Incidental Mutation 'R0925:Cdh11'
ID 83151
Institutional Source Beutler Lab
Gene Symbol Cdh11
Ensembl Gene ENSMUSG00000031673
Gene Name cadherin 11
Synonyms Cad11, osteoblast-cadherin, OB-cadherin
MMRRC Submission 039072-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0925 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 103358727-103512125 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 103361356 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 661 (I661L)
Ref Sequence ENSEMBL: ENSMUSP00000074681 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075190]
AlphaFold P55288
PDB Structure Crystal structure of mouse cadherin-11 EC1 [X-RAY DIFFRACTION]
Crystal structure of mouse cadherin-11 EC1-2 [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000075190
AA Change: I661L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074681
Gene: ENSMUSG00000031673
AA Change: I661L

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 76 157 1.99e-19 SMART
CA 181 266 3.33e-30 SMART
CA 290 382 3.37e-17 SMART
CA 405 486 1.14e-23 SMART
CA 513 600 4.77e-8 SMART
transmembrane domain 618 640 N/A INTRINSIC
Pfam:Cadherin_C 643 788 1.1e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210578
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a type II classical cadherin and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is an integral membrane protein that mediates calcium-dependent cell-cell adhesion, specifically in the context of bone development. Homozygous knockout mice for this gene exhibit impaired synovium development and reduced bone density. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
PHENOTYPE: Homozygous mutant animals appear healthy and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T C 8: 44,079,340 (GRCm39) I295V probably benign Het
Adam5 T C 8: 25,302,441 (GRCm39) Q101R probably benign Het
C2cd4c T C 10: 79,448,584 (GRCm39) N188D probably benign Het
Cdc27 A G 11: 104,416,875 (GRCm39) probably null Het
Cimip1 T A 2: 173,367,867 (GRCm39) S47T probably benign Het
Csmd1 A G 8: 16,760,634 (GRCm39) I167T probably benign Het
Dennd3 T G 15: 73,405,284 (GRCm39) F346V probably damaging Het
Dis3l A T 9: 64,248,412 (GRCm39) M1K probably null Het
Dnajb6 A T 5: 29,957,398 (GRCm39) K60I probably damaging Het
Dock10 T A 1: 80,514,657 (GRCm39) H1421L probably benign Het
Elmod3 A T 6: 72,545,921 (GRCm39) C274S probably damaging Het
Eme1 T C 11: 94,541,558 (GRCm39) E88G probably damaging Het
Fam227a A T 15: 79,505,006 (GRCm39) M475K probably benign Het
Frem2 T C 3: 53,561,394 (GRCm39) I1038V probably benign Het
Gabpb1 T A 2: 126,494,185 (GRCm39) N147Y probably damaging Het
Gmnc A G 16: 26,779,173 (GRCm39) L278P probably benign Het
Gpr153 A G 4: 152,366,331 (GRCm39) T299A probably benign Het
H2-M11 T C 17: 36,858,353 (GRCm39) V49A probably benign Het
Hemgn T A 4: 46,397,049 (GRCm39) K62N probably damaging Het
Hormad2 G A 11: 4,377,297 (GRCm39) T47M probably damaging Het
Iqcf6 A G 9: 106,504,500 (GRCm39) T55A probably benign Het
Itgam T C 7: 127,711,410 (GRCm39) F705L probably benign Het
Klk1 T A 7: 43,878,240 (GRCm39) probably null Het
Myo1f A T 17: 33,797,107 (GRCm39) I123F probably damaging Het
Nup58 T C 14: 60,457,590 (GRCm39) T538A probably damaging Het
Or52j3 T A 7: 102,836,030 (GRCm39) L74* probably null Het
Or5p81 C T 7: 108,267,400 (GRCm39) T259I probably benign Het
Pdzd2 C T 15: 12,399,356 (GRCm39) R790H probably damaging Het
Pigv T C 4: 133,389,960 (GRCm39) K74R probably benign Het
Prmt8 T C 6: 127,674,776 (GRCm39) K284R probably benign Het
Rsl1d1 A T 16: 11,017,553 (GRCm39) Y138N probably damaging Het
Scara5 AC ACC 14: 66,000,167 (GRCm39) probably benign Het
Smc4 T A 3: 68,913,548 (GRCm39) probably benign Het
Spta1 G A 1: 174,001,992 (GRCm39) V41I possibly damaging Het
Tdrd7 C A 4: 46,025,758 (GRCm39) N859K probably damaging Het
Vps13d T G 4: 144,883,121 (GRCm39) D824A probably damaging Het
Wdfy2 A T 14: 63,167,675 (GRCm39) probably null Het
Other mutations in Cdh11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00598:Cdh11 APN 8 103,377,281 (GRCm39) missense probably damaging 1.00
IGL01019:Cdh11 APN 8 103,406,377 (GRCm39) missense probably benign
IGL01286:Cdh11 APN 8 103,391,261 (GRCm39) missense probably damaging 0.98
IGL01556:Cdh11 APN 8 103,406,276 (GRCm39) missense probably damaging 1.00
IGL01964:Cdh11 APN 8 103,391,375 (GRCm39) missense probably benign 0.03
IGL02322:Cdh11 APN 8 103,374,151 (GRCm39) missense probably benign 0.01
IGL03094:Cdh11 APN 8 103,385,035 (GRCm39) missense probably benign
IGL03110:Cdh11 APN 8 103,400,502 (GRCm39) missense probably damaging 1.00
IGL03391:Cdh11 APN 8 103,400,655 (GRCm39) missense possibly damaging 0.89
R0401:Cdh11 UTSW 8 103,400,638 (GRCm39) missense probably damaging 1.00
R0466:Cdh11 UTSW 8 103,396,690 (GRCm39) missense possibly damaging 0.89
R0731:Cdh11 UTSW 8 103,394,651 (GRCm39) missense probably damaging 1.00
R1597:Cdh11 UTSW 8 103,377,343 (GRCm39) missense probably benign 0.06
R1624:Cdh11 UTSW 8 103,391,233 (GRCm39) splice site probably benign
R1829:Cdh11 UTSW 8 103,361,273 (GRCm39) missense possibly damaging 0.92
R2029:Cdh11 UTSW 8 103,406,404 (GRCm39) missense probably benign 0.00
R4191:Cdh11 UTSW 8 103,377,380 (GRCm39) missense probably damaging 0.98
R4270:Cdh11 UTSW 8 103,391,258 (GRCm39) missense possibly damaging 0.69
R4271:Cdh11 UTSW 8 103,391,258 (GRCm39) missense possibly damaging 0.69
R4455:Cdh11 UTSW 8 103,374,455 (GRCm39) missense probably benign
R4516:Cdh11 UTSW 8 103,400,594 (GRCm39) missense possibly damaging 0.59
R4900:Cdh11 UTSW 8 103,374,090 (GRCm39) splice site probably null
R5441:Cdh11 UTSW 8 103,374,178 (GRCm39) missense probably benign 0.11
R5699:Cdh11 UTSW 8 103,361,175 (GRCm39) missense probably damaging 0.96
R6170:Cdh11 UTSW 8 103,361,442 (GRCm39) missense probably benign 0.00
R6846:Cdh11 UTSW 8 103,391,276 (GRCm39) missense probably damaging 0.97
R7018:Cdh11 UTSW 8 103,360,953 (GRCm39) missense possibly damaging 0.82
R7095:Cdh11 UTSW 8 103,384,899 (GRCm39) missense probably damaging 1.00
R7497:Cdh11 UTSW 8 103,400,456 (GRCm39) missense probably benign 0.00
R7632:Cdh11 UTSW 8 103,400,515 (GRCm39) missense probably damaging 0.99
R7715:Cdh11 UTSW 8 103,391,346 (GRCm39) missense possibly damaging 0.66
R8321:Cdh11 UTSW 8 103,361,416 (GRCm39) missense probably damaging 0.99
R8529:Cdh11 UTSW 8 103,391,387 (GRCm39) missense probably benign 0.01
R8530:Cdh11 UTSW 8 103,391,387 (GRCm39) missense probably benign 0.01
R8682:Cdh11 UTSW 8 103,377,348 (GRCm39) missense probably benign 0.24
R9105:Cdh11 UTSW 8 103,360,968 (GRCm39) missense probably damaging 0.99
R9404:Cdh11 UTSW 8 103,406,254 (GRCm39) missense probably damaging 1.00
R9660:Cdh11 UTSW 8 103,384,879 (GRCm39) missense possibly damaging 0.70
R9684:Cdh11 UTSW 8 103,391,327 (GRCm39) missense probably benign 0.04
R9721:Cdh11 UTSW 8 103,406,257 (GRCm39) missense probably damaging 1.00
R9802:Cdh11 UTSW 8 103,391,276 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- AGTCGTCCACATCCACACTGTTG -3'
(R):5'- CTTGCTGATTCTTCAGAGGACTGCC -3'

Sequencing Primer
(F):5'- ACATCCACACTGTTGGGTGC -3'
(R):5'- TGCTGAAGATAGTTCCGACC -3'
Posted On 2013-11-08