Mutagenetix > Incidental Mutation

Incidental Mutation 'R0904:Pate5'

83255

Institutional Source

Beutler Lab

Gene Symbol

Pate5

Ensembl Gene

ENSMUSG00000047980

Gene Name

prostate and testis expressed 5

Synonyms

Pate-A, 9230110F15Rik, mANLP3, D730048I06Rik, Pate-C, Anlp2

MMRRC Submission

039062-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R0904 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

35749625-35755446 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 35750366 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 102 (D102G)

Ref Sequence

ENSEMBL: ENSMUSP00000051917 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054175]

AlphaFold

Q9D262

Predicted Effect

probably damaging
Transcript: ENSMUST00000054175
AA Change: D102G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000051917
Gene: ENSMUSG00000047980
AA Change: D102G

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194200

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.2%
20x: 94.7%

Validation Efficiency

89% (34/38)

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700011L22Rik	A	G	8: 79,975,118 (GRCm39)		probably benign	Het
Abca13	T	C	11: 9,248,740 (GRCm39)	V2829A	probably benign	Het
Adk	G	T	14: 21,142,496 (GRCm39)	D26Y	probably damaging	Het
Bpifb9a	T	C	2: 154,106,145 (GRCm39)		probably benign	Het
Dap	G	A	15: 31,272,526 (GRCm39)		probably benign	Het
Eqtn	A	T	4: 94,795,892 (GRCm39)	S270T	probably benign	Het
Fam193a	A	G	5: 34,619,487 (GRCm39)	D764G	probably damaging	Het
Fbxl6	A	T	15: 76,421,283 (GRCm39)		probably null	Het
Gtf3c1	A	T	7: 125,268,014 (GRCm39)		probably benign	Het
H2-D1	G	C	17: 35,482,837 (GRCm39)	M122I	probably benign	Het
Lgr6	C	T	1: 134,921,748 (GRCm39)	A199T	probably damaging	Het
Map1s	C	A	8: 71,366,832 (GRCm39)	P579Q	probably damaging	Het
Mapk10	A	G	5: 103,135,146 (GRCm39)		probably benign	Het
Mllt6	C	G	11: 97,555,824 (GRCm39)	C51W	probably damaging	Het
Mzf1	C	A	7: 12,786,698 (GRCm39)	R124L	possibly damaging	Het
Naip2	T	C	13: 100,298,362 (GRCm39)	E558G	probably benign	Het
Naip2	C	T	13: 100,298,368 (GRCm39)	G556D	probably benign	Het
Neurod2	G	T	11: 98,218,147 (GRCm39)	T339K	probably benign	Het
Nfya	G	A	17: 48,702,815 (GRCm39)	Q29*	probably null	Het
Nipbl	A	T	15: 8,391,202 (GRCm39)	D257E	probably benign	Het
Pex5	G	A	6: 124,376,896 (GRCm39)		probably benign	Het
Pramel47	A	C	5: 95,489,186 (GRCm39)	T210P	probably damaging	Het
Prx	T	A	7: 27,217,719 (GRCm39)	F879Y	probably damaging	Het
Resf1	G	A	6: 149,229,767 (GRCm39)	A938T	probably damaging	Het
Scai	G	A	2: 38,965,164 (GRCm39)	T560M	possibly damaging	Het
Slfn10-ps	T	C	11: 82,926,235 (GRCm39)		noncoding transcript	Het
Spdye4b	A	G	5: 143,181,423 (GRCm39)		probably benign	Het
Ss18l1	A	G	2: 179,701,147 (GRCm39)	Y287C	probably damaging	Het
Tpbg	C	A	9: 85,726,617 (GRCm39)	F195L	unknown	Het
Trbv16	T	C	6: 41,128,781 (GRCm39)		probably benign	Het
Unc5c	A	G	3: 141,509,601 (GRCm39)	T620A	probably benign	Het
Vangl1	A	G	3: 102,091,310 (GRCm39)	S259P	probably damaging	Het
Vmn1r52	T	A	6: 90,156,446 (GRCm39)	M71K	probably damaging	Het
Vmn2r23	A	T	6: 123,719,094 (GRCm39)	I816F	probably damaging	Het
Zfp268	T	C	4: 145,348,745 (GRCm39)	Y61H	possibly damaging	Het

Other mutations in Pate5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02732:Pate5	APN	9	35,750,345 (GRCm39)	missense	probably damaging	1.00
R1599:Pate5	UTSW	9	35,750,333 (GRCm39)	missense	probably benign	0.05
R2135:Pate5	UTSW	9	35,750,479 (GRCm39)	splice site	probably null
R4135:Pate5	UTSW	9	35,750,724 (GRCm39)	missense	possibly damaging	0.94
R4951:Pate5	UTSW	9	35,750,732 (GRCm39)	missense	probably damaging	0.99
R6455:Pate5	UTSW	9	35,755,351 (GRCm39)	nonsense	probably null
R6567:Pate5	UTSW	9	35,750,411 (GRCm39)	missense	probably benign	0.14
R8206:Pate5	UTSW	9	35,750,719 (GRCm39)	missense	possibly damaging	0.77
R8889:Pate5	UTSW	9	35,750,682 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGTGAGCTTCTCTAGCCAAATGC -3'
(R):5'- GCCTGGATGCAGAACCAGGAATTAC -3'

Sequencing Primer
(F):5'- AAACTTTGAATGCATGACCCTTCC -3'
(R):5'- GAGAAGAAGCTATATTCCTCCTCGG -3'

Posted On

2013-11-08