Incidental Mutation 'R0920:Crp'
ID 82806
Institutional Source Beutler Lab
Gene Symbol Crp
Ensembl Gene ENSMUSG00000037942
Gene Name C-reactive protein, pentraxin-related
Synonyms
MMRRC Submission 039070-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0920 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 172525623-172527533 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 172526089 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 58 (F58S)
Ref Sequence ENSEMBL: ENSMUSP00000044665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038495]
AlphaFold P14847
Predicted Effect probably damaging
Transcript: ENSMUST00000038495
AA Change: F58S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000044665
Gene: ENSMUSG00000037942
AA Change: F58S

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
PTX 20 225 4.55e-132 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194251
Meta Mutation Damage Score 0.6158 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm2 T C 4: 144,287,696 (GRCm39) probably benign Het
Adamts16 A G 13: 70,911,680 (GRCm39) probably benign Het
Adgra3 A G 5: 50,118,503 (GRCm39) V1015A probably benign Het
Armc5 G T 7: 127,839,491 (GRCm39) A270S probably damaging Het
Cacng1 A C 11: 107,596,682 (GRCm39) probably benign Het
Ccdc33 T C 9: 57,940,955 (GRCm39) D429G probably damaging Het
Ccdc88b G T 19: 6,824,017 (GRCm39) A1412E probably benign Het
Cfap298 C T 16: 90,724,267 (GRCm39) E125K probably damaging Het
Clock A T 5: 76,378,167 (GRCm39) S578T possibly damaging Het
Dlg5 T A 14: 24,226,465 (GRCm39) Q125L probably damaging Het
Eif3i T C 4: 129,489,050 (GRCm39) probably benign Het
Gucy1a2 A C 9: 3,759,472 (GRCm39) D426A probably damaging Het
Hpcal1 C T 12: 17,841,098 (GRCm39) probably benign Het
Inf2 T A 12: 112,576,721 (GRCm39) probably benign Het
Kdm7a A G 6: 39,128,256 (GRCm39) L525P probably damaging Het
Kirrel3 A T 9: 34,939,648 (GRCm39) I152F probably damaging Het
Knl1 T A 2: 118,900,309 (GRCm39) I670K probably benign Het
Krt76 T C 15: 101,800,874 (GRCm39) T141A possibly damaging Het
Ldb3 T C 14: 34,289,460 (GRCm39) T249A probably benign Het
Magi3 A T 3: 103,941,507 (GRCm39) probably null Het
Mfn1 A G 3: 32,588,385 (GRCm39) probably null Het
Myb G T 10: 21,002,133 (GRCm39) T736K possibly damaging Het
Myo5b A C 18: 74,758,712 (GRCm39) K231T probably benign Het
Myt1l T A 12: 29,936,138 (GRCm39) C909S unknown Het
Npas4 C A 19: 5,036,344 (GRCm39) E607* probably null Het
Nphp3 A G 9: 103,909,106 (GRCm39) N772S probably benign Het
Nup88 G T 11: 70,847,146 (GRCm39) P288Q possibly damaging Het
Or2l13 A T 16: 19,305,680 (GRCm39) I31F probably benign Het
Pknox1 C A 17: 31,815,865 (GRCm39) Q240K probably damaging Het
Plce1 A C 19: 38,724,965 (GRCm39) T1439P probably damaging Het
Ppp1r42 T A 1: 10,069,750 (GRCm39) N104I probably damaging Het
Prkar2a T A 9: 108,596,496 (GRCm39) probably benign Het
Stox2 C T 8: 47,646,053 (GRCm39) R469Q probably damaging Het
Syna A G 5: 134,587,956 (GRCm39) V331A probably benign Het
Vmn1r58 A T 7: 5,413,788 (GRCm39) N147K probably benign Het
Zdhhc6 A T 19: 55,300,133 (GRCm39) L148H probably damaging Het
Other mutations in Crp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00586:Crp APN 1 172,526,568 (GRCm39) missense probably benign 0.19
R1871:Crp UTSW 1 172,526,172 (GRCm39) missense possibly damaging 0.79
R4543:Crp UTSW 1 172,526,304 (GRCm39) missense probably benign
R4648:Crp UTSW 1 172,525,704 (GRCm39) start codon destroyed probably null 0.24
R5213:Crp UTSW 1 172,526,086 (GRCm39) missense probably benign 0.00
R5407:Crp UTSW 1 172,525,676 (GRCm39) start gained probably null
R5822:Crp UTSW 1 172,525,635 (GRCm39) utr 5 prime probably benign
R7816:Crp UTSW 1 172,526,277 (GRCm39) missense possibly damaging 0.73
R8786:Crp UTSW 1 172,526,293 (GRCm39) missense probably benign 0.00
R9234:Crp UTSW 1 172,526,413 (GRCm39) missense probably damaging 0.99
R9274:Crp UTSW 1 172,526,072 (GRCm39) missense possibly damaging 0.76
Predicted Primers PCR Primer
(F):5'- AGAGGACCAGATGACCCTTGATCC -3'
(R):5'- CTTTGCATCAAAGTCACCGCCATAC -3'

Sequencing Primer
(F):5'- TTGATCCCAAACTCTACCTGTAAGG -3'
(R):5'- CCAAGATGATGCTTGCATCTG -3'
Posted On 2013-11-08