Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01419:Fbxw22'

80304

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw22

Ensembl Gene

ENSMUSG00000070324

Gene Name

F-box and WD-40 domain protein 22

Synonyms

Gm5164

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL01419

Quality Score

Status

Chromosome

Chromosomal Location

109378400-109404296 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109381722 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 407 (Y407F)

Ref Sequence

ENSEMBL: ENSMUSP00000079460 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080626] [ENSMUST00000197213]

AlphaFold

Q5XG67

Predicted Effect

probably benign
Transcript: ENSMUST00000080626
AA Change: Y407F

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000079460
Gene: ENSMUSG00000070324
AA Change: Y407F

Domain	Start	End	E-Value	Type
FBOX	5	45	1.02e-5	SMART
SCOP:d1gxra_	128	220	1e-5	SMART
Blast:WD40	137	176	6e-9	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000197213

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 37,048,121 (GRCm38)	S1323P	probably damaging	Het
Abca2	A	T	2: 25,437,514 (GRCm38)	T672S	probably damaging	Het
Adamts14	A	T	10: 61,205,542 (GRCm38)		probably benign	Het
Adgrv1	T	C	13: 81,557,158 (GRCm38)	E791G	probably damaging	Het
Alkbh8	A	G	9: 3,385,354 (GRCm38)	R584G	probably damaging	Het
Apob	A	T	12: 8,002,251 (GRCm38)	I1218F	probably damaging	Het
Atp5a1	T	C	18: 77,777,533 (GRCm38)	S52P	probably damaging	Het
B4galnt3	A	G	6: 120,215,390 (GRCm38)	S462P	possibly damaging	Het
Bdkrb1	A	G	12: 105,604,781 (GRCm38)	H202R	possibly damaging	Het
Cd300lf	T	C	11: 115,126,354 (GRCm38)	K48E	probably benign	Het
Chuk	A	T	19: 44,096,981 (GRCm38)	I242K	probably damaging	Het
Csde1	A	G	3: 103,038,770 (GRCm38)	T27A	probably damaging	Het
D930048N14Rik	C	T	11: 51,654,776 (GRCm38)		probably benign	Het
Depdc7	A	T	2: 104,722,110 (GRCm38)	Y451N	possibly damaging	Het
Diaph3	C	A	14: 86,965,553 (GRCm38)	G623*	probably null	Het
Dlc1	T	C	8: 36,850,217 (GRCm38)	T435A	probably benign	Het
Dock8	A	G	19: 25,119,452 (GRCm38)	S575G	probably benign	Het
Fzd4	C	A	7: 89,407,735 (GRCm38)	A330E	probably damaging	Het
Gm17415	A	G	1: 93,421,950 (GRCm38)		probably benign	Het
Gm4788	T	C	1: 139,739,644 (GRCm38)		probably null	Het
Gnat1	C	T	9: 107,679,434 (GRCm38)		probably null	Het
Gtf3c4	T	C	2: 28,835,069 (GRCm38)	Y76C	probably damaging	Het
Heatr5b	G	A	17: 78,796,510 (GRCm38)	H1079Y	probably benign	Het
Helz	T	G	11: 107,686,514 (GRCm38)	I1897S	unknown	Het
Hspa12a	T	C	19: 58,828,249 (GRCm38)		probably null	Het
Kcne1	G	T	16: 92,348,646 (GRCm38)	F103L	probably benign	Het
Lrrc20	A	T	10: 61,548,095 (GRCm38)	S94C	probably damaging	Het
Lrrc8a	A	G	2: 30,257,099 (GRCm38)	T642A	probably benign	Het
Ly6g5b	A	G	17: 35,114,518 (GRCm38)	L106P	probably benign	Het
Lyst	A	G	13: 13,635,838 (GRCm38)	S698G	probably benign	Het
Ndrg1	A	G	15: 66,931,051 (GRCm38)	V334A	probably benign	Het
Neb	A	T	2: 52,226,533 (GRCm38)	Y964*	probably null	Het
Olfr1047	A	T	2: 86,228,629 (GRCm38)	I114N	possibly damaging	Het
Olfr1230	T	C	2: 89,296,345 (GRCm38)		probably benign	Het
Parp10	A	G	15: 76,241,388 (GRCm38)	F497L	probably damaging	Het
Pdss1	A	G	2: 22,935,577 (GRCm38)	M343V	possibly damaging	Het
Phactr3	C	T	2: 178,279,062 (GRCm38)	T231I	probably benign	Het
Plekhh2	A	T	17: 84,583,552 (GRCm38)		probably benign	Het
Ppp1r12c	A	C	7: 4,486,352 (GRCm38)		probably null	Het
Prdm2	G	T	4: 143,133,648 (GRCm38)	P1024H	probably damaging	Het
Prkacb	A	T	3: 146,755,693 (GRCm38)	M1K	probably null	Het
Prkdc	C	A	16: 15,835,166 (GRCm38)	P3835Q	probably damaging	Het
Rps27a	T	C	11: 29,546,353 (GRCm38)	T87A	probably benign	Het
Ryr2	T	A	13: 11,799,837 (GRCm38)	E683V	possibly damaging	Het
Sbk2	A	G	7: 4,957,529 (GRCm38)	L214P	probably damaging	Het
Sema4g	A	G	19: 44,997,396 (GRCm38)	S250G	probably benign	Het
Slc27a6	T	A	18: 58,609,209 (GRCm38)	D498E	probably benign	Het
Tarbp1	T	C	8: 126,428,155 (GRCm38)	D1410G	probably benign	Het
Tas2r134	T	A	2: 51,627,747 (GRCm38)	Y79*	probably null	Het
Tie1	T	C	4: 118,476,098 (GRCm38)	D857G	probably damaging	Het
Tnk2	A	G	16: 32,680,680 (GRCm38)	N432S	probably damaging	Het
Tubg2	C	A	11: 101,159,057 (GRCm38)	D176E	probably benign	Het
Ugt2b34	A	T	5: 86,891,405 (GRCm38)	W466R	probably damaging	Het
Usp47	T	A	7: 112,087,911 (GRCm38)	M692K	possibly damaging	Het
Vmn2r106	T	C	17: 20,279,545 (GRCm38)	K143E	probably benign	Het
Vmn2r118	G	A	17: 55,593,000 (GRCm38)	L635F	probably benign	Het
Vmn2r16	C	T	5: 109,362,401 (GRCm38)		probably benign	Het
Vmn2r76	A	T	7: 86,225,702 (GRCm38)	M689K	probably benign	Het
Xkr6	T	C	14: 63,818,876 (GRCm38)	Y79H	probably benign	Het
Zdhhc6	A	G	19: 55,309,754 (GRCm38)	F224L	probably benign	Het
Zfp493	T	G	13: 67,786,802 (GRCm38)	I291M	probably benign	Het

Other mutations in Fbxw22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00592:Fbxw22	APN	9	109,384,040 (GRCm38)	missense	possibly damaging	0.68
IGL00655:Fbxw22	APN	9	109,382,244 (GRCm38)	splice site	probably benign
IGL01122:Fbxw22	APN	9	109,386,671 (GRCm38)	missense	probably damaging	0.99
IGL01455:Fbxw22	APN	9	109,384,994 (GRCm38)	missense	probably benign
IGL01486:Fbxw22	APN	9	109,378,873 (GRCm38)	missense	probably damaging	1.00
IGL01734:Fbxw22	APN	9	109,383,925 (GRCm38)	missense	probably damaging	0.98
IGL02106:Fbxw22	APN	9	109,402,019 (GRCm38)	missense	possibly damaging	0.86
IGL02255:Fbxw22	APN	9	109,386,551 (GRCm38)	splice site	probably benign
IGL02466:Fbxw22	APN	9	109,385,092 (GRCm38)	missense	probably damaging	1.00
IGL02820:Fbxw22	APN	9	109,386,664 (GRCm38)	missense	probably damaging	1.00
R0395:Fbxw22	UTSW	9	109,381,685 (GRCm38)	missense	probably damaging	1.00
R0705:Fbxw22	UTSW	9	109,403,096 (GRCm38)	missense	possibly damaging	0.92
R0741:Fbxw22	UTSW	9	109,382,219 (GRCm38)	missense	probably benign	0.01
R1603:Fbxw22	UTSW	9	109,378,847 (GRCm38)	missense	probably benign	0.00
R1673:Fbxw22	UTSW	9	109,382,128 (GRCm38)	missense	possibly damaging	0.93
R1874:Fbxw22	UTSW	9	109,385,111 (GRCm38)	nonsense	probably null
R2265:Fbxw22	UTSW	9	109,383,994 (GRCm38)	missense	probably benign	0.02
R2269:Fbxw22	UTSW	9	109,383,994 (GRCm38)	missense	probably benign	0.02
R2385:Fbxw22	UTSW	9	109,382,142 (GRCm38)	missense	probably damaging	1.00
R4329:Fbxw22	UTSW	9	109,384,043 (GRCm38)	missense	probably damaging	1.00
R4695:Fbxw22	UTSW	9	109,378,871 (GRCm38)	missense	probably damaging	1.00
R4731:Fbxw22	UTSW	9	109,378,869 (GRCm38)	missense	probably benign	0.02
R4915:Fbxw22	UTSW	9	109,383,941 (GRCm38)	missense	probably damaging	1.00
R5010:Fbxw22	UTSW	9	109,403,424 (GRCm38)	missense	probably benign	0.40
R5070:Fbxw22	UTSW	9	109,385,115 (GRCm38)	missense	probably benign
R5319:Fbxw22	UTSW	9	109,383,947 (GRCm38)	missense	possibly damaging	0.52
R5571:Fbxw22	UTSW	9	109,403,088 (GRCm38)	missense	probably damaging	1.00
R5765:Fbxw22	UTSW	9	109,384,996 (GRCm38)	missense	probably benign	0.00
R5846:Fbxw22	UTSW	9	109,386,761 (GRCm38)	missense	probably benign
R6002:Fbxw22	UTSW	9	109,381,682 (GRCm38)	nonsense	probably null
R6180:Fbxw22	UTSW	9	109,386,679 (GRCm38)	missense	probably damaging	1.00
R6313:Fbxw22	UTSW	9	109,403,397 (GRCm38)	missense	probably damaging	0.99
R6860:Fbxw22	UTSW	9	109,383,962 (GRCm38)	missense	probably benign	0.01
R6949:Fbxw22	UTSW	9	109,382,076 (GRCm38)	missense	probably benign	0.06
R7084:Fbxw22	UTSW	9	109,404,223 (GRCm38)	missense	probably damaging	1.00
R7296:Fbxw22	UTSW	9	109,382,075 (GRCm38)	missense	probably benign
R8499:Fbxw22	UTSW	9	109,385,000 (GRCm38)	missense	probably benign	0.00
R9088:Fbxw22	UTSW	9	109,378,884 (GRCm38)	missense	probably damaging	1.00
R9301:Fbxw22	UTSW	9	109,386,585 (GRCm38)	missense	possibly damaging	0.60
R9501:Fbxw22	UTSW	9	109,378,852 (GRCm38)	missense	probably benign	0.01
R9600:Fbxw22	UTSW	9	109,383,918 (GRCm38)	missense	probably damaging	1.00

Posted On

2013-11-05