Incidental Mutation 'R0792:Or5p81'
ID 82457
Institutional Source Beutler Lab
Gene Symbol Or5p81
Ensembl Gene ENSMUSG00000096209
Gene Name olfactory receptor family 5 subfamily P member 81
Synonyms MOR204-34, GA_x6K02T2PBJ9-10997715-10998659, Olfr510
MMRRC Submission 038972-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R0792 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 108265625-108267569 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108267364 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 247 (H247R)
Ref Sequence ENSEMBL: ENSMUSP00000149693 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076289] [ENSMUST00000213979] [ENSMUST00000216331] [ENSMUST00000217170]
AlphaFold Q8VEW6
Predicted Effect probably damaging
Transcript: ENSMUST00000076289
AA Change: H247R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000075637
Gene: ENSMUSG00000096209
AA Change: H247R

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 3e-50 PFAM
Pfam:7tm_1 44 293 4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210621
AA Change: H247R
Predicted Effect probably damaging
Transcript: ENSMUST00000213979
AA Change: H247R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216331
AA Change: H247R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000217170
AA Change: H247R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.6%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 T C 19: 55,268,924 (GRCm39) V195A probably benign Het
Adgrb1 A G 15: 74,452,466 (GRCm39) M211V probably damaging Het
Ahnak G T 19: 8,994,098 (GRCm39) M5127I probably benign Het
Akr1c13 T C 13: 4,244,111 (GRCm39) Y55H probably damaging Het
Ap3d1 A T 10: 80,544,313 (GRCm39) H1161Q probably benign Het
Armh3 A T 19: 45,922,307 (GRCm39) probably null Het
Atp2b2 C T 6: 113,750,349 (GRCm39) R625H probably damaging Het
Bdnf G A 2: 109,554,463 (GRCm39) C239Y probably damaging Het
Bpifa5 G T 2: 154,007,539 (GRCm39) probably null Het
C9 T A 15: 6,516,243 (GRCm39) F349I probably damaging Het
Ccdc180 T C 4: 45,927,975 (GRCm39) V1170A possibly damaging Het
Celsr1 A G 15: 85,815,477 (GRCm39) V1846A probably benign Het
Cep68 A T 11: 20,190,652 (GRCm39) L120H possibly damaging Het
Cntrl T A 2: 35,045,291 (GRCm39) I781K possibly damaging Het
Cpne1 G T 2: 155,919,339 (GRCm39) Q343K probably benign Het
Dlc1 A T 8: 37,405,702 (GRCm39) I29K probably benign Het
Dnah9 T C 11: 65,786,827 (GRCm39) D3602G possibly damaging Het
Dock1 A G 7: 134,475,879 (GRCm39) S885G probably benign Het
Evpl T A 11: 116,118,549 (GRCm39) Q686L probably damaging Het
Fmo6 C T 1: 162,748,132 (GRCm39) A311T probably damaging Het
Gli1 A T 10: 127,168,446 (GRCm39) M469K probably damaging Het
Grin2c G A 11: 115,141,472 (GRCm39) P882L probably damaging Het
H2-Ob C T 17: 34,461,588 (GRCm39) T109I probably damaging Het
Jpt2 C A 17: 25,167,647 (GRCm39) A101S probably benign Het
Krt1c A G 15: 101,724,932 (GRCm39) V226A probably damaging Het
Lamc1 T C 1: 153,110,358 (GRCm39) S1106G probably benign Het
Lamc1 C A 1: 153,110,326 (GRCm39) Q1116H possibly damaging Het
Lamc1 T G 1: 153,110,341 (GRCm39) Q1111H probably damaging Het
Lrp1 G T 10: 127,403,233 (GRCm39) D2113E probably damaging Het
Lrp1 A T 10: 127,411,155 (GRCm39) D1399E probably benign Het
Ltbp4 G T 7: 27,024,485 (GRCm39) P715Q probably damaging Het
Mtor T C 4: 148,547,367 (GRCm39) V450A probably benign Het
Muc6 G A 7: 141,223,981 (GRCm39) probably benign Het
Myom1 A T 17: 71,428,131 (GRCm39) I1450F probably damaging Het
Naip6 A G 13: 100,420,274 (GRCm39) I1332T possibly damaging Het
Ncstn A G 1: 171,899,072 (GRCm39) V353A possibly damaging Het
Nt5c3 T C 6: 56,863,734 (GRCm39) T149A probably benign Het
Or5ac21 A T 16: 59,124,352 (GRCm39) I280F probably damaging Het
Paip1 T C 13: 119,566,854 (GRCm39) S54P possibly damaging Het
Prdm14 G T 1: 13,195,968 (GRCm39) A31E probably benign Het
Prr14l A G 5: 32,985,767 (GRCm39) S1243P probably damaging Het
Prss1 T C 6: 41,435,878 (GRCm39) M1T probably null Het
Raver2 T A 4: 100,960,147 (GRCm39) V209D probably damaging Het
Scube1 T A 15: 83,512,277 (GRCm39) probably null Het
Serpina3c T A 12: 104,117,805 (GRCm39) I178F probably damaging Het
Slc16a13 A T 11: 70,111,457 (GRCm39) V16E probably damaging Het
Slc30a6 T C 17: 74,722,640 (GRCm39) S236P possibly damaging Het
Sobp A C 10: 42,898,689 (GRCm39) S299A probably damaging Het
Sorcs3 C A 19: 48,694,448 (GRCm39) T574K possibly damaging Het
Trak2 A T 1: 58,942,820 (GRCm39) M862K probably benign Het
Ubox5 A T 2: 130,442,630 (GRCm39) V19E probably damaging Het
Vmn1r173 A G 7: 23,402,160 (GRCm39) T132A probably benign Het
Zfp267 A G 3: 36,218,711 (GRCm39) M244V probably benign Het
Zfp820 T C 17: 22,038,509 (GRCm39) D273G probably benign Het
Other mutations in Or5p81
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00909:Or5p81 APN 7 108,266,907 (GRCm39) missense possibly damaging 0.61
IGL00952:Or5p81 APN 7 108,267,445 (GRCm39) missense possibly damaging 0.89
IGL01358:Or5p81 APN 7 108,266,869 (GRCm39) missense possibly damaging 0.90
IGL01663:Or5p81 APN 7 108,267,098 (GRCm39) missense probably benign 0.01
IGL02686:Or5p81 APN 7 108,267,093 (GRCm39) missense probably benign 0.00
PIT4466001:Or5p81 UTSW 7 108,266,743 (GRCm39) missense possibly damaging 0.52
R0095:Or5p81 UTSW 7 108,267,252 (GRCm39) missense probably benign 0.00
R0095:Or5p81 UTSW 7 108,267,252 (GRCm39) missense probably benign 0.00
R0925:Or5p81 UTSW 7 108,267,400 (GRCm39) missense probably benign 0.00
R1829:Or5p81 UTSW 7 108,266,851 (GRCm39) missense probably benign 0.24
R2092:Or5p81 UTSW 7 108,266,869 (GRCm39) frame shift probably null
R2483:Or5p81 UTSW 7 108,266,869 (GRCm39) frame shift probably null
R3619:Or5p81 UTSW 7 108,267,057 (GRCm39) missense probably benign 0.00
R4386:Or5p81 UTSW 7 108,267,460 (GRCm39) missense probably damaging 0.99
R5298:Or5p81 UTSW 7 108,267,279 (GRCm39) missense probably benign 0.00
R5622:Or5p81 UTSW 7 108,267,289 (GRCm39) missense probably benign
R6079:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
R6138:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
R8359:Or5p81 UTSW 7 108,267,518 (GRCm39) missense probably benign 0.00
R8848:Or5p81 UTSW 7 108,266,929 (GRCm39) missense probably benign 0.03
R8994:Or5p81 UTSW 7 108,267,169 (GRCm39) missense probably damaging 0.96
R9360:Or5p81 UTSW 7 108,266,977 (GRCm39) missense probably damaging 1.00
R9439:Or5p81 UTSW 7 108,266,626 (GRCm39) start codon destroyed probably null 0.97
R9641:Or5p81 UTSW 7 108,267,516 (GRCm39) missense probably damaging 0.98
U15987:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
Z1177:Or5p81 UTSW 7 108,267,043 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTTGTGGCAATCTGCAATCCACTG -3'
(R):5'- CCAAGCTGTTTCTTCAGAGCACCC -3'

Sequencing Primer
(F):5'- CCAAACAAGTGTGTATCCAATTGC -3'
(R):5'- AGAGCACCCTTAATCTCATTATTCC -3'
Posted On 2013-11-08