Incidental Mutation 'R0791:Zfp974'
ID 82393
Institutional Source Beutler Lab
Gene Symbol Zfp974
Ensembl Gene ENSMUSG00000070709
Gene Name zinc finger protein 974
Synonyms 1700049G17Rik
MMRRC Submission 038971-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R0791 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 27606817-27628885 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 27609510 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 738 (Y738*)
Ref Sequence ENSEMBL: ENSMUSP00000096238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098639] [ENSMUST00000129341]
AlphaFold Q3UVF6
Predicted Effect probably null
Transcript: ENSMUST00000098639
AA Change: Y738*
SMART Domains Protein: ENSMUSP00000096238
Gene: ENSMUSG00000070709
AA Change: Y738*

DomainStartEndE-ValueType
ZnF_C2H2 99 121 8.81e-2 SMART
ZnF_C2H2 127 149 1.82e-3 SMART
ZnF_C2H2 155 177 3.11e-2 SMART
ZnF_C2H2 201 223 2.15e-5 SMART
ZnF_C2H2 229 251 1.18e-2 SMART
ZnF_C2H2 257 279 1.47e-3 SMART
ZnF_C2H2 285 307 1.79e-2 SMART
ZnF_C2H2 313 335 2.24e-3 SMART
ZnF_C2H2 341 363 9.73e-4 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
ZnF_C2H2 397 419 6.42e-4 SMART
ZnF_C2H2 425 447 3.63e-3 SMART
ZnF_C2H2 453 475 1.28e-3 SMART
ZnF_C2H2 481 503 1.26e-2 SMART
ZnF_C2H2 509 531 1.38e-3 SMART
ZnF_C2H2 537 559 3.83e-2 SMART
ZnF_C2H2 565 587 1.95e-3 SMART
ZnF_C2H2 593 615 4.61e-5 SMART
ZnF_C2H2 621 643 1.95e-3 SMART
ZnF_C2H2 649 671 1.03e-2 SMART
ZnF_C2H2 677 699 5.5e-3 SMART
ZnF_C2H2 705 727 2.37e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129341
SMART Domains Protein: ENSMUSP00000115940
Gene: ENSMUSG00000070709

DomainStartEndE-ValueType
KRAB 14 75 7.5e-37 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.8%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak G A 19: 8,994,098 (GRCm39) M5127I probably benign Het
Akr1c13 T C 13: 4,244,111 (GRCm39) Y55H probably damaging Het
Armh3 A T 19: 45,922,307 (GRCm39) probably null Het
Atp2b2 C T 6: 113,750,349 (GRCm39) R625H probably damaging Het
Bpifb2 T C 2: 153,720,439 (GRCm39) V66A probably benign Het
Ccdc33 T C 9: 57,936,046 (GRCm39) T950A possibly damaging Het
Ceacam19 A T 7: 19,616,557 (GRCm39) probably null Het
Cenpn T A 8: 117,667,559 (GRCm39) probably benign Het
Ces1f A T 8: 93,998,517 (GRCm39) Y160N possibly damaging Het
Clca3a1 A C 3: 144,710,615 (GRCm39) S863A probably benign Het
Cntrl T A 2: 35,045,291 (GRCm39) I781K possibly damaging Het
Dock4 C T 12: 40,754,480 (GRCm39) R490W probably damaging Het
Evpl T A 11: 116,118,549 (GRCm39) Q686L probably damaging Het
Fbxw10 A G 11: 62,738,282 (GRCm39) S59G probably benign Het
Glb1l2 A G 9: 26,681,047 (GRCm39) V218A possibly damaging Het
Gpatch1 A T 7: 34,980,801 (GRCm39) probably benign Het
Grin2c G A 11: 115,141,472 (GRCm39) P882L probably damaging Het
H2-Ob C A 17: 34,461,588 (GRCm39) T109N probably damaging Het
Ipo8 A G 6: 148,723,225 (GRCm39) V64A possibly damaging Het
Jpt2 C A 17: 25,167,647 (GRCm39) A101S probably benign Het
Lamc1 C A 1: 153,110,326 (GRCm39) Q1116H possibly damaging Het
Lamc1 T C 1: 153,110,358 (GRCm39) S1106G probably benign Het
Lamc1 T G 1: 153,110,341 (GRCm39) Q1111H probably damaging Het
Large1 A G 8: 73,775,107 (GRCm39) probably benign Het
Lig4 A T 8: 10,023,012 (GRCm39) V256E possibly damaging Het
Mpz C A 1: 170,986,343 (GRCm39) Q86K possibly damaging Het
Mrps24 A G 11: 5,654,684 (GRCm39) V90A possibly damaging Het
Mtdh A G 15: 34,116,528 (GRCm39) probably benign Het
Mtor T C 4: 148,547,367 (GRCm39) V450A probably benign Het
Mycbpap A G 11: 94,402,449 (GRCm39) probably null Het
Myo6 T A 9: 80,169,656 (GRCm39) probably benign Het
Myom1 A T 17: 71,428,131 (GRCm39) I1450F probably damaging Het
Nbas T A 12: 13,532,634 (GRCm39) S1781T probably benign Het
Nedd1 T C 10: 92,555,476 (GRCm39) E3G probably damaging Het
Nt5c3 T C 6: 56,863,734 (GRCm39) T149A probably benign Het
Or5p56 A G 7: 107,589,740 (GRCm39) H56R probably benign Het
Osbp2 G A 11: 3,661,882 (GRCm39) probably benign Het
Paip1 T C 13: 119,566,854 (GRCm39) S54P possibly damaging Het
Pole2 G A 12: 69,254,703 (GRCm39) L381F probably benign Het
Prdm14 G T 1: 13,195,968 (GRCm39) A31E probably benign Het
Ptpn14 C T 1: 189,568,637 (GRCm39) probably benign Het
Rims2 A G 15: 39,543,021 (GRCm39) probably benign Het
Rnf20 A G 4: 49,638,197 (GRCm39) N103S possibly damaging Het
Sema3g T A 14: 30,942,861 (GRCm39) probably benign Het
Slc30a6 T C 17: 74,722,640 (GRCm39) S236P possibly damaging Het
Slc5a1 T C 5: 33,315,421 (GRCm39) probably benign Het
Snx25 A T 8: 46,577,119 (GRCm39) M1K probably null Het
Synpo2 A G 3: 122,906,835 (GRCm39) V827A probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trak2 A T 1: 58,942,820 (GRCm39) M862K probably benign Het
Trim42 A T 9: 97,247,732 (GRCm39) H321Q probably damaging Het
Twnk T C 19: 44,998,693 (GRCm39) probably benign Het
Tymp T C 15: 89,259,021 (GRCm39) K221R probably damaging Het
Uaca C A 9: 60,779,341 (GRCm39) Q1243K possibly damaging Het
Vwa8 T C 14: 79,232,016 (GRCm39) probably benign Het
Wnt4 C T 4: 137,016,594 (GRCm39) R83W probably damaging Het
Zfp820 T C 17: 22,038,509 (GRCm39) D273G probably benign Het
Zkscan4 A C 13: 21,668,081 (GRCm39) E177D probably benign Het
Other mutations in Zfp974
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00836:Zfp974 APN 7 27,610,315 (GRCm39) missense possibly damaging 0.83
IGL01805:Zfp974 APN 7 27,611,689 (GRCm39) splice site probably benign
IGL02313:Zfp974 APN 7 27,611,678 (GRCm39) missense possibly damaging 0.53
IGL02449:Zfp974 APN 7 27,611,152 (GRCm39) missense probably benign
R0362:Zfp974 UTSW 7 27,626,819 (GRCm39) splice site probably benign
R0372:Zfp974 UTSW 7 27,620,120 (GRCm39) critical splice donor site probably null
R0379:Zfp974 UTSW 7 27,610,357 (GRCm39) missense probably damaging 0.98
R0699:Zfp974 UTSW 7 27,611,416 (GRCm39) missense possibly damaging 0.56
R1411:Zfp974 UTSW 7 27,610,634 (GRCm39) missense probably benign 0.00
R1567:Zfp974 UTSW 7 27,610,148 (GRCm39) missense probably damaging 0.99
R1747:Zfp974 UTSW 7 27,610,506 (GRCm39) missense possibly damaging 0.61
R1837:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1838:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1839:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R2311:Zfp974 UTSW 7 27,609,866 (GRCm39) missense possibly damaging 0.73
R4006:Zfp974 UTSW 7 27,611,677 (GRCm39) missense possibly damaging 0.86
R4303:Zfp974 UTSW 7 27,609,657 (GRCm39) missense possibly damaging 0.85
R4541:Zfp974 UTSW 7 27,625,829 (GRCm39) missense probably damaging 0.99
R4771:Zfp974 UTSW 7 27,625,733 (GRCm39) missense probably damaging 0.96
R4889:Zfp974 UTSW 7 27,610,244 (GRCm39) missense possibly damaging 0.86
R5332:Zfp974 UTSW 7 27,625,715 (GRCm39) missense probably benign 0.01
R5537:Zfp974 UTSW 7 27,611,671 (GRCm39) critical splice acceptor site probably benign
R5906:Zfp974 UTSW 7 27,610,230 (GRCm39) missense possibly damaging 0.72
R5908:Zfp974 UTSW 7 27,610,382 (GRCm39) missense probably benign 0.01
R6419:Zfp974 UTSW 7 27,610,940 (GRCm39) missense possibly damaging 0.72
R6654:Zfp974 UTSW 7 27,625,828 (GRCm39) missense probably damaging 1.00
R6731:Zfp974 UTSW 7 27,611,074 (GRCm39) missense possibly damaging 0.93
R7162:Zfp974 UTSW 7 27,610,944 (GRCm39) missense possibly damaging 0.71
R7316:Zfp974 UTSW 7 27,609,863 (GRCm39) missense possibly damaging 0.93
R7484:Zfp974 UTSW 7 27,611,559 (GRCm39) missense possibly damaging 0.72
R7663:Zfp974 UTSW 7 27,611,110 (GRCm39) missense possibly damaging 0.74
R7664:Zfp974 UTSW 7 27,610,137 (GRCm39) missense possibly damaging 0.86
R8052:Zfp974 UTSW 7 27,610,697 (GRCm39) missense probably damaging 1.00
R8698:Zfp974 UTSW 7 27,610,361 (GRCm39) missense possibly damaging 0.90
R8700:Zfp974 UTSW 7 27,609,472 (GRCm39) missense possibly damaging 0.86
R8938:Zfp974 UTSW 7 27,610,311 (GRCm39) missense possibly damaging 0.74
R8972:Zfp974 UTSW 7 27,610,589 (GRCm39) missense probably benign 0.06
R9212:Zfp974 UTSW 7 27,610,052 (GRCm39) missense possibly damaging 0.86
R9236:Zfp974 UTSW 7 27,610,342 (GRCm39) missense possibly damaging 0.51
R9335:Zfp974 UTSW 7 27,611,476 (GRCm39) missense probably benign 0.02
R9436:Zfp974 UTSW 7 27,611,094 (GRCm39) missense probably benign 0.24
R9740:Zfp974 UTSW 7 27,610,025 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCCACCTCCCTTACACGAATAGG -3'
(R):5'- AATGTCAGCACTGTGGGTCAGC -3'

Sequencing Primer
(F):5'- CGAATAGGACTCCTGGCTATTACAG -3'
(R):5'- GGGTCAGCCTTCAGATACAAGTC -3'
Posted On 2013-11-08