Incidental Mutation 'R0002:Tas2r113'
| ID |
8113 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tas2r113
|
| Ensembl Gene |
ENSMUSG00000056926 |
| Gene Name |
taste receptor, type 2, member 113 |
| Synonyms |
T2R13, mGR13, Tas2r13, mt2r58 |
| MMRRC Submission |
038298-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
R0002 (G1)
|
| Quality Score |
|
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
132869974-132870903 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 132870742 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 257
(S257T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078044
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079035]
|
| AlphaFold |
Q7M711 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079035
AA Change: S257T
PolyPhen 2
Score 0.211 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000078044
Gene: ENSMUSG00000056926
AA Change: S257T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
301 |
9.4e-78 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 85.4%
- 3x: 79.5%
- 10x: 62.0%
- 20x: 53.1%
|
| Validation Efficiency |
95% (61/64) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aco1 |
T |
C |
4: 40,176,649 (GRCm39) |
|
probably benign |
Het |
| Bcl2 |
T |
C |
1: 106,640,241 (GRCm39) |
R124G |
possibly damaging |
Het |
| Bri3 |
G |
T |
5: 144,181,312 (GRCm39) |
C6F |
probably benign |
Het |
| Chn2 |
A |
G |
6: 54,250,098 (GRCm39) |
N69S |
probably benign |
Het |
| Col5a3 |
T |
A |
9: 20,721,152 (GRCm39) |
|
probably null |
Het |
| Dhx36 |
A |
C |
3: 62,388,260 (GRCm39) |
L625W |
probably damaging |
Het |
| Exph5 |
G |
T |
9: 53,285,256 (GRCm39) |
R779I |
probably damaging |
Het |
| F5 |
T |
C |
1: 164,029,200 (GRCm39) |
F1733S |
probably damaging |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Iqch |
T |
C |
9: 63,502,025 (GRCm39) |
|
probably benign |
Het |
| Lgr6 |
C |
T |
1: 134,921,748 (GRCm39) |
A199T |
probably damaging |
Het |
| Pate14 |
A |
T |
9: 36,548,655 (GRCm39) |
D59E |
probably damaging |
Het |
| Patl2 |
G |
A |
2: 121,956,191 (GRCm39) |
|
probably benign |
Het |
| Pik3c2g |
A |
G |
6: 139,714,471 (GRCm39) |
T208A |
probably benign |
Het |
| Prkag3 |
T |
C |
1: 74,783,947 (GRCm39) |
D312G |
probably damaging |
Het |
| Slc26a5 |
T |
A |
5: 22,019,981 (GRCm39) |
I530F |
probably damaging |
Het |
| Tacc2 |
T |
A |
7: 130,223,515 (GRCm39) |
S67T |
probably damaging |
Het |
| Tnr |
T |
C |
1: 159,701,770 (GRCm39) |
Y624H |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,118,211 (GRCm39) |
L112P |
probably damaging |
Het |
|
| Other mutations in Tas2r113 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00858:Tas2r113
|
APN |
6 |
132,870,115 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01118:Tas2r113
|
APN |
6 |
132,870,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01366:Tas2r113
|
APN |
6 |
132,870,760 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01955:Tas2r113
|
APN |
6 |
132,870,817 (GRCm39) |
missense |
probably benign |
|
|
IGL02629:Tas2r113
|
APN |
6 |
132,870,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02681:Tas2r113
|
APN |
6 |
132,870,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02883:Tas2r113
|
APN |
6 |
132,870,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0309:Tas2r113
|
UTSW |
6 |
132,870,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1700:Tas2r113
|
UTSW |
6 |
132,870,755 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1748:Tas2r113
|
UTSW |
6 |
132,870,695 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1854:Tas2r113
|
UTSW |
6 |
132,870,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1974:Tas2r113
|
UTSW |
6 |
132,870,796 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4697:Tas2r113
|
UTSW |
6 |
132,870,479 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4798:Tas2r113
|
UTSW |
6 |
132,870,670 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4816:Tas2r113
|
UTSW |
6 |
132,870,745 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4906:Tas2r113
|
UTSW |
6 |
132,870,521 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6005:Tas2r113
|
UTSW |
6 |
132,870,659 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6012:Tas2r113
|
UTSW |
6 |
132,870,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6107:Tas2r113
|
UTSW |
6 |
132,869,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6603:Tas2r113
|
UTSW |
6 |
132,870,421 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7263:Tas2r113
|
UTSW |
6 |
132,870,539 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7434:Tas2r113
|
UTSW |
6 |
132,870,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7759:Tas2r113
|
UTSW |
6 |
132,870,890 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8803:Tas2r113
|
UTSW |
6 |
132,870,104 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9104:Tas2r113
|
UTSW |
6 |
132,870,116 (GRCm39) |
missense |
probably benign |
0.08 |
|
X0022:Tas2r113
|
UTSW |
6 |
132,870,259 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Posted On |
2012-11-20 |
Incidental Mutation