Mutagenetix > Incidental Mutation

Incidental Mutation 'R0881:Or8g26'

80556

Institutional Source

Beutler Lab

Gene Symbol

Or8g26

Ensembl Gene

ENSMUSG00000094970

Gene Name

olfactory receptor family 8 subfamily G member 26

Synonyms

MOR171-44, GA_x6K02T2PVTD-32881408-32882343, Olfr943

MMRRC Submission

039048-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R0881 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

39077606-39096420 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 39095984 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 170 (K170R)

Ref Sequence

ENSEMBL: ENSMUSP00000071545 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071617] [ENSMUST00000213176] [ENSMUST00000213507] [ENSMUST00000213830] [ENSMUST00000215770]

AlphaFold

Q9EQ92

Predicted Effect

probably benign
Transcript: ENSMUST00000071617
AA Change: K170R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000071545
Gene: ENSMUSG00000094970
AA Change: K170R

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srv	27	183	9.4e-7	PFAM
Pfam:7tm_4	34	311	7.4e-55	PFAM
Pfam:7tm_1	44	293	6.9e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213176
AA Change: K167R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000213507
AA Change: K167R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213716

Predicted Effect

probably benign
Transcript: ENSMUST00000213830
AA Change: K167R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000215770
AA Change: K167R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.6%
3x: 98.9%
10x: 97.0%
20x: 93.0%

Validation Efficiency

96% (51/53)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	G	A	5: 77,024,130 (GRCm39)	T174M	probably damaging	Het
Abcc9	T	A	6: 142,592,029 (GRCm39)	I732F	probably damaging	Het
Adam10	T	C	9: 70,653,519 (GRCm39)	S248P	probably damaging	Het
Adam18	A	T	8: 25,162,159 (GRCm39)		probably benign	Het
Angel2	G	A	1: 190,669,661 (GRCm39)	E114K	probably damaging	Het
Arhgap29	A	G	3: 121,808,328 (GRCm39)	T1169A	probably damaging	Het
Atp13a2	T	A	4: 140,731,242 (GRCm39)	M759K	probably damaging	Het
Atxn2l	A	G	7: 126,095,768 (GRCm39)	S450P	probably damaging	Het
B3glct	T	A	5: 149,663,034 (GRCm39)	V264E	probably damaging	Het
Bbx	A	G	16: 50,040,963 (GRCm39)		probably benign	Het
Bmp3	A	G	5: 99,020,461 (GRCm39)	N295D	possibly damaging	Het
C9	G	A	15: 6,488,349 (GRCm39)		probably benign	Het
Cacna1c	C	T	6: 118,589,586 (GRCm39)	R1446H	probably damaging	Het
Cdan1	A	T	2: 120,551,466 (GRCm39)	V1039E	probably damaging	Het
Dennd4a	T	C	9: 64,758,665 (GRCm39)		probably null	Het
Ext1	A	G	15: 53,207,879 (GRCm39)	L294P	probably benign	Het
Fsip2	C	A	2: 82,816,617 (GRCm39)	H4117N	possibly damaging	Het
Itga8	C	T	2: 12,267,003 (GRCm39)		probably null	Het
Itln1	G	T	1: 171,360,949 (GRCm39)	H48N	probably benign	Het
Kcna5	T	A	6: 126,511,957 (GRCm39)	H57L	probably benign	Het
Klhdc4	A	T	8: 122,526,226 (GRCm39)	Y304*	probably null	Het
Klhl25	A	G	7: 75,516,027 (GRCm39)	Y6C	probably damaging	Het
Lars1	C	T	18: 42,347,851 (GRCm39)	V991M	probably benign	Het
Med20	T	C	17: 47,922,605 (GRCm39)	M1T	probably null	Het
Mslnl	A	T	17: 25,961,939 (GRCm39)	H138L	possibly damaging	Het
Mycbp2	T	C	14: 103,457,449 (GRCm39)	I1583V	probably benign	Het
Nipbl	A	C	15: 8,337,096 (GRCm39)	V2093G	probably damaging	Het
Nup98	T	A	7: 101,809,923 (GRCm39)	T536S	probably damaging	Het
Opalin	T	C	19: 41,052,420 (GRCm39)		probably null	Het
Or1j12	T	G	2: 36,343,452 (GRCm39)	L285R	probably damaging	Het
Or51d1	T	A	7: 102,348,291 (GRCm39)	V282D	possibly damaging	Het
Pgm2	A	T	5: 64,250,351 (GRCm39)	T9S	unknown	Het
Piwil2	A	C	14: 70,646,376 (GRCm39)	S387A	probably benign	Het
Polr1c	T	C	17: 46,555,539 (GRCm39)	T240A	possibly damaging	Het
Polr3c	A	G	3: 96,631,163 (GRCm39)	M118T	probably damaging	Het
Pth1r	C	T	9: 110,560,641 (GRCm39)	C42Y	probably damaging	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Rictor	A	T	15: 6,821,151 (GRCm39)	M1492L	probably benign	Het
Rrbp1	T	A	2: 143,795,173 (GRCm39)	Y1277F	probably benign	Het
Scgb3a2	T	G	18: 43,897,549 (GRCm39)		probably benign	Het
Skint1	G	A	4: 111,886,054 (GRCm39)	S327N	probably benign	Het
Steap4	A	T	5: 8,030,388 (GRCm39)	S415C	probably benign	Het
Tex48	A	G	4: 63,530,228 (GRCm39)		probably benign	Het
Tox2	T	A	2: 163,163,365 (GRCm39)	S502T	probably benign	Het
Usp47	T	A	7: 111,690,643 (GRCm39)	I762K	possibly damaging	Het
Vmn2r53	T	C	7: 12,334,859 (GRCm39)	H267R	probably benign	Het
Wnt2b	A	G	3: 104,860,513 (GRCm39)		probably benign	Het
Xirp1	T	C	9: 119,847,483 (GRCm39)	N28D	possibly damaging	Het
Zeb1	T	C	18: 5,767,138 (GRCm39)	S550P	probably benign	Het

Other mutations in Or8g26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Or8g26	APN	9	39,096,388 (GRCm39)	missense	possibly damaging	0.93
IGL02858:Or8g26	APN	9	39,095,822 (GRCm39)	missense	probably damaging	1.00
IGL02890:Or8g26	APN	9	39,095,564 (GRCm39)	missense	probably damaging	1.00
IGL02996:Or8g26	APN	9	39,096,361 (GRCm39)	missense	probably damaging	1.00
R0334:Or8g26	UTSW	9	39,095,980 (GRCm39)	missense	probably benign	0.01
R2474:Or8g26	UTSW	9	39,095,846 (GRCm39)	missense	probably damaging	1.00
R3718:Or8g26	UTSW	9	39,096,361 (GRCm39)	missense	probably damaging	1.00
R4358:Or8g26	UTSW	9	39,095,864 (GRCm39)	missense	probably damaging	1.00
R4740:Or8g26	UTSW	9	39,095,664 (GRCm39)	nonsense	probably null
R4763:Or8g26	UTSW	9	39,096,256 (GRCm39)	missense	probably benign	0.15
R4788:Or8g26	UTSW	9	39,095,908 (GRCm39)	missense	probably benign	0.15
R4824:Or8g26	UTSW	9	39,095,501 (GRCm39)	missense	probably benign	0.02
R4866:Or8g26	UTSW	9	39,096,367 (GRCm39)	missense	probably damaging	1.00
R5560:Or8g26	UTSW	9	39,095,480 (GRCm39)	missense	probably benign	0.06
R6278:Or8g26	UTSW	9	39,095,594 (GRCm39)	missense	probably damaging	1.00
R7003:Or8g26	UTSW	9	39,096,239 (GRCm39)	missense	probably benign	0.01
R7721:Or8g26	UTSW	9	39,096,056 (GRCm39)	missense	probably benign	0.00
R8089:Or8g26	UTSW	9	39,095,927 (GRCm39)	missense	probably damaging	1.00
R8293:Or8g26	UTSW	9	39,095,689 (GRCm39)	missense	possibly damaging	0.48
R8818:Or8g26	UTSW	9	39,096,062 (GRCm39)	missense	probably damaging	1.00
R9423:Or8g26	UTSW	9	39,095,838 (GRCm39)	missense	probably damaging	0.98
R9481:Or8g26	UTSW	9	39,096,172 (GRCm39)	missense	possibly damaging	0.92
R9761:Or8g26	UTSW	9	39,096,146 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CACTTTTGGCATTGCAGAGTGCTAC -3'
(R):5'- AAACACAGAGGACACTTTCCCTTGG -3'

Sequencing Primer
(F):5'- GTGCTACACATTAGCTGCAATGG -3'
(R):5'- ACTCACTGATGATGGCTGTAAG -3'

Posted On

2013-11-07