Incidental Mutation 'R0948:Strn4'
ID 81706
Institutional Source Beutler Lab
Gene Symbol Strn4
Ensembl Gene ENSMUSG00000030374
Gene Name striatin, calmodulin binding protein 4
Synonyms ZIN, zinedin
MMRRC Submission 039087-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.836) question?
Stock # R0948 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 16549814-16574856 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 16571638 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 26 (C26*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019220] [ENSMUST00000108495] [ENSMUST00000185011]
AlphaFold P58404
Predicted Effect probably null
Transcript: ENSMUST00000019220
AA Change: C589*
SMART Domains Protein: ENSMUSP00000019220
Gene: ENSMUSG00000030374
AA Change: C589*

DomainStartEndE-ValueType
low complexity region 6 16 N/A INTRINSIC
low complexity region 21 60 N/A INTRINSIC
Pfam:Striatin 64 193 1.2e-44 PFAM
low complexity region 217 236 N/A INTRINSIC
low complexity region 272 284 N/A INTRINSIC
low complexity region 304 314 N/A INTRINSIC
low complexity region 367 382 N/A INTRINSIC
low complexity region 416 429 N/A INTRINSIC
WD40 434 473 5.72e-9 SMART
WD40 487 526 6.53e-4 SMART
WD40 540 579 6.99e-13 SMART
WD40 584 626 2.38e1 SMART
WD40 629 672 3.55e1 SMART
WD40 675 714 5.34e-9 SMART
WD40 717 760 1.58e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000108495
AA Change: C582*
SMART Domains Protein: ENSMUSP00000104135
Gene: ENSMUSG00000030374
AA Change: C582*

DomainStartEndE-ValueType
low complexity region 6 16 N/A INTRINSIC
low complexity region 21 60 N/A INTRINSIC
Pfam:Striatin 64 197 1.4e-45 PFAM
low complexity region 217 236 N/A INTRINSIC
low complexity region 272 284 N/A INTRINSIC
low complexity region 304 314 N/A INTRINSIC
low complexity region 367 382 N/A INTRINSIC
low complexity region 409 422 N/A INTRINSIC
WD40 427 466 5.72e-9 SMART
WD40 480 519 6.53e-4 SMART
WD40 533 572 6.99e-13 SMART
WD40 577 619 2.38e1 SMART
WD40 622 665 3.55e1 SMART
WD40 668 707 5.34e-9 SMART
WD40 710 753 1.58e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123510
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131721
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134350
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183680
Predicted Effect probably null
Transcript: ENSMUST00000184694
AA Change: C26*
Predicted Effect probably benign
Transcript: ENSMUST00000185011
SMART Domains Protein: ENSMUSP00000139290
Gene: ENSMUSG00000030374

DomainStartEndE-ValueType
low complexity region 33 51 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000184708
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.4%
  • 20x: 92.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810009A15Rik C T 19: 8,867,390 (GRCm39) T63M probably damaging Het
Abcb1a T A 5: 8,790,621 (GRCm39) probably null Het
Ahrr T C 13: 74,361,888 (GRCm39) D537G probably damaging Het
Anxa4 T A 6: 86,718,913 (GRCm39) I269F probably damaging Het
Aoc1l1 A G 6: 48,953,278 (GRCm39) Y401C probably damaging Het
Atm A T 9: 53,407,258 (GRCm39) M1160K probably benign Het
Ccdc175 A G 12: 72,177,897 (GRCm39) Y434H probably damaging Het
Col19a1 C T 1: 24,335,882 (GRCm39) A855T probably damaging Het
Cyp2a4 A G 7: 26,010,213 (GRCm39) D246G probably damaging Het
Dmbt1 T C 7: 130,694,847 (GRCm39) L840P possibly damaging Het
Dock6 A T 9: 21,712,829 (GRCm39) D2009E probably damaging Het
E2f3 C T 13: 30,169,516 (GRCm39) A46T probably damaging Het
Ect2l A T 10: 18,016,334 (GRCm39) C635S probably damaging Het
Fer1l6 A G 15: 58,435,924 (GRCm39) D439G probably benign Het
Hao1 A C 2: 134,372,693 (GRCm39) M105R probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Igsf10 A G 3: 59,238,525 (GRCm39) I552T probably damaging Het
Il31ra A G 13: 112,666,912 (GRCm39) S470P possibly damaging Het
Mfsd1 A G 3: 67,504,067 (GRCm39) N353S possibly damaging Het
Mga T A 2: 119,772,140 (GRCm39) F1667I possibly damaging Het
Niban2 A G 2: 32,812,872 (GRCm39) Y480C probably damaging Het
Nwd2 T C 5: 63,964,655 (GRCm39) V1413A probably damaging Het
Or8b1 T G 9: 38,400,244 (GRCm39) S306R probably benign Het
Or8b50 G A 9: 38,517,787 (GRCm39) V9I possibly damaging Het
Osbpl10 T A 9: 114,996,187 (GRCm39) V119E probably damaging Het
Plec C A 15: 76,089,887 (GRCm39) R151L probably benign Het
Ptpn12 T C 5: 21,203,041 (GRCm39) H579R probably benign Het
Rnase4 G T 14: 51,342,362 (GRCm39) G29C probably damaging Het
Sim1 C A 10: 50,857,423 (GRCm39) S391* probably null Het
Sobp A T 10: 42,898,205 (GRCm39) I460N probably damaging Het
Spns3 A T 11: 72,436,766 (GRCm39) D75E probably damaging Het
Tacstd2 T A 6: 67,512,102 (GRCm39) I197L probably damaging Het
Trpc6 A G 9: 8,610,416 (GRCm39) T295A possibly damaging Het
Txnl1 G T 18: 63,825,191 (GRCm39) S18R possibly damaging Het
U2surp A G 9: 95,343,550 (GRCm39) probably benign Het
Ube2frt A T 12: 36,140,934 (GRCm39) probably benign Het
Vwce A G 19: 10,630,441 (GRCm39) Y500C probably damaging Het
Wdr49 A C 3: 75,358,158 (GRCm39) S196A probably benign Het
Wfs1 T C 5: 37,124,905 (GRCm39) Y662C probably damaging Het
Wnt8b A C 19: 44,498,968 (GRCm39) D133A possibly damaging Het
Zfp329 T A 7: 12,545,395 (GRCm39) N43I probably benign Het
Zfp532 C A 18: 65,756,889 (GRCm39) A274E probably damaging Het
Zfp74 A G 7: 29,635,362 (GRCm39) probably null Het
Other mutations in Strn4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00776:Strn4 APN 7 16,564,377 (GRCm39) missense probably damaging 1.00
IGL01153:Strn4 APN 7 16,571,846 (GRCm39) missense probably damaging 1.00
IGL01748:Strn4 APN 7 16,572,227 (GRCm39) missense probably damaging 1.00
IGL03227:Strn4 APN 7 16,571,639 (GRCm39) missense possibly damaging 0.79
BB004:Strn4 UTSW 7 16,560,556 (GRCm39) missense probably null 1.00
BB014:Strn4 UTSW 7 16,560,556 (GRCm39) missense probably null 1.00
PIT4260001:Strn4 UTSW 7 16,556,434 (GRCm39) missense probably damaging 1.00
R1876:Strn4 UTSW 7 16,572,207 (GRCm39) missense probably damaging 1.00
R1918:Strn4 UTSW 7 16,567,846 (GRCm39) missense probably damaging 1.00
R2015:Strn4 UTSW 7 16,566,953 (GRCm39) missense possibly damaging 0.85
R2250:Strn4 UTSW 7 16,560,391 (GRCm39) missense probably damaging 1.00
R3435:Strn4 UTSW 7 16,571,558 (GRCm39) missense possibly damaging 0.86
R3686:Strn4 UTSW 7 16,556,506 (GRCm39) missense probably damaging 1.00
R3688:Strn4 UTSW 7 16,556,506 (GRCm39) missense probably damaging 1.00
R3887:Strn4 UTSW 7 16,556,923 (GRCm39) unclassified probably benign
R4613:Strn4 UTSW 7 16,558,088 (GRCm39) missense possibly damaging 0.50
R4730:Strn4 UTSW 7 16,562,719 (GRCm39) missense possibly damaging 0.59
R5590:Strn4 UTSW 7 16,567,799 (GRCm39) critical splice acceptor site probably null
R5924:Strn4 UTSW 7 16,572,246 (GRCm39) missense probably damaging 1.00
R6327:Strn4 UTSW 7 16,550,384 (GRCm39) missense probably benign 0.00
R6759:Strn4 UTSW 7 16,556,978 (GRCm39) missense probably damaging 1.00
R6866:Strn4 UTSW 7 16,562,710 (GRCm39) missense probably damaging 0.97
R6976:Strn4 UTSW 7 16,564,279 (GRCm39) missense probably benign 0.20
R7759:Strn4 UTSW 7 16,564,309 (GRCm39) missense probably damaging 1.00
R7779:Strn4 UTSW 7 16,565,417 (GRCm39) missense probably damaging 1.00
R7927:Strn4 UTSW 7 16,560,556 (GRCm39) missense probably null 1.00
R8174:Strn4 UTSW 7 16,562,733 (GRCm39) missense probably damaging 1.00
R8777:Strn4 UTSW 7 16,550,533 (GRCm39) missense probably damaging 1.00
R8777-TAIL:Strn4 UTSW 7 16,550,533 (GRCm39) missense probably damaging 1.00
R8868:Strn4 UTSW 7 16,560,570 (GRCm39) missense probably benign 0.25
R9226:Strn4 UTSW 7 16,559,722 (GRCm39) intron probably benign
R9341:Strn4 UTSW 7 16,573,827 (GRCm39) missense probably damaging 0.99
R9343:Strn4 UTSW 7 16,573,827 (GRCm39) missense probably damaging 0.99
R9718:Strn4 UTSW 7 16,572,496 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCCCTTGGGCCAATCAGTGTAG -3'
(R):5'- TGCCAGCTTCCAGGTCATAAAGAAC -3'

Sequencing Primer
(F):5'- GTAGCTGGTGTCCCTGACAATC -3'
(R):5'- TTCCAGGTCATAAAGAACGGTATCAC -3'
Posted On 2013-11-08