Incidental Mutation 'IGL01408:Zfp281'
ID79864
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp281
Ensembl Gene ENSMUSG00000041483
Gene Namezinc finger protein 281
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01408
Quality Score
Status
Chromosome1
Chromosomal Location136624901-136630053 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 136626115 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 277 (V277A)
Ref Sequence ENSEMBL: ENSMUSP00000107677 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047734] [ENSMUST00000112046]
Predicted Effect probably damaging
Transcript: ENSMUST00000047734
AA Change: V277A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000039003
Gene: ENSMUSG00000041483
AA Change: V277A

DomainStartEndE-ValueType
low complexity region 4 36 N/A INTRINSIC
low complexity region 83 95 N/A INTRINSIC
low complexity region 161 171 N/A INTRINSIC
low complexity region 180 191 N/A INTRINSIC
low complexity region 230 241 N/A INTRINSIC
ZnF_C2H2 258 280 3.34e-2 SMART
ZnF_C2H2 286 308 6.78e-3 SMART
ZnF_C2H2 314 336 1.43e-1 SMART
ZnF_C2H2 342 362 2.97e1 SMART
low complexity region 397 407 N/A INTRINSIC
low complexity region 488 501 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112046
AA Change: V277A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000107677
Gene: ENSMUSG00000041483
AA Change: V277A

DomainStartEndE-ValueType
low complexity region 4 36 N/A INTRINSIC
low complexity region 83 95 N/A INTRINSIC
low complexity region 161 171 N/A INTRINSIC
low complexity region 180 191 N/A INTRINSIC
low complexity region 230 241 N/A INTRINSIC
ZnF_C2H2 258 280 3.34e-2 SMART
ZnF_C2H2 286 308 6.78e-3 SMART
ZnF_C2H2 314 336 1.43e-1 SMART
ZnF_C2H2 342 362 2.97e1 SMART
low complexity region 397 407 N/A INTRINSIC
low complexity region 488 501 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180797
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality between E7.5 and E8.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530068E07Rik A G 11: 52,403,366 R145G probably damaging Het
Akr1c21 T A 13: 4,577,432 M175K probably benign Het
Apol7a C T 15: 77,389,330 A311T probably damaging Het
Atxn10 G T 15: 85,376,695 E214* probably null Het
Bmp2k C T 5: 97,086,964 Q749* probably null Het
Ccdc141 G A 2: 77,045,679 A669V probably benign Het
Cndp2 A C 18: 84,670,911 C249G probably benign Het
Cnr1 A G 4: 33,944,802 I397V possibly damaging Het
Col19a1 T C 1: 24,306,250 probably benign Het
Dbn1 T C 13: 55,482,304 probably benign Het
Dmgdh C T 13: 93,709,295 P486S probably damaging Het
Dpys A G 15: 39,793,306 V455A possibly damaging Het
Farp2 A G 1: 93,618,980 N907S probably benign Het
Fndc3c1 C T X: 106,432,772 E894K probably benign Het
Gm6685 A T 11: 28,339,473 N114K probably damaging Het
Golga3 A T 5: 110,217,809 probably null Het
Grin2c A G 11: 115,260,882 L84P probably damaging Het
Gucy2c A G 6: 136,698,011 F1001L probably benign Het
Hcn4 A G 9: 58,859,886 H910R unknown Het
Kdm4b T C 17: 56,353,518 probably benign Het
Lrrfip2 A G 9: 111,214,216 T497A probably benign Het
Man2c1 A G 9: 57,141,600 Y924C probably damaging Het
Nkain2 T A 10: 32,402,241 T63S probably damaging Het
Nlrp1a T A 11: 71,122,916 T503S probably benign Het
Olfr658 T A 7: 104,644,929 I146F possibly damaging Het
Olfr665 T C 7: 104,880,830 V41A probably benign Het
Pitrm1 T A 13: 6,573,042 C780S probably damaging Het
Plekha5 C T 6: 140,570,316 probably benign Het
Rapgef4 C T 2: 72,174,841 R193* probably null Het
Rbm20 A G 19: 53,851,613 E1011G possibly damaging Het
Rfx3 A T 19: 27,768,650 D685E probably benign Het
Ror1 T C 4: 100,333,787 S114P probably damaging Het
Slc17a6 A G 7: 51,669,115 K502E probably benign Het
Spink2 A T 5: 77,211,327 probably benign Het
Sptb A T 12: 76,613,147 I993N possibly damaging Het
Stxbp4 A G 11: 90,621,649 probably benign Het
Tes A T 6: 17,099,879 Y291F probably damaging Het
Tmtc4 G T 14: 122,925,954 probably benign Het
Trpa1 T C 1: 14,889,413 E683G probably benign Het
Vmn2r73 T C 7: 85,872,247 D171G probably benign Het
Wbp11 A G 6: 136,814,614 probably benign Het
Wfdc12 A G 2: 164,189,661 *86R probably null Het
Other mutations in Zfp281
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00531:Zfp281 APN 1 136627910 missense probably damaging 1.00
IGL02037:Zfp281 APN 1 136627447 missense possibly damaging 0.64
IGL03233:Zfp281 APN 1 136626829 missense possibly damaging 0.82
PIT4486001:Zfp281 UTSW 1 136627003 missense possibly damaging 0.48
R1514:Zfp281 UTSW 1 136626697 missense probably benign 0.00
R1784:Zfp281 UTSW 1 136625353 small insertion probably benign
R1785:Zfp281 UTSW 1 136625353 small insertion probably benign
R2049:Zfp281 UTSW 1 136625353 small insertion probably benign
R2142:Zfp281 UTSW 1 136625353 small insertion probably benign
R4086:Zfp281 UTSW 1 136626121 missense probably damaging 1.00
R4087:Zfp281 UTSW 1 136626121 missense probably damaging 1.00
R4088:Zfp281 UTSW 1 136626121 missense probably damaging 1.00
R4090:Zfp281 UTSW 1 136626121 missense probably damaging 1.00
R4819:Zfp281 UTSW 1 136625710 missense probably benign
R5380:Zfp281 UTSW 1 136625938 missense possibly damaging 0.93
R6033:Zfp281 UTSW 1 136626726 missense probably benign 0.14
R6033:Zfp281 UTSW 1 136626726 missense probably benign 0.14
R6056:Zfp281 UTSW 1 136625440 missense possibly damaging 0.93
R6213:Zfp281 UTSW 1 136625512 missense probably benign 0.01
R7402:Zfp281 UTSW 1 136625452 missense probably damaging 0.99
R7503:Zfp281 UTSW 1 136626940 missense possibly damaging 0.67
R7969:Zfp281 UTSW 1 136626034 missense probably benign 0.06
R8343:Zfp281 UTSW 1 136627882 missense probably damaging 1.00
Posted On2013-11-05