Incidental Mutation 'R0940:Nomo1'
ID 81406
Institutional Source Beutler Lab
Gene Symbol Nomo1
Ensembl Gene ENSMUSG00000030835
Gene Name nodal modulator 1
Synonyms D7Ertd156e, Nomo, PM5
MMRRC Submission 039079-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.672) question?
Stock # R0940 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 45683122-45733636 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 45683329 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 25 (E25G)
Ref Sequence ENSEMBL: ENSMUSP00000033121 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002850] [ENSMUST00000033121]
AlphaFold Q6GQT9
Predicted Effect probably benign
Transcript: ENSMUST00000002850
SMART Domains Protein: ENSMUSP00000002850
Gene: ENSMUSG00000030834

DomainStartEndE-ValueType
transmembrane domain 44 61 N/A INTRINSIC
transmembrane domain 81 100 N/A INTRINSIC
transmembrane domain 110 129 N/A INTRINSIC
transmembrane domain 142 161 N/A INTRINSIC
transmembrane domain 171 193 N/A INTRINSIC
Pfam:ABC_membrane 309 580 3.5e-29 PFAM
AAA 653 828 1.19e-9 SMART
low complexity region 871 885 N/A INTRINSIC
Pfam:ABC_membrane 942 1211 2.5e-32 PFAM
AAA 1286 1473 1.71e-10 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000033121
AA Change: E25G

PolyPhen 2 Score 0.565 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000033121
Gene: ENSMUSG00000030835
AA Change: E25G

DomainStartEndE-ValueType
low complexity region 2 21 N/A INTRINSIC
internal_repeat_1 22 215 2.35e-7 PROSPERO
Pfam:CarboxypepD_reg 322 395 3.5e-12 PFAM
Pfam:DUF2012 331 401 5.7e-10 PFAM
low complexity region 709 732 N/A INTRINSIC
low complexity region 881 893 N/A INTRINSIC
Blast:FN3 913 1017 6e-22 BLAST
low complexity region 1156 1164 N/A INTRINSIC
low complexity region 1203 1214 N/A INTRINSIC
Meta Mutation Damage Score 0.0768 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.1%
  • 10x: 98.0%
  • 20x: 96.7%
Validation Efficiency 100% (68/68)
Allele List at MGI

All alleles(8) : Gene trapped(8)

Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810064F22Rik C T 9: 22,119,367 (GRCm39) noncoding transcript Het
2610021A01Rik T G 7: 41,275,858 (GRCm39) I520M probably damaging Het
Ackr4 A G 9: 103,976,831 (GRCm39) F39L probably damaging Het
Adgre5 C T 8: 84,460,126 (GRCm39) S92N probably damaging Het
Adrb2 T C 18: 62,312,762 (GRCm39) D21G probably benign Het
Akr1c6 G A 13: 4,486,372 (GRCm39) E60K probably benign Het
Bcl7c T A 7: 127,306,503 (GRCm39) N96I possibly damaging Het
Brca1 A T 11: 101,422,969 (GRCm39) S106R possibly damaging Het
C6 A T 15: 4,764,717 (GRCm39) T138S probably benign Het
Cul3 T C 1: 80,300,564 (GRCm39) probably benign Het
Dnah8 T A 17: 31,022,217 (GRCm39) M3939K probably damaging Het
Dock4 T A 12: 40,681,626 (GRCm39) probably benign Het
Dsc2 T G 18: 20,183,116 (GRCm39) T101P probably damaging Het
Dynlt1b T C 17: 6,697,649 (GRCm39) probably benign Het
E330013P04Rik A G 19: 60,150,354 (GRCm39) noncoding transcript Het
Fggy A G 4: 95,585,238 (GRCm39) E39G probably benign Het
Fhip1a A G 3: 85,572,797 (GRCm39) V952A possibly damaging Het
Fmo6 A T 1: 162,753,795 (GRCm39) C116S probably benign Het
Gadd45a A G 6: 67,013,813 (GRCm39) I44T possibly damaging Het
Gmps A G 3: 63,883,743 (GRCm39) probably benign Het
Gnmt A G 17: 47,037,271 (GRCm39) L171P probably damaging Het
Hnrnpm G A 17: 33,868,976 (GRCm39) R523C probably damaging Het
Inpp5a T C 7: 139,105,654 (GRCm39) Y202H probably damaging Het
Kank3 C T 17: 34,036,450 (GRCm39) S106F probably damaging Het
Lmcd1 A G 6: 112,305,658 (GRCm39) D253G probably benign Het
Lrrk2 A T 15: 91,613,284 (GRCm39) I803F possibly damaging Het
Mybpc2 T C 7: 44,156,311 (GRCm39) K834R probably benign Het
Mycbp2 A T 14: 103,500,129 (GRCm39) probably benign Het
Myh4 A T 11: 67,133,689 (GRCm39) N243Y probably damaging Het
Myorg A G 4: 41,497,996 (GRCm39) Y545H probably damaging Het
Nfatc1 C T 18: 80,679,110 (GRCm39) M759I probably benign Het
Nipal4 A G 11: 46,041,139 (GRCm39) I352T possibly damaging Het
Or10j27 A G 1: 172,958,020 (GRCm39) S255P probably benign Het
Or13a19 T C 7: 139,903,065 (GRCm39) I151T probably benign Het
Or14j7 A G 17: 38,234,591 (GRCm39) I45V probably damaging Het
Or1e32 T C 11: 73,705,050 (GRCm39) N286S probably damaging Het
Or4c116 T A 2: 88,942,419 (GRCm39) I146L probably benign Het
Or5p66 T C 7: 107,886,264 (GRCm39) D23G probably benign Het
Pabpn1l A G 8: 123,349,183 (GRCm39) V78A probably benign Het
Pde6b T A 5: 108,568,203 (GRCm39) I327N possibly damaging Het
Phrf1 T C 7: 140,834,768 (GRCm39) probably benign Het
Pkm C T 9: 59,575,818 (GRCm39) probably benign Het
Plxna2 G A 1: 194,482,863 (GRCm39) V1519I probably benign Het
Ppp2cb T C 8: 34,105,689 (GRCm39) probably null Het
Prickle2 A G 6: 92,387,984 (GRCm39) Y473H probably benign Het
Prpf3 A G 3: 95,751,535 (GRCm39) W389R probably damaging Het
Psme4 G A 11: 30,765,264 (GRCm39) E544K possibly damaging Het
Relb A T 7: 19,345,767 (GRCm39) D395E probably damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rnf213 A G 11: 119,307,389 (GRCm39) N683S probably benign Het
Rtel1 T C 2: 180,964,596 (GRCm39) C102R probably benign Het
Sel1l3 C T 5: 53,301,379 (GRCm39) probably benign Het
Slc8a2 A G 7: 15,878,887 (GRCm39) T458A probably benign Het
Smc3 T A 19: 53,629,340 (GRCm39) M931K probably benign Het
Sorbs2 T C 8: 46,249,539 (GRCm39) V795A probably benign Het
Tgm3 A G 2: 129,854,326 (GRCm39) S2G probably benign Het
Tpbpa T C 13: 61,087,867 (GRCm39) T75A probably damaging Het
Trub1 A G 19: 57,473,495 (GRCm39) probably benign Het
Uggt2 A G 14: 119,328,604 (GRCm39) probably null Het
Ugt2a3 A G 5: 87,475,065 (GRCm39) V393A possibly damaging Het
Vav3 T A 3: 109,470,151 (GRCm39) M532K possibly damaging Het
Zfp616 A T 11: 73,975,850 (GRCm39) K706N probably damaging Het
Zkscan1 T C 5: 138,091,432 (GRCm39) F55S probably damaging Het
Other mutations in Nomo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Nomo1 APN 7 45,694,760 (GRCm39) missense possibly damaging 0.66
IGL00811:Nomo1 APN 7 45,732,732 (GRCm39) missense possibly damaging 0.95
IGL01710:Nomo1 APN 7 45,687,980 (GRCm39) missense probably damaging 1.00
IGL01797:Nomo1 APN 7 45,706,086 (GRCm39) missense probably damaging 0.96
IGL01973:Nomo1 APN 7 45,732,651 (GRCm39) splice site probably benign
IGL02506:Nomo1 APN 7 45,727,480 (GRCm39) missense possibly damaging 0.50
IGL02739:Nomo1 APN 7 45,693,731 (GRCm39) splice site probably null
IGL02863:Nomo1 APN 7 45,696,340 (GRCm39) missense probably damaging 0.98
P0005:Nomo1 UTSW 7 45,686,981 (GRCm39) critical splice acceptor site probably null
PIT4243001:Nomo1 UTSW 7 45,693,705 (GRCm39) missense probably damaging 1.00
R0106:Nomo1 UTSW 7 45,687,056 (GRCm39) missense probably damaging 1.00
R0106:Nomo1 UTSW 7 45,687,056 (GRCm39) missense probably damaging 1.00
R0124:Nomo1 UTSW 7 45,732,652 (GRCm39) splice site probably benign
R0239:Nomo1 UTSW 7 45,729,018 (GRCm39) critical splice donor site probably null
R0239:Nomo1 UTSW 7 45,729,018 (GRCm39) critical splice donor site probably null
R0417:Nomo1 UTSW 7 45,718,122 (GRCm39) missense possibly damaging 0.51
R0467:Nomo1 UTSW 7 45,721,911 (GRCm39) splice site probably null
R0535:Nomo1 UTSW 7 45,721,941 (GRCm39) missense probably damaging 0.99
R0829:Nomo1 UTSW 7 45,725,596 (GRCm39) splice site probably benign
R1480:Nomo1 UTSW 7 45,710,337 (GRCm39) missense probably damaging 0.98
R1601:Nomo1 UTSW 7 45,696,379 (GRCm39) missense probably damaging 0.96
R1743:Nomo1 UTSW 7 45,719,461 (GRCm39) critical splice donor site probably null
R1765:Nomo1 UTSW 7 45,715,717 (GRCm39) missense possibly damaging 0.59
R1861:Nomo1 UTSW 7 45,727,525 (GRCm39) missense probably benign 0.06
R1998:Nomo1 UTSW 7 45,683,368 (GRCm39) missense possibly damaging 0.69
R1999:Nomo1 UTSW 7 45,706,151 (GRCm39) missense possibly damaging 0.95
R2145:Nomo1 UTSW 7 45,715,928 (GRCm39) missense probably damaging 1.00
R2869:Nomo1 UTSW 7 45,696,361 (GRCm39) missense probably damaging 0.96
R2869:Nomo1 UTSW 7 45,696,361 (GRCm39) missense probably damaging 0.96
R2870:Nomo1 UTSW 7 45,696,361 (GRCm39) missense probably damaging 0.96
R2870:Nomo1 UTSW 7 45,696,361 (GRCm39) missense probably damaging 0.96
R2871:Nomo1 UTSW 7 45,696,361 (GRCm39) missense probably damaging 0.96
R2871:Nomo1 UTSW 7 45,696,361 (GRCm39) missense probably damaging 0.96
R2873:Nomo1 UTSW 7 45,696,361 (GRCm39) missense probably damaging 0.96
R4116:Nomo1 UTSW 7 45,683,320 (GRCm39) missense probably benign 0.06
R4404:Nomo1 UTSW 7 45,706,092 (GRCm39) missense probably benign 0.00
R4406:Nomo1 UTSW 7 45,706,092 (GRCm39) missense probably benign 0.00
R4560:Nomo1 UTSW 7 45,690,904 (GRCm39) missense probably damaging 0.99
R4633:Nomo1 UTSW 7 45,699,684 (GRCm39) splice site probably benign
R4651:Nomo1 UTSW 7 45,717,866 (GRCm39) missense probably damaging 0.99
R4653:Nomo1 UTSW 7 45,711,237 (GRCm39) missense probably benign 0.01
R4752:Nomo1 UTSW 7 45,706,626 (GRCm39) missense probably damaging 1.00
R4792:Nomo1 UTSW 7 45,693,643 (GRCm39) splice site probably null
R4838:Nomo1 UTSW 7 45,733,139 (GRCm39) missense unknown
R4876:Nomo1 UTSW 7 45,715,915 (GRCm39) missense probably damaging 1.00
R4915:Nomo1 UTSW 7 45,693,656 (GRCm39) missense probably benign 0.30
R4953:Nomo1 UTSW 7 45,700,155 (GRCm39) intron probably benign
R5463:Nomo1 UTSW 7 45,712,426 (GRCm39) missense possibly damaging 0.47
R5664:Nomo1 UTSW 7 45,725,581 (GRCm39) missense probably benign
R5956:Nomo1 UTSW 7 45,692,037 (GRCm39) missense possibly damaging 0.51
R6037:Nomo1 UTSW 7 45,712,423 (GRCm39) missense possibly damaging 0.64
R6037:Nomo1 UTSW 7 45,712,423 (GRCm39) missense possibly damaging 0.64
R6307:Nomo1 UTSW 7 45,683,260 (GRCm39) unclassified probably benign
R6695:Nomo1 UTSW 7 45,715,885 (GRCm39) missense probably benign 0.16
R6970:Nomo1 UTSW 7 45,695,391 (GRCm39) missense probably damaging 0.97
R7334:Nomo1 UTSW 7 45,732,692 (GRCm39) missense probably damaging 1.00
R7394:Nomo1 UTSW 7 45,715,903 (GRCm39) missense probably benign 0.26
R7556:Nomo1 UTSW 7 45,715,642 (GRCm39) missense probably damaging 1.00
R7834:Nomo1 UTSW 7 45,706,162 (GRCm39) critical splice donor site probably null
R7979:Nomo1 UTSW 7 45,690,986 (GRCm39) missense probably null
R8193:Nomo1 UTSW 7 45,692,037 (GRCm39) missense possibly damaging 0.51
R8841:Nomo1 UTSW 7 45,707,911 (GRCm39) missense probably benign 0.00
R8906:Nomo1 UTSW 7 45,722,004 (GRCm39) missense probably benign 0.06
R9049:Nomo1 UTSW 7 45,715,597 (GRCm39) missense probably benign 0.01
R9087:Nomo1 UTSW 7 45,732,748 (GRCm39) missense probably benign 0.00
R9176:Nomo1 UTSW 7 45,730,828 (GRCm39) missense possibly damaging 0.88
Z1177:Nomo1 UTSW 7 45,715,697 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- CGTGACGATGACTCTGAAGTGGAAG -3'
(R):5'- CCAAGTTCTGCAATATGGGTTGGGC -3'

Sequencing Primer
(F):5'- ACTCTGAAGTGGAAGCCTGTC -3'
(R):5'- CAGATTAGAGTTTCGGAGGTCC -3'
Posted On 2013-11-07