Incidental Mutation 'R0012:Lypd4'
ID8110
Institutional Source Beutler Lab
Gene Symbol Lypd4
Ensembl Gene ENSMUSG00000062732
Gene NameLy6/Plaur domain containing 4
Synonyms4933400F01Rik
MMRRC Submission 038307-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.128) question?
Stock #R0012 (G1)
Quality Score
Status Validated
Chromosome7
Chromosomal Location24864620-24869941 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 24865332 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 127 (L127P)
Ref Sequence ENSEMBL: ENSMUSP00000122913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000011493] [ENSMUST00000079306] [ENSMUST00000122995] [ENSMUST00000170837]
Predicted Effect probably benign
Transcript: ENSMUST00000011493
SMART Domains Protein: ENSMUSP00000011493
Gene: ENSMUSG00000011349

DomainStartEndE-ValueType
DM 38 91 6.53e-21 SMART
low complexity region 163 189 N/A INTRINSIC
Pfam:DMRT-like 242 369 3.1e-54 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000079306
AA Change: L127P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078287
Gene: ENSMUSG00000062732
AA Change: L127P

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:UPAR_LY6 142 233 7.5e-23 PFAM
low complexity region 237 244 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000122995
AA Change: L127P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000122913
Gene: ENSMUSG00000062732
AA Change: L127P

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000170837
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205486
Meta Mutation Damage Score 0.2767 question?
Coding Region Coverage
  • 1x: 78.7%
  • 3x: 69.0%
  • 10x: 44.7%
  • 20x: 26.0%
Validation Efficiency 91% (95/104)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adap1 A G 5: 139,307,734 probably benign Het
Bnip3 A G 7: 138,898,672 probably benign Het
Brwd1 A C 16: 96,059,652 S311R probably damaging Het
C2cd3 G A 7: 100,418,522 V871M possibly damaging Het
Chd2 G T 7: 73,455,519 T192K probably damaging Het
Chrna10 T C 7: 102,115,057 N40S possibly damaging Het
Copb1 T A 7: 114,237,408 K366N probably damaging Het
Dpysl4 T G 7: 139,097,883 I412S probably benign Het
E130309D02Rik A G 5: 143,314,182 L137P probably damaging Het
Fat2 A G 11: 55,262,871 V3505A probably benign Het
Fbxo24 A G 5: 137,621,994 F101S probably damaging Het
Gcnt3 T C 9: 70,034,085 I400M probably benign Het
Gm2962 T A 1: 170,925,339 probably benign Het
Gsap T A 5: 21,226,229 probably benign Het
Hipk1 A G 3: 103,763,680 M467T probably damaging Het
Hmgb4 T A 4: 128,260,725 I17F probably damaging Het
Kif17 T G 4: 138,293,748 S606A probably damaging Het
Lyst A G 13: 13,687,694 H2605R probably benign Het
Map3k4 A G 17: 12,238,189 S1289P probably damaging Het
Mob1b G A 5: 88,756,084 probably benign Het
Mthfd2l A T 5: 90,961,383 H224L probably damaging Het
Nectin2 T C 7: 19,730,744 probably benign Het
Rae1 T A 2: 173,002,673 F4I unknown Het
Ralgapa2 A G 2: 146,412,752 Y821H probably benign Het
Sharpin G T 15: 76,348,343 P156T possibly damaging Het
Slc38a4 C T 15: 96,999,629 R435H probably damaging Het
Snrnp200 T C 2: 127,228,549 V1061A probably benign Het
Suclg1 A G 6: 73,270,997 T234A possibly damaging Het
Tet2 T C 3: 133,476,558 Y1215C probably damaging Het
Tjp1 A G 7: 65,329,775 probably benign Het
Tnpo3 T C 6: 29,589,177 E58G probably damaging Het
Trp53bp2 T A 1: 182,444,718 M464K probably damaging Het
Trpm1 A G 7: 64,268,591 S560G possibly damaging Het
Unc80 T C 1: 66,507,391 S541P probably damaging Het
Ushbp1 T C 8: 71,395,040 probably benign Het
Zfp644 T G 5: 106,635,043 E1155A probably benign Het
Other mutations in Lypd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02285:Lypd4 APN 7 24865440 missense probably damaging 0.99
R0012:Lypd4 UTSW 7 24865332 missense probably damaging 1.00
R0355:Lypd4 UTSW 7 24865266 missense probably benign 0.03
R0605:Lypd4 UTSW 7 24865375 missense probably damaging 1.00
R1502:Lypd4 UTSW 7 24866828 missense probably benign
R3721:Lypd4 UTSW 7 24865459 missense probably benign 0.26
R4670:Lypd4 UTSW 7 24866726 missense probably benign 0.06
R4835:Lypd4 UTSW 7 24866696 missense probably benign 0.00
R5032:Lypd4 UTSW 7 24866815 missense probably damaging 1.00
R5642:Lypd4 UTSW 7 24865179 missense probably benign 0.01
X0063:Lypd4 UTSW 7 24865386 missense probably damaging 0.99
Posted On2012-11-20