Incidental Mutation 'R0942:Il16'
ID 82751
Institutional Source Beutler Lab
Gene Symbol Il16
Ensembl Gene ENSMUSG00000001741
Gene Name interleukin 16
Synonyms
MMRRC Submission 039081-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.255) question?
Stock # R0942 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 83292033-83394934 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 83312349 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 445 (Q445L)
Ref Sequence ENSEMBL: ENSMUSP00000001792 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001792] [ENSMUST00000153560]
AlphaFold O54824
Predicted Effect probably benign
Transcript: ENSMUST00000001792
AA Change: Q445L

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000001792
Gene: ENSMUSG00000001741
AA Change: Q445L

DomainStartEndE-ValueType
low complexity region 76 92 N/A INTRINSIC
low complexity region 99 115 N/A INTRINSIC
PDZ 222 300 6.5e-23 SMART
PDZ 361 438 3.89e-12 SMART
low complexity region 507 526 N/A INTRINSIC
low complexity region 556 577 N/A INTRINSIC
low complexity region 589 602 N/A INTRINSIC
low complexity region 647 680 N/A INTRINSIC
low complexity region 776 787 N/A INTRINSIC
low complexity region 825 839 N/A INTRINSIC
low complexity region 978 989 N/A INTRINSIC
PDZ 1115 1192 3.6e-16 SMART
low complexity region 1201 1216 N/A INTRINSIC
PDZ 1234 1310 4.11e-11 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125131
Predicted Effect probably benign
Transcript: ENSMUST00000153560
SMART Domains Protein: ENSMUSP00000118516
Gene: ENSMUSG00000001741

DomainStartEndE-ValueType
low complexity region 76 92 N/A INTRINSIC
low complexity region 99 115 N/A INTRINSIC
Meta Mutation Damage Score 0.0856 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 97.7%
  • 20x: 95.9%
Validation Efficiency 95% (40/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
PHENOTYPE: Mice homozygous for a knock-out allele display a transient but consistent increase of thymidine incorporation in anti-CD3-stimulated CD4+ T cells, but fail to show a hyperproliferative T cell phenotype using BrdU labeling. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810064F22Rik C T 9: 22,119,367 (GRCm39) noncoding transcript Het
Aass C T 6: 23,075,151 (GRCm39) probably benign Het
Abcb5 C A 12: 118,869,933 (GRCm39) V742F possibly damaging Het
Abcd4 A G 12: 84,659,602 (GRCm39) I165T probably damaging Het
Acer3 T C 7: 97,906,949 (GRCm39) Y119C probably damaging Het
Ap3d1 A T 10: 80,568,789 (GRCm39) probably benign Het
Ascc2 T A 11: 4,618,380 (GRCm39) I325N probably benign Het
Atad2b T A 12: 5,074,591 (GRCm39) I1050N probably damaging Het
Brms1l T C 12: 55,912,742 (GRCm39) V245A probably benign Het
Cadps2 T A 6: 23,263,561 (GRCm39) D1270V probably damaging Het
Cdh23 A T 10: 60,246,639 (GRCm39) M936K possibly damaging Het
Cenpj A G 14: 56,792,666 (GRCm39) probably benign Het
Dner T C 1: 84,563,030 (GRCm39) probably benign Het
Dzip1 T A 14: 119,124,609 (GRCm39) R555* probably null Het
Enpp4 A T 17: 44,412,772 (GRCm39) L254* probably null Het
Erich3 T A 3: 154,444,788 (GRCm39) D518E probably benign Het
Gli2 G A 1: 118,765,236 (GRCm39) R972C probably damaging Het
Gpc1 G A 1: 92,785,031 (GRCm39) R358H possibly damaging Het
Grb7 T C 11: 98,344,634 (GRCm39) Y346H probably damaging Het
Heg1 T C 16: 33,581,173 (GRCm39) L1192P probably damaging Het
Il17d C T 14: 57,779,777 (GRCm39) probably benign Het
Kmt2c A T 5: 25,520,301 (GRCm39) N1936K probably benign Het
Lrrc45 T C 11: 120,609,064 (GRCm39) probably benign Het
Mib2 C T 4: 155,743,917 (GRCm39) G42S probably damaging Het
Mphosph9 T A 5: 124,400,100 (GRCm39) R934* probably null Het
Nek11 T A 9: 105,172,570 (GRCm39) probably null Het
Nf1 T C 11: 79,329,537 (GRCm39) S634P probably benign Het
Or14c40 T A 7: 86,313,314 (GRCm39) M148K probably damaging Het
Pkhd1l1 T C 15: 44,396,355 (GRCm39) V1959A probably benign Het
Pkp2 G T 16: 16,043,894 (GRCm39) G216V probably benign Het
Ppp1r16a T C 15: 76,578,211 (GRCm39) L394P probably damaging Het
Ptprc G A 1: 137,996,139 (GRCm39) Q1070* probably null Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rprd2 A T 3: 95,672,730 (GRCm39) I891N probably damaging Het
Speer1e A T 5: 11,236,488 (GRCm39) T174S probably benign Het
Taf15 T C 11: 83,389,932 (GRCm39) I40T probably damaging Het
Tshz1 A G 18: 84,031,178 (GRCm39) Y1077H probably damaging Het
Ttn T C 2: 76,693,833 (GRCm39) E223G possibly damaging Het
Other mutations in Il16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Il16 APN 7 83,301,666 (GRCm39) missense probably benign 0.02
IGL01743:Il16 APN 7 83,301,507 (GRCm39) missense probably benign 0.00
IGL01770:Il16 APN 7 83,322,234 (GRCm39) splice site probably benign
IGL02025:Il16 APN 7 83,302,056 (GRCm39) missense probably damaging 1.00
IGL02317:Il16 APN 7 83,316,097 (GRCm39) missense probably damaging 1.00
IGL02412:Il16 APN 7 83,301,899 (GRCm39) missense probably benign 0.03
IGL02550:Il16 APN 7 83,323,704 (GRCm39) missense possibly damaging 0.90
IGL02568:Il16 APN 7 83,310,484 (GRCm39) missense probably damaging 1.00
IGL02578:Il16 APN 7 83,327,194 (GRCm39) critical splice donor site probably null
IGL02815:Il16 APN 7 83,300,249 (GRCm39) missense probably damaging 0.98
IGL03157:Il16 APN 7 83,371,611 (GRCm39) missense probably damaging 1.00
IGL03161:Il16 APN 7 83,371,707 (GRCm39) missense probably damaging 1.00
IGL03188:Il16 APN 7 83,337,371 (GRCm39) missense probably benign 0.00
IGL03213:Il16 APN 7 83,295,708 (GRCm39) missense probably damaging 1.00
IGL03274:Il16 APN 7 83,310,442 (GRCm39) missense probably damaging 1.00
R0201:Il16 UTSW 7 83,371,516 (GRCm39) missense probably damaging 0.99
R0309:Il16 UTSW 7 83,371,762 (GRCm39) missense probably damaging 1.00
R0597:Il16 UTSW 7 83,327,183 (GRCm39) splice site probably benign
R1018:Il16 UTSW 7 83,323,746 (GRCm39) missense probably damaging 1.00
R1434:Il16 UTSW 7 83,304,520 (GRCm39) missense probably benign
R1715:Il16 UTSW 7 83,297,936 (GRCm39) missense probably benign 0.01
R2179:Il16 UTSW 7 83,337,287 (GRCm39) splice site probably null
R2520:Il16 UTSW 7 83,301,202 (GRCm39) missense probably benign 0.03
R3425:Il16 UTSW 7 83,293,248 (GRCm39) missense probably damaging 1.00
R3761:Il16 UTSW 7 83,300,093 (GRCm39) missense possibly damaging 0.96
R3943:Il16 UTSW 7 83,301,223 (GRCm39) missense probably damaging 0.97
R4470:Il16 UTSW 7 83,300,046 (GRCm39) intron probably benign
R4530:Il16 UTSW 7 83,330,518 (GRCm39) intron probably benign
R4583:Il16 UTSW 7 83,332,107 (GRCm39) missense probably damaging 1.00
R4777:Il16 UTSW 7 83,300,104 (GRCm39) missense probably benign 0.14
R4874:Il16 UTSW 7 83,310,153 (GRCm39) missense possibly damaging 0.56
R4876:Il16 UTSW 7 83,322,302 (GRCm39) missense probably benign
R5677:Il16 UTSW 7 83,323,761 (GRCm39) missense probably damaging 1.00
R5686:Il16 UTSW 7 83,297,936 (GRCm39) missense probably benign 0.36
R5920:Il16 UTSW 7 83,301,552 (GRCm39) missense probably benign 0.03
R6115:Il16 UTSW 7 83,301,775 (GRCm39) nonsense probably null
R6459:Il16 UTSW 7 83,371,536 (GRCm39) missense probably damaging 1.00
R6459:Il16 UTSW 7 83,371,529 (GRCm39) missense probably damaging 1.00
R6601:Il16 UTSW 7 83,371,677 (GRCm39) missense probably damaging 1.00
R6616:Il16 UTSW 7 83,295,684 (GRCm39) missense probably benign 0.37
R6642:Il16 UTSW 7 83,337,335 (GRCm39) missense probably benign 0.03
R6721:Il16 UTSW 7 83,312,270 (GRCm39) critical splice donor site probably null
R7009:Il16 UTSW 7 83,295,596 (GRCm39) missense probably benign
R7144:Il16 UTSW 7 83,295,659 (GRCm39) missense probably damaging 0.97
R7346:Il16 UTSW 7 83,293,249 (GRCm39) missense probably damaging 1.00
R7403:Il16 UTSW 7 83,319,343 (GRCm39) missense probably damaging 1.00
R7499:Il16 UTSW 7 83,323,702 (GRCm39) missense probably damaging 0.99
R7814:Il16 UTSW 7 83,319,348 (GRCm39) missense possibly damaging 0.46
R7941:Il16 UTSW 7 83,332,037 (GRCm39) missense probably damaging 0.98
R8098:Il16 UTSW 7 83,295,767 (GRCm39) missense probably damaging 1.00
R8317:Il16 UTSW 7 83,304,538 (GRCm39) missense probably benign
R8437:Il16 UTSW 7 83,301,351 (GRCm39) missense probably damaging 1.00
R9094:Il16 UTSW 7 83,301,559 (GRCm39) missense probably benign
R9267:Il16 UTSW 7 83,371,757 (GRCm39) missense probably benign 0.01
R9445:Il16 UTSW 7 83,337,380 (GRCm39) nonsense probably null
R9595:Il16 UTSW 7 83,322,273 (GRCm39) nonsense probably null
R9651:Il16 UTSW 7 83,332,064 (GRCm39) missense probably damaging 0.96
Z1176:Il16 UTSW 7 83,302,035 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ACATGACTGGCAAGGCATCTTCC -3'
(R):5'- AGGGCACTTCCAGAAGCTGATTG -3'

Sequencing Primer
(F):5'- ATTTGAAGCCTACTGGGGCAC -3'
(R):5'- GGTCAGCTCTTGCAGAGTG -3'
Posted On 2013-11-08