Incidental Mutation 'R0948:Zfp74'
ID |
81708 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp74
|
Ensembl Gene |
ENSMUSG00000059975 |
Gene Name |
zinc finger protein 74 |
Synonyms |
KRAB8, 2810054M15Rik, Zfp66 |
MMRRC Submission |
039087-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.097)
|
Stock # |
R0948 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
29632086-29653579 bp(-) (GRCm39) |
Type of Mutation |
critical splice donor site (2 bp from exon) |
DNA Base Change (assembly) |
A to G
at 29635362 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000103847
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032797]
[ENSMUST00000108205]
[ENSMUST00000108211]
[ENSMUST00000108212]
|
AlphaFold |
Q80W31 |
Predicted Effect |
silent
Transcript: ENSMUST00000032797
|
SMART Domains |
Protein: ENSMUSP00000032797 Gene: ENSMUSG00000059975
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
5.02e-38 |
SMART |
ZnF_C2H2
|
179 |
201 |
1.84e-4 |
SMART |
ZnF_C2H2
|
207 |
229 |
2.36e-2 |
SMART |
ZnF_C2H2
|
235 |
257 |
1.5e-4 |
SMART |
ZnF_C2H2
|
263 |
285 |
2.79e-4 |
SMART |
ZnF_C2H2
|
291 |
313 |
3.49e-5 |
SMART |
ZnF_C2H2
|
319 |
341 |
6.42e-4 |
SMART |
ZnF_C2H2
|
347 |
369 |
5.59e-4 |
SMART |
ZnF_C2H2
|
375 |
397 |
5.21e-4 |
SMART |
ZnF_C2H2
|
403 |
425 |
3.63e-3 |
SMART |
ZnF_C2H2
|
431 |
453 |
1.82e-3 |
SMART |
ZnF_C2H2
|
459 |
481 |
1.58e-3 |
SMART |
ZnF_C2H2
|
487 |
509 |
2.12e-4 |
SMART |
ZnF_C2H2
|
515 |
537 |
1.82e-3 |
SMART |
ZnF_C2H2
|
543 |
565 |
2.24e-3 |
SMART |
ZnF_C2H2
|
571 |
593 |
8.02e-5 |
SMART |
ZnF_C2H2
|
599 |
621 |
1.04e-3 |
SMART |
ZnF_C2H2
|
627 |
649 |
1.04e-3 |
SMART |
ZnF_C2H2
|
655 |
677 |
9.88e-5 |
SMART |
|
Predicted Effect |
silent
Transcript: ENSMUST00000108205
|
SMART Domains |
Protein: ENSMUSP00000103840 Gene: ENSMUSG00000059975
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
5.02e-38 |
SMART |
ZnF_C2H2
|
179 |
201 |
1.84e-4 |
SMART |
ZnF_C2H2
|
207 |
229 |
2.36e-2 |
SMART |
ZnF_C2H2
|
235 |
257 |
1.5e-4 |
SMART |
ZnF_C2H2
|
263 |
285 |
2.79e-4 |
SMART |
ZnF_C2H2
|
291 |
313 |
3.49e-5 |
SMART |
ZnF_C2H2
|
319 |
341 |
6.42e-4 |
SMART |
ZnF_C2H2
|
347 |
369 |
5.59e-4 |
SMART |
ZnF_C2H2
|
375 |
397 |
5.21e-4 |
SMART |
ZnF_C2H2
|
403 |
425 |
3.63e-3 |
SMART |
ZnF_C2H2
|
431 |
453 |
1.82e-3 |
SMART |
ZnF_C2H2
|
459 |
481 |
1.58e-3 |
SMART |
ZnF_C2H2
|
487 |
509 |
2.12e-4 |
SMART |
ZnF_C2H2
|
515 |
537 |
1.82e-3 |
SMART |
ZnF_C2H2
|
543 |
565 |
2.24e-3 |
SMART |
ZnF_C2H2
|
571 |
593 |
8.02e-5 |
SMART |
ZnF_C2H2
|
599 |
621 |
1.04e-3 |
SMART |
ZnF_C2H2
|
627 |
649 |
1.04e-3 |
SMART |
ZnF_C2H2
|
655 |
677 |
9.88e-5 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000108211
|
SMART Domains |
Protein: ENSMUSP00000103846 Gene: ENSMUSG00000059975
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
5.02e-38 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000108212
|
SMART Domains |
Protein: ENSMUSP00000103847 Gene: ENSMUSG00000059975
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
5.02e-38 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149793
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.4%
- 20x: 92.4%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 43 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1810009A15Rik |
C |
T |
19: 8,867,390 (GRCm39) |
T63M |
probably damaging |
Het |
Abcb1a |
T |
A |
5: 8,790,621 (GRCm39) |
|
probably null |
Het |
Ahrr |
T |
C |
13: 74,361,888 (GRCm39) |
D537G |
probably damaging |
Het |
Anxa4 |
T |
A |
6: 86,718,913 (GRCm39) |
I269F |
probably damaging |
Het |
Aoc1l1 |
A |
G |
6: 48,953,278 (GRCm39) |
Y401C |
probably damaging |
Het |
Atm |
A |
T |
9: 53,407,258 (GRCm39) |
M1160K |
probably benign |
Het |
Ccdc175 |
A |
G |
12: 72,177,897 (GRCm39) |
Y434H |
probably damaging |
Het |
Col19a1 |
C |
T |
1: 24,335,882 (GRCm39) |
A855T |
probably damaging |
Het |
Cyp2a4 |
A |
G |
7: 26,010,213 (GRCm39) |
D246G |
probably damaging |
Het |
Dmbt1 |
T |
C |
7: 130,694,847 (GRCm39) |
L840P |
possibly damaging |
Het |
Dock6 |
A |
T |
9: 21,712,829 (GRCm39) |
D2009E |
probably damaging |
Het |
E2f3 |
C |
T |
13: 30,169,516 (GRCm39) |
A46T |
probably damaging |
Het |
Ect2l |
A |
T |
10: 18,016,334 (GRCm39) |
C635S |
probably damaging |
Het |
Fer1l6 |
A |
G |
15: 58,435,924 (GRCm39) |
D439G |
probably benign |
Het |
Hao1 |
A |
C |
2: 134,372,693 (GRCm39) |
M105R |
probably damaging |
Het |
Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
Igsf10 |
A |
G |
3: 59,238,525 (GRCm39) |
I552T |
probably damaging |
Het |
Il31ra |
A |
G |
13: 112,666,912 (GRCm39) |
S470P |
possibly damaging |
Het |
Mfsd1 |
A |
G |
3: 67,504,067 (GRCm39) |
N353S |
possibly damaging |
Het |
Mga |
T |
A |
2: 119,772,140 (GRCm39) |
F1667I |
possibly damaging |
Het |
Niban2 |
A |
G |
2: 32,812,872 (GRCm39) |
Y480C |
probably damaging |
Het |
Nwd2 |
T |
C |
5: 63,964,655 (GRCm39) |
V1413A |
probably damaging |
Het |
Or8b1 |
T |
G |
9: 38,400,244 (GRCm39) |
S306R |
probably benign |
Het |
Or8b50 |
G |
A |
9: 38,517,787 (GRCm39) |
V9I |
possibly damaging |
Het |
Osbpl10 |
T |
A |
9: 114,996,187 (GRCm39) |
V119E |
probably damaging |
Het |
Plec |
C |
A |
15: 76,089,887 (GRCm39) |
R151L |
probably benign |
Het |
Ptpn12 |
T |
C |
5: 21,203,041 (GRCm39) |
H579R |
probably benign |
Het |
Rnase4 |
G |
T |
14: 51,342,362 (GRCm39) |
G29C |
probably damaging |
Het |
Sim1 |
C |
A |
10: 50,857,423 (GRCm39) |
S391* |
probably null |
Het |
Sobp |
A |
T |
10: 42,898,205 (GRCm39) |
I460N |
probably damaging |
Het |
Spns3 |
A |
T |
11: 72,436,766 (GRCm39) |
D75E |
probably damaging |
Het |
Strn4 |
T |
A |
7: 16,571,638 (GRCm39) |
C26* |
probably null |
Het |
Tacstd2 |
T |
A |
6: 67,512,102 (GRCm39) |
I197L |
probably damaging |
Het |
Trpc6 |
A |
G |
9: 8,610,416 (GRCm39) |
T295A |
possibly damaging |
Het |
Txnl1 |
G |
T |
18: 63,825,191 (GRCm39) |
S18R |
possibly damaging |
Het |
U2surp |
A |
G |
9: 95,343,550 (GRCm39) |
|
probably benign |
Het |
Ube2frt |
A |
T |
12: 36,140,934 (GRCm39) |
|
probably benign |
Het |
Vwce |
A |
G |
19: 10,630,441 (GRCm39) |
Y500C |
probably damaging |
Het |
Wdr49 |
A |
C |
3: 75,358,158 (GRCm39) |
S196A |
probably benign |
Het |
Wfs1 |
T |
C |
5: 37,124,905 (GRCm39) |
Y662C |
probably damaging |
Het |
Wnt8b |
A |
C |
19: 44,498,968 (GRCm39) |
D133A |
possibly damaging |
Het |
Zfp329 |
T |
A |
7: 12,545,395 (GRCm39) |
N43I |
probably benign |
Het |
Zfp532 |
C |
A |
18: 65,756,889 (GRCm39) |
A274E |
probably damaging |
Het |
|
Other mutations in Zfp74 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0355:Zfp74
|
UTSW |
7 |
29,653,466 (GRCm39) |
start gained |
probably benign |
|
R0387:Zfp74
|
UTSW |
7 |
29,634,179 (GRCm39) |
missense |
probably benign |
0.05 |
R1757:Zfp74
|
UTSW |
7 |
29,634,486 (GRCm39) |
missense |
probably benign |
0.01 |
R1813:Zfp74
|
UTSW |
7 |
29,634,569 (GRCm39) |
missense |
probably damaging |
1.00 |
R1893:Zfp74
|
UTSW |
7 |
29,635,470 (GRCm39) |
critical splice acceptor site |
probably null |
|
R1896:Zfp74
|
UTSW |
7 |
29,634,569 (GRCm39) |
missense |
probably damaging |
1.00 |
R1958:Zfp74
|
UTSW |
7 |
29,635,136 (GRCm39) |
missense |
probably benign |
0.08 |
R2092:Zfp74
|
UTSW |
7 |
29,653,349 (GRCm39) |
start gained |
probably benign |
|
R2111:Zfp74
|
UTSW |
7 |
29,634,443 (GRCm39) |
nonsense |
probably null |
|
R4894:Zfp74
|
UTSW |
7 |
29,635,470 (GRCm39) |
critical splice acceptor site |
probably benign |
|
R5121:Zfp74
|
UTSW |
7 |
29,631,932 (GRCm39) |
splice site |
probably null |
|
R5123:Zfp74
|
UTSW |
7 |
29,634,158 (GRCm39) |
missense |
probably damaging |
1.00 |
R5129:Zfp74
|
UTSW |
7 |
29,631,880 (GRCm39) |
missense |
probably benign |
0.00 |
R5213:Zfp74
|
UTSW |
7 |
29,634,668 (GRCm39) |
missense |
probably damaging |
1.00 |
R5460:Zfp74
|
UTSW |
7 |
29,635,316 (GRCm39) |
missense |
probably benign |
0.04 |
R5519:Zfp74
|
UTSW |
7 |
29,634,559 (GRCm39) |
missense |
probably damaging |
0.99 |
R5589:Zfp74
|
UTSW |
7 |
29,633,990 (GRCm39) |
missense |
probably damaging |
1.00 |
R6287:Zfp74
|
UTSW |
7 |
29,635,201 (GRCm39) |
missense |
probably benign |
|
R6330:Zfp74
|
UTSW |
7 |
29,637,412 (GRCm39) |
missense |
probably damaging |
1.00 |
R6370:Zfp74
|
UTSW |
7 |
29,631,835 (GRCm39) |
missense |
probably damaging |
0.96 |
R6407:Zfp74
|
UTSW |
7 |
29,635,048 (GRCm39) |
missense |
probably damaging |
1.00 |
R6694:Zfp74
|
UTSW |
7 |
29,634,559 (GRCm39) |
missense |
probably damaging |
0.99 |
R6791:Zfp74
|
UTSW |
7 |
29,633,860 (GRCm39) |
missense |
probably benign |
0.02 |
R7144:Zfp74
|
UTSW |
7 |
29,634,590 (GRCm39) |
missense |
probably damaging |
0.98 |
R7662:Zfp74
|
UTSW |
7 |
29,653,278 (GRCm39) |
critical splice donor site |
probably null |
|
R7667:Zfp74
|
UTSW |
7 |
29,634,608 (GRCm39) |
missense |
probably damaging |
1.00 |
R7898:Zfp74
|
UTSW |
7 |
29,635,380 (GRCm39) |
nonsense |
probably null |
|
R7940:Zfp74
|
UTSW |
7 |
29,631,867 (GRCm39) |
missense |
probably benign |
0.07 |
R8676:Zfp74
|
UTSW |
7 |
29,634,079 (GRCm39) |
missense |
probably damaging |
1.00 |
R8864:Zfp74
|
UTSW |
7 |
29,634,235 (GRCm39) |
missense |
probably damaging |
1.00 |
R8940:Zfp74
|
UTSW |
7 |
29,634,772 (GRCm39) |
missense |
possibly damaging |
0.96 |
R9748:Zfp74
|
UTSW |
7 |
29,634,751 (GRCm39) |
missense |
probably damaging |
1.00 |
R9764:Zfp74
|
UTSW |
7 |
29,631,845 (GRCm39) |
missense |
probably benign |
0.11 |
|
Predicted Primers |
|
Posted On |
2013-11-08 |