Incidental Mutation 'R0862:Or51b6b'
ID 82150
Institutional Source Beutler Lab
Gene Symbol Or51b6b
Ensembl Gene ENSMUSG00000099687
Gene Name olfactory receptor family 51 subfamily B member 6B
Synonyms Olfr623, GA_x6K02T2PBJ9-6384836-6383883, MOR1-4
MMRRC Submission 039036-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.184) question?
Stock # R0862 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 103309451-103310525 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103309735 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 241 (T241A)
Ref Sequence ENSEMBL: ENSMUSP00000150141 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062144] [ENSMUST00000068531] [ENSMUST00000213840]
AlphaFold E9Q382
Predicted Effect probably benign
Transcript: ENSMUST00000062144
SMART Domains Protein: ENSMUSP00000049938
Gene: ENSMUSG00000045780

DomainStartEndE-ValueType
Pfam:7tm_4 27 306 3.3e-138 PFAM
Pfam:7tm_1 37 288 1.8e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000068531
AA Change: T241A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000070658
Gene: ENSMUSG00000099687
AA Change: T241A

DomainStartEndE-ValueType
Pfam:7tm_4 32 310 1.7e-112 PFAM
Pfam:7TM_GPCR_Srsx 36 299 3.1e-7 PFAM
Pfam:7tm_1 42 293 2.6e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213840
AA Change: T241A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.4030 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 94.9%
  • 20x: 87.0%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik A T 7: 40,642,480 (GRCm39) T141S probably benign Het
9230009I02Rik T C 11: 50,982,144 (GRCm39) noncoding transcript Het
Adamts13 G A 2: 26,896,336 (GRCm39) probably null Het
Chac1 C A 2: 119,183,950 (GRCm39) A184E probably damaging Het
Col11a1 G A 3: 113,932,414 (GRCm39) R113H unknown Het
Csmd1 T A 8: 16,240,040 (GRCm39) Y1124F probably damaging Het
Ctnnbl1 C T 2: 157,641,337 (GRCm39) probably benign Het
Dyrk4 T C 6: 126,854,296 (GRCm39) E499G possibly damaging Het
Fat1 T A 8: 45,471,074 (GRCm39) I1603N probably damaging Het
Fbn1 A T 2: 125,184,811 (GRCm39) C1660* probably null Het
Gapt G C 13: 110,490,273 (GRCm39) T130R probably damaging Het
Gm19684 A T 17: 36,432,792 (GRCm39) probably benign Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Map4 A G 9: 109,808,037 (GRCm39) Y34C probably damaging Het
Mapk8 C T 14: 33,114,949 (GRCm39) R189H probably damaging Het
Mgst1 C T 6: 138,124,749 (GRCm39) T21M probably damaging Het
Msh2 A G 17: 87,987,480 (GRCm39) T207A probably benign Het
Mthfd2 A G 6: 83,290,376 (GRCm39) V85A probably damaging Het
Muc4 A G 16: 32,570,820 (GRCm39) S627G probably benign Het
Nbeal2 G A 9: 110,457,263 (GRCm39) T2266I probably damaging Het
Or7g16 T C 9: 18,727,002 (GRCm39) Y196C probably damaging Het
Or8d1 T C 9: 38,766,478 (GRCm39) V40A possibly damaging Het
Pcdhb2 G A 18: 37,428,710 (GRCm39) V228I possibly damaging Het
Pdcd6ip A T 9: 113,503,578 (GRCm39) probably benign Het
Piwil2 T C 14: 70,632,823 (GRCm39) D583G probably benign Het
Plin4 T A 17: 56,410,966 (GRCm39) M1022L probably benign Het
Rbm48 A G 5: 3,640,438 (GRCm39) S314P probably benign Het
Rbms3 A T 9: 117,458,860 (GRCm39) probably benign Het
Snx14 A T 9: 88,266,049 (GRCm39) S726T possibly damaging Het
Trim43c A T 9: 88,725,087 (GRCm39) H202L probably benign Het
Trip12 A G 1: 84,721,730 (GRCm39) F1334S probably damaging Het
Tyk2 T C 9: 21,027,463 (GRCm39) H503R probably benign Het
Ubr2 G A 17: 47,278,009 (GRCm39) Q745* probably null Het
Ush2a T A 1: 188,275,015 (GRCm39) Y1829* probably null Het
Vmn2r65 T A 7: 84,592,853 (GRCm39) E451D probably benign Het
Other mutations in Or51b6b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Or51b6b APN 7 103,310,274 (GRCm39) missense probably damaging 0.99
IGL01669:Or51b6b APN 7 103,310,194 (GRCm39) missense probably benign 0.02
IGL01731:Or51b6b APN 7 103,310,053 (GRCm39) missense probably benign 0.01
IGL02057:Or51b6b APN 7 103,309,860 (GRCm39) missense probably damaging 1.00
IGL02249:Or51b6b APN 7 103,309,573 (GRCm39) missense probably damaging 0.99
IGL02937:Or51b6b APN 7 103,310,112 (GRCm39) missense probably damaging 1.00
IGL03113:Or51b6b APN 7 103,309,851 (GRCm39) missense possibly damaging 0.90
R0413:Or51b6b UTSW 7 103,309,957 (GRCm39) missense possibly damaging 0.52
R1262:Or51b6b UTSW 7 103,309,648 (GRCm39) missense probably benign 0.33
R1791:Or51b6b UTSW 7 103,310,005 (GRCm39) splice site probably null
R2327:Or51b6b UTSW 7 103,309,779 (GRCm39) missense probably damaging 1.00
R2338:Or51b6b UTSW 7 103,309,617 (GRCm39) missense possibly damaging 0.90
R4521:Or51b6b UTSW 7 103,309,539 (GRCm39) missense probably benign 0.01
R4831:Or51b6b UTSW 7 103,309,678 (GRCm39) missense probably benign 0.40
R5322:Or51b6b UTSW 7 103,309,879 (GRCm39) missense possibly damaging 0.62
R6270:Or51b6b UTSW 7 103,309,620 (GRCm39) missense possibly damaging 0.48
R6959:Or51b6b UTSW 7 103,310,050 (GRCm39) missense probably damaging 1.00
R7157:Or51b6b UTSW 7 103,309,788 (GRCm39) missense probably damaging 1.00
R7181:Or51b6b UTSW 7 103,310,020 (GRCm39) missense probably damaging 0.99
R7570:Or51b6b UTSW 7 103,310,088 (GRCm39) missense probably damaging 1.00
R9037:Or51b6b UTSW 7 103,310,382 (GRCm39) missense probably benign 0.32
R9234:Or51b6b UTSW 7 103,309,950 (GRCm39) missense possibly damaging 0.96
R9525:Or51b6b UTSW 7 103,310,142 (GRCm39) missense probably damaging 1.00
X0066:Or51b6b UTSW 7 103,309,867 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- AGCGAAGCAAACCACTCTGAATCTG -3'
(R):5'- GGAGTAACATTGACCACCATGCCC -3'

Sequencing Primer
(F):5'- AAACCACTCTGAATCTGTTTGGTC -3'
(R):5'- TTCAATCACAGGGAAATTGGC -3'
Posted On 2013-11-08