Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01405:Zfp358'

79764

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp358

Ensembl Gene

ENSMUSG00000047264

Gene Name

zinc finger protein 358

Synonyms

Zfend

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.140) question?

Stock #

IGL01405

Quality Score

Status

Chromosome

Chromosomal Location

3543138-3547208 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 3545663 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Asparagine at position 109 (D109N)

Ref Sequence

ENSEMBL: ENSMUSP00000147158 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000004683] [ENSMUST00000061508] [ENSMUST00000160338] [ENSMUST00000207318] [ENSMUST00000208306] [ENSMUST00000208423]

AlphaFold

E9Q8M1

Predicted Effect

probably benign
Transcript: ENSMUST00000004683

SMART Domains

Protein: ENSMUSP00000004683
Gene: ENSMUSG00000004567

Domain	Start	End	E-Value	Type
low complexity region	30	39	N/A	INTRINSIC
transmembrane domain	70	92	N/A	INTRINSIC
transmembrane domain	299	321	N/A	INTRINSIC
transmembrane domain	348	370	N/A	INTRINSIC
Pfam:PKD_channel	378	524	2.1e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000061508
AA Change: D82N

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000060344
Gene: ENSMUSG00000047264
AA Change: D82N

Domain	Start	End	E-Value	Type
low complexity region	24	49	N/A	INTRINSIC
ZnF_C2H2	154	176	1.47e-3	SMART
ZnF_C2H2	182	204	2.95e-3	SMART
ZnF_C2H2	210	232	1.67e-2	SMART
ZnF_C2H2	238	260	3.63e-3	SMART
ZnF_C2H2	266	288	2.4e-3	SMART
ZnF_C2H2	294	316	1.4e-4	SMART
ZnF_C2H2	322	344	4.01e-5	SMART
ZnF_C2H2	350	372	2.4e-3	SMART
ZnF_C2H2	378	400	1.84e-4	SMART
low complexity region	422	430	N/A	INTRINSIC
low complexity region	447	473	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160338

SMART Domains

Protein: ENSMUSP00000123717
Gene: ENSMUSG00000004567

Domain	Start	End	E-Value	Type
low complexity region	30	39	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000207318
AA Change: D109N

PolyPhen 2 Score 0.189 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000208306

Predicted Effect

probably benign
Transcript: ENSMUST00000208423
AA Change: D82N

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208739

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf1	G	A	17: 36,274,902 (GRCm39)	R82W	probably damaging	Het
Atxn7	T	C	14: 14,100,105 (GRCm38)	V597A	probably benign	Het
Bsg	T	A	10: 79,547,348 (GRCm39)	M205K	probably benign	Het
Ccdc18	T	C	5: 108,350,052 (GRCm39)		probably benign	Het
Cdh1	T	C	8: 107,375,633 (GRCm39)	V57A	probably damaging	Het
Ddost	A	G	4: 138,039,014 (GRCm39)	D378G	probably damaging	Het
Depdc5	A	G	5: 33,095,033 (GRCm39)	E779G	possibly damaging	Het
Elp5	T	C	11: 69,859,962 (GRCm39)	R250G	probably damaging	Het
Gnb1	A	G	4: 155,627,645 (GRCm39)	H142R	probably damaging	Het
Ift172	G	T	5: 31,419,196 (GRCm39)	Y1148*	probably null	Het
Kif5a	T	C	10: 127,081,859 (GRCm39)	N153S	probably damaging	Het
Malrd1	G	A	2: 16,106,768 (GRCm39)		probably null	Het
Man2a2	T	A	7: 80,010,682 (GRCm39)	M770L	probably benign	Het
Msh2	T	C	17: 87,985,663 (GRCm39)	L80P	probably damaging	Het
Naip5	A	T	13: 100,358,453 (GRCm39)	S928T	probably benign	Het
Or7g35	T	A	9: 19,496,501 (GRCm39)	S223T	probably benign	Het
Pla2g4d	T	C	2: 120,097,304 (GRCm39)	N765S	probably benign	Het
Plcb4	C	T	2: 135,792,267 (GRCm39)	T330I	probably damaging	Het
Ppp3ca	A	G	3: 136,574,482 (GRCm39)	I127V	probably benign	Het
Rapgef5	C	A	12: 117,685,115 (GRCm39)	T320K	probably benign	Het
Rbfa	A	G	18: 80,236,080 (GRCm39)	V223A	probably benign	Het
Rfx7	A	G	9: 72,517,626 (GRCm39)	M187V	probably benign	Het
Ric1	T	C	19: 29,544,770 (GRCm39)		probably benign	Het
Slc22a16	C	T	10: 40,461,191 (GRCm39)	T331M	probably benign	Het
Slc34a1	T	C	13: 55,559,941 (GRCm39)	S303P	probably damaging	Het
Slfn3	T	C	11: 83,105,542 (GRCm39)	V513A	possibly damaging	Het
Tbce	A	T	13: 14,178,280 (GRCm39)	I370N	probably damaging	Het
Zfp523	T	C	17: 28,423,480 (GRCm39)	S152P	probably damaging	Het
Zfp961	A	G	8: 72,721,778 (GRCm39)	N78S	possibly damaging	Het

Other mutations in Zfp358

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02301:Zfp358	APN	8	3,546,858 (GRCm39)	missense	probably benign
IGL02510:Zfp358	APN	8	3,546,786 (GRCm39)	missense	probably benign	0.04
IGL02860:Zfp358	APN	8	3,546,074 (GRCm39)	missense	probably damaging	1.00
R1018:Zfp358	UTSW	8	3,546,843 (GRCm39)	nonsense	probably null
R1960:Zfp358	UTSW	8	3,545,742 (GRCm39)	missense	possibly damaging	0.46
R2047:Zfp358	UTSW	8	3,545,934 (GRCm39)	missense	probably damaging	1.00
R2202:Zfp358	UTSW	8	3,546,995 (GRCm39)	missense	possibly damaging	0.80
R2354:Zfp358	UTSW	8	3,545,454 (GRCm39)	missense	possibly damaging	0.95
R4688:Zfp358	UTSW	8	3,545,493 (GRCm39)	missense	probably damaging	1.00
R4689:Zfp358	UTSW	8	3,546,146 (GRCm39)	splice site	probably null
R4876:Zfp358	UTSW	8	3,546,170 (GRCm39)	missense	probably damaging	0.98
R5830:Zfp358	UTSW	8	3,545,846 (GRCm39)	missense	probably benign	0.36
R6589:Zfp358	UTSW	8	3,545,907 (GRCm39)	missense	probably damaging	0.99
R6834:Zfp358	UTSW	8	3,545,613 (GRCm39)	missense	probably benign	0.19
R9043:Zfp358	UTSW	8	3,545,810 (GRCm39)	missense	probably benign	0.01
R9357:Zfp358	UTSW	8	3,545,568 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-11-05