Mutagenetix > Incidental Mutations

Incidental Mutation 'R0881:Mslnl'

80580

Institutional Source

Beutler Lab

Gene Symbol

Mslnl

Ensembl Gene

ENSMUSG00000041062

Gene Name

mesothelin-like

Synonyms

MMRRC Submission

039048-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0881 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

25736040-25748330 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 25742965 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 138 (H138L)

Ref Sequence

ENSEMBL: ENSMUSP00000049020 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047098]

AlphaFold

Q8C160

Predicted Effect

possibly damaging
Transcript: ENSMUST00000047098
AA Change: H138L

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: H138L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Mesothelin	29	589	2.8e-70	PFAM
low complexity region	633	653	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000102319

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.6%
3x: 98.9%
10x: 97.0%
20x: 93.0%

Validation Efficiency

96% (51/53)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	G	A	5: 76,876,283	T174M	probably damaging	Het
Abcc9	T	A	6: 142,646,303	I732F	probably damaging	Het
Adam10	T	C	9: 70,746,237	S248P	probably damaging	Het
Adam18	A	T	8: 24,672,143		probably benign	Het
Angel2	G	A	1: 190,937,464	E114K	probably damaging	Het
Arhgap29	A	G	3: 122,014,679	T1169A	probably damaging	Het
Atp13a2	T	A	4: 141,003,931	M759K	probably damaging	Het
Atxn2l	A	G	7: 126,496,596	S450P	probably damaging	Het
B3glct	T	A	5: 149,739,569	V264E	probably damaging	Het
Bbx	A	G	16: 50,220,600		probably benign	Het
Bmp3	A	G	5: 98,872,602	N295D	possibly damaging	Het
C9	G	A	15: 6,458,868		probably benign	Het
Cacna1c	C	T	6: 118,612,625	R1446H	probably damaging	Het
Cdan1	A	T	2: 120,720,985	V1039E	probably damaging	Het
Dennd4a	T	C	9: 64,851,383		probably null	Het
Ext1	A	G	15: 53,344,483	L294P	probably benign	Het
Fsip2	C	A	2: 82,986,273	H4117N	possibly damaging	Het
Itga8	C	T	2: 12,262,192		probably null	Het
Itln1	G	T	1: 171,533,381	H48N	probably benign	Het
Kcna5	T	A	6: 126,534,994	H57L	probably benign	Het
Klhdc4	A	T	8: 121,799,487	Y304*	probably null	Het
Klhl25	A	G	7: 75,866,279	Y6C	probably damaging	Het
Lars	C	T	18: 42,214,786	V991M	probably benign	Het
Med20	T	C	17: 47,611,680	M1T	probably null	Het
Mycbp2	T	C	14: 103,220,013	I1583V	probably benign	Het
Nipbl	A	C	15: 8,307,612	V2093G	probably damaging	Het
Nup98	T	A	7: 102,160,716	T536S	probably damaging	Het
Olfr340	T	G	2: 36,453,440	L285R	probably damaging	Het
Olfr557	T	A	7: 102,699,084	V282D	possibly damaging	Het
Olfr943	A	G	9: 39,184,688	K170R	probably benign	Het
Opalin	T	C	19: 41,063,981		probably null	Het
Pgm1	A	T	5: 64,093,008	T9S	unknown	Het
Piwil2	A	C	14: 70,408,927	S387A	probably benign	Het
Polr1c	T	C	17: 46,244,613	T240A	possibly damaging	Het
Polr3c	A	G	3: 96,723,847	M118T	probably damaging	Het
Pth1r	C	T	9: 110,731,573	C42Y	probably damaging	Het
Ptpro	T	A	6: 137,443,594	V1007D	probably damaging	Het
Rictor	A	T	15: 6,791,670	M1492L	probably benign	Het
Rrbp1	T	A	2: 143,953,253	Y1277F	probably benign	Het
Scgb3a2	T	G	18: 43,764,484		probably benign	Het
Skint1	G	A	4: 112,028,857	S327N	probably benign	Het
Steap4	A	T	5: 7,980,388	S415C	probably benign	Het
Tex48	A	G	4: 63,611,991		probably benign	Het
Tox2	T	A	2: 163,321,445	S502T	probably benign	Het
Usp47	T	A	7: 112,091,436	I762K	possibly damaging	Het
Vmn2r53	T	C	7: 12,600,932	H267R	probably benign	Het
Wnt2b	A	G	3: 104,953,197		probably benign	Het
Xirp1	T	C	9: 120,018,417	N28D	possibly damaging	Het
Zeb1	T	C	18: 5,767,138	S550P	probably benign	Het

Other mutations in Mslnl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01621:Mslnl	APN	17	25743667	unclassified	probably benign
IGL01629:Mslnl	APN	17	25744775	missense	possibly damaging	0.95
IGL02084:Mslnl	APN	17	25746151	missense	probably benign	0.07
IGL02408:Mslnl	APN	17	25747998	missense	possibly damaging	0.80
IGL02726:Mslnl	APN	17	25744103	critical splice donor site	probably null
IGL03387:Mslnl	APN	17	25744077	missense	probably benign	0.06
R0561:Mslnl	UTSW	17	25743203	nonsense	probably null
R1295:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1296:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1582:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1629:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1630:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1631:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1632:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1794:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1850:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1866:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1876:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1914:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2166:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2241:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2243:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2247:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2282:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2284:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2852:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2877:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2878:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2919:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2920:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3026:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3405:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3406:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3411:Mslnl	UTSW	17	25744517	missense	probably benign	0.05
R3434:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3546:Mslnl	UTSW	17	25744969	missense	probably damaging	0.98
R3612:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3729:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3730:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3802:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3804:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3894:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3895:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4454:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4455:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4456:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4457:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4561:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4562:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4564:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4600:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4601:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4610:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4704:Mslnl	UTSW	17	25738978	missense	possibly damaging	0.73
R5155:Mslnl	UTSW	17	25738968	nonsense	probably null
R5257:Mslnl	UTSW	17	25746165	missense	probably benign	0.00
R5456:Mslnl	UTSW	17	25743159	missense	probably damaging	0.98
R5645:Mslnl	UTSW	17	25737842	missense	possibly damaging	0.95
R6007:Mslnl	UTSW	17	25746775	missense	probably benign	0.00
R6083:Mslnl	UTSW	17	25737902	missense	possibly damaging	0.83
R6142:Mslnl	UTSW	17	25744557	missense	probably damaging	1.00
R6761:Mslnl	UTSW	17	25746073	missense	probably damaging	1.00
R7058:Mslnl	UTSW	17	25743212	missense	probably benign	0.03
R7156:Mslnl	UTSW	17	25743210	missense	probably benign	0.20
R7467:Mslnl	UTSW	17	25736921	start codon destroyed	probably benign	0.33
R7687:Mslnl	UTSW	17	25743183	missense	probably damaging	0.97
R7807:Mslnl	UTSW	17	25746777	missense	probably benign	0.03
R8682:Mslnl	UTSW	17	25746988	missense	probably benign
R8735:Mslnl	UTSW	17	25745088	missense	probably benign	0.09
R8742:Mslnl	UTSW	17	25745073	missense	probably damaging	1.00
R9208:Mslnl	UTSW	17	25742720	missense	possibly damaging	0.94
RF007:Mslnl	UTSW	17	25743228	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- GTGACAGTCCCCTTATCATGTGCC -3'
(R):5'- GCAGTCACAATTTGTGCTGCCTCC -3'

Sequencing Primer
(F):5'- ATCATGTGCCTGCCAGTG -3'
(R):5'- TCTGAAGCACTGAGCTGTAGG -3'

Posted On

2013-11-07