Incidental Mutation 'IGL01411:Ccdc33'
ID 80050
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccdc33
Ensembl Gene ENSMUSG00000037716
Gene Name coiled-coil domain containing 33
Synonyms LOC382077, 4930535E21Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01411
Quality Score
Status
Chromosome 9
Chromosomal Location 58028677-58118823 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 58117636 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149337 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098681] [ENSMUST00000098682] [ENSMUST00000128021] [ENSMUST00000136154] [ENSMUST00000215944]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000098681
Predicted Effect probably benign
Transcript: ENSMUST00000098682
SMART Domains Protein: ENSMUSP00000096279
Gene: ENSMUSG00000037716

DomainStartEndE-ValueType
C2 281 385 5.79e-3 SMART
coiled coil region 598 636 N/A INTRINSIC
coiled coil region 657 745 N/A INTRINSIC
coiled coil region 884 922 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000128021
SMART Domains Protein: ENSMUSP00000117832
Gene: ENSMUSG00000032327

DomainStartEndE-ValueType
Pfam:RBP_receptor 40 87 8.1e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131007
Predicted Effect probably benign
Transcript: ENSMUST00000136154
SMART Domains Protein: ENSMUSP00000119062
Gene: ENSMUSG00000032327

DomainStartEndE-ValueType
Pfam:RBP_receptor 40 199 1.7e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145886
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146741
Predicted Effect probably benign
Transcript: ENSMUST00000215944
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf G A 19: 31,911,229 E36K possibly damaging Het
Alox8 A T 11: 69,188,690 S257R probably benign Het
Apc2 T C 10: 80,315,078 S1960P probably damaging Het
Arhgap35 T C 7: 16,564,267 N291S probably benign Het
AW551984 A T 9: 39,593,791 D468E possibly damaging Het
B3gnt6 A C 7: 98,194,523 F77V probably damaging Het
C1qtnf7 A T 5: 43,609,061 M1L probably benign Het
Calm3 T C 7: 16,917,484 T63A probably benign Het
Cdh4 C T 2: 179,780,403 R107C probably damaging Het
Cdr2l A G 11: 115,382,366 E15G probably damaging Het
Chil6 A G 3: 106,388,825 W365R probably damaging Het
Ckap5 G T 2: 91,601,011 R1525L probably benign Het
Col6a6 T A 9: 105,785,958 K127* probably null Het
Dclre1b A G 3: 103,803,323 V298A probably damaging Het
Fat1 T A 8: 45,026,800 V2961E probably damaging Het
Fhit T C 14: 9,573,483 D126G probably benign Het
Gpc1 T C 1: 92,857,014 F303S probably damaging Het
Hsd17b4 T A 18: 50,191,814 V698D probably damaging Het
Itpr2 C T 6: 146,376,062 probably null Het
Klhl4 A T X: 114,522,394 D168V probably damaging Het
Krt42 A G 11: 100,263,341 L405P possibly damaging Het
Lrp1 A T 10: 127,581,765 C85* probably null Het
Lrp2 A G 2: 69,482,267 L2559P probably damaging Het
Maob T G X: 16,712,569 R448S possibly damaging Het
Mast3 A G 8: 70,779,583 V1250A possibly damaging Het
Mfsd4b5 C T 10: 39,970,727 V286M probably damaging Het
Mlip A G 9: 77,239,417 I198T possibly damaging Het
Mocs3 T C 2: 168,231,377 V248A probably damaging Het
Nxf2 T A X: 134,952,112 R367S probably benign Het
Olfr1404 T G 1: 173,216,128 V159G probably benign Het
Olfr617 T C 7: 103,584,117 W32R probably damaging Het
Parva T C 7: 112,577,010 probably benign Het
Pot1a A T 6: 25,750,144 probably benign Het
Ptpra T C 2: 130,544,439 I603T probably damaging Het
Rad9a T C 19: 4,201,337 K33E probably benign Het
Rimbp3 A G 16: 17,211,094 D794G probably damaging Het
Sept5 G A 16: 18,624,930 R90C probably damaging Het
Skint8 T A 4: 111,936,906 N164K probably damaging Het
Slc30a3 T G 5: 31,090,080 I73L probably benign Het
Stab2 A T 10: 86,980,008 probably benign Het
Tnc C T 4: 64,000,722 V1155M probably damaging Het
Ttc13 T G 8: 124,683,285 Q525P probably damaging Het
Ttn T C 2: 76,720,135 E31601G probably damaging Het
Unc5a A T 13: 55,002,928 D577V probably damaging Het
Usp18 G A 6: 121,261,421 V176M probably benign Het
Vmn1r184 T C 7: 26,266,895 V22A probably benign Het
Vmn1r33 T A 6: 66,611,881 I230F probably damaging Het
Vmn1r51 A G 6: 90,129,404 I101V probably benign Het
Vmn2r108 T A 17: 20,471,020 M414L probably benign Het
Vmn2r87 A C 10: 130,472,560 V603G probably benign Het
Wt1 A G 2: 105,132,974 Y16C probably damaging Het
Wwp2 C T 8: 107,506,345 T159I probably benign Het
Xirp2 T C 2: 67,514,083 F2223L probably benign Het
Zan T A 5: 137,388,893 H4966L unknown Het
Other mutations in Ccdc33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Ccdc33 APN 9 58069974 splice site probably benign
IGL01403:Ccdc33 APN 9 58117385 missense probably damaging 1.00
IGL01714:Ccdc33 APN 9 58029870 missense possibly damaging 0.91
IGL02028:Ccdc33 APN 9 58076578 missense probably benign 0.13
IGL02158:Ccdc33 APN 9 58030419 missense probably damaging 0.99
IGL02174:Ccdc33 APN 9 58033655 missense probably benign 0.45
IGL02805:Ccdc33 APN 9 58098591 missense probably benign 0.43
R0276:Ccdc33 UTSW 9 58058392 missense probably damaging 0.99
R0537:Ccdc33 UTSW 9 58117454 missense probably damaging 1.00
R0737:Ccdc33 UTSW 9 58082048 missense probably damaging 0.99
R0789:Ccdc33 UTSW 9 58117214 splice site probably benign
R0791:Ccdc33 UTSW 9 58028763 missense possibly damaging 0.66
R0920:Ccdc33 UTSW 9 58033672 missense probably damaging 0.99
R1541:Ccdc33 UTSW 9 58117466 missense probably damaging 0.99
R1759:Ccdc33 UTSW 9 58117446 missense possibly damaging 0.84
R1857:Ccdc33 UTSW 9 58032708 missense possibly damaging 0.66
R1976:Ccdc33 UTSW 9 58117162 nonsense probably null
R1982:Ccdc33 UTSW 9 58117168 missense probably benign 0.07
R2044:Ccdc33 UTSW 9 58031112 missense possibly damaging 0.93
R2224:Ccdc33 UTSW 9 58082022 missense probably damaging 1.00
R2225:Ccdc33 UTSW 9 58082022 missense probably damaging 1.00
R2227:Ccdc33 UTSW 9 58082022 missense probably damaging 1.00
R2369:Ccdc33 UTSW 9 58076630 missense probably benign 0.44
R3899:Ccdc33 UTSW 9 58032917 missense probably damaging 0.99
R4468:Ccdc33 UTSW 9 58029952 missense possibly damaging 0.93
R4468:Ccdc33 UTSW 9 58069872 missense possibly damaging 0.67
R4703:Ccdc33 UTSW 9 58033670 missense possibly damaging 0.86
R4705:Ccdc33 UTSW 9 58117557 missense probably benign 0.01
R4790:Ccdc33 UTSW 9 58029957 missense probably damaging 0.96
R4817:Ccdc33 UTSW 9 58067535 missense probably damaging 0.98
R4879:Ccdc33 UTSW 9 58067556 missense possibly damaging 0.86
R4931:Ccdc33 UTSW 9 58069851 missense probably damaging 1.00
R5015:Ccdc33 UTSW 9 58118635 missense probably damaging 1.00
R5223:Ccdc33 UTSW 9 58032984 missense possibly damaging 0.91
R5327:Ccdc33 UTSW 9 58086577 missense probably benign 0.00
R5528:Ccdc33 UTSW 9 58028795 missense probably benign 0.06
R5534:Ccdc33 UTSW 9 58117167 missense possibly damaging 0.83
R5786:Ccdc33 UTSW 9 58029952 missense possibly damaging 0.93
R5844:Ccdc33 UTSW 9 58033206 splice site probably benign
R5975:Ccdc33 UTSW 9 58117478 missense possibly damaging 0.49
R6120:Ccdc33 UTSW 9 58086600 missense probably damaging 1.00
R6256:Ccdc33 UTSW 9 58101918 splice site probably null
R6363:Ccdc33 UTSW 9 58114335 missense probably benign 0.00
R6610:Ccdc33 UTSW 9 58069136 missense possibly damaging 0.66
R6767:Ccdc33 UTSW 9 58033244 missense possibly damaging 0.96
R7072:Ccdc33 UTSW 9 58111984 makesense probably null
R7121:Ccdc33 UTSW 9 58080884 missense probably benign 0.00
R7182:Ccdc33 UTSW 9 58034173 splice site probably null
R7239:Ccdc33 UTSW 9 58032909 nonsense probably null
R7655:Ccdc33 UTSW 9 58118465 missense probably damaging 0.97
R7656:Ccdc33 UTSW 9 58118465 missense probably damaging 0.97
R7868:Ccdc33 UTSW 9 58069091 missense probably benign
R8215:Ccdc33 UTSW 9 58032712 missense probably benign 0.18
R9139:Ccdc33 UTSW 9 58076559 missense probably benign 0.04
R9204:Ccdc33 UTSW 9 58031105 missense probably benign 0.33
R9280:Ccdc33 UTSW 9 58058266 missense probably benign
R9297:Ccdc33 UTSW 9 58086593 missense possibly damaging 0.85
R9318:Ccdc33 UTSW 9 58086593 missense possibly damaging 0.85
R9361:Ccdc33 UTSW 9 58117625 missense possibly damaging 0.96
RF003:Ccdc33 UTSW 9 58058291 missense probably benign 0.18
Z1176:Ccdc33 UTSW 9 58117416 missense probably benign 0.01
Z1177:Ccdc33 UTSW 9 58118585 missense possibly damaging 0.56
Posted On 2013-11-05