|Institutional Source||Beutler Lab|
|Gene Name||RNA binding motif, single stranded interacting protein|
|Is this an essential gene?||Probably non essential (E-score: 0.111)|
|Stock #||R0862 (G1)|
|Chromosomal Location||116572746-117629913 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to T at 117629792 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000131371 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000164018]|
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||100% (40/40)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Rbms3||
(F):5'- TCATCGGTCACACTGAGGCATAAAC -3'
(R):5'- CGTTGTTACTCTGTTGCAGGCAAG -3'
(F):5'- TGGAATTTAAACTCTGACACGC -3'
(R):5'- TGTTGCAGGCAAGTAGCCC -3'