Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01419:Vmn2r118'

80327

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL01419

Quality Score

Status

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 55593000 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 635 (L635F)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably benign
Transcript: ENSMUST00000168440
AA Change: L635F

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: L635F

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 37,048,121	S1323P	probably damaging	Het
Abca2	A	T	2: 25,437,514	T672S	probably damaging	Het
Adamts14	A	T	10: 61,205,542		probably benign	Het
Adgrv1	T	C	13: 81,557,158	E791G	probably damaging	Het
Alkbh8	A	G	9: 3,385,354	R584G	probably damaging	Het
Apob	A	T	12: 8,002,251	I1218F	probably damaging	Het
Atp5a1	T	C	18: 77,777,533	S52P	probably damaging	Het
B4galnt3	A	G	6: 120,215,390	S462P	possibly damaging	Het
Bdkrb1	A	G	12: 105,604,781	H202R	possibly damaging	Het
Cd300lf	T	C	11: 115,126,354	K48E	probably benign	Het
Chuk	A	T	19: 44,096,981	I242K	probably damaging	Het
Csde1	A	G	3: 103,038,770	T27A	probably damaging	Het
D930048N14Rik	C	T	11: 51,654,776		probably benign	Het
Depdc7	A	T	2: 104,722,110	Y451N	possibly damaging	Het
Diaph3	C	A	14: 86,965,553	G623*	probably null	Het
Dlc1	T	C	8: 36,850,217	T435A	probably benign	Het
Dock8	A	G	19: 25,119,452	S575G	probably benign	Het
Fbxw22	T	A	9: 109,381,722	Y407F	probably benign	Het
Fzd4	C	A	7: 89,407,735	A330E	probably damaging	Het
Gm17415	A	G	1: 93,421,950		probably benign	Het
Gm4788	T	C	1: 139,739,644		probably null	Het
Gnat1	C	T	9: 107,679,434		probably null	Het
Gtf3c4	T	C	2: 28,835,069	Y76C	probably damaging	Het
Heatr5b	G	A	17: 78,796,510	H1079Y	probably benign	Het
Helz	T	G	11: 107,686,514	I1897S	unknown	Het
Hspa12a	T	C	19: 58,828,249		probably null	Het
Kcne1	G	T	16: 92,348,646	F103L	probably benign	Het
Lrrc20	A	T	10: 61,548,095	S94C	probably damaging	Het
Lrrc8a	A	G	2: 30,257,099	T642A	probably benign	Het
Ly6g5b	A	G	17: 35,114,518	L106P	probably benign	Het
Lyst	A	G	13: 13,635,838	S698G	probably benign	Het
Ndrg1	A	G	15: 66,931,051	V334A	probably benign	Het
Neb	A	T	2: 52,226,533	Y964*	probably null	Het
Olfr1047	A	T	2: 86,228,629	I114N	possibly damaging	Het
Olfr1230	T	C	2: 89,296,345		probably benign	Het
Parp10	A	G	15: 76,241,388	F497L	probably damaging	Het
Pdss1	A	G	2: 22,935,577	M343V	possibly damaging	Het
Phactr3	C	T	2: 178,279,062	T231I	probably benign	Het
Plekhh2	A	T	17: 84,583,552		probably benign	Het
Ppp1r12c	A	C	7: 4,486,352		probably null	Het
Prdm2	G	T	4: 143,133,648	P1024H	probably damaging	Het
Prkacb	A	T	3: 146,755,693	M1K	probably null	Het
Prkdc	C	A	16: 15,835,166	P3835Q	probably damaging	Het
Rps27a	T	C	11: 29,546,353	T87A	probably benign	Het
Ryr2	T	A	13: 11,799,837	E683V	possibly damaging	Het
Sbk2	A	G	7: 4,957,529	L214P	probably damaging	Het
Sema4g	A	G	19: 44,997,396	S250G	probably benign	Het
Slc27a6	T	A	18: 58,609,209	D498E	probably benign	Het
Tarbp1	T	C	8: 126,428,155	D1410G	probably benign	Het
Tas2r134	T	A	2: 51,627,747	Y79*	probably null	Het
Tie1	T	C	4: 118,476,098	D857G	probably damaging	Het
Tnk2	A	G	16: 32,680,680	N432S	probably damaging	Het
Tubg2	C	A	11: 101,159,057	D176E	probably benign	Het
Ugt2b34	A	T	5: 86,891,405	W466R	probably damaging	Het
Usp47	T	A	7: 112,087,911	M692K	possibly damaging	Het
Vmn2r106	T	C	17: 20,279,545	K143E	probably benign	Het
Vmn2r16	C	T	5: 109,362,401		probably benign	Het
Vmn2r76	A	T	7: 86,225,702	M689K	probably benign	Het
Xkr6	T	C	14: 63,818,876	Y79H	probably benign	Het
Zdhhc6	A	G	19: 55,309,754	F224L	probably benign	Het
Zfp493	T	G	13: 67,786,802	I291M	probably benign	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55592708	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55593204	missense	probably damaging	1.00
IGL01796:Vmn2r118	APN	17	55608585	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55592990	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55592619	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55610517	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55624598	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55610870	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55592655	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55607996	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55608616	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55608643	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55611021	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55610970	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55610772	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55608466	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55608620	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55593237	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55610643	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55608083	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55611530	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55592456	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55610406	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55611556	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55592882	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55592925	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55624650	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55608421	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55610347	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55610665	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55610860	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55592581	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55592894	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55592765	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55593103	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55624494	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55592871	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55608093	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55592996	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55592714	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55592348	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55610440	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55592853	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55593242	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55608484	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55610936	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55610423	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55608057	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55608642	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55610216	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55610835	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55611649	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55610207	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55592837	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55611009	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55608415	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55593218	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55610655	nonsense	probably null

Posted On

2013-11-05