Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01410:Trak2'

79963

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trak2

Ensembl Gene

ENSMUSG00000026028

Gene Name

trafficking protein, kinesin binding 2

Synonyms

2900022D04Rik, GRIF-1, CALS-C, OIP98, GRIF1, Als2cr3, 4733401O11Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01410

Quality Score

Status

Chromosome

Chromosomal Location

58939608-59012589 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 58962766 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 132 (I132N)

Ref Sequence

ENSEMBL: ENSMUSP00000134253 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027186] [ENSMUST00000173590] [ENSMUST00000174120]

AlphaFold

Q6P9N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000027186
AA Change: I132N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000027186
Gene: ENSMUSG00000026028
AA Change: I132N

Domain	Start	End	E-Value	Type
Pfam:HAP1_N	48	353	2.5e-135	PFAM
Pfam:Milton	426	565	3e-26	PFAM
low complexity region	663	673	N/A	INTRINSIC
low complexity region	693	714	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000173590

SMART Domains

Protein: ENSMUSP00000134499
Gene: ENSMUSG00000026028

Domain	Start	End	E-Value	Type
Pfam:HAP1_N	2	52	9.4e-10	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000174120
AA Change: I132N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000134253
Gene: ENSMUSG00000026028
AA Change: I132N

Domain	Start	End	E-Value	Type
Pfam:HAP1_N	47	354	1.3e-129	PFAM
Pfam:Milton	411	565	1.1e-41	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174359

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	T	A	1: 58,145,184 (GRCm39)		probably null	Het
Aspm	C	T	1: 139,410,182 (GRCm39)	T1359I	probably benign	Het
Atp13a2	A	G	4: 140,719,509 (GRCm39)	D26G	probably benign	Het
Atrnl1	G	A	19: 58,119,536 (GRCm39)	A1343T	probably damaging	Het
Ccsap	A	C	8: 124,585,969 (GRCm39)	S61A	probably damaging	Het
Cdh1	A	T	8: 107,384,485 (GRCm39)	M318L	probably benign	Het
Cfap69	G	A	5: 5,696,979 (GRCm39)	P106S	probably damaging	Het
Cfp	G	A	X: 20,795,963 (GRCm39)	T88I	probably damaging	Het
Chst1	A	T	2: 92,444,475 (GRCm39)	I316F	probably damaging	Het
Col7a1	A	T	9: 108,793,686 (GRCm39)	D1382V	unknown	Het
Cr2	T	A	1: 194,845,542 (GRCm39)	M514L	possibly damaging	Het
Cubn	G	A	2: 13,470,719 (GRCm39)	H558Y	probably benign	Het
Cul9	A	T	17: 46,839,572 (GRCm39)	M802K	probably damaging	Het
Dennd2d	A	T	3: 106,398,542 (GRCm39)	I169L	probably damaging	Het
Dnah11	T	A	12: 118,010,991 (GRCm39)	K162*	probably null	Het
Dnah3	T	A	7: 119,566,943 (GRCm39)	T2428S	possibly damaging	Het
Dock11	T	A	X: 35,301,296 (GRCm39)	H1284Q	probably damaging	Het
Flrt2	T	A	12: 95,745,966 (GRCm39)	D101E	probably damaging	Het
Gabrr2	G	A	4: 33,085,626 (GRCm39)	V349M	probably damaging	Het
Gli2	C	A	1: 118,764,621 (GRCm39)	V1177L	probably benign	Het
Gm16506	A	G	14: 43,961,630 (GRCm39)	Y206H	probably benign	Het
Gm5612	C	T	9: 18,338,869 (GRCm39)		probably benign	Het
Gvin3	C	T	7: 106,202,258 (GRCm39)		noncoding transcript	Het
Heg1	C	T	16: 33,545,936 (GRCm39)	T460I	possibly damaging	Het
Lgals9	T	G	11: 78,863,977 (GRCm39)	D56A	probably damaging	Het
Lpgat1	A	T	1: 191,508,544 (GRCm39)		probably null	Het
Megf6	T	A	4: 154,337,020 (GRCm39)		probably null	Het
Megf8	G	A	7: 25,059,296 (GRCm39)	M2265I	probably benign	Het
Memo1	G	A	17: 74,548,976 (GRCm39)	R121*	probably null	Het
Morc1	T	C	16: 48,432,677 (GRCm39)	V715A	probably benign	Het
Mycbp2	A	T	14: 103,466,928 (GRCm39)		probably null	Het
Ncapg2	T	A	12: 116,388,270 (GRCm39)	V318D	possibly damaging	Het
Ndst1	T	C	18: 60,833,517 (GRCm39)	Y498C	probably damaging	Het
Nod1	C	T	6: 54,921,341 (GRCm39)	A326T	probably damaging	Het
Or2ag15	A	G	7: 106,340,706 (GRCm39)	V145A	probably benign	Het
Or4c11	T	A	2: 88,695,864 (GRCm39)	M305K	probably benign	Het
Peg3	T	C	7: 6,710,624 (GRCm39)	S1533G	probably benign	Het
Pgc	G	T	17: 48,045,165 (GRCm39)	G361V	probably damaging	Het
Phka1	C	T	X: 101,629,712 (GRCm39)	R477H	probably damaging	Het
Plagl2	C	T	2: 153,074,574 (GRCm39)	R109Q	probably damaging	Het
Prr36	T	A	8: 4,266,230 (GRCm39)	I107F	probably benign	Het
Ptpdc1	T	A	13: 48,740,080 (GRCm39)	R450S	probably damaging	Het
Ptprb	A	T	10: 116,138,179 (GRCm39)	D361V	possibly damaging	Het
Rbm44	A	G	1: 91,096,551 (GRCm39)	D970G	probably benign	Het
Scrn2	T	G	11: 96,921,396 (GRCm39)	V52G	probably benign	Het
Sdk1	C	T	5: 142,197,875 (GRCm39)	T2176I	probably benign	Het
Serpina1d	T	A	12: 103,729,993 (GRCm39)	E396D	probably benign	Het
Slc38a5	A	C	X: 8,146,070 (GRCm39)	Q465P	probably benign	Het
Slc38a5	G	T	X: 8,146,071 (GRCm39)	Q465H	probably benign	Het
Smarca1	T	C	X: 46,981,255 (GRCm39)	T48A	possibly damaging	Het
Trank1	A	G	9: 111,194,117 (GRCm39)	T714A	probably benign	Het
Trank1	T	C	9: 111,194,327 (GRCm39)	S784P	probably benign	Het
Trp53i13	G	A	11: 77,399,083 (GRCm39)		probably benign	Het
Trrap	A	C	5: 144,767,831 (GRCm39)	D2596A	probably benign	Het
Ttyh1	A	T	7: 4,127,656 (GRCm39)	T19S	probably damaging	Het
Tyk2	C	T	9: 21,020,660 (GRCm39)	V947M	probably damaging	Het
Ugt2b34	G	A	5: 87,040,689 (GRCm39)	A411V	possibly damaging	Het
Virma	T	A	4: 11,518,929 (GRCm39)	Y725*	probably null	Het
Vmn1r192	A	G	13: 22,372,079 (GRCm39)	L47P	probably damaging	Het
Vmn2r74	T	C	7: 85,610,500 (GRCm39)	D64G	possibly damaging	Het

Other mutations in Trak2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01982:Trak2	APN	1	58,965,814 (GRCm39)	missense	possibly damaging	0.94
IGL02154:Trak2	APN	1	58,947,888 (GRCm39)	missense	probably damaging	1.00
IGL02399:Trak2	APN	1	58,949,204 (GRCm39)	missense	probably benign	0.00
IGL02732:Trak2	APN	1	58,949,222 (GRCm39)	missense	probably benign	0.19
IGL02734:Trak2	APN	1	58,949,222 (GRCm39)	missense	probably benign	0.19
IGL03147:Trak2	UTSW	1	58,949,222 (GRCm39)	missense	probably benign	0.19
P0041:Trak2	UTSW	1	58,949,123 (GRCm39)	missense	probably damaging	1.00
R0079:Trak2	UTSW	1	58,965,883 (GRCm39)	missense	probably damaging	1.00
R0791:Trak2	UTSW	1	58,942,820 (GRCm39)	missense	probably benign
R0792:Trak2	UTSW	1	58,942,820 (GRCm39)	missense	probably benign
R1099:Trak2	UTSW	1	58,961,000 (GRCm39)	missense	probably benign	0.05
R1899:Trak2	UTSW	1	58,985,495 (GRCm39)	start codon destroyed	probably null	0.98
R1903:Trak2	UTSW	1	58,958,014 (GRCm39)	splice site	probably null
R2292:Trak2	UTSW	1	58,974,916 (GRCm39)	missense	probably damaging	0.99
R2312:Trak2	UTSW	1	58,974,941 (GRCm39)	missense	probably damaging	1.00
R3720:Trak2	UTSW	1	58,985,404 (GRCm39)	critical splice donor site	probably null
R4966:Trak2	UTSW	1	58,958,480 (GRCm39)	missense	probably damaging	1.00
R5088:Trak2	UTSW	1	58,974,967 (GRCm39)	missense	probably benign	0.06
R5730:Trak2	UTSW	1	58,960,966 (GRCm39)	missense	probably damaging	1.00
R5840:Trak2	UTSW	1	58,958,432 (GRCm39)	missense	probably damaging	1.00
R5981:Trak2	UTSW	1	58,947,849 (GRCm39)	missense	probably benign	0.01
R6000:Trak2	UTSW	1	58,950,971 (GRCm39)	missense	possibly damaging	0.71
R6053:Trak2	UTSW	1	58,943,228 (GRCm39)	missense	possibly damaging	0.62
R6894:Trak2	UTSW	1	58,950,892 (GRCm39)	missense	probably damaging	1.00
R6916:Trak2	UTSW	1	58,949,184 (GRCm39)	missense	probably benign	0.06
R7096:Trak2	UTSW	1	58,942,749 (GRCm39)	missense	probably damaging	1.00
R7544:Trak2	UTSW	1	58,960,227 (GRCm39)	splice site	probably null
R7847:Trak2	UTSW	1	58,974,977 (GRCm39)	missense	possibly damaging	0.88
R7889:Trak2	UTSW	1	58,957,983 (GRCm39)	missense	probably damaging	1.00
R8039:Trak2	UTSW	1	58,985,447 (GRCm39)	missense	probably benign	0.16
R8313:Trak2	UTSW	1	58,960,306 (GRCm39)	nonsense	probably null
R8728:Trak2	UTSW	1	58,974,934 (GRCm39)	missense	probably benign	0.01
R8930:Trak2	UTSW	1	58,974,967 (GRCm39)	missense	probably benign
R8932:Trak2	UTSW	1	58,974,967 (GRCm39)	missense	probably benign
R9263:Trak2	UTSW	1	58,985,481 (GRCm39)	missense	probably benign	0.01
R9291:Trak2	UTSW	1	58,943,058 (GRCm39)	missense	probably damaging	1.00
R9404:Trak2	UTSW	1	58,960,296 (GRCm39)	missense	possibly damaging	0.53
R9670:Trak2	UTSW	1	58,985,463 (GRCm39)	nonsense	probably null
X0067:Trak2	UTSW	1	58,947,691 (GRCm39)	missense	probably benign	0.18

Posted On

2013-11-05