Incidental Mutation 'R0864:Vmn1r36'
| ID |
82247 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r36
|
| Ensembl Gene |
ENSMUSG00000115482 |
| Gene Name |
vomeronasal 1 receptor 36 |
| Synonyms |
V1rc11 |
| MMRRC Submission |
039038-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.134)
|
| Stock # |
R0864 (G1)
|
| Quality Score |
169 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
66692956-66693873 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 66693840 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 12
(T12A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153849
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177072]
[ENSMUST00000226142]
[ENSMUST00000226635]
[ENSMUST00000226728]
[ENSMUST00000226829]
|
| AlphaFold |
Q8R2E3 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000177072
AA Change: T12A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000135070
Gene: ENSMUSG00000093764
AA Change: T12A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
4.2e-55 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203829
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226142
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000226635
AA Change: T12A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226728
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226829
AA Change: T12A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.1%
- 10x: 97.3%
- 20x: 93.8%
|
| Validation Efficiency |
93% (39/42) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acvr2a |
A |
G |
2: 48,784,798 (GRCm39) |
|
probably benign |
Het |
| Alx4 |
A |
G |
2: 93,473,200 (GRCm39) |
Y66C |
probably damaging |
Het |
| Apol7e |
T |
A |
15: 77,601,993 (GRCm39) |
V197E |
probably damaging |
Het |
| Chac1 |
C |
A |
2: 119,183,950 (GRCm39) |
A184E |
probably damaging |
Het |
| Clmn |
G |
A |
12: 104,756,274 (GRCm39) |
T192I |
possibly damaging |
Het |
| Csmd1 |
T |
A |
8: 16,240,040 (GRCm39) |
Y1124F |
probably damaging |
Het |
| Ctnnbl1 |
C |
T |
2: 157,641,337 (GRCm39) |
|
probably benign |
Het |
| D430041D05Rik |
G |
A |
2: 104,060,773 (GRCm39) |
P1374S |
possibly damaging |
Het |
| Dyrk4 |
T |
C |
6: 126,854,296 (GRCm39) |
E499G |
possibly damaging |
Het |
| Fat1 |
T |
A |
8: 45,471,074 (GRCm39) |
I1603N |
probably damaging |
Het |
| Fbn1 |
A |
T |
2: 125,184,811 (GRCm39) |
C1660* |
probably null |
Het |
| Gapt |
G |
C |
13: 110,490,273 (GRCm39) |
T130R |
probably damaging |
Het |
| Hpn |
T |
C |
7: 30,808,426 (GRCm39) |
I41V |
probably benign |
Het |
| Iqca1 |
C |
A |
1: 90,070,453 (GRCm39) |
G133V |
probably null |
Het |
| Map4 |
A |
G |
9: 109,808,037 (GRCm39) |
Y34C |
probably damaging |
Het |
| Mapk8 |
C |
T |
14: 33,114,949 (GRCm39) |
R189H |
probably damaging |
Het |
| Mprip |
T |
C |
11: 59,649,587 (GRCm39) |
V1097A |
probably benign |
Het |
| Msh2 |
A |
G |
17: 87,987,480 (GRCm39) |
T207A |
probably benign |
Het |
| Muc4 |
A |
G |
16: 32,570,820 (GRCm39) |
S627G |
probably benign |
Het |
| Nbeal2 |
G |
A |
9: 110,457,263 (GRCm39) |
T2266I |
probably damaging |
Het |
| Pdcd6ip |
A |
T |
9: 113,503,578 (GRCm39) |
|
probably benign |
Het |
| Pdk2 |
A |
G |
11: 94,918,759 (GRCm39) |
Y339H |
probably damaging |
Het |
| Piwil2 |
T |
C |
14: 70,632,823 (GRCm39) |
D583G |
probably benign |
Het |
| Plin4 |
T |
A |
17: 56,410,966 (GRCm39) |
M1022L |
probably benign |
Het |
| Pmpca |
G |
A |
2: 26,283,221 (GRCm39) |
|
probably null |
Het |
| Rbbp4 |
G |
T |
4: 129,214,344 (GRCm39) |
|
probably benign |
Het |
| Rbbp8 |
G |
A |
18: 11,865,241 (GRCm39) |
|
probably benign |
Het |
| Rbms3 |
A |
T |
9: 117,458,860 (GRCm39) |
|
probably benign |
Het |
| Snx14 |
A |
T |
9: 88,266,049 (GRCm39) |
S726T |
possibly damaging |
Het |
| Supt4a |
T |
A |
11: 87,633,913 (GRCm39) |
S88T |
probably benign |
Het |
| Tmem245 |
G |
T |
4: 56,890,837 (GRCm39) |
H321Q |
probably damaging |
Het |
| Trim43c |
A |
T |
9: 88,725,087 (GRCm39) |
H202L |
probably benign |
Het |
| Trip12 |
A |
G |
1: 84,721,730 (GRCm39) |
F1334S |
probably damaging |
Het |
| Ywhae |
T |
G |
11: 75,650,256 (GRCm39) |
|
probably null |
Het |
| Zc3h4 |
T |
A |
7: 16,154,104 (GRCm39) |
S131T |
probably damaging |
Het |
| Zfp280b |
C |
T |
10: 75,874,139 (GRCm39) |
T6M |
probably benign |
Het |
|
| Other mutations in Vmn1r36 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01384:Vmn1r36
|
APN |
6 |
66,693,446 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0610:Vmn1r36
|
UTSW |
6 |
66,693,404 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1754:Vmn1r36
|
UTSW |
6 |
66,693,517 (GRCm39) |
frame shift |
probably null |
|
|
R1813:Vmn1r36
|
UTSW |
6 |
66,693,756 (GRCm39) |
missense |
probably benign |
|
|
R1844:Vmn1r36
|
UTSW |
6 |
66,693,747 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1896:Vmn1r36
|
UTSW |
6 |
66,693,756 (GRCm39) |
missense |
probably benign |
|
|
R2987:Vmn1r36
|
UTSW |
6 |
66,693,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4852:Vmn1r36
|
UTSW |
6 |
66,693,872 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R4899:Vmn1r36
|
UTSW |
6 |
66,693,549 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5985:Vmn1r36
|
UTSW |
6 |
66,693,855 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6235:Vmn1r36
|
UTSW |
6 |
66,693,230 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7313:Vmn1r36
|
UTSW |
6 |
66,693,107 (GRCm39) |
missense |
probably benign |
|
|
R7511:Vmn1r36
|
UTSW |
6 |
66,693,914 (GRCm39) |
start gained |
probably benign |
|
|
R8046:Vmn1r36
|
UTSW |
6 |
66,692,964 (GRCm39) |
nonsense |
probably null |
|
|
R8143:Vmn1r36
|
UTSW |
6 |
66,693,036 (GRCm39) |
nonsense |
probably null |
|
|
R8870:Vmn1r36
|
UTSW |
6 |
66,693,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8871:Vmn1r36
|
UTSW |
6 |
66,693,442 (GRCm39) |
nonsense |
probably null |
|
|
R9194:Vmn1r36
|
UTSW |
6 |
66,693,036 (GRCm39) |
nonsense |
probably null |
|
|
R9335:Vmn1r36
|
UTSW |
6 |
66,693,430 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACACTCAGGAGGCAGGTGATGC -3'
(R):5'- GAGGCTCAGGTGTAATAAAGGCCC -3'
Sequencing Primer
(F):5'- GCCTTACATATGAAGTCATTGCC -3'
(R):5'- gggatgggaggtgggag -3'
|
| Posted On |
2013-11-08 |
Incidental Mutation