Mutagenetix > Incidental Mutation

Incidental Mutation 'R0927:Lrba'

80477

Institutional Source

Beutler Lab

Gene Symbol

Lrba

Ensembl Gene

ENSMUSG00000028080

Gene Name

LPS-responsive beige-like anchor

Synonyms

Lba, D3Ertd775e

MMRRC Submission

039074-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0927 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

86131987-86689999 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 86687540 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 2815 (I2815T)

Ref Sequence

ENSEMBL: ENSMUSP00000103261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107635] [ENSMUST00000194759] [ENSMUST00000195524]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000107635
AA Change: I2815T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000103261
Gene: ENSMUSG00000028080
AA Change: I2815T

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	211	377	4.6e-13	PFAM
Pfam:DUF4704	446	717	2.5e-109	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2049	7e-88	PFAM
Pfam:PH_BEACH	2075	2172	9.1e-31	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART
WD40	2760	2798	1.79e-1	SMART
WD40	2801	2840	4.28e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194490

Predicted Effect

probably benign
Transcript: ENSMUST00000194759

SMART Domains

Protein: ENSMUSP00000142043
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	205	377	8.1e-18	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2050	1.6e-92	PFAM
Pfam:PH_BEACH	2068	2172	8.3e-32	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000195524
AA Change: I719T

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000141734
Gene: ENSMUSG00000028080
AA Change: I719T

Domain	Start	End	E-Value	Type
Pfam:PH_BEACH	3	76	3.6e-20	PFAM
Beach	107	384	2.87e-207	SMART
WD40	482	519	7.4e0	SMART
WD40	522	565	1.72e0	SMART
WD40	581	620	3.99e-1	SMART
WD40	664	702	1.79e-1	SMART
WD40	705	744	4.28e0	SMART

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.0%
20x: 93.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased numbers of myeloid-derived suppressor cells and regulatory T cells, abnormal NK cell physiology, impaired rejection of allogeneic, xenogeneic and missing self bone-marrow grafts, and resistance to acute graft vs host disease. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb8	T	C	5: 24,607,317 (GRCm39)	L363P	probably damaging	Het
Adam12	T	A	7: 133,599,959 (GRCm39)	H85L	probably damaging	Het
Adam34	A	T	8: 44,104,621 (GRCm39)	H341Q	probably damaging	Het
Adam34l	A	T	8: 44,078,160 (GRCm39)	M688K	probably benign	Het
Adam7	A	G	14: 68,754,133 (GRCm39)	L322P	probably damaging	Het
Adcy5	T	A	16: 34,976,613 (GRCm39)	S49T	probably benign	Het
Arfgap2	T	C	2: 91,104,150 (GRCm39)	S374P	probably benign	Het
Arpp19	G	A	9: 74,944,967 (GRCm39)		probably benign	Het
Baz1a	T	C	12: 54,941,773 (GRCm39)	K1478E	probably damaging	Het
Cdc27	G	T	11: 104,396,467 (GRCm39)	A812E	possibly damaging	Het
Chtf8	G	A	8: 107,612,150 (GRCm39)	T263I	probably damaging	Het
Clcn6	T	C	4: 148,113,849 (GRCm39)	N70D	probably benign	Het
Cntnap5c	A	T	17: 58,349,553 (GRCm39)	T289S	possibly damaging	Het
Dzip3	T	C	16: 48,795,840 (GRCm39)	N177S	probably damaging	Het
Edar	G	T	10: 58,465,313 (GRCm39)		probably null	Het
Enam	T	A	5: 88,641,919 (GRCm39)	N244K	possibly damaging	Het
Fbxw10	A	G	11: 62,767,770 (GRCm39)	K874E	probably damaging	Het
Glra3	A	G	8: 56,578,239 (GRCm39)	E432G	possibly damaging	Het
Grin3b	G	A	10: 79,807,062 (GRCm39)	R110Q	probably benign	Het
Herc3	T	A	6: 58,845,748 (GRCm39)	V423D	possibly damaging	Het
Ifit2	A	T	19: 34,550,984 (GRCm39)	T175S	probably benign	Het
Kcnj8	T	G	6: 142,511,627 (GRCm39)	I327L	possibly damaging	Het
Kcns2	A	T	15: 34,839,242 (GRCm39)	I202F	probably benign	Het
Kif12	T	C	4: 63,087,010 (GRCm39)	R305G	possibly damaging	Het
Limch1	A	G	5: 67,154,576 (GRCm39)	D362G	probably damaging	Het
Lrrtm1	G	T	6: 77,221,843 (GRCm39)	M433I	probably damaging	Het
Myh7b	A	G	2: 155,462,040 (GRCm39)	D312G	probably damaging	Het
Nrxn1	A	T	17: 90,344,758 (GRCm39)	I382N	probably damaging	Het
Nudt6	C	T	3: 37,459,502 (GRCm39)	R161H	probably benign	Het
Or10w1	T	A	19: 13,631,816 (GRCm39)	W8R	probably damaging	Het
Or11g2	A	C	14: 50,856,044 (GRCm39)	M122L	possibly damaging	Het
Or4m1	A	T	14: 50,558,186 (GRCm39)	Y35*	probably null	Het
Or7e166	C	T	9: 19,624,945 (GRCm39)	A274V	probably benign	Het
Pmf1	A	T	3: 88,303,369 (GRCm39)	V64D	probably damaging	Het
Pomgnt1	T	A	4: 116,009,048 (GRCm39)	V29D	probably damaging	Het
Pramel22	T	A	4: 143,380,790 (GRCm39)	H411L	possibly damaging	Het
Pramel26	A	T	4: 143,539,378 (GRCm39)	D38E	probably benign	Het
Prex1	C	T	2: 166,428,457 (GRCm39)	A925T	probably benign	Het
Pus3	A	G	9: 35,476,327 (GRCm39)	Y72C	probably damaging	Het
Rnf20	T	C	4: 49,642,176 (GRCm39)	S247P	probably damaging	Het
Rnf213	T	A	11: 119,305,396 (GRCm39)	D542E	probably benign	Het
Sidt1	T	C	16: 44,063,895 (GRCm39)	D786G	probably benign	Het
Sirt6	A	T	10: 81,458,475 (GRCm39)	D219E	probably damaging	Het
Slc36a2	A	T	11: 55,072,411 (GRCm39)	I67N	probably damaging	Het
Slc47a1	A	G	11: 61,264,248 (GRCm39)	F57S	probably damaging	Het
Spg11	T	A	2: 121,924,968 (GRCm39)	T756S	probably damaging	Het
Sptbn1	C	A	11: 30,071,591 (GRCm39)	R1447L	probably damaging	Het
Tcf7l2	A	G	19: 55,907,387 (GRCm39)	M340V	probably damaging	Het
Thap1	T	C	8: 26,652,733 (GRCm39)	V157A	probably benign	Het
Ubash3b	G	A	9: 40,934,853 (GRCm39)	Q354*	probably null	Het
Ubtd1	G	A	19: 42,020,460 (GRCm39)	W68*	probably null	Het
Wdr64	G	T	1: 175,620,647 (GRCm39)	R793L	probably damaging	Het
Zbtb24	C	T	10: 41,327,432 (GRCm39)	T106I	probably benign	Het
Zbtb26	T	C	2: 37,326,337 (GRCm39)	N233S	possibly damaging	Het
Zcchc24	A	T	14: 25,757,585 (GRCm39)	N99K	possibly damaging	Het

Other mutations in Lrba

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Lrba	APN	3	86,267,089 (GRCm39)	missense	probably benign	0.00
IGL00788:Lrba	APN	3	86,234,992 (GRCm39)	missense	probably damaging	0.97
IGL01139:Lrba	APN	3	86,549,969 (GRCm39)	missense	possibly damaging	0.88
IGL01302:Lrba	APN	3	86,202,707 (GRCm39)	missense	probably damaging	1.00
IGL01612:Lrba	APN	3	86,683,484 (GRCm39)	missense	possibly damaging	0.89
IGL01718:Lrba	APN	3	86,258,555 (GRCm39)	missense	probably damaging	1.00
IGL01719:Lrba	APN	3	86,234,903 (GRCm39)	splice site	probably benign
IGL01730:Lrba	APN	3	86,648,731 (GRCm39)	missense	possibly damaging	0.89
IGL01735:Lrba	APN	3	86,234,968 (GRCm39)	missense	probably benign	0.28
IGL01875:Lrba	APN	3	86,217,354 (GRCm39)	missense	probably damaging	1.00
IGL01884:Lrba	APN	3	86,217,719 (GRCm39)	missense	possibly damaging	0.86
IGL02264:Lrba	APN	3	86,687,569 (GRCm39)	missense	probably damaging	0.99
IGL02638:Lrba	APN	3	86,232,380 (GRCm39)	missense	probably damaging	0.97
IGL02647:Lrba	APN	3	86,267,038 (GRCm39)	missense	probably benign	0.00
IGL02664:Lrba	APN	3	86,233,038 (GRCm39)	missense	possibly damaging	0.84
IGL02728:Lrba	APN	3	86,683,356 (GRCm39)	missense	probably damaging	0.99
IGL02730:Lrba	APN	3	86,235,506 (GRCm39)	missense	probably damaging	1.00
IGL02883:Lrba	APN	3	86,352,720 (GRCm39)	missense	probably damaging	0.99
IGL02883:Lrba	APN	3	86,261,513 (GRCm39)	missense	probably damaging	1.00
IGL02948:Lrba	APN	3	86,217,691 (GRCm39)	splice site	probably null
IGL03090:Lrba	APN	3	86,680,448 (GRCm39)	missense	probably benign	0.01
molasses	UTSW	3	86,261,614 (GRCm39)	critical splice donor site	probably null
oscar	UTSW	3	86,257,611 (GRCm39)	nonsense	probably null
oscar2	UTSW	3	86,571,765 (GRCm39)	nonsense	probably null
P0023:Lrba	UTSW	3	86,325,242 (GRCm39)	missense	probably damaging	1.00
PIT4802001:Lrba	UTSW	3	86,571,801 (GRCm39)	nonsense	probably null
R0077:Lrba	UTSW	3	86,449,995 (GRCm39)	missense	probably damaging	0.99
R0189:Lrba	UTSW	3	86,275,816 (GRCm39)	missense	probably damaging	1.00
R0217:Lrba	UTSW	3	86,550,029 (GRCm39)	missense	probably damaging	1.00
R0349:Lrba	UTSW	3	86,447,312 (GRCm39)	missense	probably damaging	1.00
R0396:Lrba	UTSW	3	86,202,486 (GRCm39)	missense	probably damaging	1.00
R0417:Lrba	UTSW	3	86,622,961 (GRCm39)	missense	probably damaging	1.00
R0536:Lrba	UTSW	3	86,622,839 (GRCm39)	missense	probably damaging	1.00
R0712:Lrba	UTSW	3	86,205,297 (GRCm39)	nonsense	probably null
R0722:Lrba	UTSW	3	86,513,296 (GRCm39)	critical splice donor site	probably null
R0828:Lrba	UTSW	3	86,515,677 (GRCm39)	splice site	probably null
R1120:Lrba	UTSW	3	86,202,499 (GRCm39)	missense	probably damaging	1.00
R1141:Lrba	UTSW	3	86,526,865 (GRCm39)	missense	probably damaging	1.00
R1276:Lrba	UTSW	3	86,571,833 (GRCm39)	missense	probably damaging	1.00
R1449:Lrba	UTSW	3	86,261,585 (GRCm39)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,644,449 (GRCm39)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,644,449 (GRCm39)	missense	probably damaging	1.00
R1474:Lrba	UTSW	3	86,687,573 (GRCm39)	splice site	probably benign
R1558:Lrba	UTSW	3	86,258,622 (GRCm39)	missense	probably damaging	1.00
R1596:Lrba	UTSW	3	86,257,611 (GRCm39)	nonsense	probably null
R1652:Lrba	UTSW	3	86,447,245 (GRCm39)	missense	probably damaging	1.00
R1800:Lrba	UTSW	3	86,259,175 (GRCm39)	missense	probably benign	0.00
R1819:Lrba	UTSW	3	86,449,941 (GRCm39)	missense	possibly damaging	0.80
R1862:Lrba	UTSW	3	86,680,510 (GRCm39)	critical splice donor site	probably null
R1917:Lrba	UTSW	3	86,571,808 (GRCm39)	missense	probably damaging	1.00
R1965:Lrba	UTSW	3	86,513,175 (GRCm39)	critical splice acceptor site	probably null
R1966:Lrba	UTSW	3	86,513,175 (GRCm39)	critical splice acceptor site	probably null
R1969:Lrba	UTSW	3	86,515,696 (GRCm39)	missense	probably damaging	0.99
R2011:Lrba	UTSW	3	86,217,324 (GRCm39)	missense	probably damaging	0.99
R2179:Lrba	UTSW	3	86,261,588 (GRCm39)	missense	probably damaging	1.00
R2186:Lrba	UTSW	3	86,211,643 (GRCm39)	missense	probably damaging	1.00
R2281:Lrba	UTSW	3	86,683,410 (GRCm39)	missense	possibly damaging	0.46
R2359:Lrba	UTSW	3	86,256,057 (GRCm39)	missense	probably benign	0.01
R2412:Lrba	UTSW	3	86,235,007 (GRCm39)	missense	probably damaging	1.00
R2496:Lrba	UTSW	3	86,439,394 (GRCm39)	missense	probably damaging	1.00
R3153:Lrba	UTSW	3	86,192,526 (GRCm39)	missense	probably damaging	0.99
R3708:Lrba	UTSW	3	86,192,331 (GRCm39)	missense	possibly damaging	0.80
R3746:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3747:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3748:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3749:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3750:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3758:Lrba	UTSW	3	86,683,356 (GRCm39)	missense	probably damaging	0.99
R3975:Lrba	UTSW	3	86,258,562 (GRCm39)	missense	probably damaging	1.00
R4210:Lrba	UTSW	3	86,267,433 (GRCm39)	missense	probably damaging	1.00
R4258:Lrba	UTSW	3	86,352,656 (GRCm39)	missense	probably damaging	1.00
R4657:Lrba	UTSW	3	86,644,471 (GRCm39)	missense	probably damaging	1.00
R4713:Lrba	UTSW	3	86,267,175 (GRCm39)	missense	probably benign	0.13
R4716:Lrba	UTSW	3	86,550,021 (GRCm39)	missense	probably damaging	0.99
R4811:Lrba	UTSW	3	86,683,448 (GRCm39)	missense	probably damaging	1.00
R4827:Lrba	UTSW	3	86,267,457 (GRCm39)	missense	possibly damaging	0.85
R4840:Lrba	UTSW	3	86,526,816 (GRCm39)	critical splice acceptor site	probably null
R4920:Lrba	UTSW	3	86,571,765 (GRCm39)	nonsense	probably null
R4948:Lrba	UTSW	3	86,192,335 (GRCm39)	missense	probably damaging	1.00
R4970:Lrba	UTSW	3	86,132,678 (GRCm39)	missense	probably benign	0.23
R4985:Lrba	UTSW	3	86,234,743 (GRCm39)	splice site	probably null
R4993:Lrba	UTSW	3	86,267,344 (GRCm39)	missense	probably damaging	1.00
R5107:Lrba	UTSW	3	86,267,086 (GRCm39)	missense	possibly damaging	0.47
R5112:Lrba	UTSW	3	86,132,678 (GRCm39)	missense	probably benign	0.23
R5122:Lrba	UTSW	3	86,256,461 (GRCm39)	nonsense	probably null
R5155:Lrba	UTSW	3	86,258,607 (GRCm39)	missense	probably benign	0.25
R5194:Lrba	UTSW	3	86,235,526 (GRCm39)	missense	probably damaging	1.00
R5280:Lrba	UTSW	3	86,232,329 (GRCm39)	missense	possibly damaging	0.94
R5445:Lrba	UTSW	3	86,275,902 (GRCm39)	missense	probably benign
R5469:Lrba	UTSW	3	86,449,948 (GRCm39)	missense	probably damaging	1.00
R5513:Lrba	UTSW	3	86,449,948 (GRCm39)	missense	probably damaging	1.00
R5578:Lrba	UTSW	3	86,664,814 (GRCm39)	missense	probably benign	0.27
R5740:Lrba	UTSW	3	86,235,649 (GRCm39)	missense	probably damaging	1.00
R5868:Lrba	UTSW	3	86,226,911 (GRCm39)	missense	probably damaging	1.00
R6104:Lrba	UTSW	3	86,261,099 (GRCm39)	missense	probably damaging	1.00
R6166:Lrba	UTSW	3	86,261,614 (GRCm39)	critical splice donor site	probably null
R6279:Lrba	UTSW	3	86,256,171 (GRCm39)	missense	probably benign	0.26
R6330:Lrba	UTSW	3	86,255,664 (GRCm39)	missense	probably benign	0.07
R6367:Lrba	UTSW	3	86,275,869 (GRCm39)	missense	probably benign	0.42
R6571:Lrba	UTSW	3	86,267,367 (GRCm39)	missense	probably damaging	1.00
R6584:Lrba	UTSW	3	86,571,883 (GRCm39)	missense	probably damaging	1.00
R6698:Lrba	UTSW	3	86,211,732 (GRCm39)	missense	probably damaging	0.99
R6763:Lrba	UTSW	3	86,261,570 (GRCm39)	missense	probably damaging	1.00
R6834:Lrba	UTSW	3	86,257,593 (GRCm39)	missense	probably benign	0.00
R6951:Lrba	UTSW	3	86,653,180 (GRCm39)	missense	probably benign	0.01
R6969:Lrba	UTSW	3	86,526,897 (GRCm39)	missense	probably benign	0.21
R7045:Lrba	UTSW	3	86,192,398 (GRCm39)	missense	probably benign	0.03
R7133:Lrba	UTSW	3	86,302,238 (GRCm39)	splice site	probably null
R7182:Lrba	UTSW	3	86,648,765 (GRCm39)	frame shift	probably null
R7214:Lrba	UTSW	3	86,235,633 (GRCm39)	missense	probably damaging	1.00
R7224:Lrba	UTSW	3	86,302,553 (GRCm39)	missense	probably damaging	1.00
R7243:Lrba	UTSW	3	86,658,823 (GRCm39)	splice site	probably null
R7350:Lrba	UTSW	3	86,259,209 (GRCm39)	missense	probably damaging	0.96
R7380:Lrba	UTSW	3	86,232,381 (GRCm39)	missense	probably damaging	1.00
R7492:Lrba	UTSW	3	86,571,835 (GRCm39)	missense	probably damaging	1.00
R7651:Lrba	UTSW	3	86,648,773 (GRCm39)	nonsense	probably null
R7729:Lrba	UTSW	3	86,225,474 (GRCm39)	missense	probably damaging	1.00
R7754:Lrba	UTSW	3	86,352,704 (GRCm39)	missense	probably damaging	1.00
R7762:Lrba	UTSW	3	86,439,508 (GRCm39)	missense	probably damaging	0.99
R7855:Lrba	UTSW	3	86,222,737 (GRCm39)	missense	possibly damaging	0.94
R7867:Lrba	UTSW	3	86,275,896 (GRCm39)	missense	probably damaging	1.00
R7912:Lrba	UTSW	3	86,622,872 (GRCm39)	missense	probably damaging	1.00
R7995:Lrba	UTSW	3	86,526,858 (GRCm39)	missense	probably damaging	1.00
R8013:Lrba	UTSW	3	86,325,278 (GRCm39)	missense	probably damaging	1.00
R8014:Lrba	UTSW	3	86,325,278 (GRCm39)	missense	probably damaging	1.00
R8024:Lrba	UTSW	3	86,202,708 (GRCm39)	nonsense	probably null
R8027:Lrba	UTSW	3	86,325,219 (GRCm39)	missense	probably benign	0.05
R8090:Lrba	UTSW	3	86,255,796 (GRCm39)	missense	probably benign
R8111:Lrba	UTSW	3	86,235,012 (GRCm39)	missense	probably damaging	1.00
R8118:Lrba	UTSW	3	86,261,533 (GRCm39)	missense	probably benign
R8204:Lrba	UTSW	3	86,222,710 (GRCm39)	missense	possibly damaging	0.95
R8239:Lrba	UTSW	3	86,449,882 (GRCm39)	missense	probably damaging	1.00
R8509:Lrba	UTSW	3	86,255,483 (GRCm39)	missense	probably benign	0.04
R8532:Lrba	UTSW	3	86,664,790 (GRCm39)	missense	probably damaging	1.00
R8726:Lrba	UTSW	3	86,261,062 (GRCm39)	missense	probably benign
R8744:Lrba	UTSW	3	86,211,640 (GRCm39)	missense	probably benign	0.08
R8782:Lrba	UTSW	3	86,549,976 (GRCm39)	missense	probably benign	0.00
R8784:Lrba	UTSW	3	86,283,235 (GRCm39)	missense	probably damaging	1.00
R8922:Lrba	UTSW	3	86,263,973 (GRCm39)	missense	probably damaging	1.00
R8964:Lrba	UTSW	3	86,258,552 (GRCm39)	missense	probably benign	0.22
R8971:Lrba	UTSW	3	86,522,388 (GRCm39)	missense	probably benign	0.00
R9046:Lrba	UTSW	3	86,302,543 (GRCm39)	missense	possibly damaging	0.94
R9155:Lrba	UTSW	3	86,202,508 (GRCm39)	missense	probably damaging	1.00
R9236:Lrba	UTSW	3	86,261,066 (GRCm39)	missense	probably benign	0.05
R9266:Lrba	UTSW	3	86,198,774 (GRCm39)	missense	probably benign	0.08
R9297:Lrba	UTSW	3	86,280,873 (GRCm39)	missense	probably damaging	1.00
R9404:Lrba	UTSW	3	86,205,224 (GRCm39)	missense	probably damaging	0.99
R9617:Lrba	UTSW	3	86,267,169 (GRCm39)	missense	probably benign
R9640:Lrba	UTSW	3	86,526,875 (GRCm39)	nonsense	probably null
R9779:Lrba	UTSW	3	86,233,078 (GRCm39)	missense	probably damaging	1.00
X0065:Lrba	UTSW	3	86,232,396 (GRCm39)	missense	possibly damaging	0.95
X0065:Lrba	UTSW	3	86,205,206 (GRCm39)	missense	probably damaging	1.00
Z1176:Lrba	UTSW	3	86,658,839 (GRCm39)	missense	possibly damaging	0.85
Z1176:Lrba	UTSW	3	86,622,845 (GRCm39)	missense	probably benign	0.31
Z1177:Lrba	UTSW	3	86,447,356 (GRCm39)	missense	probably null	1.00

Predicted Primers

PCR Primer
(F):5'- AAGATTCCTTCCACACTGTGCCAC -3'
(R):5'- GTTACCATGACACACATCTGAGCCC -3'

Sequencing Primer
(F):5'- ACACTGTGCCACTTGCC -3'
(R):5'- gaaaaacatgtagaaaaccagcc -3'

Posted On

2013-11-07