Incidental Mutation 'R0863:Or10ab5'
ID 82195
Institutional Source Beutler Lab
Gene Symbol Or10ab5
Ensembl Gene ENSMUSG00000049280
Gene Name olfactory receptor family 10 subfamily AB member 5
Synonyms GA_x6K02T2PBJ9-10976304-10975339, Olfr509, MOR267-14
MMRRC Submission 039037-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R0863 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 108244816-108245781 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108244865 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 306 (I306T)
Ref Sequence ENSEMBL: ENSMUSP00000150157 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061690] [ENSMUST00000213756] [ENSMUST00000214861] [ENSMUST00000215075]
AlphaFold Q8VF20
Predicted Effect probably benign
Transcript: ENSMUST00000061690
AA Change: I306T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000053819
Gene: ENSMUSG00000049280
AA Change: I306T

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.8e-42 PFAM
Pfam:7tm_1 39 288 1.5e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213756
AA Change: I306T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000214861
AA Change: I306T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215075
AA Change: I306T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 97.4%
  • 20x: 94.8%
Validation Efficiency 94% (59/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310016G11Rik A G 7: 44,327,232 (GRCm39) noncoding transcript Het
4930433I11Rik A T 7: 40,642,480 (GRCm39) T141S probably benign Het
Abca14 A T 7: 119,815,453 (GRCm39) T234S probably benign Het
Acap1 C A 11: 69,777,882 (GRCm39) V119L probably damaging Het
Actr2 C T 11: 20,030,760 (GRCm39) V163I probably benign Het
Adcy4 T C 14: 56,021,056 (GRCm39) Y27C probably damaging Het
Arnt2 T A 7: 83,914,792 (GRCm39) K524M probably damaging Het
Brca1 T C 11: 101,415,596 (GRCm39) Y846C probably benign Het
Capn7 T A 14: 31,091,714 (GRCm39) C704S possibly damaging Het
Cep350 T A 1: 155,737,981 (GRCm39) I2621L probably benign Het
Col11a1 G A 3: 113,932,414 (GRCm39) R113H unknown Het
Ctnnbl1 C T 2: 157,641,337 (GRCm39) probably benign Het
Cul9 T C 17: 46,848,748 (GRCm39) probably null Het
Erc2 A C 14: 27,747,105 (GRCm39) N345T probably benign Het
Fank1 A G 7: 133,482,352 (GRCm39) R73G possibly damaging Het
Fes A T 7: 80,030,634 (GRCm39) W552R probably damaging Het
Fsd2 A G 7: 81,191,913 (GRCm39) V488A possibly damaging Het
Gfm1 T C 3: 67,381,928 (GRCm39) S705P probably damaging Het
Gm9493 A T 19: 23,597,173 (GRCm39) Q23L probably benign Het
Gucy1b2 T C 14: 62,656,511 (GRCm39) D282G probably benign Het
H2-Ab1 T C 17: 34,486,328 (GRCm39) I129T probably damaging Het
H2-M10.3 T A 17: 36,677,582 (GRCm39) Y232F probably damaging Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Lonp1 T C 17: 56,925,331 (GRCm39) K487R probably damaging Het
Ltbp1 A G 17: 75,559,381 (GRCm39) Y290C probably damaging Het
Ms4a10 C T 19: 10,945,957 (GRCm39) G58D probably damaging Het
Muc5b A G 7: 141,421,454 (GRCm39) S4315G probably benign Het
Nlrp1b T A 11: 71,072,173 (GRCm39) T557S probably benign Het
Nlrp3 A G 11: 59,456,676 (GRCm39) D946G probably benign Het
Obscn T C 11: 58,886,241 (GRCm39) probably benign Het
Oga C T 19: 45,771,425 (GRCm39) A49T probably benign Het
Or5p50 T C 7: 107,422,581 (GRCm39) S32G probably benign Het
Or7e173 A T 9: 19,938,509 (GRCm39) S242T probably damaging Het
Pask A T 1: 93,242,061 (GRCm39) F1219I probably damaging Het
Pcdhb2 G A 18: 37,428,710 (GRCm39) V228I possibly damaging Het
Phf1 T C 17: 27,156,114 (GRCm39) probably benign Het
Plec G A 15: 76,058,280 (GRCm39) Q3751* probably null Het
Plscr1l1 A T 9: 92,233,140 (GRCm39) I88L possibly damaging Het
Ppp1r12c G T 7: 4,489,365 (GRCm39) Q240K probably damaging Het
Ralgapa1 A T 12: 55,809,466 (GRCm39) Y436* probably null Het
Ralgapa1 C A 12: 55,829,562 (GRCm39) probably benign Het
Scel T A 14: 103,823,916 (GRCm39) S381R possibly damaging Het
Sema4a C T 3: 88,355,456 (GRCm39) probably benign Het
Sltm A G 9: 70,469,190 (GRCm39) T150A probably benign Het
Spag1 G T 15: 36,192,193 (GRCm39) K217N probably damaging Het
Ssh1 C T 5: 114,104,792 (GRCm39) R9H probably damaging Het
St3gal4 C A 9: 34,964,744 (GRCm39) V155F probably damaging Het
Stxbp5 C T 10: 9,684,784 (GRCm39) E539K possibly damaging Het
Tbc1d7 G T 13: 43,308,161 (GRCm39) probably benign Het
Thnsl2 A T 6: 71,111,208 (GRCm39) L220* probably null Het
Tinf2 G A 14: 55,917,566 (GRCm39) P308S probably benign Het
Tnf T C 17: 35,420,120 (GRCm39) probably benign Het
Ttc21b T C 2: 66,073,117 (GRCm39) I190V probably benign Het
Ttn T C 2: 76,537,391 (GRCm39) T34846A probably benign Het
Ube4a A G 9: 44,861,114 (GRCm39) V232A possibly damaging Het
Uri1 A T 7: 37,669,100 (GRCm39) D122E probably damaging Het
Vmn2r94 T G 17: 18,477,973 (GRCm39) Q146P probably damaging Het
Zan T A 5: 137,456,901 (GRCm39) E1278D unknown Het
Zfhx4 T A 3: 5,310,375 (GRCm39) S919R possibly damaging Het
Other mutations in Or10ab5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Or10ab5 APN 7 108,245,043 (GRCm39) missense possibly damaging 0.47
IGL02015:Or10ab5 APN 7 108,245,220 (GRCm39) missense probably damaging 0.99
IGL02721:Or10ab5 APN 7 108,245,582 (GRCm39) nonsense probably null
IGL03170:Or10ab5 APN 7 108,245,307 (GRCm39) missense probably benign 0.00
R0746:Or10ab5 UTSW 7 108,245,248 (GRCm39) missense probably damaging 1.00
R1791:Or10ab5 UTSW 7 108,245,571 (GRCm39) missense probably benign 0.30
R4128:Or10ab5 UTSW 7 108,245,633 (GRCm39) missense probably benign 0.03
R5290:Or10ab5 UTSW 7 108,245,755 (GRCm39) missense probably benign
R5878:Or10ab5 UTSW 7 108,244,946 (GRCm39) missense probably damaging 1.00
R6030:Or10ab5 UTSW 7 108,245,433 (GRCm39) missense possibly damaging 0.87
R6030:Or10ab5 UTSW 7 108,245,433 (GRCm39) missense possibly damaging 0.87
R6545:Or10ab5 UTSW 7 108,245,662 (GRCm39) missense probably damaging 1.00
R7699:Or10ab5 UTSW 7 108,244,879 (GRCm39) missense probably damaging 1.00
R7700:Or10ab5 UTSW 7 108,244,879 (GRCm39) missense probably damaging 1.00
R8247:Or10ab5 UTSW 7 108,245,370 (GRCm39) missense probably damaging 0.97
R9021:Or10ab5 UTSW 7 108,245,428 (GRCm39) nonsense probably null
R9041:Or10ab5 UTSW 7 108,245,589 (GRCm39) missense probably damaging 1.00
Z1176:Or10ab5 UTSW 7 108,244,974 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TGGTGGTACTCCACAACAGTTTAAAGG -3'
(R):5'- CCCTCTGCCAAGGGAAGGTATAAGAC -3'

Sequencing Primer
(F):5'- ccttaattcctaacagaagcagac -3'
(R):5'- GGTATAAGACCTTTTCAACTTGCTC -3'
Posted On 2013-11-08