Incidental Mutation 'IGL01419:Vmn2r106'
| ID |
80311 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r106
|
| Ensembl Gene |
ENSMUSG00000091656 |
| Gene Name |
vomeronasal 2, receptor 106 |
| Synonyms |
EG224576 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
IGL01419
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
20487809-20505692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20499807 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 143
(K143E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126534
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167464]
|
| AlphaFold |
E9PY92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167464
AA Change: K143E
PolyPhen 2
Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: K143E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
471 |
3.8e-37 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.7e-22 |
PFAM |
|
Pfam:7tm_3
|
596 |
835 |
1.3e-49 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca2 |
A |
T |
2: 25,327,526 (GRCm39) |
T672S |
probably damaging |
Het |
| Adamts14 |
A |
T |
10: 61,041,321 (GRCm39) |
|
probably benign |
Het |
| Adgrv1 |
T |
C |
13: 81,705,277 (GRCm39) |
E791G |
probably damaging |
Het |
| Alkbh8 |
A |
G |
9: 3,385,354 (GRCm39) |
R584G |
probably damaging |
Het |
| Apob |
A |
T |
12: 8,052,251 (GRCm39) |
I1218F |
probably damaging |
Het |
| Atp5f1a |
T |
C |
18: 77,865,233 (GRCm39) |
S52P |
probably damaging |
Het |
| B4galnt3 |
A |
G |
6: 120,192,351 (GRCm39) |
S462P |
possibly damaging |
Het |
| Bdkrb1 |
A |
G |
12: 105,571,040 (GRCm39) |
H202R |
possibly damaging |
Het |
| Bltp1 |
T |
C |
3: 37,102,270 (GRCm39) |
S1323P |
probably damaging |
Het |
| Cd300lf |
T |
C |
11: 115,017,180 (GRCm39) |
K48E |
probably benign |
Het |
| Cfhr4 |
T |
C |
1: 139,667,382 (GRCm39) |
|
probably null |
Het |
| Chuk |
A |
T |
19: 44,085,420 (GRCm39) |
I242K |
probably damaging |
Het |
| Csde1 |
A |
G |
3: 102,946,086 (GRCm39) |
T27A |
probably damaging |
Het |
| D930048N14Rik |
C |
T |
11: 51,545,603 (GRCm39) |
|
probably benign |
Het |
| Depdc7 |
A |
T |
2: 104,552,455 (GRCm39) |
Y451N |
possibly damaging |
Het |
| Diaph3 |
C |
A |
14: 87,202,989 (GRCm39) |
G623* |
probably null |
Het |
| Dlc1 |
T |
C |
8: 37,317,371 (GRCm39) |
T435A |
probably benign |
Het |
| Dock8 |
A |
G |
19: 25,096,816 (GRCm39) |
S575G |
probably benign |
Het |
| Fbxw22 |
T |
A |
9: 109,210,790 (GRCm39) |
Y407F |
probably benign |
Het |
| Fzd4 |
C |
A |
7: 89,056,943 (GRCm39) |
A330E |
probably damaging |
Het |
| Gm17415 |
A |
G |
1: 93,349,672 (GRCm39) |
|
probably benign |
Het |
| Gnat1 |
C |
T |
9: 107,556,633 (GRCm39) |
|
probably null |
Het |
| Gtf3c4 |
T |
C |
2: 28,725,081 (GRCm39) |
Y76C |
probably damaging |
Het |
| Heatr5b |
G |
A |
17: 79,103,939 (GRCm39) |
H1079Y |
probably benign |
Het |
| Helz |
T |
G |
11: 107,577,340 (GRCm39) |
I1897S |
unknown |
Het |
| Hspa12a |
T |
C |
19: 58,816,681 (GRCm39) |
|
probably null |
Het |
| Kcne1 |
G |
T |
16: 92,145,534 (GRCm39) |
F103L |
probably benign |
Het |
| Lrrc20 |
A |
T |
10: 61,383,874 (GRCm39) |
S94C |
probably damaging |
Het |
| Lrrc8a |
A |
G |
2: 30,147,111 (GRCm39) |
T642A |
probably benign |
Het |
| Ly6g5b |
A |
G |
17: 35,333,494 (GRCm39) |
L106P |
probably benign |
Het |
| Lyst |
A |
G |
13: 13,810,423 (GRCm39) |
S698G |
probably benign |
Het |
| Ndrg1 |
A |
G |
15: 66,802,900 (GRCm39) |
V334A |
probably benign |
Het |
| Neb |
A |
T |
2: 52,116,545 (GRCm39) |
Y964* |
probably null |
Het |
| Or4c123 |
T |
C |
2: 89,126,689 (GRCm39) |
|
probably benign |
Het |
| Or8k3 |
A |
T |
2: 86,058,973 (GRCm39) |
I114N |
possibly damaging |
Het |
| Parp10 |
A |
G |
15: 76,125,588 (GRCm39) |
F497L |
probably damaging |
Het |
| Pdss1 |
A |
G |
2: 22,825,589 (GRCm39) |
M343V |
possibly damaging |
Het |
| Phactr3 |
C |
T |
2: 177,920,855 (GRCm39) |
T231I |
probably benign |
Het |
| Plekhh2 |
A |
T |
17: 84,890,980 (GRCm39) |
|
probably benign |
Het |
| Ppp1r12c |
A |
C |
7: 4,489,351 (GRCm39) |
|
probably null |
Het |
| Prdm2 |
G |
T |
4: 142,860,218 (GRCm39) |
P1024H |
probably damaging |
Het |
| Prkacb |
A |
T |
3: 146,461,448 (GRCm39) |
M1K |
probably null |
Het |
| Prkdc |
C |
A |
16: 15,653,030 (GRCm39) |
P3835Q |
probably damaging |
Het |
| Rps27a |
T |
C |
11: 29,496,353 (GRCm39) |
T87A |
probably benign |
Het |
| Ryr2 |
T |
A |
13: 11,814,723 (GRCm39) |
E683V |
possibly damaging |
Het |
| Sbk2 |
A |
G |
7: 4,960,528 (GRCm39) |
L214P |
probably damaging |
Het |
| Sema4g |
A |
G |
19: 44,985,835 (GRCm39) |
S250G |
probably benign |
Het |
| Slc27a6 |
T |
A |
18: 58,742,281 (GRCm39) |
D498E |
probably benign |
Het |
| Tarbp1 |
T |
C |
8: 127,154,894 (GRCm39) |
D1410G |
probably benign |
Het |
| Tas2r134 |
T |
A |
2: 51,517,759 (GRCm39) |
Y79* |
probably null |
Het |
| Tie1 |
T |
C |
4: 118,333,295 (GRCm39) |
D857G |
probably damaging |
Het |
| Tnk2 |
A |
G |
16: 32,499,498 (GRCm39) |
N432S |
probably damaging |
Het |
| Tubg2 |
C |
A |
11: 101,049,883 (GRCm39) |
D176E |
probably benign |
Het |
| Ugt2b34 |
A |
T |
5: 87,039,264 (GRCm39) |
W466R |
probably damaging |
Het |
| Usp47 |
T |
A |
7: 111,687,118 (GRCm39) |
M692K |
possibly damaging |
Het |
| Vmn2r118 |
G |
A |
17: 55,900,000 (GRCm39) |
L635F |
probably benign |
Het |
| Vmn2r16 |
C |
T |
5: 109,510,267 (GRCm39) |
|
probably benign |
Het |
| Vmn2r76 |
A |
T |
7: 85,874,910 (GRCm39) |
M689K |
probably benign |
Het |
| Xkr6 |
T |
C |
14: 64,056,325 (GRCm39) |
Y79H |
probably benign |
Het |
| Zdhhc6 |
A |
G |
19: 55,298,186 (GRCm39) |
F224L |
probably benign |
Het |
| Zfp493 |
T |
G |
13: 67,934,921 (GRCm39) |
I291M |
probably benign |
Het |
|
| Other mutations in Vmn2r106 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00979:Vmn2r106
|
APN |
17 |
20,497,837 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01313:Vmn2r106
|
APN |
17 |
20,498,651 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01574:Vmn2r106
|
APN |
17 |
20,488,572 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01796:Vmn2r106
|
APN |
17 |
20,488,314 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01893:Vmn2r106
|
APN |
17 |
20,497,730 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01895:Vmn2r106
|
APN |
17 |
20,499,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02378:Vmn2r106
|
APN |
17 |
20,497,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02430:Vmn2r106
|
APN |
17 |
20,499,158 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02664:Vmn2r106
|
APN |
17 |
20,488,344 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03308:Vmn2r106
|
APN |
17 |
20,498,785 (GRCm39) |
nonsense |
probably null |
|
|
IGL03384:Vmn2r106
|
APN |
17 |
20,488,405 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0401:Vmn2r106
|
UTSW |
17 |
20,499,281 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0842:Vmn2r106
|
UTSW |
17 |
20,488,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0964:Vmn2r106
|
UTSW |
17 |
20,487,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1235:Vmn2r106
|
UTSW |
17 |
20,499,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1709:Vmn2r106
|
UTSW |
17 |
20,499,373 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1712:Vmn2r106
|
UTSW |
17 |
20,498,997 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1770:Vmn2r106
|
UTSW |
17 |
20,488,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2049:Vmn2r106
|
UTSW |
17 |
20,488,566 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2245:Vmn2r106
|
UTSW |
17 |
20,488,423 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2336:Vmn2r106
|
UTSW |
17 |
20,488,470 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2910:Vmn2r106
|
UTSW |
17 |
20,498,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3025:Vmn2r106
|
UTSW |
17 |
20,499,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3944:Vmn2r106
|
UTSW |
17 |
20,487,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4081:Vmn2r106
|
UTSW |
17 |
20,487,818 (GRCm39) |
nonsense |
probably null |
|
|
R4153:Vmn2r106
|
UTSW |
17 |
20,488,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4356:Vmn2r106
|
UTSW |
17 |
20,499,910 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4426:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4590:Vmn2r106
|
UTSW |
17 |
20,497,728 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4661:Vmn2r106
|
UTSW |
17 |
20,487,885 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5106:Vmn2r106
|
UTSW |
17 |
20,499,395 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5341:Vmn2r106
|
UTSW |
17 |
20,497,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5509:Vmn2r106
|
UTSW |
17 |
20,498,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5826:Vmn2r106
|
UTSW |
17 |
20,499,133 (GRCm39) |
missense |
probably benign |
|
|
R5859:Vmn2r106
|
UTSW |
17 |
20,505,583 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5937:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
nonsense |
probably null |
|
|
R5972:Vmn2r106
|
UTSW |
17 |
20,498,738 (GRCm39) |
missense |
probably benign |
|
|
R6056:Vmn2r106
|
UTSW |
17 |
20,487,806 (GRCm39) |
splice site |
probably null |
|
|
R6108:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6114:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6115:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6132:Vmn2r106
|
UTSW |
17 |
20,488,666 (GRCm39) |
missense |
probably benign |
|
|
R6208:Vmn2r106
|
UTSW |
17 |
20,488,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6217:Vmn2r106
|
UTSW |
17 |
20,488,501 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6289:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Vmn2r106
|
UTSW |
17 |
20,498,667 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6390:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6391:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6392:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6405:Vmn2r106
|
UTSW |
17 |
20,499,361 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6427:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6435:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6436:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6437:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6511:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6512:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6587:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6703:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6730:Vmn2r106
|
UTSW |
17 |
20,499,096 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6961:Vmn2r106
|
UTSW |
17 |
20,488,646 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Vmn2r106
|
UTSW |
17 |
20,499,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7379:Vmn2r106
|
UTSW |
17 |
20,488,037 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7402:Vmn2r106
|
UTSW |
17 |
20,487,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7497:Vmn2r106
|
UTSW |
17 |
20,488,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7692:Vmn2r106
|
UTSW |
17 |
20,505,490 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8539:Vmn2r106
|
UTSW |
17 |
20,499,271 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8827:Vmn2r106
|
UTSW |
17 |
20,487,868 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8872:Vmn2r106
|
UTSW |
17 |
20,488,401 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9118:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9254:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9379:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Posted On |
2013-11-05 |
Incidental Mutation