Incidental Mutation 'IGL01405:Zfp961'
ID79789
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp961
Ensembl Gene ENSMUSG00000052446
Gene Namezinc finger protein 961
SynonymsA230105L22Rik, BC049349
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01405
Quality Score
Status
Chromosome8
Chromosomal Location71951038-71993792 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 71967934 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 78 (N78S)
Ref Sequence ENSEMBL: ENSMUSP00000122942 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109997] [ENSMUST00000131237] [ENSMUST00000132848] [ENSMUST00000136516] [ENSMUST00000138304] [ENSMUST00000145256]
Predicted Effect probably benign
Transcript: ENSMUST00000109997
AA Change: N97S

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000105623
Gene: ENSMUSG00000052446
AA Change: N97S

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
ZnF_C2H2 172 194 3.07e-1 SMART
ZnF_C2H2 199 221 1.36e-2 SMART
ZnF_C2H2 226 248 3.29e-1 SMART
ZnF_C2H2 254 276 3.34e-2 SMART
ZnF_C2H2 282 304 9.58e-3 SMART
ZnF_C2H2 310 332 2.17e-1 SMART
ZnF_C2H2 338 360 1.04e-3 SMART
ZnF_C2H2 366 388 2.24e-3 SMART
ZnF_C2H2 394 416 2.24e-3 SMART
ZnF_C2H2 421 443 4.61e-5 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000131237
AA Change: N78S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000122942
Gene: ENSMUSG00000052446
AA Change: N78S

DomainStartEndE-ValueType
KRAB 6 63 1.14e-18 SMART
ZnF_C2H2 125 147 1.69e-3 SMART
ZnF_C2H2 153 175 3.07e-1 SMART
ZnF_C2H2 180 202 1.36e-2 SMART
ZnF_C2H2 207 229 3.29e-1 SMART
ZnF_C2H2 235 257 3.34e-2 SMART
ZnF_C2H2 263 285 9.58e-3 SMART
ZnF_C2H2 291 313 2.17e-1 SMART
ZnF_C2H2 319 341 1.04e-3 SMART
ZnF_C2H2 347 369 2.24e-3 SMART
ZnF_C2H2 375 397 2.24e-3 SMART
ZnF_C2H2 402 424 4.61e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132848
AA Change: N97S

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000114730
Gene: ENSMUSG00000052446
AA Change: N97S

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136516
SMART Domains Protein: ENSMUSP00000122589
Gene: ENSMUSG00000052446

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
ZnF_C2H2 172 194 3.07e-1 SMART
ZnF_C2H2 199 221 1.36e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136878
Predicted Effect probably benign
Transcript: ENSMUST00000138304
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139781
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144807
Predicted Effect probably benign
Transcript: ENSMUST00000145256
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147033
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151168
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf1 G A 17: 35,964,010 R82W probably damaging Het
Atxn7 T C 14: 14,100,105 V597A probably benign Het
Bsg T A 10: 79,711,514 M205K probably benign Het
Ccdc18 T C 5: 108,202,186 probably benign Het
Cdh1 T C 8: 106,649,001 V57A probably damaging Het
Ddost A G 4: 138,311,703 D378G probably damaging Het
Depdc5 A G 5: 32,937,689 E779G possibly damaging Het
Elp5 T C 11: 69,969,136 R250G probably damaging Het
Gnb1 A G 4: 155,543,188 H142R probably damaging Het
Ift172 G T 5: 31,261,852 Y1148* probably null Het
Kif5a T C 10: 127,245,990 N153S probably damaging Het
Malrd1 G A 2: 16,101,957 probably null Het
Man2a2 T A 7: 80,360,934 M770L probably benign Het
Msh2 T C 17: 87,678,235 L80P probably damaging Het
Naip5 A T 13: 100,221,945 S928T probably benign Het
Olfr855 T A 9: 19,585,205 S223T probably benign Het
Pla2g4d T C 2: 120,266,823 N765S probably benign Het
Plcb4 C T 2: 135,950,347 T330I probably damaging Het
Ppp3ca A G 3: 136,868,721 I127V probably benign Het
Rapgef5 C A 12: 117,721,380 T320K probably benign Het
Rbfa A G 18: 80,192,865 V223A probably benign Het
Rfx7 A G 9: 72,610,344 M187V probably benign Het
Ric1 T C 19: 29,567,370 probably benign Het
Slc22a16 C T 10: 40,585,195 T331M probably benign Het
Slc34a1 T C 13: 55,412,128 S303P probably damaging Het
Slfn3 T C 11: 83,214,716 V513A possibly damaging Het
Tbce A T 13: 14,003,695 I370N probably damaging Het
Zfp358 G A 8: 3,495,663 D109N probably benign Het
Zfp523 T C 17: 28,204,506 S152P probably damaging Het
Other mutations in Zfp961
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Zfp961 APN 8 71968428 missense probably damaging 1.00
IGL00801:Zfp961 APN 8 71965888 missense probably damaging 1.00
IGL00825:Zfp961 APN 8 71968044 missense possibly damaging 0.91
IGL03100:Zfp961 APN 8 71967910 makesense probably null
R0969:Zfp961 UTSW 8 71968295 missense probably damaging 1.00
R4851:Zfp961 UTSW 8 71969003 unclassified probably benign
R5502:Zfp961 UTSW 8 71968059 missense probably damaging 0.99
R5813:Zfp961 UTSW 8 71968226 missense probably damaging 1.00
R6762:Zfp961 UTSW 8 71966114 missense possibly damaging 0.53
R6902:Zfp961 UTSW 8 71968678 missense probably damaging 1.00
R7858:Zfp961 UTSW 8 71951105 missense unknown
R7941:Zfp961 UTSW 8 71951105 missense unknown
X0027:Zfp961 UTSW 8 71967949 missense possibly damaging 0.89
Posted On2013-11-05