Incidental Mutation 'R0908:Gle1'
ID 83380
Institutional Source Beutler Lab
Gene Symbol Gle1
Ensembl Gene ENSMUSG00000019715
Gene Name GLE1 RNA export mediator
Synonyms 4933405K21Rik
MMRRC Submission 039066-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0908 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 29825421-29849444 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 29826133 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 71 (S71P)
Ref Sequence ENSEMBL: ENSMUSP00000019859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019859] [ENSMUST00000046571] [ENSMUST00000113756] [ENSMUST00000113759]
AlphaFold Q8R322
Predicted Effect probably benign
Transcript: ENSMUST00000019859
AA Change: S71P

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000019859
Gene: ENSMUSG00000019715
AA Change: S71P

DomainStartEndE-ValueType
low complexity region 67 88 N/A INTRINSIC
low complexity region 91 105 N/A INTRINSIC
coiled coil region 154 275 N/A INTRINSIC
coiled coil region 306 356 N/A INTRINSIC
Pfam:GLE1 397 650 2.4e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000046571
SMART Domains Protein: ENSMUSP00000049272
Gene: ENSMUSG00000026790

DomainStartEndE-ValueType
internal_repeat_2 120 138 1.77e-5 PROSPERO
coiled coil region 139 211 N/A INTRINSIC
internal_repeat_2 218 236 1.77e-5 PROSPERO
internal_repeat_1 262 298 8.12e-7 PROSPERO
internal_repeat_1 461 495 8.12e-7 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000113756
SMART Domains Protein: ENSMUSP00000109385
Gene: ENSMUSG00000026790

DomainStartEndE-ValueType
internal_repeat_2 120 138 1.77e-5 PROSPERO
coiled coil region 139 211 N/A INTRINSIC
internal_repeat_2 218 236 1.77e-5 PROSPERO
internal_repeat_1 262 298 8.12e-7 PROSPERO
internal_repeat_1 461 495 8.12e-7 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000113759
SMART Domains Protein: ENSMUSP00000109388
Gene: ENSMUSG00000026790

DomainStartEndE-ValueType
internal_repeat_2 120 138 1.82e-5 PROSPERO
coiled coil region 139 211 N/A INTRINSIC
internal_repeat_2 218 236 1.82e-5 PROSPERO
internal_repeat_1 262 299 1.55e-6 PROSPERO
internal_repeat_1 462 496 1.55e-6 PROSPERO
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148983
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154490
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157723
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.4%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T A 3: 137,775,838 (GRCm39) F1676I probably damaging Het
Afg2a T A 3: 37,485,772 (GRCm39) probably null Het
Atp8a2 T C 14: 60,097,719 (GRCm39) K770E probably benign Het
Atp8b3 T C 10: 80,355,918 (GRCm39) T1265A probably benign Het
Cep112 T C 11: 108,555,323 (GRCm39) V679A possibly damaging Het
Cts8 A T 13: 61,398,730 (GRCm39) Y259N probably damaging Het
Depdc7 A G 2: 104,558,437 (GRCm39) S195P probably benign Het
Dio2 A T 12: 90,696,422 (GRCm39) C189S probably damaging Het
Dmc1 A G 15: 79,469,890 (GRCm39) L189P probably damaging Het
Ehmt1 A G 2: 24,694,900 (GRCm39) Y1016H probably damaging Het
Gykl1 T A 18: 52,828,441 (GRCm39) *550K probably null Het
Klhl32 T C 4: 24,682,092 (GRCm39) D197G probably damaging Het
Krt78 G A 15: 101,859,336 (GRCm39) T287M probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Mrpl1 A T 5: 96,409,942 (GRCm39) I272L probably benign Het
Naip2 T C 13: 100,298,362 (GRCm39) E558G probably benign Het
Naip2 C T 13: 100,298,368 (GRCm39) G556D probably benign Het
Or52e19 T C 7: 102,959,780 (GRCm39) V284A possibly damaging Het
Or8g23 T C 9: 38,971,243 (GRCm39) T240A probably damaging Het
Pak3 TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC X: 142,526,889 (GRCm39) probably benign Het
Pde5a A T 3: 122,572,650 (GRCm39) I344L probably benign Het
Prl7c1 A G 13: 27,957,717 (GRCm39) I241T possibly damaging Het
Rp1 T C 1: 4,414,878 (GRCm39) E2078G probably benign Het
Scamp3 T C 3: 89,086,746 (GRCm39) probably null Het
Septin8 A G 11: 53,428,697 (GRCm39) H414R probably benign Het
Spef2 T A 15: 9,614,281 (GRCm39) probably null Het
Txlnb A G 10: 17,674,925 (GRCm39) N26S probably damaging Het
Vmn1r11 G T 6: 57,115,049 (GRCm39) V201L probably damaging Het
Other mutations in Gle1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00329:Gle1 APN 2 29,829,301 (GRCm39) splice site probably benign
IGL01880:Gle1 APN 2 29,833,762 (GRCm39) missense possibly damaging 0.53
IGL02293:Gle1 APN 2 29,847,772 (GRCm39) missense probably benign 0.00
IGL02859:Gle1 APN 2 29,839,240 (GRCm39) missense probably damaging 1.00
IGL03368:Gle1 APN 2 29,833,805 (GRCm39) missense probably damaging 1.00
R0535:Gle1 UTSW 2 29,847,817 (GRCm39) missense probably damaging 1.00
R0608:Gle1 UTSW 2 29,830,240 (GRCm39) missense probably benign 0.01
R0839:Gle1 UTSW 2 29,848,462 (GRCm39) missense probably benign 0.28
R1102:Gle1 UTSW 2 29,834,066 (GRCm39) missense possibly damaging 0.88
R1202:Gle1 UTSW 2 29,839,277 (GRCm39) missense probably damaging 1.00
R1302:Gle1 UTSW 2 29,842,564 (GRCm39) splice site probably null
R2184:Gle1 UTSW 2 29,839,030 (GRCm39) missense probably damaging 1.00
R2213:Gle1 UTSW 2 29,839,313 (GRCm39) missense probably damaging 0.97
R4151:Gle1 UTSW 2 29,834,056 (GRCm39) missense probably damaging 1.00
R4172:Gle1 UTSW 2 29,828,538 (GRCm39) missense probably benign
R4732:Gle1 UTSW 2 29,830,244 (GRCm39) missense probably damaging 0.96
R4733:Gle1 UTSW 2 29,830,244 (GRCm39) missense probably damaging 0.96
R4775:Gle1 UTSW 2 29,826,073 (GRCm39) missense possibly damaging 0.86
R4817:Gle1 UTSW 2 29,826,223 (GRCm39) missense probably benign 0.00
R4824:Gle1 UTSW 2 29,830,215 (GRCm39) missense possibly damaging 0.82
R4869:Gle1 UTSW 2 29,826,032 (GRCm39) missense possibly damaging 0.69
R4909:Gle1 UTSW 2 29,826,092 (GRCm39) missense probably benign 0.01
R5036:Gle1 UTSW 2 29,826,223 (GRCm39) missense probably benign 0.00
R5298:Gle1 UTSW 2 29,838,955 (GRCm39) missense probably benign 0.02
R5903:Gle1 UTSW 2 29,830,293 (GRCm39) missense probably benign 0.00
R6345:Gle1 UTSW 2 29,826,127 (GRCm39) missense probably benign 0.00
R6529:Gle1 UTSW 2 29,825,539 (GRCm39) missense possibly damaging 0.56
R7144:Gle1 UTSW 2 29,833,805 (GRCm39) missense probably damaging 1.00
R7984:Gle1 UTSW 2 29,828,588 (GRCm39) missense probably damaging 0.99
R8154:Gle1 UTSW 2 29,828,619 (GRCm39) critical splice donor site probably null
R8203:Gle1 UTSW 2 29,825,522 (GRCm39) missense probably benign
R8348:Gle1 UTSW 2 29,832,556 (GRCm39) missense possibly damaging 0.86
R9276:Gle1 UTSW 2 29,829,514 (GRCm39) missense possibly damaging 0.51
R9367:Gle1 UTSW 2 29,839,014 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTAGCAGGCTCCCTAGTGACCG -3'
(R):5'- CCTTGCAGCCAACAAGTCTTTTGTC -3'

Sequencing Primer
(F):5'- tgggaggcagaggcagg -3'
(R):5'- GCCAACAAGTCTTTTGTCTTAAGC -3'
Posted On 2013-11-08