Incidental Mutation 'R0865:Or7e178'
ID 82305
Institutional Source Beutler Lab
Gene Symbol Or7e178
Ensembl Gene ENSMUSG00000066896
Gene Name olfactory receptor family 7 subfamily E member 178
Synonyms MTPCR34, MOR145-1, Olfr18, GA_x6K02T2PVTD-14054886-14053957
MMRRC Submission 039039-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0865 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 20225188-20247390 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20226045 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 57 (Y57F)
Ref Sequence ENSEMBL: ENSMUSP00000083664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086473] [ENSMUST00000212943]
AlphaFold Q0VAX9
Predicted Effect probably damaging
Transcript: ENSMUST00000086473
AA Change: Y57F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083664
Gene: ENSMUSG00000066896
AA Change: Y57F

DomainStartEndE-ValueType
Pfam:7tm_4 53 330 1.2e-54 PFAM
Pfam:7TM_GPCR_Srsx 57 234 3.2e-9 PFAM
Pfam:7tm_1 63 312 4.7e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211895
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211961
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212727
Predicted Effect probably damaging
Transcript: ENSMUST00000212943
AA Change: Y49F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220241
Meta Mutation Damage Score 0.1440 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 99.0%
  • 10x: 97.5%
  • 20x: 95.2%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck5 A G 15: 76,479,843 (GRCm39) E581G probably damaging Het
Adcy5 A G 16: 35,094,841 (GRCm39) N666S probably damaging Het
Apcs T C 1: 172,721,782 (GRCm39) D188G probably benign Het
Arih2 A G 9: 108,526,499 (GRCm39) probably benign Het
AU040320 A G 4: 126,742,677 (GRCm39) K981E possibly damaging Het
Brwd1 A T 16: 95,869,784 (GRCm39) I81K probably damaging Het
Cacng8 T A 7: 3,460,625 (GRCm39) I136N possibly damaging Het
Cdh22 A T 2: 165,022,976 (GRCm39) W32R probably damaging Het
Cel A G 2: 28,450,627 (GRCm39) S133P probably damaging Het
Clasp2 A G 9: 113,740,568 (GRCm39) T495A possibly damaging Het
Clock A T 5: 76,414,271 (GRCm39) probably benign Het
Cox6a2 A G 7: 127,804,995 (GRCm39) probably benign Het
Cyp2b19 C A 7: 26,461,654 (GRCm39) probably benign Het
Dnah11 G A 12: 118,154,579 (GRCm39) Q234* probably null Het
Gga3 A T 11: 115,483,285 (GRCm39) N91K probably damaging Het
Idh1 T C 1: 65,200,315 (GRCm39) T350A probably benign Het
Ints11 A G 4: 155,971,564 (GRCm39) probably null Het
Itgb1 A G 8: 129,436,732 (GRCm39) probably null Het
Kank4 A T 4: 98,662,900 (GRCm39) probably benign Het
Kansl1 A T 11: 104,315,194 (GRCm39) D281E probably benign Het
Kmt2a T C 9: 44,730,067 (GRCm39) probably benign Het
Kpna4 T C 3: 69,008,750 (GRCm39) E145G probably damaging Het
Lacc1 A G 14: 77,271,584 (GRCm39) I201T possibly damaging Het
Larp7 T C 3: 127,337,884 (GRCm39) K392E probably damaging Het
Lbh T A 17: 73,228,224 (GRCm39) M23K probably benign Het
Myo15a A T 11: 60,382,514 (GRCm39) E361V probably damaging Het
Ncor2 A G 5: 125,116,046 (GRCm39) S470P probably benign Het
Ngef T A 1: 87,412,323 (GRCm39) M449L probably benign Het
Odad1 A G 7: 45,591,512 (GRCm39) T259A probably benign Het
Or2w3 T C 11: 58,556,478 (GRCm39) I31T possibly damaging Het
Peak1 A T 9: 56,165,116 (GRCm39) D937E probably benign Het
Pnpla7 A G 2: 24,872,135 (GRCm39) K72E probably benign Het
Ptprn T G 1: 75,224,782 (GRCm39) probably null Het
Scgn C T 13: 24,146,102 (GRCm39) probably null Het
Sdk2 T C 11: 113,741,748 (GRCm39) I824V probably benign Het
Slc38a3 A G 9: 107,532,847 (GRCm39) S326P probably damaging Het
Spen A G 4: 141,199,181 (GRCm39) S3126P probably benign Het
Tbcd T C 11: 121,493,815 (GRCm39) C902R possibly damaging Het
Tmem63b T C 17: 45,972,445 (GRCm39) I721V probably benign Het
Trim30c A G 7: 104,039,658 (GRCm39) S46P probably damaging Het
Trim59 T C 3: 68,944,941 (GRCm39) D133G probably damaging Het
Trpm7 A T 2: 126,641,159 (GRCm39) probably null Het
Ttll10 A G 4: 156,128,135 (GRCm39) L391P probably damaging Het
Ttn T C 2: 76,623,585 (GRCm39) T15331A possibly damaging Het
Vmn1r237 C T 17: 21,534,976 (GRCm39) T233I probably damaging Het
Vmn2r115 A T 17: 23,565,382 (GRCm39) D423V possibly damaging Het
Vmn2r25 T A 6: 123,829,976 (GRCm39) R58S probably benign Het
Vmn2r71 A T 7: 85,268,516 (GRCm39) I240F probably benign Het
Wdr3 A G 3: 100,060,112 (GRCm39) probably benign Het
Zc3h14 T C 12: 98,745,528 (GRCm39) probably null Het
Zc3hav1 C T 6: 38,330,837 (GRCm39) probably benign Het
Zfp335 A T 2: 164,741,415 (GRCm39) probably null Het
Other mutations in Or7e178
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01992:Or7e178 APN 9 20,226,015 (GRCm39) missense probably damaging 1.00
IGL02412:Or7e178 APN 9 20,225,935 (GRCm39) missense probably benign
IGL03288:Or7e178 APN 9 20,247,207 (GRCm39) critical splice donor site probably null
IGL03395:Or7e178 APN 9 20,225,847 (GRCm39) missense probably damaging 1.00
R0332:Or7e178 UTSW 9 20,225,352 (GRCm39) missense probably benign 0.00
R0346:Or7e178 UTSW 9 20,225,707 (GRCm39) missense probably benign 0.20
R0569:Or7e178 UTSW 9 20,225,875 (GRCm39) missense probably damaging 1.00
R0798:Or7e178 UTSW 9 20,225,495 (GRCm39) nonsense probably null
R1082:Or7e178 UTSW 9 20,225,765 (GRCm39) missense possibly damaging 0.52
R1905:Or7e178 UTSW 9 20,226,142 (GRCm39) missense probably benign
R4245:Or7e178 UTSW 9 20,225,629 (GRCm39) missense possibly damaging 0.87
R5566:Or7e178 UTSW 9 20,225,265 (GRCm39) missense probably benign
R6306:Or7e178 UTSW 9 20,225,742 (GRCm39) missense probably benign 0.25
R6721:Or7e178 UTSW 9 20,225,576 (GRCm39) missense probably benign 0.24
R6787:Or7e178 UTSW 9 20,247,221 (GRCm39) missense probably benign
R6930:Or7e178 UTSW 9 20,225,395 (GRCm39) missense probably damaging 1.00
R7196:Or7e178 UTSW 9 20,225,494 (GRCm39) missense probably benign 0.38
R7711:Or7e178 UTSW 9 20,225,319 (GRCm39) missense possibly damaging 0.66
R8023:Or7e178 UTSW 9 20,225,545 (GRCm39) missense probably benign 0.00
R8029:Or7e178 UTSW 9 20,225,643 (GRCm39) missense possibly damaging 0.59
R8050:Or7e178 UTSW 9 20,225,941 (GRCm39) missense probably damaging 1.00
R8058:Or7e178 UTSW 9 20,225,476 (GRCm39) missense probably damaging 0.99
R8159:Or7e178 UTSW 9 20,226,015 (GRCm39) missense possibly damaging 0.96
R8201:Or7e178 UTSW 9 20,225,908 (GRCm39) missense probably benign 0.10
R9022:Or7e178 UTSW 9 20,225,268 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCACCAGGTGATGGCATTCTAAG -3'
(R):5'- AAATTCAGAGGCACTGTTGGGTACTG -3'

Sequencing Primer
(F):5'- CATCTGAGTCAGGCATCCTGAATAG -3'
(R):5'- CCGTATCTCAGAATTCCACCTCA -3'
Posted On 2013-11-08