Incidental Mutation 'R0928:Zer1'
ID 80600
Institutional Source Beutler Lab
Gene Symbol Zer1
Ensembl Gene ENSMUSG00000039686
Gene Name zyg-11 related, cell cycle regulator
Synonyms Zyg11bl, C230075L19Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.134) question?
Stock # R0928 (G1)
Quality Score 133
Status Not validated
Chromosome 2
Chromosomal Location 29987295-30014597 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 29991775 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000109307 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044751] [ENSMUST00000044751] [ENSMUST00000113677] [ENSMUST00000113677]
AlphaFold Q80ZJ6
Predicted Effect probably null
Transcript: ENSMUST00000044751
SMART Domains Protein: ENSMUSP00000046441
Gene: ENSMUSG00000039686

DomainStartEndE-ValueType
SCOP:d1jdha_ 405 774 3e-15 SMART
Blast:ARM 440 480 2e-18 BLAST
Blast:ARM 524 569 4e-24 BLAST
Blast:ARM 571 613 6e-22 BLAST
Blast:ARM 617 656 7e-8 BLAST
Blast:ARM 686 724 6e-18 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000044751
SMART Domains Protein: ENSMUSP00000046441
Gene: ENSMUSG00000039686

DomainStartEndE-ValueType
SCOP:d1jdha_ 405 774 3e-15 SMART
Blast:ARM 440 480 2e-18 BLAST
Blast:ARM 524 569 4e-24 BLAST
Blast:ARM 571 613 6e-22 BLAST
Blast:ARM 617 656 7e-8 BLAST
Blast:ARM 686 724 6e-18 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000113677
SMART Domains Protein: ENSMUSP00000109307
Gene: ENSMUSG00000039686

DomainStartEndE-ValueType
SCOP:d1jdha_ 392 761 3e-15 SMART
Blast:ARM 427 467 2e-18 BLAST
Blast:ARM 511 556 4e-24 BLAST
Blast:ARM 558 600 2e-21 BLAST
Blast:ARM 604 643 7e-8 BLAST
Blast:ARM 673 711 6e-18 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000113677
SMART Domains Protein: ENSMUSP00000109307
Gene: ENSMUSG00000039686

DomainStartEndE-ValueType
SCOP:d1jdha_ 392 761 3e-15 SMART
Blast:ARM 427 467 2e-18 BLAST
Blast:ARM 511 556 4e-24 BLAST
Blast:ARM 558 600 2e-21 BLAST
Blast:ARM 604 643 7e-8 BLAST
Blast:ARM 673 711 6e-18 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133354
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152068
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152285
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154231
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.1%
  • 10x: 93.0%
  • 20x: 75.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T A 1: 71,388,333 (GRCm39) D179V probably benign Het
Abcc1 T C 16: 14,207,849 (GRCm39) probably null Het
Adad1 G A 3: 37,130,889 (GRCm39) probably null Het
Apobec4 T C 1: 152,632,028 (GRCm39) Y19H probably damaging Het
Bco2 T A 9: 50,457,231 (GRCm39) T104S probably damaging Het
Bnc1 A G 7: 81,623,250 (GRCm39) V659A probably benign Het
Ccdc168 C A 1: 44,096,388 (GRCm39) S1570I possibly damaging Het
Ccs T C 19: 4,875,988 (GRCm39) E184G probably damaging Het
Cfap70 T G 14: 20,493,987 (GRCm39) K97N probably damaging Het
Cracdl T C 1: 37,663,663 (GRCm39) D745G possibly damaging Het
Daam2 T C 17: 49,795,255 (GRCm39) I313V probably benign Het
Dach1 T C 14: 98,153,268 (GRCm39) S467G probably damaging Het
Dnah11 A G 12: 118,009,297 (GRCm39) S2122P probably damaging Het
Dnah3 T A 7: 119,629,274 (GRCm39) D1427V probably damaging Het
Dnai1 T C 4: 41,602,566 (GRCm39) F97L possibly damaging Het
Dsc1 A T 18: 20,243,306 (GRCm39) probably null Het
En2 A T 5: 28,375,329 (GRCm39) K291* probably null Het
Eps15 T C 4: 109,170,160 (GRCm39) V154A possibly damaging Het
Etnk1 A G 6: 143,130,429 (GRCm39) I183V probably benign Het
Fcrlb A T 1: 170,735,509 (GRCm39) V255D possibly damaging Het
Fry A T 5: 150,360,549 (GRCm39) E52V probably damaging Het
Garre1 A T 7: 33,947,671 (GRCm39) probably null Het
Gm57858 A C 3: 36,079,515 (GRCm39) N258K possibly damaging Het
Gtf2h4 T C 17: 35,981,777 (GRCm39) Y152C probably damaging Het
Hao1 C A 2: 134,347,536 (GRCm39) L256F possibly damaging Het
Helz T A 11: 107,517,519 (GRCm39) I685K probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Izumo2 A T 7: 44,364,847 (GRCm39) I171F possibly damaging Het
Krt87 C A 15: 101,389,161 (GRCm39) C57F probably benign Het
Mapkbp1 A G 2: 119,845,849 (GRCm39) H400R probably benign Het
Megf6 T A 4: 154,261,504 (GRCm39) V43E probably damaging Het
Mmut T C 17: 41,248,174 (GRCm39) I67T probably benign Het
Ninl A T 2: 150,805,395 (GRCm39) V396E probably damaging Het
Nvl A T 1: 180,921,467 (GRCm39) V844E probably benign Het
Or2b6 C T 13: 21,823,126 (GRCm39) C189Y probably damaging Het
P2rx3 A T 2: 84,865,642 (GRCm39) M1K probably null Het
Pabpn1l T C 8: 123,349,358 (GRCm39) T20A probably benign Het
Ppp3r2 C A 4: 49,681,439 (GRCm39) probably null Het
Prmt6 C T 3: 110,157,998 (GRCm39) G97D probably damaging Het
Prmt9 T C 8: 78,307,805 (GRCm39) V823A probably damaging Het
Skic3 T G 13: 76,261,711 (GRCm39) L142W probably damaging Het
Skint11 C A 4: 114,101,798 (GRCm39) D79E possibly damaging Het
Slc17a8 T A 10: 89,434,545 (GRCm39) H194L probably damaging Het
Slco6c1 T A 1: 97,032,573 (GRCm39) I293F possibly damaging Het
Tcl1b4 A T 12: 105,168,865 (GRCm39) H43L probably benign Het
Tm9sf1 T C 14: 55,873,914 (GRCm39) D528G probably damaging Het
Tpbpb C T 13: 61,049,989 (GRCm39) V47I probably benign Het
Ttn G T 2: 76,737,876 (GRCm39) probably benign Het
Usp28 T G 9: 48,942,191 (GRCm39) S341A possibly damaging Het
Vwa5a T C 9: 38,639,303 (GRCm39) Y345H probably damaging Het
Wdr11 C A 7: 129,208,377 (GRCm39) D377E probably damaging Het
Other mutations in Zer1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Zer1 APN 2 29,998,232 (GRCm39) critical splice donor site probably null
IGL01630:Zer1 APN 2 29,991,843 (GRCm39) missense probably damaging 1.00
IGL02126:Zer1 APN 2 29,994,928 (GRCm39) missense probably benign 0.10
IGL02338:Zer1 APN 2 30,003,405 (GRCm39) missense probably damaging 1.00
IGL02817:Zer1 APN 2 29,993,406 (GRCm39) missense probably damaging 0.99
PIT4402001:Zer1 UTSW 2 29,991,132 (GRCm39) missense probably damaging 0.96
PIT4495001:Zer1 UTSW 2 29,993,555 (GRCm39) missense probably benign 0.01
R0390:Zer1 UTSW 2 29,998,225 (GRCm39) splice site probably benign
R0506:Zer1 UTSW 2 29,991,819 (GRCm39) missense probably damaging 1.00
R0606:Zer1 UTSW 2 29,994,809 (GRCm39) splice site probably benign
R1167:Zer1 UTSW 2 29,998,258 (GRCm39) missense probably benign 0.00
R1819:Zer1 UTSW 2 30,000,230 (GRCm39) missense probably benign 0.18
R2040:Zer1 UTSW 2 29,998,286 (GRCm39) missense probably damaging 1.00
R2041:Zer1 UTSW 2 29,998,286 (GRCm39) missense probably damaging 1.00
R2042:Zer1 UTSW 2 29,998,286 (GRCm39) missense probably damaging 1.00
R2092:Zer1 UTSW 2 29,998,286 (GRCm39) missense probably damaging 1.00
R2168:Zer1 UTSW 2 29,994,887 (GRCm39) missense probably damaging 1.00
R2243:Zer1 UTSW 2 29,991,139 (GRCm39) missense probably damaging 0.99
R2254:Zer1 UTSW 2 29,998,286 (GRCm39) missense probably damaging 1.00
R2255:Zer1 UTSW 2 29,998,286 (GRCm39) missense probably damaging 1.00
R2311:Zer1 UTSW 2 29,991,834 (GRCm39) missense probably damaging 0.99
R2993:Zer1 UTSW 2 29,991,909 (GRCm39) missense probably damaging 1.00
R3010:Zer1 UTSW 2 30,003,297 (GRCm39) missense probably benign 0.13
R3731:Zer1 UTSW 2 30,000,923 (GRCm39) missense probably benign 0.44
R4038:Zer1 UTSW 2 29,997,535 (GRCm39) missense probably damaging 1.00
R5241:Zer1 UTSW 2 29,994,982 (GRCm39) missense probably damaging 1.00
R5433:Zer1 UTSW 2 29,990,998 (GRCm39) intron probably benign
R5443:Zer1 UTSW 2 30,001,008 (GRCm39) missense probably damaging 1.00
R5524:Zer1 UTSW 2 29,994,866 (GRCm39) missense probably damaging 1.00
R5936:Zer1 UTSW 2 29,997,679 (GRCm39) missense probably damaging 0.97
R5999:Zer1 UTSW 2 29,995,009 (GRCm39) missense probably damaging 1.00
R6598:Zer1 UTSW 2 30,003,286 (GRCm39) missense probably damaging 1.00
R6965:Zer1 UTSW 2 29,991,059 (GRCm39) missense possibly damaging 0.87
R7030:Zer1 UTSW 2 30,001,033 (GRCm39) missense probably benign 0.00
R7190:Zer1 UTSW 2 29,993,444 (GRCm39) missense probably damaging 1.00
R7218:Zer1 UTSW 2 29,995,024 (GRCm39) missense probably damaging 1.00
R7252:Zer1 UTSW 2 29,991,904 (GRCm39) missense probably damaging 0.99
R7383:Zer1 UTSW 2 30,001,253 (GRCm39) missense probably damaging 1.00
R7417:Zer1 UTSW 2 29,992,834 (GRCm39) missense probably damaging 1.00
R7459:Zer1 UTSW 2 30,003,337 (GRCm39) missense probably damaging 1.00
R7463:Zer1 UTSW 2 30,003,449 (GRCm39) start gained probably benign
R7466:Zer1 UTSW 2 29,991,496 (GRCm39) splice site probably null
R7477:Zer1 UTSW 2 29,997,988 (GRCm39) missense probably null 0.34
R7719:Zer1 UTSW 2 30,001,243 (GRCm39) missense probably damaging 1.00
R7813:Zer1 UTSW 2 30,000,385 (GRCm39) missense probably damaging 1.00
R7976:Zer1 UTSW 2 29,997,520 (GRCm39) missense probably damaging 0.99
R8239:Zer1 UTSW 2 29,991,147 (GRCm39) critical splice acceptor site probably null
R8350:Zer1 UTSW 2 29,991,862 (GRCm39) missense probably damaging 1.00
R8404:Zer1 UTSW 2 29,995,035 (GRCm39) critical splice acceptor site probably null
R8842:Zer1 UTSW 2 30,001,062 (GRCm39) missense possibly damaging 0.65
R8896:Zer1 UTSW 2 29,993,430 (GRCm39) missense probably damaging 0.99
R8906:Zer1 UTSW 2 30,001,035 (GRCm39) missense probably benign 0.31
R8929:Zer1 UTSW 2 30,000,881 (GRCm39) missense probably damaging 1.00
R9050:Zer1 UTSW 2 30,001,294 (GRCm39) missense probably damaging 1.00
R9066:Zer1 UTSW 2 30,000,686 (GRCm39) missense probably damaging 1.00
R9277:Zer1 UTSW 2 30,001,297 (GRCm39) missense probably benign 0.00
R9322:Zer1 UTSW 2 30,000,923 (GRCm39) missense probably benign 0.00
R9577:Zer1 UTSW 2 29,991,050 (GRCm39) missense probably damaging 1.00
R9733:Zer1 UTSW 2 29,997,643 (GRCm39) missense probably benign 0.00
X0026:Zer1 UTSW 2 29,994,907 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGTTTACCATACACAGCGTGGCAG -3'
(R):5'- GCCGACGGCATTGAGGTTTCTTAC -3'

Sequencing Primer
(F):5'- TATGTAACATGCATAAGAGACAGGC -3'
(R):5'- GCATTGAGGTTTCTTACAACGC -3'
Posted On 2013-11-07