Incidental Mutation 'R0853:Ralyl'
ID 82608
Institutional Source Beutler Lab
Gene Symbol Ralyl
Ensembl Gene ENSMUSG00000039717
Gene Name RALY RNA binding protein-like
Synonyms 0710005M24Rik
MMRRC Submission 039032-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.136) question?
Stock # R0853 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 13536715-14247347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 14011566 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 4 (Y4C)
Ref Sequence ENSEMBL: ENSMUSP00000104009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108372] [ENSMUST00000171075] [ENSMUST00000192209] [ENSMUST00000193117] [ENSMUST00000211860]
AlphaFold Q8BTF8
Predicted Effect probably damaging
Transcript: ENSMUST00000108372
AA Change: Y4C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000104009
Gene: ENSMUSG00000039717
AA Change: Y4C

DomainStartEndE-ValueType
low complexity region 53 69 N/A INTRINSIC
coiled coil region 119 182 N/A INTRINSIC
low complexity region 201 214 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000171075
AA Change: Y4C

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000125848
Gene: ENSMUSG00000039717
AA Change: Y4C

DomainStartEndE-ValueType
low complexity region 53 69 N/A INTRINSIC
coiled coil region 119 156 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000192209
AA Change: Y4C

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000142094
Gene: ENSMUSG00000039717
AA Change: Y4C

DomainStartEndE-ValueType
low complexity region 53 69 N/A INTRINSIC
coiled coil region 119 156 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193117
Predicted Effect probably benign
Transcript: ENSMUST00000211860
Meta Mutation Damage Score 0.0643 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 93.9%
Validation Efficiency 93% (42/45)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amotl1 G T 9: 14,504,074 (GRCm39) P378Q probably damaging Het
Angpt4 A G 2: 151,780,847 (GRCm39) E365G probably damaging Het
Asb6 G A 2: 30,717,042 (GRCm39) P61L possibly damaging Het
Atp8a2 T C 14: 60,097,719 (GRCm39) K770E probably benign Het
Atxn7 C A 14: 14,089,465 (GRCm38) probably benign Het
Cacul1 A T 19: 60,522,664 (GRCm39) I290N probably damaging Het
Ccser2 A C 14: 36,662,367 (GRCm39) S272R probably benign Het
Cfh T A 1: 140,033,228 (GRCm39) H772L probably damaging Het
Cldn6 T G 17: 23,900,438 (GRCm39) I134S probably damaging Het
Col3a1 T A 1: 45,382,484 (GRCm39) probably benign Het
Fam118a T C 15: 84,932,726 (GRCm39) F156S possibly damaging Het
Fgd4 T A 16: 16,292,251 (GRCm39) probably benign Het
Gckr G C 5: 31,462,392 (GRCm39) A242P probably damaging Het
Gcnt4 A G 13: 97,083,343 (GRCm39) D213G probably damaging Het
Hace1 T A 10: 45,524,779 (GRCm39) V237E probably damaging Het
Herc3 T C 6: 58,853,549 (GRCm39) L570P probably damaging Het
Hk1 T A 10: 62,107,495 (GRCm39) K827* probably null Het
Hyal6 T C 6: 24,734,072 (GRCm39) F2L probably benign Het
Jak2 C A 19: 29,262,326 (GRCm39) Y382* probably null Het
Kat8 C T 7: 127,524,396 (GRCm39) H425Y probably benign Het
Kcnj3 T C 2: 55,327,235 (GRCm39) F8S possibly damaging Het
Klk1 T A 7: 43,870,922 (GRCm39) probably benign Het
Klra8 T C 6: 130,095,977 (GRCm39) Y205C probably damaging Het
Kpnb1 T C 11: 97,078,237 (GRCm39) E26G probably damaging Het
Mroh2a A G 1: 88,186,386 (GRCm39) S64G probably benign Het
Naip2 T C 13: 100,298,362 (GRCm39) E558G probably benign Het
Naip2 C T 13: 100,298,368 (GRCm39) G556D probably benign Het
Nphp3 T C 9: 103,909,132 (GRCm39) S781P probably benign Het
Nqo2 A T 13: 34,163,560 (GRCm39) H73L probably benign Het
P3h3 G T 6: 124,831,896 (GRCm39) D296E probably benign Het
Pah G A 10: 87,412,080 (GRCm39) probably null Het
Pcdhb4 T G 18: 37,442,938 (GRCm39) Y749* probably null Het
Pdgfrb C A 18: 61,213,399 (GRCm39) N914K probably damaging Het
Rapgef6 T A 11: 54,559,503 (GRCm39) I1052N probably damaging Het
Sdk2 G A 11: 113,712,241 (GRCm39) T1642I probably benign Het
Siglec1 G A 2: 130,926,942 (GRCm39) T207M probably damaging Het
Taf1b T C 12: 24,564,827 (GRCm39) L148P probably benign Het
Tbx20 A G 9: 24,636,908 (GRCm39) M393T probably benign Het
Tdp1 G A 12: 99,901,326 (GRCm39) R536H probably damaging Het
Tubgcp5 T A 7: 55,464,599 (GRCm39) probably benign Het
Vezf1 A T 11: 88,068,435 (GRCm38) probably benign Het
Vmn1r58 G T 7: 5,413,324 (GRCm39) T302K probably damaging Het
Zfp1002 A T 2: 150,097,398 (GRCm39) S38R probably benign Het
Other mutations in Ralyl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02508:Ralyl APN 3 14,172,332 (GRCm39) splice site probably benign
IGL02626:Ralyl APN 3 13,842,094 (GRCm39) missense probably benign 0.00
IGL02950:Ralyl APN 3 14,104,781 (GRCm39) missense probably damaging 1.00
PIT4498001:Ralyl UTSW 3 14,172,299 (GRCm39) missense probably damaging 0.99
R1061:Ralyl UTSW 3 14,180,761 (GRCm39) missense probably damaging 1.00
R1068:Ralyl UTSW 3 13,841,949 (GRCm39) missense probably damaging 1.00
R1655:Ralyl UTSW 3 14,172,296 (GRCm39) missense probably damaging 1.00
R1796:Ralyl UTSW 3 14,208,493 (GRCm39) missense possibly damaging 0.77
R1838:Ralyl UTSW 3 14,208,472 (GRCm39) missense probably damaging 1.00
R4706:Ralyl UTSW 3 14,104,850 (GRCm39) critical splice donor site probably null
R5505:Ralyl UTSW 3 13,841,980 (GRCm39) missense probably damaging 1.00
R5510:Ralyl UTSW 3 13,842,005 (GRCm39) missense probably damaging 1.00
R6844:Ralyl UTSW 3 13,841,938 (GRCm39) missense probably damaging 1.00
R6919:Ralyl UTSW 3 13,842,091 (GRCm39) missense probably damaging 1.00
R7876:Ralyl UTSW 3 14,104,850 (GRCm39) critical splice donor site probably null
R8297:Ralyl UTSW 3 14,104,836 (GRCm39) missense probably benign 0.33
R9292:Ralyl UTSW 3 14,172,312 (GRCm39) missense probably benign 0.06
R9686:Ralyl UTSW 3 13,841,887 (GRCm39) splice site probably benign
Predicted Primers PCR Primer
(F):5'- AGAATGGTATTGCCCTGGCTTTCAC -3'
(R):5'- ACTGAGAAGTTTGGCAGGACATAGC -3'

Sequencing Primer
(F):5'- CACTGTGTGATTGCTGGTTACC -3'
(R):5'- CCCTGCATGAATGAAGGCTG -3'
Posted On 2013-11-08