Incidental Mutation 'R0865:Zc3h14'
ID 82318
Institutional Source Beutler Lab
Gene Symbol Zc3h14
Ensembl Gene ENSMUSG00000021012
Gene Name zinc finger CCCH type containing 14
Synonyms 2700069A02Rik, 1010001P15Rik, 1700016A15Rik
MMRRC Submission 039039-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0865 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 98713223-98754012 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 98745528 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105732 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021399] [ENSMUST00000057000] [ENSMUST00000110104] [ENSMUST00000110105] [ENSMUST00000221532]
AlphaFold Q8BJ05
Predicted Effect probably benign
Transcript: ENSMUST00000021399
SMART Domains Protein: ENSMUSP00000021399
Gene: ENSMUSG00000021012

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
coiled coil region 69 91 N/A INTRINSIC
ZnF_C3H1 170 193 7.16e-1 SMART
ZnF_C3H1 195 214 5.27e1 SMART
ZnF_C3H1 250 272 5.55e0 SMART
Pfam:zf-CCCH_2 273 290 1.3e-3 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000057000
SMART Domains Protein: ENSMUSP00000055879
Gene: ENSMUSG00000021012

DomainStartEndE-ValueType
low complexity region 298 306 N/A INTRINSIC
low complexity region 313 320 N/A INTRINSIC
ZnF_C3H1 440 463 7.16e-1 SMART
ZnF_C3H1 465 484 5.27e1 SMART
ZnF_C3H1 520 542 5.55e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110104
SMART Domains Protein: ENSMUSP00000105731
Gene: ENSMUSG00000021012

DomainStartEndE-ValueType
low complexity region 298 306 N/A INTRINSIC
low complexity region 313 320 N/A INTRINSIC
ZnF_C3H1 465 488 7.16e-1 SMART
ZnF_C3H1 490 509 5.27e1 SMART
ZnF_C3H1 545 567 5.55e0 SMART
Predicted Effect probably null
Transcript: ENSMUST00000110105
SMART Domains Protein: ENSMUSP00000105732
Gene: ENSMUSG00000021012

DomainStartEndE-ValueType
low complexity region 298 306 N/A INTRINSIC
low complexity region 313 320 N/A INTRINSIC
ZnF_C3H1 596 619 7.16e-1 SMART
ZnF_C3H1 621 640 5.27e1 SMART
ZnF_C3H1 676 698 5.55e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000221532
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221576
Predicted Effect probably benign
Transcript: ENSMUST00000223451
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222461
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222146
Meta Mutation Damage Score 0.9494 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 99.0%
  • 10x: 97.5%
  • 20x: 95.2%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]
PHENOTYPE: Homozygous knockout results in impaired spatial working memory, enlarged anterior lateral ventricles in the brain, small testes and reduced litter size. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck5 A G 15: 76,479,843 (GRCm39) E581G probably damaging Het
Adcy5 A G 16: 35,094,841 (GRCm39) N666S probably damaging Het
Apcs T C 1: 172,721,782 (GRCm39) D188G probably benign Het
Arih2 A G 9: 108,526,499 (GRCm39) probably benign Het
AU040320 A G 4: 126,742,677 (GRCm39) K981E possibly damaging Het
Brwd1 A T 16: 95,869,784 (GRCm39) I81K probably damaging Het
Cacng8 T A 7: 3,460,625 (GRCm39) I136N possibly damaging Het
Cdh22 A T 2: 165,022,976 (GRCm39) W32R probably damaging Het
Cel A G 2: 28,450,627 (GRCm39) S133P probably damaging Het
Clasp2 A G 9: 113,740,568 (GRCm39) T495A possibly damaging Het
Clock A T 5: 76,414,271 (GRCm39) probably benign Het
Cox6a2 A G 7: 127,804,995 (GRCm39) probably benign Het
Cyp2b19 C A 7: 26,461,654 (GRCm39) probably benign Het
Dnah11 G A 12: 118,154,579 (GRCm39) Q234* probably null Het
Gga3 A T 11: 115,483,285 (GRCm39) N91K probably damaging Het
Idh1 T C 1: 65,200,315 (GRCm39) T350A probably benign Het
Ints11 A G 4: 155,971,564 (GRCm39) probably null Het
Itgb1 A G 8: 129,436,732 (GRCm39) probably null Het
Kank4 A T 4: 98,662,900 (GRCm39) probably benign Het
Kansl1 A T 11: 104,315,194 (GRCm39) D281E probably benign Het
Kmt2a T C 9: 44,730,067 (GRCm39) probably benign Het
Kpna4 T C 3: 69,008,750 (GRCm39) E145G probably damaging Het
Lacc1 A G 14: 77,271,584 (GRCm39) I201T possibly damaging Het
Larp7 T C 3: 127,337,884 (GRCm39) K392E probably damaging Het
Lbh T A 17: 73,228,224 (GRCm39) M23K probably benign Het
Myo15a A T 11: 60,382,514 (GRCm39) E361V probably damaging Het
Ncor2 A G 5: 125,116,046 (GRCm39) S470P probably benign Het
Ngef T A 1: 87,412,323 (GRCm39) M449L probably benign Het
Odad1 A G 7: 45,591,512 (GRCm39) T259A probably benign Het
Or2w3 T C 11: 58,556,478 (GRCm39) I31T possibly damaging Het
Or7e178 T A 9: 20,226,045 (GRCm39) Y57F probably damaging Het
Peak1 A T 9: 56,165,116 (GRCm39) D937E probably benign Het
Pnpla7 A G 2: 24,872,135 (GRCm39) K72E probably benign Het
Ptprn T G 1: 75,224,782 (GRCm39) probably null Het
Scgn C T 13: 24,146,102 (GRCm39) probably null Het
Sdk2 T C 11: 113,741,748 (GRCm39) I824V probably benign Het
Slc38a3 A G 9: 107,532,847 (GRCm39) S326P probably damaging Het
Spen A G 4: 141,199,181 (GRCm39) S3126P probably benign Het
Tbcd T C 11: 121,493,815 (GRCm39) C902R possibly damaging Het
Tmem63b T C 17: 45,972,445 (GRCm39) I721V probably benign Het
Trim30c A G 7: 104,039,658 (GRCm39) S46P probably damaging Het
Trim59 T C 3: 68,944,941 (GRCm39) D133G probably damaging Het
Trpm7 A T 2: 126,641,159 (GRCm39) probably null Het
Ttll10 A G 4: 156,128,135 (GRCm39) L391P probably damaging Het
Ttn T C 2: 76,623,585 (GRCm39) T15331A possibly damaging Het
Vmn1r237 C T 17: 21,534,976 (GRCm39) T233I probably damaging Het
Vmn2r115 A T 17: 23,565,382 (GRCm39) D423V possibly damaging Het
Vmn2r25 T A 6: 123,829,976 (GRCm39) R58S probably benign Het
Vmn2r71 A T 7: 85,268,516 (GRCm39) I240F probably benign Het
Wdr3 A G 3: 100,060,112 (GRCm39) probably benign Het
Zc3hav1 C T 6: 38,330,837 (GRCm39) probably benign Het
Zfp335 A T 2: 164,741,415 (GRCm39) probably null Het
Other mutations in Zc3h14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00835:Zc3h14 APN 12 98,713,783 (GRCm39) critical splice donor site probably null
IGL00946:Zc3h14 APN 12 98,726,142 (GRCm39) splice site probably benign
IGL00969:Zc3h14 APN 12 98,725,102 (GRCm39) missense probably benign 0.00
IGL01626:Zc3h14 APN 12 98,745,445 (GRCm39) missense possibly damaging 0.72
IGL01891:Zc3h14 APN 12 98,725,206 (GRCm39) unclassified probably benign
IGL02119:Zc3h14 APN 12 98,730,154 (GRCm39) missense probably benign 0.00
IGL02484:Zc3h14 APN 12 98,740,560 (GRCm39) missense probably benign 0.14
IGL02744:Zc3h14 APN 12 98,751,234 (GRCm39) missense possibly damaging 0.67
IGL02894:Zc3h14 APN 12 98,725,202 (GRCm39) critical splice donor site probably null
R0408:Zc3h14 UTSW 12 98,730,082 (GRCm39) missense probably damaging 1.00
R0739:Zc3h14 UTSW 12 98,723,460 (GRCm39) missense probably damaging 0.99
R0926:Zc3h14 UTSW 12 98,724,849 (GRCm39) missense possibly damaging 0.94
R1530:Zc3h14 UTSW 12 98,751,262 (GRCm39) missense probably damaging 1.00
R1735:Zc3h14 UTSW 12 98,724,839 (GRCm39) missense probably damaging 1.00
R1743:Zc3h14 UTSW 12 98,745,448 (GRCm39) missense probably benign 0.04
R1848:Zc3h14 UTSW 12 98,719,091 (GRCm39) missense possibly damaging 0.89
R1851:Zc3h14 UTSW 12 98,726,613 (GRCm39) nonsense probably null
R1978:Zc3h14 UTSW 12 98,730,181 (GRCm39) missense probably damaging 0.97
R2011:Zc3h14 UTSW 12 98,746,527 (GRCm39) missense possibly damaging 0.76
R2198:Zc3h14 UTSW 12 98,719,069 (GRCm39) missense possibly damaging 0.94
R2198:Zc3h14 UTSW 12 98,719,068 (GRCm39) missense probably damaging 1.00
R2263:Zc3h14 UTSW 12 98,724,773 (GRCm39) missense probably benign 0.32
R3762:Zc3h14 UTSW 12 98,724,902 (GRCm39) missense probably damaging 1.00
R4210:Zc3h14 UTSW 12 98,751,658 (GRCm39) missense probably damaging 1.00
R4353:Zc3h14 UTSW 12 98,730,219 (GRCm39) missense possibly damaging 0.70
R4360:Zc3h14 UTSW 12 98,746,456 (GRCm39) missense probably benign 0.09
R4814:Zc3h14 UTSW 12 98,719,107 (GRCm39) missense probably damaging 1.00
R4815:Zc3h14 UTSW 12 98,719,107 (GRCm39) missense probably damaging 1.00
R4817:Zc3h14 UTSW 12 98,719,107 (GRCm39) missense probably damaging 1.00
R4947:Zc3h14 UTSW 12 98,726,083 (GRCm39) missense probably benign
R5077:Zc3h14 UTSW 12 98,723,465 (GRCm39) critical splice donor site probably null
R5431:Zc3h14 UTSW 12 98,746,324 (GRCm39) missense possibly damaging 0.94
R5783:Zc3h14 UTSW 12 98,723,434 (GRCm39) missense probably damaging 0.99
R5850:Zc3h14 UTSW 12 98,745,414 (GRCm39) missense probably damaging 0.97
R6034:Zc3h14 UTSW 12 98,737,632 (GRCm39) missense probably benign 0.01
R6034:Zc3h14 UTSW 12 98,737,632 (GRCm39) missense probably benign 0.01
R6291:Zc3h14 UTSW 12 98,726,087 (GRCm39) missense probably damaging 1.00
R6338:Zc3h14 UTSW 12 98,724,849 (GRCm39) missense possibly damaging 0.94
R6595:Zc3h14 UTSW 12 98,723,285 (GRCm39) missense probably damaging 0.98
R6737:Zc3h14 UTSW 12 98,751,305 (GRCm39) missense probably damaging 1.00
R6932:Zc3h14 UTSW 12 98,737,336 (GRCm39) intron probably benign
R7074:Zc3h14 UTSW 12 98,724,859 (GRCm39) missense possibly damaging 0.96
R7204:Zc3h14 UTSW 12 98,737,615 (GRCm39) missense probably damaging 1.00
R7237:Zc3h14 UTSW 12 98,746,408 (GRCm39) missense probably benign 0.34
R7267:Zc3h14 UTSW 12 98,751,988 (GRCm39) missense probably damaging 1.00
R8753:Zc3h14 UTSW 12 98,724,831 (GRCm39) missense probably benign 0.12
R9169:Zc3h14 UTSW 12 98,745,505 (GRCm39) missense probably damaging 1.00
R9610:Zc3h14 UTSW 12 98,737,663 (GRCm39) missense possibly damaging 0.92
RF020:Zc3h14 UTSW 12 98,746,541 (GRCm39) critical splice donor site probably null
RF024:Zc3h14 UTSW 12 98,725,120 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAACCCTTCTCTGCCTTAGGCAAAG -3'
(R):5'- GGAACCACGCAAGCCTTAGTCC -3'

Sequencing Primer
(F):5'- GGCCAATTTTTTTGGCTCAGATTAC -3'
(R):5'- ACCTTGCAGAAGGATTTCCTG -3'
Posted On 2013-11-08