Incidental Mutation 'R0884:Cyp2a12'
ID 81045
Institutional Source Beutler Lab
Gene Symbol Cyp2a12
Ensembl Gene ENSMUSG00000060407
Gene Name cytochrome P450, family 2, subfamily a, polypeptide 12
Synonyms
MMRRC Submission 039051-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R0884 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 26728515-26736243 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 26731967 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 236 (I236T)
Ref Sequence ENSEMBL: ENSMUSP00000074990 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075552]
AlphaFold P56593
Predicted Effect probably benign
Transcript: ENSMUST00000075552
AA Change: I236T

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000074990
Gene: ENSMUSG00000060407
AA Change: I236T

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:p450 33 489 7.3e-153 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207016
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 A T 14: 118,790,700 (GRCm39) I844N possibly damaging Het
Acbd3 CGAGGAGGAGGAGGAGGA CGAGGAGGAGGAGGA 1: 180,574,624 (GRCm39) probably benign Het
Adam6b A T 12: 113,454,615 (GRCm39) R477S probably damaging Het
Aqp7 T A 4: 41,034,929 (GRCm39) T175S possibly damaging Het
Bclaf1 A T 10: 20,197,822 (GRCm39) R22* probably null Het
Bend7 A T 2: 4,749,055 (GRCm39) K57N probably damaging Het
Bicc1 A C 10: 70,794,677 (GRCm39) V160G probably damaging Het
Cacna2d4 C T 6: 119,284,247 (GRCm39) R745W probably damaging Het
Cep72 A G 13: 74,203,000 (GRCm39) probably null Het
Cobl A G 11: 12,325,908 (GRCm39) I196T possibly damaging Het
Cux1 T G 5: 136,336,689 (GRCm39) D941A probably damaging Het
Dennd2b A G 7: 109,156,552 (GRCm39) L66P probably damaging Het
Depdc5 T A 5: 33,075,322 (GRCm39) V500D possibly damaging Het
Dhx35 T C 2: 158,673,631 (GRCm39) I354T probably damaging Het
Dnase1l2 A G 17: 24,660,854 (GRCm39) V170A possibly damaging Het
Eif4g3 C A 4: 137,879,087 (GRCm39) N588K possibly damaging Het
Epsti1 A T 14: 78,168,715 (GRCm39) R117S probably damaging Het
Fam53a T C 5: 33,758,160 (GRCm39) E321G probably benign Het
Fat4 C A 3: 39,037,007 (GRCm39) T3553K possibly damaging Het
Fer1l4 T C 2: 155,861,233 (GRCm39) T1978A possibly damaging Het
Gabarapl2 A T 8: 112,669,137 (GRCm39) I32F probably damaging Het
Gje1 G T 10: 14,592,484 (GRCm39) S99R possibly damaging Het
Gosr1 A G 11: 76,620,972 (GRCm39) I239T probably benign Het
Gpnmb T C 6: 49,024,847 (GRCm39) V293A possibly damaging Het
Hyi T A 4: 118,217,414 (GRCm39) I62N probably damaging Het
Il4ra A G 7: 125,173,835 (GRCm39) I267V probably damaging Het
Kcnd2 A T 6: 21,216,540 (GRCm39) Q81H probably benign Het
Ksr1 A T 11: 78,912,329 (GRCm39) H675Q possibly damaging Het
Lpcat4 A G 2: 112,073,077 (GRCm39) N208S probably damaging Het
Muc17 T A 5: 137,171,146 (GRCm39) T162S possibly damaging Het
Mup3 T A 4: 62,005,411 (GRCm39) I20F possibly damaging Het
Nebl A C 2: 17,415,929 (GRCm39) S327A probably benign Het
Nfatc4 A C 14: 56,064,101 (GRCm39) D126A probably damaging Het
Nmt2 A T 2: 3,315,822 (GRCm39) R271* probably null Het
Nol7 G A 13: 43,554,091 (GRCm39) V133I probably benign Het
Or1e1c A T 11: 73,265,715 (GRCm39) I47F probably benign Het
Or51ag1 C T 7: 103,156,069 (GRCm39) W28* probably null Het
Pde4d A T 13: 110,087,474 (GRCm39) I670L probably damaging Het
Phlpp1 T A 1: 106,317,395 (GRCm39) probably null Het
Pigz A G 16: 31,760,794 (GRCm39) probably null Het
Pramel21 A G 4: 143,341,754 (GRCm39) D61G probably benign Het
Prrg4 A T 2: 104,669,707 (GRCm39) Y137N probably damaging Het
Rbm28 A T 6: 29,155,153 (GRCm39) S217T possibly damaging Het
Ryr2 T C 13: 11,569,415 (GRCm39) D4963G probably damaging Het
Slc35b2 T A 17: 45,877,751 (GRCm39) F293I probably damaging Het
Slc35f1 A T 10: 52,965,443 (GRCm39) Y286F probably damaging Het
Slc6a18 G T 13: 73,815,156 (GRCm39) A384D probably damaging Het
Syt9 A G 7: 107,035,768 (GRCm39) I262V probably damaging Het
Tln2 C A 9: 67,278,015 (GRCm39) R333L probably damaging Het
Tnrc6b ACAGCAGCAGCAGCAGCAGCAG ACAGCAGCAGCAGCAGCAG 15: 80,786,756 (GRCm39) probably benign Het
Ttn G A 2: 76,581,410 (GRCm39) T14834I possibly damaging Het
Uggt1 T C 1: 36,214,159 (GRCm39) S177G probably benign Het
Zfp454 A G 11: 50,764,764 (GRCm39) S223P probably benign Het
Zmat4 A G 8: 24,505,143 (GRCm39) T128A probably benign Het
Other mutations in Cyp2a12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02191:Cyp2a12 APN 7 26,736,036 (GRCm39) missense probably benign 0.00
IGL02306:Cyp2a12 APN 7 26,732,008 (GRCm39) missense probably damaging 1.00
IGL02667:Cyp2a12 APN 7 26,730,583 (GRCm39) missense probably damaging 1.00
IGL02943:Cyp2a12 APN 7 26,731,967 (GRCm39) missense probably benign 0.07
IGL03025:Cyp2a12 APN 7 26,730,631 (GRCm39) missense probably benign 0.00
IGL03230:Cyp2a12 APN 7 26,729,017 (GRCm39) missense possibly damaging 0.48
PIT4243001:Cyp2a12 UTSW 7 26,734,198 (GRCm39) missense probably benign 0.00
PIT4618001:Cyp2a12 UTSW 7 26,734,198 (GRCm39) missense probably benign 0.00
R0655:Cyp2a12 UTSW 7 26,736,046 (GRCm39) missense probably benign 0.15
R0659:Cyp2a12 UTSW 7 26,733,563 (GRCm39) missense probably damaging 1.00
R0743:Cyp2a12 UTSW 7 26,731,967 (GRCm39) missense probably benign 0.07
R2118:Cyp2a12 UTSW 7 26,736,071 (GRCm39) makesense probably null
R2119:Cyp2a12 UTSW 7 26,736,071 (GRCm39) makesense probably null
R2120:Cyp2a12 UTSW 7 26,736,071 (GRCm39) makesense probably null
R2121:Cyp2a12 UTSW 7 26,736,071 (GRCm39) makesense probably null
R2122:Cyp2a12 UTSW 7 26,736,071 (GRCm39) makesense probably null
R2124:Cyp2a12 UTSW 7 26,736,071 (GRCm39) makesense probably null
R2144:Cyp2a12 UTSW 7 26,734,194 (GRCm39) missense possibly damaging 0.95
R2153:Cyp2a12 UTSW 7 26,732,042 (GRCm39) missense probably benign 0.01
R2171:Cyp2a12 UTSW 7 26,729,057 (GRCm39) missense probably damaging 1.00
R2182:Cyp2a12 UTSW 7 26,730,571 (GRCm39) missense probably damaging 1.00
R2297:Cyp2a12 UTSW 7 26,734,057 (GRCm39) missense possibly damaging 0.92
R4392:Cyp2a12 UTSW 7 26,728,700 (GRCm39) missense probably damaging 0.98
R4900:Cyp2a12 UTSW 7 26,730,640 (GRCm39) nonsense probably null
R4960:Cyp2a12 UTSW 7 26,733,575 (GRCm39) missense probably benign 0.11
R5111:Cyp2a12 UTSW 7 26,736,046 (GRCm39) missense possibly damaging 0.89
R5143:Cyp2a12 UTSW 7 26,736,036 (GRCm39) missense probably benign 0.00
R5223:Cyp2a12 UTSW 7 26,735,888 (GRCm39) critical splice acceptor site probably null
R5268:Cyp2a12 UTSW 7 26,730,643 (GRCm39) missense probably benign 0.00
R5493:Cyp2a12 UTSW 7 26,728,550 (GRCm39) missense unknown
R5524:Cyp2a12 UTSW 7 26,730,656 (GRCm39) missense probably benign 0.00
R5806:Cyp2a12 UTSW 7 26,728,504 (GRCm39) splice site probably null
R6320:Cyp2a12 UTSW 7 26,730,577 (GRCm39) missense possibly damaging 0.75
R6823:Cyp2a12 UTSW 7 26,733,581 (GRCm39) missense possibly damaging 0.77
R7958:Cyp2a12 UTSW 7 26,728,677 (GRCm39) missense probably benign 0.13
R8093:Cyp2a12 UTSW 7 26,736,054 (GRCm39) missense probably damaging 0.96
R8191:Cyp2a12 UTSW 7 26,730,529 (GRCm39) missense probably benign 0.00
R8259:Cyp2a12 UTSW 7 26,732,083 (GRCm39) nonsense probably null
R9083:Cyp2a12 UTSW 7 26,735,944 (GRCm39) missense probably damaging 0.99
R9084:Cyp2a12 UTSW 7 26,735,944 (GRCm39) missense probably damaging 0.99
R9085:Cyp2a12 UTSW 7 26,735,944 (GRCm39) missense probably damaging 0.99
R9086:Cyp2a12 UTSW 7 26,735,944 (GRCm39) missense probably damaging 0.99
RF021:Cyp2a12 UTSW 7 26,734,785 (GRCm39) missense possibly damaging 0.73
Z1088:Cyp2a12 UTSW 7 26,734,845 (GRCm39) missense possibly damaging 0.70
Predicted Primers PCR Primer
(F):5'- TCGCCTGGATTGTAAGACAATGACC -3'
(R):5'- CCATACCCTGGCTTGCATAAGGAAG -3'

Sequencing Primer
(F):5'- agttcagttcccagcacc -3'
(R):5'- CATCATGGGGACTTAATGGGC -3'
Posted On 2013-11-07