|Institutional Source||Beutler Lab|
|Gene Name||proline, glutamic acid and leucine rich protein 1|
|Is this an essential gene?||Probably essential (E-score: 0.955)|
|Stock #||R0879 (G1)|
|Chromosomal Location||70392883-70410031 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 70395297 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000019065 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000019065]|
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||100% (41/41)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pelp1||
(F):5'- AGATGCCTCCTCCTTATCGTAGTGG -3'
(R):5'- GGCAGCTCTCCTTACAACAGTTCC -3'
(F):5'- TGGATGGCACAGCACCTATG -3'
(R):5'- ACAACAGTTCCTGCTGTCG -3'