Incidental Mutation 'R0963:Zfp955a'
| ID |
81414 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp955a
|
| Ensembl Gene |
ENSMUSG00000094441 |
| Gene Name |
zinc finger protein 955A |
| Synonyms |
AI842447 |
| MMRRC Submission |
039092-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
R0963 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
33458692-33474119 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 33462726 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Asparagine
at position 56
(S56N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000008830
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000008830]
|
| AlphaFold |
Q80XR7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000008830
AA Change: S56N
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000008830
Gene: ENSMUSG00000094441
AA Change: S56N
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
71 |
7.08e-15 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
5.72e-1 |
SMART |
|
ZnF_C2H2
|
290 |
312 |
6.57e-1 |
SMART |
|
ZnF_C2HC
|
291 |
307 |
9.75e0 |
SMART |
|
ZnF_C2H2
|
318 |
340 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
346 |
368 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
374 |
396 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
402 |
424 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
430 |
452 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
458 |
480 |
6.57e-1 |
SMART |
|
ZnF_C2HC
|
459 |
475 |
4.03e1 |
SMART |
|
ZnF_C2H2
|
486 |
508 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
514 |
536 |
2.36e-2 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.1%
- 20x: 94.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adarb2 |
A |
G |
13: 8,722,451 (GRCm39) |
D369G |
probably damaging |
Het |
| Adcy7 |
T |
C |
8: 89,038,893 (GRCm39) |
V303A |
probably damaging |
Het |
| Afap1l1 |
A |
T |
18: 61,870,001 (GRCm39) |
Y610N |
probably damaging |
Het |
| Agr3 |
T |
A |
12: 35,984,433 (GRCm39) |
H53Q |
probably benign |
Het |
| Akr1d1 |
A |
G |
6: 37,507,209 (GRCm39) |
I10M |
probably damaging |
Het |
| Atp4b |
G |
T |
8: 13,440,014 (GRCm39) |
H111N |
probably benign |
Het |
| Bbs7 |
G |
T |
3: 36,667,412 (GRCm39) |
A8E |
probably benign |
Het |
| Bsn |
C |
T |
9: 107,989,006 (GRCm39) |
V2249M |
possibly damaging |
Het |
| Cpt1a |
T |
C |
19: 3,431,634 (GRCm39) |
S685P |
probably damaging |
Het |
| Dhx57 |
A |
T |
17: 80,582,956 (GRCm39) |
H163Q |
probably benign |
Het |
| Duox2 |
A |
C |
2: 122,117,653 (GRCm39) |
C894G |
probably benign |
Het |
| Ecm1 |
T |
C |
3: 95,643,900 (GRCm39) |
T209A |
possibly damaging |
Het |
| Glo1 |
T |
C |
17: 30,819,085 (GRCm39) |
N79S |
probably benign |
Het |
| Htra1 |
T |
A |
7: 130,584,009 (GRCm39) |
M388K |
possibly damaging |
Het |
| Iqca1 |
C |
A |
1: 90,070,453 (GRCm39) |
G133V |
probably null |
Het |
| Jag2 |
C |
T |
12: 112,878,934 (GRCm39) |
E496K |
probably damaging |
Het |
| Kcnh2 |
C |
T |
5: 24,527,670 (GRCm39) |
R894H |
probably damaging |
Het |
| Khdc1c |
A |
G |
1: 21,439,833 (GRCm39) |
N128S |
probably benign |
Het |
| Lamc1 |
T |
C |
1: 153,119,132 (GRCm39) |
N829S |
probably benign |
Het |
| Leprotl1 |
T |
C |
8: 34,606,189 (GRCm39) |
Y33C |
probably damaging |
Het |
| Lypd11 |
A |
T |
7: 24,423,047 (GRCm39) |
D90E |
probably benign |
Het |
| Map3k3 |
T |
A |
11: 106,014,618 (GRCm39) |
S130T |
probably benign |
Het |
| Mip |
C |
T |
10: 128,061,854 (GRCm39) |
A35V |
probably benign |
Het |
| Ms4a19 |
T |
C |
19: 11,118,921 (GRCm39) |
T63A |
possibly damaging |
Het |
| Myh15 |
A |
G |
16: 48,952,512 (GRCm39) |
R861G |
probably damaging |
Het |
| Myom1 |
A |
C |
17: 71,384,762 (GRCm39) |
I718L |
possibly damaging |
Het |
| Naip6 |
C |
T |
13: 100,452,983 (GRCm39) |
R26H |
probably benign |
Het |
| Or52e4 |
G |
A |
7: 104,706,179 (GRCm39) |
C242Y |
probably damaging |
Het |
| Pde6b |
A |
G |
5: 108,578,534 (GRCm39) |
E824G |
probably benign |
Het |
| Pramel24 |
T |
A |
4: 143,453,678 (GRCm39) |
I262N |
possibly damaging |
Het |
| Rbm19 |
T |
G |
5: 120,268,799 (GRCm39) |
S476A |
possibly damaging |
Het |
| Rpl39l |
T |
A |
16: 9,992,162 (GRCm39) |
|
probably null |
Het |
| Sec24b |
A |
G |
3: 129,834,554 (GRCm39) |
S79P |
probably benign |
Het |
| Slc15a2 |
G |
A |
16: 36,594,935 (GRCm39) |
A146V |
probably damaging |
Het |
| Slmap |
T |
C |
14: 26,189,675 (GRCm39) |
Y161C |
probably damaging |
Het |
| Smc4 |
T |
A |
3: 68,933,259 (GRCm39) |
C652S |
probably damaging |
Het |
| Stab1 |
A |
G |
14: 30,869,231 (GRCm39) |
I1499T |
probably damaging |
Het |
| Tnnt1 |
A |
G |
7: 4,510,594 (GRCm39) |
L209P |
probably damaging |
Het |
| Trim52 |
T |
G |
14: 106,344,973 (GRCm39) |
S210R |
probably benign |
Het |
| Tsc22d1 |
T |
A |
14: 76,656,039 (GRCm39) |
N82K |
possibly damaging |
Het |
| Wdr75 |
T |
C |
1: 45,856,470 (GRCm39) |
Y498H |
probably benign |
Het |
|
| Other mutations in Zfp955a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01115:Zfp955a
|
APN |
17 |
33,461,554 (GRCm39) |
nonsense |
probably null |
|
|
IGL01859:Zfp955a
|
APN |
17 |
33,462,693 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02612:Zfp955a
|
APN |
17 |
33,463,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02894:Zfp955a
|
APN |
17 |
33,461,426 (GRCm39) |
nonsense |
probably null |
|
|
IGL02933:Zfp955a
|
APN |
17 |
33,462,683 (GRCm39) |
splice site |
probably null |
|
|
R0145:Zfp955a
|
UTSW |
17 |
33,461,430 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0577:Zfp955a
|
UTSW |
17 |
33,461,068 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1588:Zfp955a
|
UTSW |
17 |
33,460,791 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1614:Zfp955a
|
UTSW |
17 |
33,461,306 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1704:Zfp955a
|
UTSW |
17 |
33,460,699 (GRCm39) |
nonsense |
probably null |
|
|
R1994:Zfp955a
|
UTSW |
17 |
33,460,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2043:Zfp955a
|
UTSW |
17 |
33,461,527 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2091:Zfp955a
|
UTSW |
17 |
33,461,731 (GRCm39) |
nonsense |
probably null |
|
|
R2091:Zfp955a
|
UTSW |
17 |
33,461,731 (GRCm39) |
nonsense |
probably null |
|
|
R4077:Zfp955a
|
UTSW |
17 |
33,460,675 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4078:Zfp955a
|
UTSW |
17 |
33,460,675 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4689:Zfp955a
|
UTSW |
17 |
33,461,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4735:Zfp955a
|
UTSW |
17 |
33,460,696 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4870:Zfp955a
|
UTSW |
17 |
33,460,699 (GRCm39) |
nonsense |
probably null |
|
|
R4904:Zfp955a
|
UTSW |
17 |
33,461,162 (GRCm39) |
nonsense |
probably null |
|
|
R5180:Zfp955a
|
UTSW |
17 |
33,461,592 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6006:Zfp955a
|
UTSW |
17 |
33,460,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7132:Zfp955a
|
UTSW |
17 |
33,460,589 (GRCm39) |
nonsense |
probably null |
|
|
R7403:Zfp955a
|
UTSW |
17 |
33,462,720 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7457:Zfp955a
|
UTSW |
17 |
33,463,025 (GRCm39) |
nonsense |
probably null |
|
|
R7547:Zfp955a
|
UTSW |
17 |
33,461,797 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8263:Zfp955a
|
UTSW |
17 |
33,463,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8265:Zfp955a
|
UTSW |
17 |
33,463,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8330:Zfp955a
|
UTSW |
17 |
33,463,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8947:Zfp955a
|
UTSW |
17 |
33,460,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9052:Zfp955a
|
UTSW |
17 |
33,461,279 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9352:Zfp955a
|
UTSW |
17 |
33,461,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9557:Zfp955a
|
UTSW |
17 |
33,461,107 (GRCm39) |
nonsense |
probably null |
|
|
R9683:Zfp955a
|
UTSW |
17 |
33,461,587 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9784:Zfp955a
|
UTSW |
17 |
33,461,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Zfp955a
|
UTSW |
17 |
33,461,888 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
X0062:Zfp955a
|
UTSW |
17 |
33,460,976 (GRCm39) |
missense |
probably benign |
0.37 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCACAAAGTCCACATGAGTGAGTA -3'
(R):5'- GCAGGCTTTTCCCATCATTCTTCTAACA -3'
Sequencing Primer
(F):5'- TCTCAAGCTCAGGAAAGGTTTACG -3'
(R):5'- ggattcttaccaaaagaagctctac -3'
|
| Posted On |
2013-11-07 |
Incidental Mutation