Incidental Mutation 'IGL01410:Virma'
ID79954
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Virma
Ensembl Gene ENSMUSG00000040720
Gene Namevir like m6A methyltransferase associated
Synonyms1110037F02Rik
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01410
Quality Score
Status
Chromosome4
Chromosomal Location11485958-11550684 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 11518929 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 725 (Y725*)
Ref Sequence ENSEMBL: ENSMUSP00000103943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055372] [ENSMUST00000059914] [ENSMUST00000108307]
Predicted Effect probably null
Transcript: ENSMUST00000055372
AA Change: Y675*
SMART Domains Protein: ENSMUSP00000063188
Gene: ENSMUSG00000040720
AA Change: Y675*

DomainStartEndE-ValueType
low complexity region 139 153 N/A INTRINSIC
low complexity region 172 198 N/A INTRINSIC
low complexity region 236 267 N/A INTRINSIC
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1008 1020 N/A INTRINSIC
low complexity region 1112 1124 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000059914
AA Change: Y675*
SMART Domains Protein: ENSMUSP00000058078
Gene: ENSMUSG00000040720
AA Change: Y675*

DomainStartEndE-ValueType
low complexity region 139 153 N/A INTRINSIC
low complexity region 172 198 N/A INTRINSIC
low complexity region 236 267 N/A INTRINSIC
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1008 1020 N/A INTRINSIC
low complexity region 1112 1124 N/A INTRINSIC
low complexity region 1224 1232 N/A INTRINSIC
low complexity region 1443 1458 N/A INTRINSIC
low complexity region 1460 1474 N/A INTRINSIC
low complexity region 1618 1634 N/A INTRINSIC
low complexity region 1684 1697 N/A INTRINSIC
low complexity region 1750 1757 N/A INTRINSIC
low complexity region 1796 1808 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000108307
AA Change: Y725*
SMART Domains Protein: ENSMUSP00000103943
Gene: ENSMUSG00000040720
AA Change: Y725*

DomainStartEndE-ValueType
Pfam:VIR_N 5 266 2e-110 PFAM
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1058 1070 N/A INTRINSIC
low complexity region 1162 1174 N/A INTRINSIC
low complexity region 1274 1282 N/A INTRINSIC
low complexity region 1493 1508 N/A INTRINSIC
low complexity region 1510 1524 N/A INTRINSIC
low complexity region 1668 1684 N/A INTRINSIC
low complexity region 1734 1747 N/A INTRINSIC
low complexity region 1800 1807 N/A INTRINSIC
low complexity region 1846 1858 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 T A 1: 58,106,025 probably null Het
Aspm C T 1: 139,482,444 T1359I probably benign Het
Atp13a2 A G 4: 140,992,198 D26G probably benign Het
Atrnl1 G A 19: 58,131,104 A1343T probably damaging Het
Ccsap A C 8: 123,859,230 S61A probably damaging Het
Cdh1 A T 8: 106,657,853 M318L probably benign Het
Cfap69 G A 5: 5,646,979 P106S probably damaging Het
Cfp G A X: 20,929,724 T88I probably damaging Het
Chst1 A T 2: 92,614,130 I316F probably damaging Het
Col7a1 A T 9: 108,964,618 D1382V unknown Het
Cr2 T A 1: 195,163,234 M514L possibly damaging Het
Cubn G A 2: 13,465,908 H558Y probably benign Het
Cul9 A T 17: 46,528,646 M802K probably damaging Het
Dennd2d A T 3: 106,491,226 I169L probably damaging Het
Dnah11 T A 12: 118,047,256 K162* probably null Het
Dnah3 T A 7: 119,967,720 T2428S possibly damaging Het
Dock11 T A X: 36,037,643 H1284Q probably damaging Het
Flrt2 T A 12: 95,779,192 D101E probably damaging Het
Gabrr2 G A 4: 33,085,626 V349M probably damaging Het
Gli2 C A 1: 118,836,891 V1177L probably benign Het
Gm16506 A G 14: 43,724,173 Y206H probably benign Het
Gm1966 C T 7: 106,603,051 noncoding transcript Het
Gm5612 C T 9: 18,427,573 probably benign Het
Heg1 C T 16: 33,725,566 T460I possibly damaging Het
Lgals9 T G 11: 78,973,151 D56A probably damaging Het
Lpgat1 A T 1: 191,776,432 probably null Het
Megf6 T A 4: 154,252,563 probably null Het
Megf8 G A 7: 25,359,871 M2265I probably benign Het
Memo1 G A 17: 74,241,981 R121* probably null Het
Morc1 T C 16: 48,612,314 V715A probably benign Het
Mycbp2 A T 14: 103,229,492 probably null Het
Ncapg2 T A 12: 116,424,650 V318D possibly damaging Het
Ndst1 T C 18: 60,700,445 Y498C probably damaging Het
Nod1 C T 6: 54,944,356 A326T probably damaging Het
Olfr1206 T A 2: 88,865,520 M305K probably benign Het
Olfr697 A G 7: 106,741,499 V145A probably benign Het
Peg3 T C 7: 6,707,625 S1533G probably benign Het
Pgc G T 17: 47,734,240 G361V probably damaging Het
Phka1 C T X: 102,586,106 R477H probably damaging Het
Plagl2 C T 2: 153,232,654 R109Q probably damaging Het
Prr36 T A 8: 4,216,230 I107F probably benign Het
Ptpdc1 T A 13: 48,586,604 R450S probably damaging Het
Ptprb A T 10: 116,302,274 D361V possibly damaging Het
Rbm44 A G 1: 91,168,829 D970G probably benign Het
Scrn2 T G 11: 97,030,570 V52G probably benign Het
Sdk1 C T 5: 142,212,120 T2176I probably benign Het
Serpina1d T A 12: 103,763,734 E396D probably benign Het
Slc38a5 A C X: 8,279,831 Q465P probably benign Het
Slc38a5 G T X: 8,279,832 Q465H probably benign Het
Smarca1 T C X: 47,892,378 T48A possibly damaging Het
Trak2 A T 1: 58,923,607 I132N probably damaging Het
Trank1 T C 9: 111,365,259 S784P probably benign Het
Trank1 A G 9: 111,365,049 T714A probably benign Het
Trp53i13 G A 11: 77,508,257 probably benign Het
Trrap A C 5: 144,831,021 D2596A probably benign Het
Ttyh1 A T 7: 4,124,657 T19S probably damaging Het
Tyk2 C T 9: 21,109,364 V947M probably damaging Het
Ugt2b34 G A 5: 86,892,830 A411V possibly damaging Het
Vmn1r192 A G 13: 22,187,909 L47P probably damaging Het
Vmn2r74 T C 7: 85,961,292 D64G possibly damaging Het
Other mutations in Virma
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Virma APN 4 11519424 splice site probably benign
IGL00477:Virma APN 4 11519006 missense probably damaging 0.99
IGL01293:Virma APN 4 11521114 missense probably damaging 1.00
IGL01531:Virma APN 4 11528753 missense probably damaging 1.00
IGL01672:Virma APN 4 11527792 missense probably damaging 1.00
IGL01724:Virma APN 4 11528672 missense probably damaging 1.00
IGL01747:Virma APN 4 11526877 missense probably damaging 1.00
IGL01776:Virma APN 4 11527792 missense probably damaging 1.00
IGL02064:Virma APN 4 11513163 missense possibly damaging 0.87
IGL02243:Virma APN 4 11546031 missense probably damaging 1.00
IGL02244:Virma APN 4 11546031 missense probably damaging 1.00
IGL02445:Virma APN 4 11527029 missense probably damaging 0.97
IGL02546:Virma APN 4 11494804 missense probably damaging 0.99
IGL02807:Virma APN 4 11507079 splice site probably benign
IGL02967:Virma APN 4 11514096 missense probably benign 0.01
IGL03211:Virma APN 4 11548770 nonsense probably null
IGL03242:Virma APN 4 11527669 missense possibly damaging 0.70
IGL03256:Virma APN 4 11542207 splice site probably benign
IGL03327:Virma APN 4 11518984 missense probably benign 0.00
IGL03346:Virma APN 4 11518984 missense probably benign 0.00
PIT4802001:Virma UTSW 4 11546008 missense probably damaging 0.99
R0142:Virma UTSW 4 11548783 missense probably benign 0.04
R0355:Virma UTSW 4 11528626 nonsense probably null
R0522:Virma UTSW 4 11519416 critical splice donor site probably null
R0600:Virma UTSW 4 11498769 missense probably damaging 0.99
R1435:Virma UTSW 4 11528621 missense probably damaging 1.00
R1489:Virma UTSW 4 11521164 missense probably damaging 1.00
R1568:Virma UTSW 4 11528776 missense probably damaging 0.99
R1616:Virma UTSW 4 11544954 missense probably damaging 1.00
R1655:Virma UTSW 4 11494786 missense probably damaging 1.00
R1695:Virma UTSW 4 11494814 missense probably damaging 0.98
R1835:Virma UTSW 4 11540511 missense probably benign 0.02
R1951:Virma UTSW 4 11513907 missense probably benign 0.00
R1991:Virma UTSW 4 11519242 missense probably benign 0.06
R2145:Virma UTSW 4 11548726 splice site probably benign
R2172:Virma UTSW 4 11527843 missense possibly damaging 0.82
R2217:Virma UTSW 4 11544924 missense probably damaging 1.00
R2218:Virma UTSW 4 11544924 missense probably damaging 1.00
R2248:Virma UTSW 4 11518927 missense probably damaging 1.00
R2342:Virma UTSW 4 11501316 missense probably damaging 1.00
R3424:Virma UTSW 4 11513177 nonsense probably null
R4397:Virma UTSW 4 11513901 missense possibly damaging 0.81
R4449:Virma UTSW 4 11498828 critical splice donor site probably null
R4660:Virma UTSW 4 11513505 missense probably damaging 1.00
R4698:Virma UTSW 4 11528636 missense probably damaging 0.99
R4878:Virma UTSW 4 11544971 missense probably damaging 1.00
R4937:Virma UTSW 4 11521147 nonsense probably null
R5031:Virma UTSW 4 11542116 nonsense probably null
R5040:Virma UTSW 4 11528746 missense probably benign 0.01
R5061:Virma UTSW 4 11494840 missense possibly damaging 0.95
R5091:Virma UTSW 4 11519392 missense probably benign 0.00
R5137:Virma UTSW 4 11546297 missense probably damaging 1.00
R5262:Virma UTSW 4 11539926 missense probably benign 0.01
R5297:Virma UTSW 4 11494819 missense probably damaging 1.00
R5730:Virma UTSW 4 11542154 missense probably benign 0.44
R5818:Virma UTSW 4 11513319 missense possibly damaging 0.92
R5835:Virma UTSW 4 11514036 missense probably damaging 1.00
R6125:Virma UTSW 4 11521172 missense probably damaging 0.98
R6197:Virma UTSW 4 11505498 missense probably damaging 0.96
R6222:Virma UTSW 4 11527820 missense probably damaging 1.00
R6793:Virma UTSW 4 11539968 missense probably damaging 1.00
R7028:Virma UTSW 4 11519249 missense possibly damaging 0.50
R7356:Virma UTSW 4 11513595 missense probably damaging 0.99
R7383:Virma UTSW 4 11514026 missense probably damaging 0.98
R7391:Virma UTSW 4 11508099 missense probably damaging 0.99
R7425:Virma UTSW 4 11546211 missense possibly damaging 0.95
R7556:Virma UTSW 4 11518927 missense probably damaging 1.00
R7715:Virma UTSW 4 11549682 missense probably damaging 1.00
R7715:Virma UTSW 4 11513016 splice site probably null
R8048:Virma UTSW 4 11539918 nonsense probably null
R8050:Virma UTSW 4 11528643 missense probably benign 0.22
X0020:Virma UTSW 4 11486055 missense probably benign 0.00
Posted On2013-11-05