Incidental Mutation 'R0948:Zfp74'
ID 81708
Institutional Source Beutler Lab
Gene Symbol Zfp74
Ensembl Gene ENSMUSG00000059975
Gene Name zinc finger protein 74
Synonyms KRAB8, 2810054M15Rik, Zfp66
MMRRC Submission 039087-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R0948 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 29632086-29653579 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 29635362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103847 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032797] [ENSMUST00000108205] [ENSMUST00000108211] [ENSMUST00000108212]
AlphaFold Q80W31
Predicted Effect silent
Transcript: ENSMUST00000032797
SMART Domains Protein: ENSMUSP00000032797
Gene: ENSMUSG00000059975

DomainStartEndE-ValueType
KRAB 8 68 5.02e-38 SMART
ZnF_C2H2 179 201 1.84e-4 SMART
ZnF_C2H2 207 229 2.36e-2 SMART
ZnF_C2H2 235 257 1.5e-4 SMART
ZnF_C2H2 263 285 2.79e-4 SMART
ZnF_C2H2 291 313 3.49e-5 SMART
ZnF_C2H2 319 341 6.42e-4 SMART
ZnF_C2H2 347 369 5.59e-4 SMART
ZnF_C2H2 375 397 5.21e-4 SMART
ZnF_C2H2 403 425 3.63e-3 SMART
ZnF_C2H2 431 453 1.82e-3 SMART
ZnF_C2H2 459 481 1.58e-3 SMART
ZnF_C2H2 487 509 2.12e-4 SMART
ZnF_C2H2 515 537 1.82e-3 SMART
ZnF_C2H2 543 565 2.24e-3 SMART
ZnF_C2H2 571 593 8.02e-5 SMART
ZnF_C2H2 599 621 1.04e-3 SMART
ZnF_C2H2 627 649 1.04e-3 SMART
ZnF_C2H2 655 677 9.88e-5 SMART
Predicted Effect silent
Transcript: ENSMUST00000108205
SMART Domains Protein: ENSMUSP00000103840
Gene: ENSMUSG00000059975

DomainStartEndE-ValueType
KRAB 8 68 5.02e-38 SMART
ZnF_C2H2 179 201 1.84e-4 SMART
ZnF_C2H2 207 229 2.36e-2 SMART
ZnF_C2H2 235 257 1.5e-4 SMART
ZnF_C2H2 263 285 2.79e-4 SMART
ZnF_C2H2 291 313 3.49e-5 SMART
ZnF_C2H2 319 341 6.42e-4 SMART
ZnF_C2H2 347 369 5.59e-4 SMART
ZnF_C2H2 375 397 5.21e-4 SMART
ZnF_C2H2 403 425 3.63e-3 SMART
ZnF_C2H2 431 453 1.82e-3 SMART
ZnF_C2H2 459 481 1.58e-3 SMART
ZnF_C2H2 487 509 2.12e-4 SMART
ZnF_C2H2 515 537 1.82e-3 SMART
ZnF_C2H2 543 565 2.24e-3 SMART
ZnF_C2H2 571 593 8.02e-5 SMART
ZnF_C2H2 599 621 1.04e-3 SMART
ZnF_C2H2 627 649 1.04e-3 SMART
ZnF_C2H2 655 677 9.88e-5 SMART
Predicted Effect probably null
Transcript: ENSMUST00000108211
SMART Domains Protein: ENSMUSP00000103846
Gene: ENSMUSG00000059975

DomainStartEndE-ValueType
KRAB 8 68 5.02e-38 SMART
Predicted Effect probably null
Transcript: ENSMUST00000108212
SMART Domains Protein: ENSMUSP00000103847
Gene: ENSMUSG00000059975

DomainStartEndE-ValueType
KRAB 8 68 5.02e-38 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149793
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.4%
  • 20x: 92.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810009A15Rik C T 19: 8,867,390 (GRCm39) T63M probably damaging Het
Abcb1a T A 5: 8,790,621 (GRCm39) probably null Het
Ahrr T C 13: 74,361,888 (GRCm39) D537G probably damaging Het
Anxa4 T A 6: 86,718,913 (GRCm39) I269F probably damaging Het
Aoc1l1 A G 6: 48,953,278 (GRCm39) Y401C probably damaging Het
Atm A T 9: 53,407,258 (GRCm39) M1160K probably benign Het
Ccdc175 A G 12: 72,177,897 (GRCm39) Y434H probably damaging Het
Col19a1 C T 1: 24,335,882 (GRCm39) A855T probably damaging Het
Cyp2a4 A G 7: 26,010,213 (GRCm39) D246G probably damaging Het
Dmbt1 T C 7: 130,694,847 (GRCm39) L840P possibly damaging Het
Dock6 A T 9: 21,712,829 (GRCm39) D2009E probably damaging Het
E2f3 C T 13: 30,169,516 (GRCm39) A46T probably damaging Het
Ect2l A T 10: 18,016,334 (GRCm39) C635S probably damaging Het
Fer1l6 A G 15: 58,435,924 (GRCm39) D439G probably benign Het
Hao1 A C 2: 134,372,693 (GRCm39) M105R probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Igsf10 A G 3: 59,238,525 (GRCm39) I552T probably damaging Het
Il31ra A G 13: 112,666,912 (GRCm39) S470P possibly damaging Het
Mfsd1 A G 3: 67,504,067 (GRCm39) N353S possibly damaging Het
Mga T A 2: 119,772,140 (GRCm39) F1667I possibly damaging Het
Niban2 A G 2: 32,812,872 (GRCm39) Y480C probably damaging Het
Nwd2 T C 5: 63,964,655 (GRCm39) V1413A probably damaging Het
Or8b1 T G 9: 38,400,244 (GRCm39) S306R probably benign Het
Or8b50 G A 9: 38,517,787 (GRCm39) V9I possibly damaging Het
Osbpl10 T A 9: 114,996,187 (GRCm39) V119E probably damaging Het
Plec C A 15: 76,089,887 (GRCm39) R151L probably benign Het
Ptpn12 T C 5: 21,203,041 (GRCm39) H579R probably benign Het
Rnase4 G T 14: 51,342,362 (GRCm39) G29C probably damaging Het
Sim1 C A 10: 50,857,423 (GRCm39) S391* probably null Het
Sobp A T 10: 42,898,205 (GRCm39) I460N probably damaging Het
Spns3 A T 11: 72,436,766 (GRCm39) D75E probably damaging Het
Strn4 T A 7: 16,571,638 (GRCm39) C26* probably null Het
Tacstd2 T A 6: 67,512,102 (GRCm39) I197L probably damaging Het
Trpc6 A G 9: 8,610,416 (GRCm39) T295A possibly damaging Het
Txnl1 G T 18: 63,825,191 (GRCm39) S18R possibly damaging Het
U2surp A G 9: 95,343,550 (GRCm39) probably benign Het
Ube2frt A T 12: 36,140,934 (GRCm39) probably benign Het
Vwce A G 19: 10,630,441 (GRCm39) Y500C probably damaging Het
Wdr49 A C 3: 75,358,158 (GRCm39) S196A probably benign Het
Wfs1 T C 5: 37,124,905 (GRCm39) Y662C probably damaging Het
Wnt8b A C 19: 44,498,968 (GRCm39) D133A possibly damaging Het
Zfp329 T A 7: 12,545,395 (GRCm39) N43I probably benign Het
Zfp532 C A 18: 65,756,889 (GRCm39) A274E probably damaging Het
Other mutations in Zfp74
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0355:Zfp74 UTSW 7 29,653,466 (GRCm39) start gained probably benign
R0387:Zfp74 UTSW 7 29,634,179 (GRCm39) missense probably benign 0.05
R1757:Zfp74 UTSW 7 29,634,486 (GRCm39) missense probably benign 0.01
R1813:Zfp74 UTSW 7 29,634,569 (GRCm39) missense probably damaging 1.00
R1893:Zfp74 UTSW 7 29,635,470 (GRCm39) critical splice acceptor site probably null
R1896:Zfp74 UTSW 7 29,634,569 (GRCm39) missense probably damaging 1.00
R1958:Zfp74 UTSW 7 29,635,136 (GRCm39) missense probably benign 0.08
R2092:Zfp74 UTSW 7 29,653,349 (GRCm39) start gained probably benign
R2111:Zfp74 UTSW 7 29,634,443 (GRCm39) nonsense probably null
R4894:Zfp74 UTSW 7 29,635,470 (GRCm39) critical splice acceptor site probably benign
R5121:Zfp74 UTSW 7 29,631,932 (GRCm39) splice site probably null
R5123:Zfp74 UTSW 7 29,634,158 (GRCm39) missense probably damaging 1.00
R5129:Zfp74 UTSW 7 29,631,880 (GRCm39) missense probably benign 0.00
R5213:Zfp74 UTSW 7 29,634,668 (GRCm39) missense probably damaging 1.00
R5460:Zfp74 UTSW 7 29,635,316 (GRCm39) missense probably benign 0.04
R5519:Zfp74 UTSW 7 29,634,559 (GRCm39) missense probably damaging 0.99
R5589:Zfp74 UTSW 7 29,633,990 (GRCm39) missense probably damaging 1.00
R6287:Zfp74 UTSW 7 29,635,201 (GRCm39) missense probably benign
R6330:Zfp74 UTSW 7 29,637,412 (GRCm39) missense probably damaging 1.00
R6370:Zfp74 UTSW 7 29,631,835 (GRCm39) missense probably damaging 0.96
R6407:Zfp74 UTSW 7 29,635,048 (GRCm39) missense probably damaging 1.00
R6694:Zfp74 UTSW 7 29,634,559 (GRCm39) missense probably damaging 0.99
R6791:Zfp74 UTSW 7 29,633,860 (GRCm39) missense probably benign 0.02
R7144:Zfp74 UTSW 7 29,634,590 (GRCm39) missense probably damaging 0.98
R7662:Zfp74 UTSW 7 29,653,278 (GRCm39) critical splice donor site probably null
R7667:Zfp74 UTSW 7 29,634,608 (GRCm39) missense probably damaging 1.00
R7898:Zfp74 UTSW 7 29,635,380 (GRCm39) nonsense probably null
R7940:Zfp74 UTSW 7 29,631,867 (GRCm39) missense probably benign 0.07
R8676:Zfp74 UTSW 7 29,634,079 (GRCm39) missense probably damaging 1.00
R8864:Zfp74 UTSW 7 29,634,235 (GRCm39) missense probably damaging 1.00
R8940:Zfp74 UTSW 7 29,634,772 (GRCm39) missense possibly damaging 0.96
R9748:Zfp74 UTSW 7 29,634,751 (GRCm39) missense probably damaging 1.00
R9764:Zfp74 UTSW 7 29,631,845 (GRCm39) missense probably benign 0.11
Predicted Primers
Posted On 2013-11-08