Incidental Mutation 'R0017:Ifit2'
ID 8247
Institutional Source Beutler Lab
Gene Symbol Ifit2
Ensembl Gene ENSMUSG00000045932
Gene Name interferon-induced protein with tetratricopeptide repeats 2
Synonyms Ifi54
MMRRC Submission 038312-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R0017 (G1)
Quality Score
Status Validated
Chromosome 19
Chromosomal Location 34528094-34553819 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 34550973 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 171 (N171I)
Ref Sequence ENSEMBL: ENSMUSP00000099890 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102826] [ENSMUST00000149829]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000102826
AA Change: N171I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000099890
Gene: ENSMUSG00000045932
AA Change: N171I

DomainStartEndE-ValueType
Pfam:TPR_2 95 127 4e-4 PFAM
Pfam:TPR_8 95 127 3.8e-4 PFAM
Blast:TPR 138 171 7e-11 BLAST
Blast:TPR 172 208 2e-9 BLAST
low complexity region 211 222 N/A INTRINSIC
Pfam:TPR_19 225 286 4e-8 PFAM
low complexity region 396 406 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000149829
Meta Mutation Damage Score 0.3785 question?
Coding Region Coverage
  • 1x: 79.1%
  • 3x: 69.1%
  • 10x: 41.8%
  • 20x: 21.2%
Validation Efficiency 93% (76/82)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susuceptibility to VSV infection with increased lethality and brain viral titer. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik G T 17: 9,226,938 (GRCm39) probably benign Het
Adgrv1 T C 13: 81,727,065 (GRCm39) N429S probably benign Het
Cdca8 T C 4: 124,814,168 (GRCm39) T208A probably benign Het
Dcdc5 G A 2: 106,187,541 (GRCm39) noncoding transcript Het
Fig4 A G 10: 41,149,003 (GRCm39) Y150H possibly damaging Het
Fsip2 G A 2: 82,822,416 (GRCm39) V6050M probably damaging Het
Gpld1 A G 13: 25,174,101 (GRCm39) D842G probably damaging Het
Hmgcr A G 13: 96,788,597 (GRCm39) probably benign Het
Ipo11 T A 13: 107,023,238 (GRCm39) I416L probably benign Het
Kcnab1 G A 3: 65,264,527 (GRCm39) V259M probably damaging Het
Kif5c A G 2: 49,622,725 (GRCm39) T526A probably benign Het
Nucb2 A G 7: 116,132,386 (GRCm39) D331G probably benign Het
Pfdn6 T C 17: 34,158,538 (GRCm39) R79G probably damaging Het
Pkd1 G T 17: 24,797,513 (GRCm39) probably null Het
Ptpro T C 6: 137,393,825 (GRCm39) V831A probably benign Het
Reg3b T A 6: 78,349,844 (GRCm39) M128K possibly damaging Het
Rif1 A G 2: 52,006,686 (GRCm39) T2207A probably benign Het
Rpa1 A C 11: 75,205,687 (GRCm39) N223K probably null Het
Rras2 T C 7: 113,647,490 (GRCm39) probably benign Het
Scyl3 T A 1: 163,767,538 (GRCm39) I204N possibly damaging Het
Slc45a1 C A 4: 150,714,023 (GRCm39) D741Y possibly damaging Het
Slco1a5 A T 6: 142,182,061 (GRCm39) probably benign Het
Smg5 G T 3: 88,258,412 (GRCm39) R461L probably damaging Het
Sync G A 4: 129,187,537 (GRCm39) V190M probably damaging Het
Tshr A T 12: 91,504,660 (GRCm39) I533F possibly damaging Het
Tsn T C 1: 118,228,589 (GRCm39) D211G probably damaging Het
Ttn G A 2: 76,621,988 (GRCm39) T15518I probably benign Het
Vapb A G 2: 173,613,397 (GRCm39) T99A probably benign Het
Zfp280d A T 9: 72,246,292 (GRCm39) probably null Het
Other mutations in Ifit2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Ifit2 APN 19 34,550,702 (GRCm39) missense probably damaging 1.00
IGL02261:Ifit2 APN 19 34,551,624 (GRCm39) missense probably damaging 1.00
IGL02375:Ifit2 APN 19 34,551,737 (GRCm39) missense probably benign 0.01
Pushup UTSW 19 34,551,445 (GRCm39) missense probably benign 0.38
R0017:Ifit2 UTSW 19 34,550,973 (GRCm39) missense probably damaging 1.00
R0682:Ifit2 UTSW 19 34,551,012 (GRCm39) missense probably benign 0.13
R0927:Ifit2 UTSW 19 34,550,984 (GRCm39) missense probably benign 0.03
R1462:Ifit2 UTSW 19 34,550,586 (GRCm39) missense probably null 0.12
R1462:Ifit2 UTSW 19 34,550,586 (GRCm39) missense probably null 0.12
R1526:Ifit2 UTSW 19 34,550,602 (GRCm39) missense probably benign 0.00
R2084:Ifit2 UTSW 19 34,550,750 (GRCm39) missense probably damaging 1.00
R3971:Ifit2 UTSW 19 34,551,441 (GRCm39) missense probably benign 0.00
R4008:Ifit2 UTSW 19 34,551,445 (GRCm39) missense probably benign 0.38
R4010:Ifit2 UTSW 19 34,551,445 (GRCm39) missense probably benign 0.38
R4011:Ifit2 UTSW 19 34,551,445 (GRCm39) missense probably benign 0.38
R4359:Ifit2 UTSW 19 34,550,544 (GRCm39) missense possibly damaging 0.85
R5179:Ifit2 UTSW 19 34,550,976 (GRCm39) missense probably damaging 1.00
R5240:Ifit2 UTSW 19 34,551,796 (GRCm39) missense probably benign 0.02
R5424:Ifit2 UTSW 19 34,551,458 (GRCm39) missense probably benign 0.19
R5528:Ifit2 UTSW 19 34,550,937 (GRCm39) missense possibly damaging 0.63
R6605:Ifit2 UTSW 19 34,550,897 (GRCm39) nonsense probably null
R7172:Ifit2 UTSW 19 34,550,894 (GRCm39) missense probably benign 0.24
R7424:Ifit2 UTSW 19 34,550,598 (GRCm39) missense probably benign 0.37
R8090:Ifit2 UTSW 19 34,550,662 (GRCm39) missense possibly damaging 0.70
R8356:Ifit2 UTSW 19 34,550,908 (GRCm39) nonsense probably null
R8553:Ifit2 UTSW 19 34,550,538 (GRCm39) missense probably benign 0.00
X0023:Ifit2 UTSW 19 34,551,650 (GRCm39) missense possibly damaging 0.59
X0064:Ifit2 UTSW 19 34,551,323 (GRCm39) missense probably benign 0.06
Posted On 2012-11-21