|Institutional Source||Beutler Lab|
|Gene Name||oxytocin receptor|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0930 (G1)|
|Chromosomal Location||112473683-112489943 bp(-) (GRCm38)|
|Type of Mutation||unclassified|
|DNA Base Change (assembly)||A to T at 112489637 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000145300 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000053306] [ENSMUST00000204027]|
|Predicted Effect||probably damaging
AA Change: L54Q
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: L54Q
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.6319|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Oxtr||
(F):5'- ATTTGACCAGACGACACAGCAGG -3'
(R):5'- TTTAAAGAGCCTCAAGGCCGGGTG -3'
(F):5'- CGACACAGCAGGTCGGG -3'
(R):5'- GTGCTCCCTCAGGGTCG -3'