Mutagenetix > Incidental Mutation

Incidental Mutation 'R0865:Vmn1r237'

82325

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r237

Ensembl Gene

ENSMUSG00000058030

Gene Name

vomeronasal 1 receptor 237

Synonyms

V1rf3

MMRRC Submission

039039-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R0865 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

21534279-21535148 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 21534976 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 233 (T233I)

Ref Sequence

ENSEMBL: ENSMUSP00000076531 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077301]

AlphaFold

Q8R296

Predicted Effect

probably damaging
Transcript: ENSMUST00000077301
AA Change: T233I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000076531
Gene: ENSMUSG00000058030
AA Change: T233I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	289	7.1e-17	PFAM
Pfam:V1R	34	289	1.9e-34	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.6%
3x: 99.0%
10x: 97.5%
20x: 95.2%

Validation Efficiency

98% (53/54)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck5	A	G	15: 76,479,843 (GRCm39)	E581G	probably damaging	Het
Adcy5	A	G	16: 35,094,841 (GRCm39)	N666S	probably damaging	Het
Apcs	T	C	1: 172,721,782 (GRCm39)	D188G	probably benign	Het
Arih2	A	G	9: 108,526,499 (GRCm39)		probably benign	Het
AU040320	A	G	4: 126,742,677 (GRCm39)	K981E	possibly damaging	Het
Brwd1	A	T	16: 95,869,784 (GRCm39)	I81K	probably damaging	Het
Cacng8	T	A	7: 3,460,625 (GRCm39)	I136N	possibly damaging	Het
Cdh22	A	T	2: 165,022,976 (GRCm39)	W32R	probably damaging	Het
Cel	A	G	2: 28,450,627 (GRCm39)	S133P	probably damaging	Het
Clasp2	A	G	9: 113,740,568 (GRCm39)	T495A	possibly damaging	Het
Clock	A	T	5: 76,414,271 (GRCm39)		probably benign	Het
Cox6a2	A	G	7: 127,804,995 (GRCm39)		probably benign	Het
Cyp2b19	C	A	7: 26,461,654 (GRCm39)		probably benign	Het
Dnah11	G	A	12: 118,154,579 (GRCm39)	Q234*	probably null	Het
Gga3	A	T	11: 115,483,285 (GRCm39)	N91K	probably damaging	Het
Idh1	T	C	1: 65,200,315 (GRCm39)	T350A	probably benign	Het
Ints11	A	G	4: 155,971,564 (GRCm39)		probably null	Het
Itgb1	A	G	8: 129,436,732 (GRCm39)		probably null	Het
Kank4	A	T	4: 98,662,900 (GRCm39)		probably benign	Het
Kansl1	A	T	11: 104,315,194 (GRCm39)	D281E	probably benign	Het
Kmt2a	T	C	9: 44,730,067 (GRCm39)		probably benign	Het
Kpna4	T	C	3: 69,008,750 (GRCm39)	E145G	probably damaging	Het
Lacc1	A	G	14: 77,271,584 (GRCm39)	I201T	possibly damaging	Het
Larp7	T	C	3: 127,337,884 (GRCm39)	K392E	probably damaging	Het
Lbh	T	A	17: 73,228,224 (GRCm39)	M23K	probably benign	Het
Myo15a	A	T	11: 60,382,514 (GRCm39)	E361V	probably damaging	Het
Ncor2	A	G	5: 125,116,046 (GRCm39)	S470P	probably benign	Het
Ngef	T	A	1: 87,412,323 (GRCm39)	M449L	probably benign	Het
Odad1	A	G	7: 45,591,512 (GRCm39)	T259A	probably benign	Het
Or2w3	T	C	11: 58,556,478 (GRCm39)	I31T	possibly damaging	Het
Or7e178	T	A	9: 20,226,045 (GRCm39)	Y57F	probably damaging	Het
Peak1	A	T	9: 56,165,116 (GRCm39)	D937E	probably benign	Het
Pnpla7	A	G	2: 24,872,135 (GRCm39)	K72E	probably benign	Het
Ptprn	T	G	1: 75,224,782 (GRCm39)		probably null	Het
Scgn	C	T	13: 24,146,102 (GRCm39)		probably null	Het
Sdk2	T	C	11: 113,741,748 (GRCm39)	I824V	probably benign	Het
Slc38a3	A	G	9: 107,532,847 (GRCm39)	S326P	probably damaging	Het
Spen	A	G	4: 141,199,181 (GRCm39)	S3126P	probably benign	Het
Tbcd	T	C	11: 121,493,815 (GRCm39)	C902R	possibly damaging	Het
Tmem63b	T	C	17: 45,972,445 (GRCm39)	I721V	probably benign	Het
Trim30c	A	G	7: 104,039,658 (GRCm39)	S46P	probably damaging	Het
Trim59	T	C	3: 68,944,941 (GRCm39)	D133G	probably damaging	Het
Trpm7	A	T	2: 126,641,159 (GRCm39)		probably null	Het
Ttll10	A	G	4: 156,128,135 (GRCm39)	L391P	probably damaging	Het
Ttn	T	C	2: 76,623,585 (GRCm39)	T15331A	possibly damaging	Het
Vmn2r115	A	T	17: 23,565,382 (GRCm39)	D423V	possibly damaging	Het
Vmn2r25	T	A	6: 123,829,976 (GRCm39)	R58S	probably benign	Het
Vmn2r71	A	T	7: 85,268,516 (GRCm39)	I240F	probably benign	Het
Wdr3	A	G	3: 100,060,112 (GRCm39)		probably benign	Het
Zc3h14	T	C	12: 98,745,528 (GRCm39)		probably null	Het
Zc3hav1	C	T	6: 38,330,837 (GRCm39)		probably benign	Het
Zfp335	A	T	2: 164,741,415 (GRCm39)		probably null	Het

Other mutations in Vmn1r237

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01300:Vmn1r237	APN	17	21,534,337 (GRCm39)	missense	probably damaging	0.97
IGL02746:Vmn1r237	APN	17	21,534,480 (GRCm39)	missense	possibly damaging	0.96
IGL03112:Vmn1r237	APN	17	21,534,368 (GRCm39)	nonsense	probably null
IGL03351:Vmn1r237	APN	17	21,535,099 (GRCm39)	missense	probably benign	0.06
BB009:Vmn1r237	UTSW	17	21,534,725 (GRCm39)	missense	probably benign	0.01
BB019:Vmn1r237	UTSW	17	21,534,725 (GRCm39)	missense	probably benign	0.01
R0478:Vmn1r237	UTSW	17	21,535,081 (GRCm39)	missense	probably damaging	1.00
R0514:Vmn1r237	UTSW	17	21,534,932 (GRCm39)	missense	possibly damaging	0.63
R0616:Vmn1r237	UTSW	17	21,534,885 (GRCm39)	missense	probably damaging	1.00
R1590:Vmn1r237	UTSW	17	21,534,301 (GRCm39)	missense	probably damaging	0.99
R3022:Vmn1r237	UTSW	17	21,534,709 (GRCm39)	missense	probably damaging	0.99
R4241:Vmn1r237	UTSW	17	21,534,925 (GRCm39)	missense	possibly damaging	0.63
R4242:Vmn1r237	UTSW	17	21,534,925 (GRCm39)	missense	possibly damaging	0.63
R4646:Vmn1r237	UTSW	17	21,534,400 (GRCm39)	missense	probably benign	0.02
R5144:Vmn1r237	UTSW	17	21,534,688 (GRCm39)	missense	possibly damaging	0.96
R5229:Vmn1r237	UTSW	17	21,534,633 (GRCm39)	missense	probably benign	0.00
R5334:Vmn1r237	UTSW	17	21,534,942 (GRCm39)	missense	probably benign	0.00
R5800:Vmn1r237	UTSW	17	21,535,069 (GRCm39)	missense	probably benign	0.05
R5898:Vmn1r237	UTSW	17	21,534,813 (GRCm39)	missense	probably damaging	0.99
R6190:Vmn1r237	UTSW	17	21,534,556 (GRCm39)	missense	probably damaging	1.00
R6472:Vmn1r237	UTSW	17	21,534,616 (GRCm39)	missense	probably benign	0.16
R6811:Vmn1r237	UTSW	17	21,534,648 (GRCm39)	missense	probably benign	0.02
R7932:Vmn1r237	UTSW	17	21,534,725 (GRCm39)	missense	probably benign	0.01
R8008:Vmn1r237	UTSW	17	21,534,456 (GRCm39)	missense	probably damaging	1.00
R8086:Vmn1r237	UTSW	17	21,534,509 (GRCm39)	missense	possibly damaging	0.61
R9568:Vmn1r237	UTSW	17	21,534,777 (GRCm39)	missense	probably benign
R9631:Vmn1r237	UTSW	17	21,534,660 (GRCm39)	missense	probably benign	0.28
X0011:Vmn1r237	UTSW	17	21,534,317 (GRCm39)	missense	possibly damaging	0.62

Predicted Primers

PCR Primer
(F):5'- AGCCAAGTCTCCCAGTTACATTGC -3'
(R):5'- TGGAGATCACCAGAAAGGGACTCAC -3'

Sequencing Primer
(F):5'- CATTACACGCCTAAGGGTGTATG -3'
(R):5'- CTCACAGTTGGGAAACATGC -3'

Posted On

2013-11-08