Incidental Mutation 'R0880:Ifi209'
ID 80449
Institutional Source Beutler Lab
Gene Symbol Ifi209
Ensembl Gene ENSMUSG00000043263
Gene Name interferon activated gene 209
Synonyms Ifix, Pyhin-1, Pyhin1
MMRRC Submission 039047-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R0880 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 173458483-173475494 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 173472379 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 407 (S407T)
Ref Sequence ENSEMBL: ENSMUSP00000061900 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056071] [ENSMUST00000193727]
AlphaFold Q8BV49
Predicted Effect probably damaging
Transcript: ENSMUST00000056071
AA Change: S407T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000061900
Gene: ENSMUSG00000043263
AA Change: S407T

DomainStartEndE-ValueType
PYRIN 6 83 3.54e-17 SMART
low complexity region 152 169 N/A INTRINSIC
Pfam:HIN 231 396 4.2e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193727
SMART Domains Protein: ENSMUSP00000142161
Gene: ENSMUSG00000043263

DomainStartEndE-ValueType
PYRIN 6 83 1.7e-21 SMART
low complexity region 152 169 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200598
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.6%
  • 20x: 92.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 A G 6: 128,537,609 (GRCm39) Y701H possibly damaging Het
Akap6 A G 12: 53,186,291 (GRCm39) D1235G possibly damaging Het
Arhgef18 A G 8: 3,439,032 (GRCm39) probably benign Het
Astn2 A G 4: 65,566,567 (GRCm39) Y812H probably damaging Het
Bmpr1b G T 3: 141,576,557 (GRCm39) S92* probably null Het
Camsap2 T C 1: 136,208,708 (GRCm39) D934G probably benign Het
Cdh23 A G 10: 60,242,200 (GRCm39) V1076A possibly damaging Het
Cdhr1 T C 14: 36,802,591 (GRCm39) D624G possibly damaging Het
Cfap57 A T 4: 118,439,035 (GRCm39) Y830* probably null Het
Eml3 A G 19: 8,918,279 (GRCm39) D790G possibly damaging Het
Ess2 A G 16: 17,729,051 (GRCm39) V40A probably damaging Het
Gucy2c T C 6: 136,686,830 (GRCm39) probably null Het
Helz2 A C 2: 180,877,928 (GRCm39) S957A probably benign Het
Iftap T A 2: 101,406,455 (GRCm39) T158S probably benign Het
Muc6 T C 7: 141,217,270 (GRCm39) T2403A possibly damaging Het
Nfe2 T C 15: 103,157,689 (GRCm39) N101D probably damaging Het
Nsf A T 11: 103,804,198 (GRCm39) V178D possibly damaging Het
P4ha3 A G 7: 99,955,116 (GRCm39) T324A probably benign Het
Pdia3 G A 2: 121,262,858 (GRCm39) G275S probably damaging Het
Rhbdf1 T C 11: 32,163,432 (GRCm39) probably null Het
Samd9l G A 6: 3,377,064 (GRCm39) L66F probably damaging Het
Speg T C 1: 75,381,705 (GRCm39) F1024S probably damaging Het
Sspo A G 6: 48,452,869 (GRCm39) N2859S possibly damaging Het
Tnfrsf21 G A 17: 43,348,733 (GRCm39) W115* probably null Het
Other mutations in Ifi209
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Ifi209 APN 1 173,466,529 (GRCm39) missense possibly damaging 0.88
IGL02598:Ifi209 APN 1 173,472,281 (GRCm39) missense probably damaging 0.99
IGL02712:Ifi209 APN 1 173,470,267 (GRCm39) missense possibly damaging 0.68
IGL03131:Ifi209 APN 1 173,468,800 (GRCm39) missense possibly damaging 0.86
IGL03368:Ifi209 APN 1 173,470,057 (GRCm39) missense possibly damaging 0.91
R1317:Ifi209 UTSW 1 173,465,029 (GRCm39) missense possibly damaging 0.96
R1640:Ifi209 UTSW 1 173,464,931 (GRCm39) missense probably damaging 0.98
R1769:Ifi209 UTSW 1 173,468,728 (GRCm39) missense probably benign 0.11
R2349:Ifi209 UTSW 1 173,470,122 (GRCm39) missense probably damaging 1.00
R5096:Ifi209 UTSW 1 173,472,300 (GRCm39) missense probably benign 0.17
R5369:Ifi209 UTSW 1 173,464,873 (GRCm39) start codon destroyed probably null 1.00
R5484:Ifi209 UTSW 1 173,468,640 (GRCm39) missense probably benign 0.18
R5532:Ifi209 UTSW 1 173,466,542 (GRCm39) missense probably damaging 0.99
R5551:Ifi209 UTSW 1 173,468,763 (GRCm39) missense probably benign 0.01
R5554:Ifi209 UTSW 1 173,468,763 (GRCm39) missense probably benign 0.01
R5749:Ifi209 UTSW 1 173,464,893 (GRCm39) missense probably damaging 1.00
R5960:Ifi209 UTSW 1 173,466,382 (GRCm39) splice site probably null
R6401:Ifi209 UTSW 1 173,472,269 (GRCm39) missense probably damaging 0.99
R7042:Ifi209 UTSW 1 173,470,236 (GRCm39) missense probably benign 0.34
R7304:Ifi209 UTSW 1 173,470,156 (GRCm39) missense possibly damaging 0.88
R7521:Ifi209 UTSW 1 173,470,261 (GRCm39) missense probably damaging 0.97
R7742:Ifi209 UTSW 1 173,470,198 (GRCm39) missense probably damaging 1.00
R7763:Ifi209 UTSW 1 173,470,445 (GRCm39) missense probably damaging 1.00
R7975:Ifi209 UTSW 1 173,468,722 (GRCm39) missense probably benign 0.24
R8498:Ifi209 UTSW 1 173,470,069 (GRCm39) missense probably benign 0.05
R8873:Ifi209 UTSW 1 173,470,156 (GRCm39) missense probably damaging 1.00
R9178:Ifi209 UTSW 1 173,464,969 (GRCm39) missense probably damaging 1.00
R9673:Ifi209 UTSW 1 173,470,332 (GRCm39) missense probably damaging 1.00
R9752:Ifi209 UTSW 1 173,472,235 (GRCm39) missense probably damaging 0.99
Z1088:Ifi209 UTSW 1 173,468,712 (GRCm39) missense probably benign 0.00
Z1088:Ifi209 UTSW 1 173,464,973 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCTACCTCGTATCTCAACCTATAGCTC -3'
(R):5'- GATCTGTGTGTCAGGGTGACAAGAAAA -3'

Sequencing Primer
(F):5'- GCCATTTCTCATGGAATGAGC -3'
(R):5'- gcctccaactcatacatatcaac -3'
Posted On 2013-11-07