Incidental Mutation 'R0882:Myb'
ID 80653
Institutional Source Beutler Lab
Gene Symbol Myb
Ensembl Gene ENSMUSG00000019982
Gene Name myeloblastosis oncogene
Synonyms c-myb
MMRRC Submission 039049-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0882 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 21000834-21036883 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 21032259 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 41 (T41A)
Ref Sequence ENSEMBL: ENSMUSP00000020158 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020158] [ENSMUST00000188495]
AlphaFold P06876
PDB Structure CRYSTAL STRUCTURE OF C-MYB R1 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF C-MYB R2R3 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF C-MYB R2 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF C-MYB R2 V103L MUTANT [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX1 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX2 [X-RAY DIFFRACTION]
STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE [SOLUTION NMR]
STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES [SOLUTION NMR]
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1 [SOLUTION NMR]
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1 [SOLUTION NMR]
>> 8 additional structures at PDB <<
Predicted Effect possibly damaging
Transcript: ENSMUST00000020158
AA Change: T41A

PolyPhen 2 Score 0.752 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000020158
Gene: ENSMUSG00000019982
AA Change: T41A

DomainStartEndE-ValueType
low complexity region 7 27 N/A INTRINSIC
SANT 39 88 9.52e-20 SMART
SANT 91 140 2.04e-19 SMART
SANT 143 191 1.75e-18 SMART
low complexity region 227 239 N/A INTRINSIC
Pfam:LMSTEN 267 313 4e-29 PFAM
Pfam:Cmyb_C 399 559 1.5e-64 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180680
Predicted Effect noncoding transcript
Transcript: ENSMUST00000186446
Predicted Effect probably benign
Transcript: ENSMUST00000188495
AA Change: T41A

PolyPhen 2 Score 0.335 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000139699
Gene: ENSMUSG00000019982
AA Change: T41A

DomainStartEndE-ValueType
low complexity region 7 27 N/A INTRINSIC
SANT 39 88 9.52e-20 SMART
SANT 91 140 2.04e-19 SMART
SANT 143 191 1.75e-18 SMART
low complexity region 227 239 N/A INTRINSIC
Pfam:LMSTEN 266 313 3.6e-32 PFAM
low complexity region 409 421 N/A INTRINSIC
Pfam:Cmyb_C 516 682 8.5e-66 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214539
Meta Mutation Damage Score 0.1776 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.0%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G A 5: 77,024,130 (GRCm39) T174M probably damaging Het
Adh1 A T 3: 137,992,558 (GRCm39) I225F possibly damaging Het
Agap2 A G 10: 126,923,319 (GRCm39) K691E unknown Het
Alcam T C 16: 52,073,573 (GRCm39) D564G possibly damaging Het
Apbb2 T A 5: 66,557,598 (GRCm39) T289S probably damaging Het
Cacna1c C T 6: 118,589,586 (GRCm39) R1446H probably damaging Het
Cep68 T C 11: 20,189,393 (GRCm39) I540V probably benign Het
Ctla4 T C 1: 60,948,397 (GRCm39) V23A probably benign Het
Dnah7b T A 1: 46,379,292 (GRCm39) D3675E probably benign Het
Fam209 G T 2: 172,314,555 (GRCm39) V15F probably benign Het
Fat3 A G 9: 15,942,664 (GRCm39) V1236A possibly damaging Het
Gabbr2 A G 4: 46,718,904 (GRCm39) I38T probably damaging Het
Gdpd4 T C 7: 97,615,505 (GRCm39) I110T probably damaging Het
Gm4841 C T 18: 60,402,852 (GRCm39) A414T possibly damaging Het
Gtf3c4 A T 2: 28,724,782 (GRCm39) Y176N probably damaging Het
H2bc18 G A 3: 96,177,060 (GRCm39) probably null Het
Igsf9b T C 9: 27,230,612 (GRCm39) Y264H probably damaging Het
Itih4 A T 14: 30,614,231 (GRCm39) N394Y probably damaging Het
Kmt2c T C 5: 25,500,605 (GRCm39) T3815A possibly damaging Het
Lrwd1 T C 5: 136,152,254 (GRCm39) probably null Het
Mc3r A G 2: 172,091,711 (GRCm39) K311R probably benign Het
Nfix T C 8: 85,454,554 (GRCm39) D201G probably damaging Het
Nos1 T C 5: 118,085,512 (GRCm39) V1280A probably damaging Het
Or51a5 A C 7: 102,771,782 (GRCm39) S66A probably benign Het
Or8a1b T C 9: 37,623,168 (GRCm39) M136V probably benign Het
Pcdh15 A G 10: 74,178,488 (GRCm39) T582A probably damaging Het
Pcdhb12 C A 18: 37,570,375 (GRCm39) A507E probably damaging Het
Pdia3 G A 2: 121,262,858 (GRCm39) G275S probably damaging Het
Pkp2 C A 16: 16,087,575 (GRCm39) A753E probably damaging Het
Plekha3 G A 2: 76,513,142 (GRCm39) V76I possibly damaging Het
Pnpla6 T C 8: 3,567,081 (GRCm39) L33P probably damaging Het
Pot1b C T 17: 55,973,400 (GRCm39) probably benign Het
Prr5l T C 2: 101,588,886 (GRCm39) E88G possibly damaging Het
Prss57 G A 10: 79,621,699 (GRCm39) H97Y probably damaging Het
Rttn C T 18: 88,991,813 (GRCm39) Q131* probably null Het
Scaf11 G T 15: 96,316,176 (GRCm39) S1129R possibly damaging Het
Slc25a20 T A 9: 108,559,189 (GRCm39) M185K possibly damaging Het
Sorbs3 T A 14: 70,445,021 (GRCm39) E19V probably damaging Het
Srgap2 A T 1: 131,217,253 (GRCm39) C1020S probably benign Het
Thoc2l T C 5: 104,666,875 (GRCm39) S466P probably benign Het
Tmem109 T C 19: 10,849,205 (GRCm39) R217G possibly damaging Het
Trio A T 15: 27,732,980 (GRCm39) I2967N probably damaging Het
Vars2 T C 17: 35,968,191 (GRCm39) E899G probably benign Het
Vmn2r109 A G 17: 20,774,842 (GRCm39) probably benign Het
Vps53 A G 11: 75,973,485 (GRCm39) F170L probably damaging Het
Zc2hc1a G A 3: 7,591,422 (GRCm39) S149N possibly damaging Het
Zfp820 A G 17: 22,042,817 (GRCm39) probably benign Het
Zhx3 A C 2: 160,622,629 (GRCm39) F513V probably damaging Het
Other mutations in Myb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00654:Myb APN 10 21,017,725 (GRCm39) missense probably damaging 0.99
IGL00707:Myb APN 10 21,024,283 (GRCm39) missense probably damaging 1.00
IGL00796:Myb APN 10 21,017,698 (GRCm39) missense probably benign 0.00
IGL01012:Myb APN 10 21,022,159 (GRCm39) missense probably benign 0.03
IGL01082:Myb APN 10 21,028,843 (GRCm39) missense probably damaging 1.00
IGL01365:Myb APN 10 21,028,401 (GRCm39) missense probably benign 0.31
IGL01906:Myb APN 10 21,028,533 (GRCm39) missense probably damaging 1.00
IGL02560:Myb APN 10 21,028,347 (GRCm39) missense probably damaging 1.00
Huang_river UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
PIT4495001:Myb UTSW 10 21,028,521 (GRCm39) missense probably damaging 0.98
R0385:Myb UTSW 10 21,030,611 (GRCm39) missense possibly damaging 0.73
R0442:Myb UTSW 10 21,002,095 (GRCm39) missense probably benign 0.05
R0759:Myb UTSW 10 21,020,927 (GRCm39) missense probably benign 0.01
R0920:Myb UTSW 10 21,002,133 (GRCm39) missense possibly damaging 0.80
R1401:Myb UTSW 10 21,028,844 (GRCm39) missense probably damaging 1.00
R1651:Myb UTSW 10 21,002,097 (GRCm39) missense probably damaging 1.00
R1752:Myb UTSW 10 21,032,336 (GRCm39) missense possibly damaging 0.89
R1879:Myb UTSW 10 21,017,876 (GRCm39) missense probably benign 0.24
R1971:Myb UTSW 10 21,016,555 (GRCm39) missense probably benign 0.00
R4355:Myb UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
R4611:Myb UTSW 10 21,021,223 (GRCm39) missense probably damaging 1.00
R4650:Myb UTSW 10 21,028,840 (GRCm39) missense probably damaging 1.00
R4888:Myb UTSW 10 21,002,137 (GRCm39) missense probably benign 0.01
R5121:Myb UTSW 10 21,002,137 (GRCm39) missense probably benign 0.01
R5922:Myb UTSW 10 21,028,826 (GRCm39) missense probably damaging 1.00
R5955:Myb UTSW 10 21,028,398 (GRCm39) missense probably damaging 1.00
R6116:Myb UTSW 10 21,030,653 (GRCm39) missense probably damaging 1.00
R6150:Myb UTSW 10 21,017,668 (GRCm39) missense probably damaging 1.00
R6207:Myb UTSW 10 21,021,221 (GRCm39) missense probably benign
R6656:Myb UTSW 10 21,028,844 (GRCm39) missense probably damaging 1.00
R6801:Myb UTSW 10 21,020,865 (GRCm39) splice site probably null
R6824:Myb UTSW 10 21,021,019 (GRCm39) missense probably benign 0.00
R6884:Myb UTSW 10 21,028,431 (GRCm39) missense probably damaging 1.00
R6977:Myb UTSW 10 21,028,551 (GRCm39) missense probably damaging 0.96
R7562:Myb UTSW 10 21,017,653 (GRCm39) splice site probably null
R7651:Myb UTSW 10 21,032,273 (GRCm39) missense probably damaging 1.00
R7747:Myb UTSW 10 21,032,324 (GRCm39) missense possibly damaging 0.89
R8346:Myb UTSW 10 21,002,136 (GRCm39) missense probably benign 0.00
R8683:Myb UTSW 10 21,026,405 (GRCm39) missense possibly damaging 0.53
R8829:Myb UTSW 10 21,021,130 (GRCm39) missense probably damaging 0.96
R9227:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9228:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9240:Myb UTSW 10 21,016,500 (GRCm39) missense probably damaging 1.00
R9304:Myb UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
R9408:Myb UTSW 10 21,026,275 (GRCm39) missense probably benign 0.21
R9517:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9576:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9577:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9610:Myb UTSW 10 21,030,627 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTGGGAGAGAAGAACACGAGCATTC -3'
(R):5'- AGTAACAGGTTCAAACATGCAGAGCAA -3'

Sequencing Primer
(F):5'- CACATGTAGCTTAGCCGAGA -3'
(R):5'- CCAGAATGCAGAAAACCTCATTG -3'
Posted On 2013-11-07