Incidental Mutation 'R0009:Coro1a'
ID8094
Institutional Source Beutler Lab
Gene Symbol Coro1a
Ensembl Gene ENSMUSG00000030707
Gene Namecoronin, actin binding protein 1A
SynonymsClabp, Lmb3, coronin 1, p57
MMRRC Submission 038304-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R0009 (G1)
Quality Score
Status Validated
Chromosome7
Chromosomal Location126699773-126707787 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 126701413 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146177 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032949] [ENSMUST00000106364] [ENSMUST00000106369] [ENSMUST00000130498] [ENSMUST00000131415] [ENSMUST00000135087] [ENSMUST00000173108] [ENSMUST00000173116] [ENSMUST00000205515]
Predicted Effect probably benign
Transcript: ENSMUST00000032949
SMART Domains Protein: ENSMUSP00000032949
Gene: ENSMUSG00000030707

DomainStartEndE-ValueType
DUF1899 4 68 1.6e-33 SMART
WD40 67 110 1.39e-7 SMART
WD40 120 160 2.42e-7 SMART
WD40 163 204 6.09e-4 SMART
DUF1900 258 392 1.23e-89 SMART
PDB:2AKF|C 430 461 3e-13 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000052145
Predicted Effect probably benign
Transcript: ENSMUST00000106364
SMART Domains Protein: ENSMUSP00000101972
Gene: ENSMUSG00000030707

DomainStartEndE-ValueType
DUF1899 4 68 1.6e-33 SMART
WD40 67 110 1.39e-7 SMART
WD40 120 160 2.42e-7 SMART
WD40 163 204 6.09e-4 SMART
DUF1900 258 392 1.23e-89 SMART
Pfam:Trimer_CC 410 461 4.1e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106369
SMART Domains Protein: ENSMUSP00000101977
Gene: ENSMUSG00000047721

DomainStartEndE-ValueType
Pfam:BolA 10 54 4.7e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123511
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126193
Predicted Effect probably benign
Transcript: ENSMUST00000130498
SMART Domains Protein: ENSMUSP00000114873
Gene: ENSMUSG00000047721

DomainStartEndE-ValueType
Pfam:BolA 12 79 1.2e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131415
SMART Domains Protein: ENSMUSP00000117931
Gene: ENSMUSG00000030707

DomainStartEndE-ValueType
DUF1899 4 68 1.6e-33 SMART
WD40 67 110 1.39e-7 SMART
WD40 120 160 2.42e-7 SMART
WD40 163 204 6.09e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133718
Predicted Effect probably benign
Transcript: ENSMUST00000135087
SMART Domains Protein: ENSMUSP00000115960
Gene: ENSMUSG00000030707

DomainStartEndE-ValueType
DUF1899 4 68 1.6e-33 SMART
WD40 67 110 1.39e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140896
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144571
Predicted Effect probably benign
Transcript: ENSMUST00000173108
SMART Domains Protein: ENSMUSP00000134123
Gene: ENSMUSG00000030707

DomainStartEndE-ValueType
DUF1899 4 68 1.6e-33 SMART
WD40 67 110 1.39e-7 SMART
WD40 120 160 2.42e-7 SMART
WD40 163 204 6.09e-4 SMART
DUF1900 258 365 3.06e-53 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173116
SMART Domains Protein: ENSMUSP00000133555
Gene: ENSMUSG00000030707

DomainStartEndE-ValueType
DUF1899 4 68 1.6e-33 SMART
WD40 67 110 1.39e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174579
Predicted Effect probably benign
Transcript: ENSMUST00000205515
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206275
Coding Region Coverage
  • 1x: 79.7%
  • 3x: 70.1%
  • 10x: 44.5%
  • 20x: 24.1%
Validation Efficiency 93% (78/84)
MGI Phenotype FUNCTION: This gene encodes a member of the WD repeat coronin family. The encoded protein may bind actin and interact with microtubules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
PHENOTYPE: Mice homozygous for null or hypomorph alleles of this gene display lower peripheral T cell counts resulting from defects in T cell migration and increased rates of apoptosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg T G 15: 60,919,633 probably benign Het
Afm C A 5: 90,545,384 probably benign Het
Aplnr T A 2: 85,137,276 probably null Het
Arih2 T A 9: 108,611,727 H264L probably damaging Het
Ccdc116 T C 16: 17,144,039 E15G probably damaging Het
Cfap53 A G 18: 74,299,176 H45R probably benign Het
Chd3 A G 11: 69,349,906 L1569P probably damaging Het
Cntn2 G A 1: 132,516,180 Q457* probably null Het
Cracr2b T A 7: 141,463,759 L91Q probably damaging Het
Ctdspl T C 9: 119,020,046 probably null Het
Dnase1 T C 16: 4,038,946 V147A probably damaging Het
Glud1 G A 14: 34,334,268 G300S probably benign Het
Gm4847 C T 1: 166,630,486 V433I probably benign Het
Herc2 T C 7: 56,207,812 S4048P probably benign Het
Hp1bp3 T A 4: 138,221,683 I19K probably benign Het
Il1a C T 2: 129,309,074 D10N probably damaging Het
Il22ra2 A T 10: 19,624,458 N39I probably damaging Het
Magi2 A T 5: 20,611,055 Y747F probably benign Het
Mcc C T 18: 44,445,933 E803K probably damaging Het
Rims2 T A 15: 39,534,966 M1087K probably damaging Het
Riox2 C A 16: 59,489,367 D361E probably benign Het
Slc35e1 A T 8: 72,484,709 N318K probably damaging Het
Slc9a2 A T 1: 40,763,602 E604V probably benign Het
Tbx19 A T 1: 165,160,520 S15T possibly damaging Het
Tm4sf5 C T 11: 70,510,712 A179V probably damaging Het
Trappc11 A T 8: 47,503,320 C874S possibly damaging Het
Trpm3 T A 19: 22,914,446 Y885N probably damaging Het
Unc5a T A 13: 55,002,879 C505S probably damaging Het
Xpo5 T C 17: 46,204,786 probably benign Het
Other mutations in Coro1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01445:Coro1a APN 7 126701529 missense probably benign 0.00
IGL02307:Coro1a APN 7 126701564 missense probably damaging 1.00
IGL02380:Coro1a APN 7 126703116 nonsense probably null
coralina UTSW 7 126703049 missense probably damaging 1.00
holiday UTSW 7 126700644 splice site probably null
R0009:Coro1a UTSW 7 126701413 splice site probably benign
R0394:Coro1a UTSW 7 126700640 missense probably benign 0.01
R1275:Coro1a UTSW 7 126700583 critical splice donor site probably null
R1552:Coro1a UTSW 7 126699952 missense probably benign 0.13
R1598:Coro1a UTSW 7 126701692 missense possibly damaging 0.71
R1618:Coro1a UTSW 7 126701547 missense probably benign 0.05
R2116:Coro1a UTSW 7 126702022 missense probably damaging 1.00
R4591:Coro1a UTSW 7 126702992 missense probably damaging 1.00
R5159:Coro1a UTSW 7 126703049 missense probably damaging 1.00
R5261:Coro1a UTSW 7 126700644 splice site probably null
R6002:Coro1a UTSW 7 126703080 missense probably benign 0.00
R7237:Coro1a UTSW 7 126700306 missense probably benign
R7560:Coro1a UTSW 7 126703134 missense probably damaging 0.99
RF007:Coro1a UTSW 7 126701852 missense probably damaging 0.99
Posted On2012-11-20