Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01411:Vmn2r108'

80033

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL01411

Quality Score

Status

Chromosome

Chromosomal Location

20462373-20481236 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20471020 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 414 (M414L)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

Predicted Effect

probably benign
Transcript: ENSMUST00000167314
AA Change: M414L

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: M414L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	G	A	19: 31,911,229	E36K	possibly damaging	Het
Alox8	A	T	11: 69,188,690	S257R	probably benign	Het
Apc2	T	C	10: 80,315,078	S1960P	probably damaging	Het
Arhgap35	T	C	7: 16,564,267	N291S	probably benign	Het
AW551984	A	T	9: 39,593,791	D468E	possibly damaging	Het
B3gnt6	A	C	7: 98,194,523	F77V	probably damaging	Het
C1qtnf7	A	T	5: 43,609,061	M1L	probably benign	Het
Calm3	T	C	7: 16,917,484	T63A	probably benign	Het
Ccdc33	G	A	9: 58,117,636		probably benign	Het
Cdh4	C	T	2: 179,780,403	R107C	probably damaging	Het
Cdr2l	A	G	11: 115,382,366	E15G	probably damaging	Het
Chil6	A	G	3: 106,388,825	W365R	probably damaging	Het
Ckap5	G	T	2: 91,601,011	R1525L	probably benign	Het
Col6a6	T	A	9: 105,785,958	K127*	probably null	Het
Dclre1b	A	G	3: 103,803,323	V298A	probably damaging	Het
Fat1	T	A	8: 45,026,800	V2961E	probably damaging	Het
Fhit	T	C	14: 9,573,483	D126G	probably benign	Het
Gpc1	T	C	1: 92,857,014	F303S	probably damaging	Het
Hsd17b4	T	A	18: 50,191,814	V698D	probably damaging	Het
Itpr2	C	T	6: 146,376,062		probably null	Het
Klhl4	A	T	X: 114,522,394	D168V	probably damaging	Het
Krt42	A	G	11: 100,263,341	L405P	possibly damaging	Het
Lrp1	A	T	10: 127,581,765	C85*	probably null	Het
Lrp2	A	G	2: 69,482,267	L2559P	probably damaging	Het
Maob	T	G	X: 16,712,569	R448S	possibly damaging	Het
Mast3	A	G	8: 70,779,583	V1250A	possibly damaging	Het
Mfsd4b5	C	T	10: 39,970,727	V286M	probably damaging	Het
Mlip	A	G	9: 77,239,417	I198T	possibly damaging	Het
Mocs3	T	C	2: 168,231,377	V248A	probably damaging	Het
Nxf2	T	A	X: 134,952,112	R367S	probably benign	Het
Olfr1404	T	G	1: 173,216,128	V159G	probably benign	Het
Olfr617	T	C	7: 103,584,117	W32R	probably damaging	Het
Parva	T	C	7: 112,577,010		probably benign	Het
Pot1a	A	T	6: 25,750,144		probably benign	Het
Ptpra	T	C	2: 130,544,439	I603T	probably damaging	Het
Rad9a	T	C	19: 4,201,337	K33E	probably benign	Het
Rimbp3	A	G	16: 17,211,094	D794G	probably damaging	Het
Sept5	G	A	16: 18,624,930	R90C	probably damaging	Het
Skint8	T	A	4: 111,936,906	N164K	probably damaging	Het
Slc30a3	T	G	5: 31,090,080	I73L	probably benign	Het
Stab2	A	T	10: 86,980,008		probably benign	Het
Tnc	C	T	4: 64,000,722	V1155M	probably damaging	Het
Ttc13	T	G	8: 124,683,285	Q525P	probably damaging	Het
Ttn	T	C	2: 76,720,135	E31601G	probably damaging	Het
Unc5a	A	T	13: 55,002,928	D577V	probably damaging	Het
Usp18	G	A	6: 121,261,421	V176M	probably benign	Het
Vmn1r184	T	C	7: 26,266,895	V22A	probably benign	Het
Vmn1r33	T	A	6: 66,611,881	I230F	probably damaging	Het
Vmn1r51	A	G	6: 90,129,404	I101V	probably benign	Het
Vmn2r87	A	C	10: 130,472,560	V603G	probably benign	Het
Wt1	A	G	2: 105,132,974	Y16C	probably damaging	Het
Wwp2	C	T	8: 107,506,345	T159I	probably benign	Het
Xirp2	T	C	2: 67,514,083	F2223L	probably benign	Het
Zan	T	A	5: 137,388,893	H4966L	unknown	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20462512	missense	probably damaging	0.98
IGL01143:Vmn2r108	APN	17	20462465	missense	possibly damaging	0.82
IGL01311:Vmn2r108	APN	17	20462677	nonsense	probably null
IGL01414:Vmn2r108	APN	17	20471680	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20463281	missense	probably damaging	1.00
IGL01748:Vmn2r108	APN	17	20463214	missense	probably benign	0.03
IGL01769:Vmn2r108	APN	17	20471018	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20471725	missense	possibly damaging	0.77
IGL02041:Vmn2r108	APN	17	20463136	missense	probably damaging	1.00
IGL02049:Vmn2r108	APN	17	20471346	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20469143	missense	probably damaging	1.00
IGL02939:Vmn2r108	APN	17	20471283	missense	probably benign	0.05
IGL03202:Vmn2r108	APN	17	20471057	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20463017	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20471635	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20462834	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20471459	missense	probably benign
R0836:Vmn2r108	UTSW	17	20471459	missense	probably benign
R0943:Vmn2r108	UTSW	17	20471135	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20462845	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20472361	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20472121	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20462524	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20469073	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20470990	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20469101	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20481033	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20481033	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20472315	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20462670	missense	probably benign
R4470:Vmn2r108	UTSW	17	20462728	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20471374	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20472370	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20462629	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20481187	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20470192	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20471493	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20471604	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20471403	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20471028	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20462917	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20463136	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20472283	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20471318	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20463006	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20481140	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20472185	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20462382	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20463109	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20471398	missense	probably damaging	0.98
R6324:Vmn2r108	UTSW	17	20471715	nonsense	probably null
R6364:Vmn2r108	UTSW	17	20470998	missense	probably benign	0.00
R6446:Vmn2r108	UTSW	17	20472347	nonsense	probably null
R6541:Vmn2r108	UTSW	17	20481218	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20471083	missense	possibly damaging	0.67
R7063:Vmn2r108	UTSW	17	20481148	missense	probably damaging	1.00
R7092:Vmn2r108	UTSW	17	20481076	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20462500	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20462776	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20472270	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20472195	missense	probably benign	0.02
X0022:Vmn2r108	UTSW	17	20471109	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20471113	missense	probably benign	0.01

Posted On

2013-11-05