Incidental Mutation 'R0928:Cracdl'
ID 80582
Institutional Source Beutler Lab
Gene Symbol Cracdl
Ensembl Gene ENSMUSG00000026090
Gene Name capping protein inhibiting regulator of actin like
Synonyms 2010300C02Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0928 (G1)
Quality Score 81
Status Not validated
Chromosome 1
Chromosomal Location 37650758-37758905 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 37663663 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 745 (D745G)
Ref Sequence ENSEMBL: ENSMUSP00000123803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162875]
AlphaFold E9Q3M9
Predicted Effect unknown
Transcript: ENSMUST00000160023
AA Change: D220G
SMART Domains Protein: ENSMUSP00000125015
Gene: ENSMUSG00000026090
AA Change: D220G

DomainStartEndE-ValueType
internal_repeat_1 2 65 4.52e-24 PROSPERO
internal_repeat_1 65 128 4.52e-24 PROSPERO
low complexity region 181 194 N/A INTRINSIC
low complexity region 223 237 N/A INTRINSIC
low complexity region 263 279 N/A INTRINSIC
low complexity region 441 465 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000162875
AA Change: D745G

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000123803
Gene: ENSMUSG00000026090
AA Change: D745G

DomainStartEndE-ValueType
low complexity region 13 43 N/A INTRINSIC
Pfam:DUF4592 130 243 1.8e-33 PFAM
low complexity region 347 366 N/A INTRINSIC
internal_repeat_2 387 461 2.31e-5 PROSPERO
internal_repeat_3 404 474 3.67e-5 PROSPERO
internal_repeat_1 411 526 3.02e-34 PROSPERO
internal_repeat_2 485 559 2.31e-5 PROSPERO
internal_repeat_1 537 652 3.02e-34 PROSPERO
internal_repeat_3 570 698 3.67e-5 PROSPERO
low complexity region 705 718 N/A INTRINSIC
low complexity region 747 761 N/A INTRINSIC
low complexity region 787 803 N/A INTRINSIC
low complexity region 965 989 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.1%
  • 10x: 93.0%
  • 20x: 75.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T A 1: 71,388,333 (GRCm39) D179V probably benign Het
Abcc1 T C 16: 14,207,849 (GRCm39) probably null Het
Adad1 G A 3: 37,130,889 (GRCm39) probably null Het
Apobec4 T C 1: 152,632,028 (GRCm39) Y19H probably damaging Het
Bco2 T A 9: 50,457,231 (GRCm39) T104S probably damaging Het
Bnc1 A G 7: 81,623,250 (GRCm39) V659A probably benign Het
Ccdc168 C A 1: 44,096,388 (GRCm39) S1570I possibly damaging Het
Ccs T C 19: 4,875,988 (GRCm39) E184G probably damaging Het
Cfap70 T G 14: 20,493,987 (GRCm39) K97N probably damaging Het
Daam2 T C 17: 49,795,255 (GRCm39) I313V probably benign Het
Dach1 T C 14: 98,153,268 (GRCm39) S467G probably damaging Het
Dnah11 A G 12: 118,009,297 (GRCm39) S2122P probably damaging Het
Dnah3 T A 7: 119,629,274 (GRCm39) D1427V probably damaging Het
Dnai1 T C 4: 41,602,566 (GRCm39) F97L possibly damaging Het
Dsc1 A T 18: 20,243,306 (GRCm39) probably null Het
En2 A T 5: 28,375,329 (GRCm39) K291* probably null Het
Eps15 T C 4: 109,170,160 (GRCm39) V154A possibly damaging Het
Etnk1 A G 6: 143,130,429 (GRCm39) I183V probably benign Het
Fcrlb A T 1: 170,735,509 (GRCm39) V255D possibly damaging Het
Fry A T 5: 150,360,549 (GRCm39) E52V probably damaging Het
Garre1 A T 7: 33,947,671 (GRCm39) probably null Het
Gm57858 A C 3: 36,079,515 (GRCm39) N258K possibly damaging Het
Gtf2h4 T C 17: 35,981,777 (GRCm39) Y152C probably damaging Het
Hao1 C A 2: 134,347,536 (GRCm39) L256F possibly damaging Het
Helz T A 11: 107,517,519 (GRCm39) I685K probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Izumo2 A T 7: 44,364,847 (GRCm39) I171F possibly damaging Het
Krt87 C A 15: 101,389,161 (GRCm39) C57F probably benign Het
Mapkbp1 A G 2: 119,845,849 (GRCm39) H400R probably benign Het
Megf6 T A 4: 154,261,504 (GRCm39) V43E probably damaging Het
Mmut T C 17: 41,248,174 (GRCm39) I67T probably benign Het
Ninl A T 2: 150,805,395 (GRCm39) V396E probably damaging Het
Nvl A T 1: 180,921,467 (GRCm39) V844E probably benign Het
Or2b6 C T 13: 21,823,126 (GRCm39) C189Y probably damaging Het
P2rx3 A T 2: 84,865,642 (GRCm39) M1K probably null Het
Pabpn1l T C 8: 123,349,358 (GRCm39) T20A probably benign Het
Ppp3r2 C A 4: 49,681,439 (GRCm39) probably null Het
Prmt6 C T 3: 110,157,998 (GRCm39) G97D probably damaging Het
Prmt9 T C 8: 78,307,805 (GRCm39) V823A probably damaging Het
Skic3 T G 13: 76,261,711 (GRCm39) L142W probably damaging Het
Skint11 C A 4: 114,101,798 (GRCm39) D79E possibly damaging Het
Slc17a8 T A 10: 89,434,545 (GRCm39) H194L probably damaging Het
Slco6c1 T A 1: 97,032,573 (GRCm39) I293F possibly damaging Het
Tcl1b4 A T 12: 105,168,865 (GRCm39) H43L probably benign Het
Tm9sf1 T C 14: 55,873,914 (GRCm39) D528G probably damaging Het
Tpbpb C T 13: 61,049,989 (GRCm39) V47I probably benign Het
Ttn G T 2: 76,737,876 (GRCm39) probably benign Het
Usp28 T G 9: 48,942,191 (GRCm39) S341A possibly damaging Het
Vwa5a T C 9: 38,639,303 (GRCm39) Y345H probably damaging Het
Wdr11 C A 7: 129,208,377 (GRCm39) D377E probably damaging Het
Zer1 A G 2: 29,991,775 (GRCm39) probably null Het
Other mutations in Cracdl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01376:Cracdl APN 1 37,667,425 (GRCm39) missense probably damaging 0.99
IGL01413:Cracdl APN 1 37,651,387 (GRCm39) missense possibly damaging 0.85
IGL01812:Cracdl APN 1 37,664,446 (GRCm39) missense probably benign 0.06
IGL02183:Cracdl APN 1 37,664,459 (GRCm39) missense possibly damaging 0.93
IGL02498:Cracdl APN 1 37,662,926 (GRCm39) missense probably benign
IGL02713:Cracdl APN 1 37,663,218 (GRCm39) missense possibly damaging 0.72
IGL02736:Cracdl APN 1 37,676,954 (GRCm39) missense probably damaging 1.00
FR4449:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4449:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4548:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4976:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0055:Cracdl UTSW 1 37,663,337 (GRCm39) missense probably benign 0.18
R0153:Cracdl UTSW 1 37,663,720 (GRCm39) missense probably benign
R0523:Cracdl UTSW 1 37,683,710 (GRCm39) start codon destroyed probably null 0.94
R0699:Cracdl UTSW 1 37,651,411 (GRCm39) missense possibly damaging 0.85
R1457:Cracdl UTSW 1 37,665,093 (GRCm39) nonsense probably null
R1759:Cracdl UTSW 1 37,664,791 (GRCm39) missense probably benign 0.00
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R2289:Cracdl UTSW 1 37,651,342 (GRCm39) missense possibly damaging 0.53
R2421:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2422:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2509:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2510:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2511:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R3893:Cracdl UTSW 1 37,670,539 (GRCm39) missense probably benign 0.00
R4351:Cracdl UTSW 1 37,663,993 (GRCm39) missense probably benign
R4454:Cracdl UTSW 1 37,663,834 (GRCm39) missense probably damaging 1.00
R4788:Cracdl UTSW 1 37,670,556 (GRCm39) missense probably damaging 1.00
R4798:Cracdl UTSW 1 37,664,046 (GRCm39) missense probably benign 0.12
R5599:Cracdl UTSW 1 37,652,424 (GRCm39) missense possibly damaging 0.53
R5920:Cracdl UTSW 1 37,677,062 (GRCm39) missense probably damaging 1.00
R6051:Cracdl UTSW 1 37,663,306 (GRCm39) missense probably damaging 0.98
R6106:Cracdl UTSW 1 37,652,493 (GRCm39) missense possibly damaging 0.53
R6794:Cracdl UTSW 1 37,676,936 (GRCm39) splice site probably null
R6828:Cracdl UTSW 1 37,663,898 (GRCm39) missense possibly damaging 0.53
R6930:Cracdl UTSW 1 37,664,026 (GRCm39) missense possibly damaging 0.73
R7044:Cracdl UTSW 1 37,651,361 (GRCm39) missense possibly damaging 0.85
R7069:Cracdl UTSW 1 37,670,982 (GRCm39) missense probably damaging 1.00
R7149:Cracdl UTSW 1 37,651,352 (GRCm39) nonsense probably null
R7296:Cracdl UTSW 1 37,653,699 (GRCm39) missense possibly damaging 0.53
R7698:Cracdl UTSW 1 37,664,452 (GRCm39) missense probably benign 0.12
R7714:Cracdl UTSW 1 37,663,858 (GRCm39) missense probably benign 0.33
R8071:Cracdl UTSW 1 37,663,010 (GRCm39) nonsense probably null
R8205:Cracdl UTSW 1 37,664,047 (GRCm39) missense probably benign 0.06
R8443:Cracdl UTSW 1 37,652,537 (GRCm39) missense probably benign 0.33
R8720:Cracdl UTSW 1 37,652,522 (GRCm39) missense possibly damaging 0.53
R8917:Cracdl UTSW 1 37,676,993 (GRCm39) missense probably damaging 0.99
R9056:Cracdl UTSW 1 37,663,553 (GRCm39) missense possibly damaging 0.91
R9158:Cracdl UTSW 1 37,670,442 (GRCm39) missense probably damaging 0.99
R9290:Cracdl UTSW 1 37,663,634 (GRCm39) missense probably damaging 0.97
R9483:Cracdl UTSW 1 37,670,496 (GRCm39) missense probably damaging 1.00
R9641:Cracdl UTSW 1 37,663,592 (GRCm39) missense possibly damaging 0.85
X0025:Cracdl UTSW 1 37,664,026 (GRCm39) missense probably benign 0.33
Predicted Primers PCR Primer
(F):5'- AGTTTTGAGGGTCACCACCCATTG -3'
(R):5'- TCATGGAGCCTCCTAATAGGGACAC -3'

Sequencing Primer
(F):5'- TTTGGCAGCACCTGAAGGTC -3'
(R):5'- TTGGAGACACCTTCAGATACAG -3'
Posted On 2013-11-07