 (GRCm39) missense probably damaging 1.00
IGL02138:Igkv5-37 APN 6 69,940,435 (GRCm39) missense probably damaging 0.99
IGL02303:Igkv5-37 APN 6 69,940,473 (GRCm39) missense probably damaging 0.97
R4740:Igkv5-37 UTSW 6 69,940,306 (GRCm39) missense probably damaging 1.00
R6149:Igkv5-37 UTSW 6 69,940,472 (GRCm39) missense probably damaging 0.99
R6539:Igkv5-37 UTSW 6 69,940,800 (GRCm39) missense probably benign 0.22
R7800:Igkv5-37 UTSW 6 69,940,499 (GRCm39) missense possibly damaging 0.83
R8193:Igkv5-37 UTSW 6 69,940,796 (GRCm39) critical splice donor site probably benign
R8197:Igkv5-37 UTSW 6 69,940,841 (GRCm39) missense possibly damaging 0.85
R8771:Igkv5-37 UTSW 6 69,940,423 (GRCm39) missense probably damaging 0.99
Posted On 2013-11-05