Incidental Mutation 'P0027:Olfr354'
ID8210
Institutional Source Beutler Lab
Gene Symbol Olfr354
Ensembl Gene ENSMUSG00000055088
Gene Nameolfactory receptor 354
SynonymsGA_x6K02T2NLDC-33601476-33602429, MOR127-4
MMRRC Submission 038280-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.138) question?
Stock #P0027 (G1)
Quality Score
Status Validated
Chromosome2
Chromosomal Location36905680-36916038 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 36907570 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 208 (V208A)
Ref Sequence ENSEMBL: ENSMUSP00000149298 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068475] [ENSMUST00000217479]
Predicted Effect probably benign
Transcript: ENSMUST00000068475
AA Change: V208A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000068986
Gene: ENSMUSG00000055088
AA Change: V208A

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 2.1e-62 PFAM
Pfam:7tm_1 44 293 2.9e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121665
Predicted Effect probably benign
Transcript: ENSMUST00000217479
AA Change: V208A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218102
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 82.6%
  • 3x: 72.9%
  • 10x: 45.3%
  • 20x: 23.4%
Validation Efficiency 93% (53/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bicd2 C A 13: 49,379,651 P571Q probably benign Het
Camta2 A G 11: 70,684,005 I75T probably damaging Het
Casp1 A T 9: 5,299,851 H108L probably benign Het
Copa A G 1: 172,111,948 E593G possibly damaging Het
Ftsj3 C A 11: 106,254,808 M66I possibly damaging Het
Kdm2a C T 19: 4,343,245 probably benign Het
Klhl14 T C 18: 21,558,135 Y446C probably damaging Het
Lims1 A G 10: 58,418,455 N344D probably benign Het
Marco A T 1: 120,474,712 W502R probably damaging Het
Ms4a10 T C 19: 10,964,128 D159G probably damaging Het
Msi2 A T 11: 88,394,597 M207K probably damaging Het
Myh15 C T 16: 49,081,208 T249I possibly damaging Het
Nap1l5 T A 6: 58,906,825 N48I probably damaging Het
Nup188 A G 2: 30,322,681 D632G probably damaging Het
Papd7 G A 13: 69,506,955 R224* probably null Het
Phactr4 G C 4: 132,371,090 T252R probably damaging Het
Sec14l2 C T 11: 4,103,673 probably null Het
Sim2 C A 16: 94,109,422 H228N probably benign Het
Tmem26 A G 10: 68,778,718 E321G probably benign Het
Yif1b T C 7: 29,238,613 probably null Het
Other mutations in Olfr354
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01942:Olfr354 APN 2 36907857 missense probably benign
IGL02573:Olfr354 APN 2 36907554 missense probably damaging 1.00
R0040:Olfr354 UTSW 2 36907458 missense probably damaging 1.00
R0610:Olfr354 UTSW 2 36907659 missense probably damaging 1.00
R0760:Olfr354 UTSW 2 36907221 missense probably benign 0.25
R1727:Olfr354 UTSW 2 36907393 missense probably benign 0.00
R2972:Olfr354 UTSW 2 36907404 missense probably benign 0.03
R4671:Olfr354 UTSW 2 36907393 missense probably benign 0.00
R4750:Olfr354 UTSW 2 36907716 missense probably benign 0.13
R5043:Olfr354 UTSW 2 36906965 missense probably benign 0.01
R5400:Olfr354 UTSW 2 36907821 missense probably damaging 1.00
R5543:Olfr354 UTSW 2 36907357 missense possibly damaging 0.75
R5792:Olfr354 UTSW 2 36907101 missense probably benign 0.00
R6639:Olfr354 UTSW 2 36907678 missense probably damaging 1.00
R6876:Olfr354 UTSW 2 36907822 missense probably damaging 1.00
T0722:Olfr354 UTSW 2 36907570 missense probably benign 0.00
Z1176:Olfr354 UTSW 2 36907701 missense possibly damaging 0.95
Posted On2012-11-20